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- Steinhorn, Benjamin S., et al. Show all 9 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2014 v.111 no.9 pp. 3383-3388
- AMP-activated protein kinase; adenosine diphosphate; antagonists; biosensors; cardiovascular diseases; cytosol; drug therapy; endothelial cells; endothelial nitric oxide synthase; endothelium; energy; fluorescence; guanosinetriphosphatase; hydrogen peroxide; image analysis; microfilaments; mitochondria; neoplasms; phospholipids; phosphorylation; receptor protein-tyrosine kinase; receptors; signal transduction; transcriptional activation; tyrosine
- ... ADP activates a family of cell surface receptors that modulate signaling pathways in a broad range of cells. ADP receptor antagonists are widely used to treat cardiovascular disease states. These studies identify a critical role for the stable reactive oxygen species hydrogen peroxide (H ₂O ₂) in mediating cellular responses activated by the G protein-coupled P2Y1 receptor for ADP. We found that A ...
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