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- Spengler, Mary L., et al. Show all 11 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.37 pp. E2457
- animal models; circadian rhythm; fibroblasts; genes; hepatocytes; immune response; immunomodulators; linkage (genetics); mice; mutation; pathogens; transcription (genetics); transcription factor NF-kappa B; transcriptional activation
- ... The circadian clock controls many physiological parameters including immune response to infectious agents, which is mediated by activation of the transcription factor NF-κB. It is widely accepted that circadian regulation is based on periodic changes in gene expression that are triggered by transcriptional activity of the CLOCK/BMAL1 complex. Through the use of a mouse model system we show that da ...
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