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1. Staphylococcus aureus-targeting peptide/surfactant assemblies for antibacterial therapy

Author:
Jian Jiang; Zhilong Xu; Jie Chen; Ze Xu; Ying Huang; Juqun Xi; Lei Fan
Source:
Colloids and surfaces 2022 v.214 pp. 112444
ISSN:
0927-7765
Subject:
methicillin-resistant Staphylococcus aureus,   etc   ; peptides; surfactants; therapeutics;     Show all 4 Subjects
Abstract:
... To address the challenge from microbial resistance, this work developed a surfactant with 18-carbon single hydrocarbon chain and multi-amine head groups (C18N3). After assembling with Staphylococcus aureus-targeting peptide (CARG), the obtained C18N3/CARG assemblies exhibited excellent antimicrobial activities against Staphylococcus aureus and methicillin-resistant Staphylococcus aureus in vitro a ...
DOI:
10.1016/j.colsurfb.2022.112444

2. Visible-light-induced bactericidal properties of a novel thiophene-based linear conjugated polymer/TiO₂ heterojunction

Author:
Juan Du; Renming Liu; Enwei Zhu; Haiyong Guo; Zhiyi Li; Chunbo Liu; Guangbo Che
Source:
Journal of materials chemistry B 2022 v.10 no.5 pp. 737-747
ISSN:
2050-7518
Subject:
Staphylococcus aureus,   etc   ; absorption; irradiation; light; photocatalysis; photocatalysts; polymerization; polymers;     Show all 8 Subjects
Abstract:
... The low utilization of visible light and the fast recombination of photogenerated electron–hole pairs are the two intrinsic defects that have hindered the antibacterial applications of TiO₂. The addition of organic photocatalytic agents to form heterojunctions with TiO₂ powder can effectively address these problems. A novel linear conjugated polymer poly[(thiophene–ethylene–thiophene)-thiophene-3- ...
DOI:
10.1039/d1tb02333k

3. Chimeric mutants of staphylococcal hemolysin, which act as both one‐component and two‐component hemolysin, created by grafting the stem domain

Author:
Nouran Ghanem; Natsuki Kanagami; Takashi Matsui; Kein Takeda; Jun Kaneko; Yasuyuki Shiraishi; Christian A. Choe; Tomomi Uchikubo‐Kamo; Mikako Shirouzu; Tsubasa Hashimoto; Tomohisa Ogawa; Tomoaki Matsuura; Po‐Ssu Huang; Takeshi Yokoyama; Yoshikazu Tanaka
Source:
FEBS journal 2022 v.289 no.12 pp. 3505-3520
ISSN:
1742-464X
Subject:
Staphylococcus aureus,   etc   ; cell membranes; electron microscopy; erythrocytes; hemolysins; transmembrane proteins;     Show all 6 Subjects
Abstract:
... Staphylococcus aureus expresses several hemolytic pore‐forming toxins (PFTs), which are all commonly composed of three domains: cap, rim and stem. PFTs are expressed as soluble monomers and assemble to form a transmembrane β‐barrel pore in the erythrocyte cell membrane. The stem domain undergoes dramatic conformational changes to form a pore. Staphylococcal PFTs are classified into two groups: one ...
DOI:
10.1111/febs.16354

4. Cost-Effective Screening of Antimicrobial Performance of Multiple Metal–Organic Frameworks via a Droplet-Based Batch Synthesis Platform

Author:
Chuan Fan; Lirong Wang; Yong Luo; Yongchao Song; Tailin Xu; Xueji Zhang
Source:
ACS sustainable chemistry & engineering 2022 v.10 no.19 pp. 6476-6482
ISSN:
2168-0485
Subject:
Staphylococcus aureus,   etc   ; Escherichia coli; cost effectiveness; droplets; green chemistry; pollution;     Show all 6 Subjects
Abstract:
... Metal–organic frameworks (MOFs) have recently been widely used in antimicrobial fields due to their adjustable composition and morphology. The inherent properties of MOFs (e.g., their shape, size, and metal element) are highly related to their antibacterial performance. The traditional beaker-based synthesis system to evaluate antibacterial properties of MOFs often leads to high reagent costs and ...
DOI:
10.1021/acssuschemeng.2c01725

5. Characteristics of chitosan fiber and their effects towards improvement of antibacterial activity

Author:
Jianhui Li; Jimin Fu; Xiao Tian; Tao Hua; Tszyin Poon; Mingkin Koo; Wingming Chan
Source:
Carbohydrate polymers 2022 v.280 pp. 119031
ISSN:
0144-8617
Subject:
Staphylococcus aureus,   etc   ; Candida albicans; Escherichia coli; antibacterial properties; chitosan; molecular weight;     Show all 6 Subjects
Abstract:
... We selected eight kinds of chitosan fibers to characterize and analyze their composition, surface morphology, and mechanical properties. Crucially, we investigated their antibacterial activity against Escherichia coli, Staphylococcus aureus and Candida albicans and the dependence on the molecular weight (Mw) and the degree of deacetylation (DD). On that basis, the relationship between antibacteria ...
DOI:
10.1016/j.carbpol.2021.119031

6. Defects and bacterial pathogens in udders of non-dairy breed ewes from New Zealand

Author:
Anne L. Ridler; Gabby Rout-Brown; Kate J. Flay; Niluka Velathanthiri; Alex Grinberg
Source:
New Zealand journal of agricultural research 2022 v.65 no.2-3 pp. 163-171
ISSN:
1175-8775
Subject:
Staphylococcus aureus,   etc   ; agricultural research; bacterial culture; hardness; milk; udders; New Zealand;     Show all 7 Subjects
Abstract:
... The objectives of this study were to identify the prevalence, incidence and range of udder defects in non-dairy breed ewes in New Zealand and to investigate the range of bacteria present in milk samples. The udders of 5700 mixed-age ewes on 11 sheep farms in the lower North Island of New Zealand were examined and scored at weaning. The majority were examined again 4–6 weeks later. Milk samples wer ...
DOI:
10.1080/00288233.2021.1905005

7. Pharmacodynamics of ceftriaxone for the treatment of methicillin‐susceptible Staphylococcus aureus: is it a viable treatment option?

Author:
A.J. Heffernan; F.B. Sime; S. Mohd Sazlly Lim; S. Adiraju; S.C. Wallis; J. Lipman; G.D. Grant; J.A. Roberts
Source:
International journal of antimicrobial agents 2022 v.59 no.3 pp. 106537
ISSN:
0924-8579
Subject:
Staphylococcus aureus,   etc   ; bacterial growth; ceftriaxone; inoculum; minimum inhibitory concentration; models; pharmacodynamics;     Show all 7 Subjects
Abstract:
... Ceftriaxone is a broad-spectrum cephalosporin that may be one option to treat methicillin-susceptible Staphylococcus aureus (MSSA). Although MSSA may be susceptible to ceftriaxone, the minimum inhibitory concentration (MIC) is generally two- to four-fold higher than other susceptible bacterial pathogens. This study aimed to explore the pharmacodynamics of ceftriaxone against MSSA and to determine ...
DOI:
10.1016/j.ijantimicag.2022.106537

8. Protein FT-IR amide bands are beneficial to bacterial typing

Author:
Jinghang Xie; Fan Yang; Haimei Shi; Jintao Yan; Hao Shen; Shaoning Yu; Ning Gan; Bin Feng; Li Wang
Source:
International journal of biological macromolecules 2022 v.207 pp. 358-364
ISSN:
0141-8130
Subject:
Staphylococcus aureus,   etc   ; Escherichia coli; Klebsiella pneumoniae; bacterial proteins; nucleic acids; polysaccharides;     Show all 6 Subjects
Abstract:
... Bacterial FT-IR signals are extremely specific and highly reproducible, making FT-IR an efficient tool for bacterial typing at the subspecies level. The polysaccharide and nucleic acid FT-IR regions (1200–900 cm⁻¹) are recommended as a precise and reproducible pattern for bacterial typing. However, proteins are the major macromolecules present in bacteria, and the FT-IR spectral region of proteins ...
DOI:
10.1016/j.ijbiomac.2022.02.161

9. Synthesis and antibacterial properties of new monomethyl fumaric acid‐modified chitosan oligosaccharide derivatives

Author:
Lingyu Zhao; Imran Mahmood Khan; Bin Wang; Lin Yue; Yin Zhang; Zhouping Wang; Wenshui Xia
Source:
International journal of food science & technology 2022 v.57 no.5 pp. 2872-2878
ISSN:
0950-5423
Subject:
Staphylococcus aureus,   etc   ; Escherichia coli; chitosan; food safety; fumaric acid; oligosaccharides; technology;     Show all 7 Subjects
Abstract:
... Inventions into chitosan oligosaccharide (COS) derivatives over recent decades have hugely broadened their application in food safety. Herein, monomethyl fumaric acid (MFA) was grafted on the OH position of COS to synthesise new COS‐O‐MFA derivatives and evaluated their in vitro antibacterial properties. The degrees of substitution (DS) of the derivatives yielded almost 15% with the range of 0.093 ...
DOI:
10.1111/ijfs.15556

10. Synthesis of silver nanoclusters in colloidal scaffold for biolabeling and antimicrobial applications

Author:
Jiaxin Xu; Mohankandhasamy Ramasamy; Teresa Tang; Yi Wang; Weinan Zhao; Kam Chiu Tam
Source:
Journal of colloid and interface science 2022 v.623 pp. 883-896
ISSN:
0021-9797
Subject:
Staphylococcus aureus,   etc   ; Escherichia; lighting; nanogels; nanosilver; photoirradiation; silver; ultraviolet radiation; yeasts;     Show all 9 Subjects
Abstract:
... A robust method to prepare silver nanoclusters (AgNCs) inside a methacrylic acid-ethyl acrylate (MAA-EA) nanogel is proposed, where AgNCs were produced within the nanogel scaffold via UV-photoreduction. The impact of UV irradiation time on the formation of AgNCs and their application in biolabeling and antimicrobial properties were examined. The AgNCs formation is described by two stages; (1) Agₙ ...
DOI:
10.1016/j.jcis.2022.05.084

11. Temporal sensing platform based on anodic dissolution of Ag and cathodic biocatalysis of oxygen reduction for Staphylococcus aureus detection

Author:
Bin Chen; Qin Tao; Fanglin Qiao; Yunjie Fei; Yuanjian Liu; Xiaohui Xiong; Songqin Liu
Source:
Food chemistry 2022 v.383 pp. 132404
ISSN:
0308-8146
Subject:
Staphylococcus aureus,   etc   ; biocatalysis; cathodes; detection limit; electrochemiluminescence; electrochemistry; food chemistry; oxygen;     Show all 8 Subjects
Abstract:
... An Ag@C hybrid bipolar electrode (BPE) sensing platform has been established for the temporal detection of Staphylococcus aureus (S. aureus) in food. Combining the advantages of anodic dissolution of Ag and cathodic biocatalysis of oxygen (O₂) reduction, this strategy showed an ultralow detection limit down to 10 CFU mL⁻¹. As the formation of Ag@C completely quenched the electrochemiluminescence ( ...
DOI:
10.1016/j.foodchem.2022.132404

12. Urban stormwater disinfection, quality variability during storage and influence on the freshwater algae: Implications for reuse safety

Author:
Shanshan Fan; Gang Wen; An Liu
Source:
Journal of environmental sciences (China) 2023 v.124 pp. 655-666
ISSN:
1001-0742
Subject:
Staphylococcus aureus,   etc   ; Escherichia coli; chlorination; disinfection; filtration; freshwater; stormwater; wastewater treatment; China;     Show all 9 Subjects
Abstract:
... Stormwater reuse is one of the most important ways to mitigate water resource shortage. However, urban stormwater contains many bacteria species, which threaten the reuse safety. Therefore, stormwater disinfection is highly needed. Although disinfection has been widely conducted in the drinking water and reclaimed water, it is rarely carried out for stormwater. This study collected the roof stormw ...
DOI:
10.1016/j.jes.2021.11.034

13. Host Environment Shapes S. aureus Social Behavior as Revealed by Microscopy Pattern Formation and Dynamic Aggregation Analysis

Author:
Natsuko Rivera-Yoshida; Marta Bottagisio; Davide Attanasi; Paolo Savadori; Elena De Vecchi; Alessandro Bidossi; Alessio Franci
Source:
Microorganisms 2022 v.10 no.3 pp. -
ISSN:
2076-2607
Subject:
Staphylococcus aureus,   etc   ; biofilm; confocal microscopy; immune system; orthopedics; phenotype; plankton; social behavior;     Show all 8 Subjects
Abstract:
... Understanding how bacteria adapt their social behavior to environmental changes is of crucial importance from both biological and clinical perspectives. Staphylococcus aureus is among the most common infecting agents in orthopedics, but its recalcitrance to the immune system and to antimicrobial treatments in the physiological microenvironment are still poorly understood. By means of optical and c ...
DOI:
10.3390/microorganisms10030526

14. Imidazole-stabilized gold nanoclusters with thiol depletion capacity for antibacterial application

Author:
Fang Gong; Rui Peng; Qing Wu; Hean Zhang; Yufeng Luo; Qianling Cui
Source:
Colloids and surfaces 2022 v.641 pp. 128608
ISSN:
0927-7757
Subject:
Staphylococcus aureus,   etc   ; antibacterial properties; imidazole; ligands; nanogold; oxidative stress; pH; temperature; thiols;     Show all 9 Subjects
Abstract:
... Surface ligand plays a crucial role in regulating the physicochemical properties and functionalities of gold nanoclusters (AuNCs). Compared to the widely studied thiolate-stabilized AuNCs, the reports on imidazole-based ligands to protect AuNCs are still rare. Herein, we report the facile preparation of imidazole-stabilized AuNCs using 1-vinylimidazole as both a reducing and capping agent. The coo ...
DOI:
10.1016/j.colsurfa.2022.128608

15. Insights into the role of F26 residue in the FMN: ATP adenylyltransferase activity of Staphylococcus aureus FAD synthetase

Author:
Anusree Lohithakshan; Raja Narayanasamy; Prashant Deshmukh; Dandamudi Usharani; Ravi Kumar
Source:
Biochimica et biophysica acta 2022 v.1870 no.5 pp. 140781
ISSN:
1570-9639
Subject:
Staphylococcus aureus,   etc   ; amino acid sequences; flavin-adenine dinucleotide; flavoproteins; molecular dynamics; mutants;     Show all 6 Subjects
Abstract:
... The bifunctional flavin adenine dinucleotide synthetase (FADS) synthesizes the flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) co-factors essential for the function of flavoproteins. The Staphylococcus aureus FADS (SaFADS) produces FMN from riboflavin (RF) by ATP:riboflavin kinase (RFK) activity at its C-terminal domain. The N-terminal domain converts FMN to FAD under a reducing ...
DOI:
10.1016/j.bbapap.2022.140781

16. Superoxide Radical-Mediated Self-Synthesized Au/MoO₃–ₓ Hybrids with Enhanced Peroxidase-like Activity and Photothermal Effect for Anti-MRSA Therapy

Author:
Mengyu Cao; Zhishang Chang; Jinshan Tan; Xiaoning Wang; Pengfei Zhang; Sen Lin; Jingquan Liu; Aihua Li
Source:
ACS applied materials & interfaces 2022 v.14 no.11 pp. 13025-13037
ISSN:
1944-8252
Subject:
methicillin-resistant Staphylococcus aureus,   etc   ; biofilm; biosafety; mortality; peroxidase; superoxide anion; therapeutics; toxicity;     Show all 8 Subjects
Abstract:
... A rapid increase in methicillin-resistant Staphylococcus aureus (MRSA) induced infection has been noticed in recent years and the biofilm formed by MRSA further delays wound healing, causing a high mortality rate. Hence, a safe and effective superoxide radical (O₂•–) mediated self-synthesis strategy is developed to prepare Au-doped MoO₃–ₓ (Au/MoO₃–ₓ) plasmonic-semiconductor hybrid for the eliminat ...
DOI:
10.1021/acsami.1c23676

17. Weigela florida inhibits the expression of inflammatory mediators induced by Pseudomonas aeruginosa and Staphylococcus aureus infection

Author:
Hyo Bin Kim; Soomin Cho; Yeji Lee; Weihui Wu; Un-Hwan Ha
Source:
journal of microbiology 2022 v.60 no.6 pp. 649-656
ISSN:
1976-3794
Subject:
Staphylococcus aureus,   etc   ; Pseudomonas aeruginosa; Weigela florida; bacterial infections; cytokines; macrophages; microbiology; phosphorylation;     Show all 8 Subjects
Abstract:
... Inflammatory responses involve the action of inflammatory mediators that are necessary for the clearance of invading bacterial pathogens. However, excessive production of inflammatory mediators can damage tissues, thereby impairing bacterial clearance. Here, we examined the effects of Weigela florida on the expression of inflammatory cytokines induced by Pseudomonas aeruginosa or Staphylococcus au ...
DOI:
10.1007/s12275-022-1638-6

18. Directed Inter-domain Motions Enable the IsdH Staphylococcus aureus Receptor to Rapidly Extract Heme from Human Hemoglobin

Author:
Joseph Clayton; Kat Ellis-Guardiola; Brendan J. Mahoney; Jess Soule; William Liu; Robert T. Clubb; Jeff Wereszczynski
Source:
Journal of molecular biology 2022 v.434 no.12 pp. 167623
ISSN:
0022-2836
Subject:
Staphylococcus aureus,   etc   ; amino acid sequences; heme; hemoglobin; humans; iron; molecular biology; mutants; solvents;     Show all 9 Subjects
Abstract:
... Pathogenic Staphylococcus aureus actively acquires iron from human hemoglobin (Hb) using the IsdH surface receptor. Heme extraction is mediated by a tri-domain unit within the receptor that contains its second (N2) and third (N3) NEAT domains joined by a helical linker domain. Extraction occurs within a dynamic complex, in which receptors engage each globin chain; the N2 domain tightly binds to Hb ...
DOI:
10.1016/j.jmb.2022.167623

19. Metallosurfactant based synthetic liposomes as a substitute for phospholipids to safely store curcumin

Author:
Baljinder Kaur; Navdeep Kaur; Tanvi Sharma; Gurpreet Kaur; Ganga Ram Chaudhary
Source:
Colloids and surfaces 2022 v.217 pp. 112621
ISSN:
0927-7765
Subject:
methicillin-resistant Staphylococcus aureus,   etc   ; DNA; cholesterol; curcumin; drugs; hydrolysis; hydrophobicity; micelles; phospholipids; therapeutics;     Show all 10 Subjects
Abstract:
... Curcumin has shown remarkable therapeutic utilization for various medical conditions. Still, its limited chemical stability and rapid hydrolysis capped its applications to a certain extent. Approaches have been made in the past to surpass these shortcomings by encapsulating the drug in surfactant-based micelles or liposomes and so far, natural surfactants have been used to do this bidding. Through ...
DOI:
10.1016/j.colsurfb.2022.112621

20. New Tripeptide Derivatives Asperripeptides A–C from Vietnamese Mangrove-Derived Fungus Aspergillus terreus LM.5.2

Author:
Elena V. Girich; Anton B. Rasin; Roman S. Popov; Ekaterina A. Yurchenko; Ekaterina A. Chingizova; Phan Thi Hoai Trinh; Ngo Thi Duy Ngoc; Mikhail V. Pivkin; Olesya I. Zhuravleva; Anton N. Yurchenko
Source:
Marine drugs 2022 v.20 no.1 pp. -
ISSN:
1660-3397
Subject:
Staphylococcus aureus,   etc   ; Aspergillus terreus; cinnamic acid; cytotoxicity; fungi; neoplasm cells; sortase A; tripeptides;     Show all 8 Subjects
Abstract:
... Three new tripeptide derivatives asterripeptides A–C (1–3) were isolated from Vietnamese mangrove-derived fungus Aspergillus terreus LM.5.2. Structures of isolated compounds were determined by a combination of NMR and ESIMS techniques. The absolute configurations of all stereocenters were determined using the Murfey’s method. The isolated compounds 1–3 contain a rare fungi cinnamic acid residue. T ...
DOI:
10.3390/md20010077