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You searched for: Author "Stephen Spatz" Remove constraint Author: "Stephen Spatz"
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1. Circulation and Molecular Characterization of Hemorrhagic Enteritis Virus in Commercial Turkey and Meat Chicken Flocks in Australia

Author:
Stephen Spatz,   et al.   ; Priscilla F. Gerber; Peter Gray; Sheridan Alfirevich; Stephen W. Walkden-Brown;     Show all 5 Authors
Source:
Avian diseases 2022 v.66 no.1 pp. 53-59
ISSN:
0005-2086
Subject:
Aviadenovirus; DNA; blood serum; chickens; genome; genomics; meat; seroprevalence; spleen; vaccines; virulence; viruses; Australia
Abstract:
... Currently, there is no available vaccine against hemorrhagic enteritis virus (HEV) in Australia. Although it is assumed that subclinical HEV infections occur and may be associated with an increase in colibacillosis in Australian commercial turkey flocks, the prevalence of infection with this virus in the country is largely unknown. The aims of this study were to determine the extent of HEV infecti ...
DOI:
10.1637/21-00095

2. Pervasive Differential Splicing in Marek’s Disease Virus Can Discriminate CVI-988 Vaccine Strain from RB-1B Very Virulent Strain in Chicken Embryonic Fibroblasts

Author:
Stephen Spatz,   et al.   ; Yashar Sadigh; Abdessamad Tahiri-Alaoui; Venugopal Nair; Paolo Ribeca;     Show all 5 Authors
Source:
Viruses 2020 v.12 no.3 pp. -
ISSN:
1999-4915
Subject:
Mardivirus; Marek disease; RNA; chickens; fibroblasts; pathogenesis; poultry health; sequence homology; transcriptome; vaccines; virulence; virulent strains
Abstract:
... Marek’s disease is a major scourge challenging poultry health worldwide. It is caused by the highly contagious Marek’s disease virus (MDV), an alphaherpesvirus. Here, we showed that, similar to other members of its Herpesviridae family, MDV also presents a complex landscape of splicing events, most of which are uncharacterised and/or not annotated. Quite strikingly, and although the biological rel ...
DOI:
10.3390/v12030329

3. Genetic stability of a Newcastle disease virus vectored infectious laryngotracheitis virus vaccine after serial passages in chicken embryos

Author:
Stephen Spatz,   et al.   ; Qingzhong Yu; Yufeng Li; Kiril Dimitrov; Claudio L. Afonso; Laszlo Zsak;     Show all 6 Authors
Source:
Vaccine 2020 v.38 no.4 pp. 925-932
ISSN:
0264-410X
Subject:
Avian orthoavulavirus 1; Gallid alphaherpesvirus 1; chick embryos; chicken eggs; chickens; fluorescent antibody technique; genes; genetic stability; glycoproteins; growth models; high-throughput nucleotide sequencing; recombinant vaccines; reverse transcriptase polymerase chain reaction; single nucleotide polymorphism; virulence; viruses
Abstract:
... Previously, we have demonstrated that the recombinant Newcastle disease virus (NDV) expressing the infectious laryngotracheitis virus (ILTV) glycoprotein D (gD) conferred protection against both virulent NDV and ILTV challenges in chickens. In this study, we evaluated the genetic stability of the recombinant vaccine after eight serial passages in embryonated chicken eggs (ECE). The vaccine master ...
DOI:
10.1016/j.vaccine.2019.10.074
CHORUS:
10.1016/j.vaccine.2019.10.074

4. Generation of Newcastle diease virus (NDV) recombinants expressing the infectious laryngotracheitis virus (ILTV) glycoprotein gB or gD as dual vaccines

Author:
Stephen Spatz,   et al.   ; Wei Zhao; Laszlo Zsak; Qingzhong Yu;     Show all 4 Authors
Source:
Vaccine design: Methods and protocols, Volume 2: Vaccines for Veterinary Diseases 2016 v.1404 pp. 89-101
ISSN:
1064-3745
Subject:
chickens; Newcastle disease; Gallid alphaherpesvirus 1; respiratory tract diseases; live vaccines; virulence; Avian orthoavulavirus 1; viral proteins; viruses; recombinant vaccines; vaccine development; viral vaccines; genetic vectors; glycoproteins
Abstract:
... Infectious laryngotracheitis (ILT) is a highly contagious acute respiratory disease of chickens caused by infection of infectious laryngotracheitis virus (ILTV). The current commercial ILT vaccines are either not safe or less effective. Therefore, there is a pressing need to develop safer and more efficacious ILTV vaccines. Newcastle disease (ND), caused by infection with virulent Newcastle diseas ...
Handle:
10113/62588
DOI:
10.1007/978-1-4939-3389-1_6

5. Newcastle disease virus vectored infectious laryngotracheitis vaccines protect commercial broiler chickens in the presence of maternally derived antibodies

Author:
Stephen Spatz,   et al.   ; Qingzhong Yu; Yufeng Li; Jilong Yang; Wei Zhao; Zhenyu Zhang; Guoyuan Wen; Maricarmen Garcia; Laszlo Zsak;     Show all 9 Authors
Source:
Vaccine 2017 v.35 no.5 pp. 789-795
ISSN:
0264-410X
Subject:
neutralization; broiler chickens; hemagglutination; Gallid alphaherpesvirus 1; antibodies; vaccines; secondary immunization; Avian orthoavulavirus 1; tissues; maternal immunity; virulence; glycoproteins
Abstract:
... Newcastle disease virus (NDV) recombinants expressing the infectious laryngotracheitis virus (ILTV) glycoproteins B and D have previously been demonstrated to confer complete clinical protection against virulent ILTV and NDV challenges in naive chickens. We extended this study to assess whether maternally derived antibody (MDA) against NDV and ILTV would interfere with protection in vaccinated bro ...
Handle:
10113/5603951
DOI:
10.1016/j.vaccine.2016.12.038
CHORUS:
10.1016/j.vaccine.2016.12.038
Chorus Open Access:
10.1016/j.vaccine.2016.12.038

6. Molecular epidemiology of infectious laryngotracheitis: a review

Author:
Stephen Spatz,   et al.   ; Kimberly R. Menendez; Maricarmen García; Nathaniel L. Tablante;     Show all 4 Authors
Source:
Avian pathology 2014 v.43 no.2 pp. 108-117
ISSN:
1465-3338
Subject:
Gallid alphaherpesvirus 1; viral diseases of animals and humans; poultry production; respiratory tract diseases; live vaccines; poultry diseases; viral antigens; disease outbreaks; genes; molecular epidemiology; nucleotide sequences; vaccination; genetic variation; virulence; disease incidence
Abstract:
... Infectious laryngotracheitis (ILT) is an economically important respiratory disease of poultry that affects the poultry industry worldwide. The disease is caused by gallid herpesvirus I (GaHV-1), a member of the genus Iltovirus , family Herpesviridae , subfamily Alphaherpesvirinae . The current incidence of the disease is heavily influenced by live attenuated vaccines, which have been used extensi ...
Handle:
10113/60113
DOI:
10.1080/03079457.2014.886004
PubMed:
24460399

7. Genomic sequence analysis of the United States infectious laryngotracheitis vaccine strains chicken embryo origin (CEO) and tissue culture origin (TCO)

Author:
Stephen Spatz,   et al.   ; Maricarmen García; Jeremy Volkening; Sylva Riblet;     Show all 4 Authors
Source:
Virology 2013 v.440 no.1 pp. 64-74
ISSN:
0042-6822
Subject:
chickens; Gallid alphaherpesvirus 1; hybrids; open reading frames; high-throughput nucleotide sequencing; vaccines; phylogeny; mutation; genes; genomics; strains; virulence; glycoproteins; tissue culture; United States
Abstract:
... The genomic sequences of low and high passages of the United States infectious laryngotracheitis (ILT) vaccine strains CEO and TCO were determined using hybrid next generation sequencing in order to define genomic changes associated with attenuation and reversion to virulence. Phylogenetic analysis of available full genomes grouped strains into three major clades: TCO, CEO, and Australian. Compara ...
Handle:
10113/62776
DOI:
10.1016/j.virol.2013.02.007

8. A phylogenomic analysis of Marek’s disease virus (MDV) reveals independent paths to virulence in Eurasia and North America

Author:
Stephen Spatz,   et al.   ; Jakob Trimpert; Nicole Groenke; Maria Jenckel; Shulin He; Dusan Kunec; Moriah Szpara; Nikolaus Osterrieder; Dino McMahon;     Show all 9 Authors
Source:
Evolutionary applications 2017 v.10 no.10 pp. 1091-1101
ISSN:
1752-4571
Subject:
Gallid alphaherpesvirus 2; Marek disease; chickens; disease control; emerging diseases; evolutionary adaptation; genetic variation; genotype; geographical variation; intensive livestock farming; mutation; phenotype; phylogeny; phylogeography; poultry production; vaccination; viral genome; virulence; virulent strains; Eurasia; North America
Abstract:
... Virulence determines the impact a pathogen has on the fitness of its host, yet current understanding of the evolutionary origins and causes of virulence of many pathogens is surprisingly incomplete. Here, we explore the evolution of Marek's disease virus (MDV), a herpesvirus commonly afflicting chickens and rarely other avian species. The history of MDV in the 20th century represents an important ...
Handle:
10113/6472307
DOI:
10.1111/eva.12515
PubMed:
29151863
PubMed Central:
PMC5680632

9. Protective efficacy of a recombinant bacterial artificial chromosome clone of a very virulent Marek’s disease virus containing a reticuloendotheliosis virus long terminal repeat

Author:
Stephen Spatz,   et al.   ; Jody K. Mays; Alexis Black-Pyrkosz; Aly M. Fadly; John R. Dunn;     Show all 5 Authors
Source:
Avian pathology 2016 v.45 no.6 pp. 657-666
ISSN:
1465-3338
Subject:
Mardivirus; Marek disease; Reticuloendotheliosis virus; T-lymphocytes; antibodies; atrophy; bacterial artificial chromosomes; chickens; lymphoma; mortality; nerve tissue; terminal repeat sequences; vaccination; vaccines; virulence; virulent strains; viruses
Abstract:
... Marek’s disease virus (MDV), an alphaherpesvirus, causes Marek’s disease (MD), a lymphoproliferative disease in poultry characterized by T-cell lymphomas, nerve lesions, and mortality. Vaccination is used worldwide to control MD, but increasingly virulent field strains can overcome this protection, driving a need to create new vaccines. Previous studies revealed that insertion of reticuloendotheli ...
DOI:
10.1080/03079457.2016.1197376

10. Genetic diversity of infectious laryngotracheitis virus during in vivo coinfection parallels viral replication and arises from recombination hot spots within the genome

Author:
Stephen Spatz,   et al.   ; Carlos Loncoman; Carol Hartley; Mauricio Coppo; Paola Vaz; Andres Diaz-Mendez; Glenn Browning; Maricarmen Garcia; Joanne Devlin;     Show all 9 Authors
Source:
Applied and environmental microbiology 2017 v.8 no.23 pp. 1-18
ISSN:
0099-2240
Subject:
Gallid alphaherpesvirus 1; animal health; chickens; control methods; disease control; evolution; genetic recombination; genetic variation; genome; genotyping; industry; mixed infection; poultry diseases; progeny; respiratory tract diseases; single nucleotide polymorphism; specific pathogen-free animals; vaccines; virulence; virus replication; viruses
Abstract:
... Recombination is a feature of many alphaherpesviruses that infect people and animals. Infectious laryngotracheitis virus (ILTV; Gallid alphaherpesvirus 1) causes respiratory disease in chickens, resulting in significant production losses in poultry industries worldwide. Natural (field) ILTV recombination is widespread, particularly recombination between attenuated ILTV vaccine strains to create vi ...
Handle:
10113/6471139
DOI:
10.1128/AEM.01532-17
PubMed:
28939604
PubMed Central:
PMC5691407

11. Newcastle Disease Virus (NDV) Recombinants Expressing Infectious Laryngotracheitis Virus (ILTV) Glycoproteins gB and gD Protect Chickens against ILTV and NDV Challenges

Author:
Stephen Spatz,   et al.   ; Wei Zhao; Zhenyu Zhang; Guoyuan Wen; Maricarmen Garcia; Laszlo Zsak; Qingzhong Yu;     Show all 7 Authors
Source:
Journal of virology 2014 v.88 no.15 pp. 8397-8406
ISSN:
0022-538X
Subject:
disease prevention; Avian orthoavulavirus 1; vaccination; broiler chickens; Gallid alphaherpesvirus 1; aerosols; viruses; virulence; glycoproteins; genetic recombination; vaccine development; drinking water; fluorescent antibody technique; adverse effects; tissue culture; weight gain; protein synthesis; specific pathogen-free animals; live vaccines; viral proteins; recombinant vaccines; genetic vectors
Abstract:
... Infectious laryngotracheitis (ILT) is a highly contagious acute respiratory disease of chickens caused by infectious laryngotracheitis virus (ILTV). The disease is controlled mainly through biosecurity and vaccination with live attenuated strains of ILTV and vectored vaccines based on turkey herpesvirus (HVT) and fowlpox virus (FPV). The current live attenuated vaccines (chicken embryo origin [CEO ...
Handle:
10113/59865
DOI:
10.1128/JVI.01321-14
PubMed:
no direct match
PubMed Central:
PMC4135966

12. Thermal Inactivation of Avian Viral and Bacterial Pathogens in an Effluent Treatment System Within a Biosafety Level 2 and 3 Enhanced Facility

Author:
Stephen Spatz,   et al.   ; Revis Chmielewski; Michael Day; Qingzhong Yu; Richard Gast; Laslo Zsak; David Swayne;     Show all 7 Authors
Source:
Applied Biosafety 2011 v.16 no.4 pp. 206-217
ISSN:
1535-6760
Subject:
Rotavirus; biosafety; energy-dispersive X-ray analysis; Avian orthoavulavirus 1; biomedical research; Protoparvovirus; heat tolerance; Salmonella Enteritidis; Avian metapneumovirus; sterilizing; viruses; bacterial infections; laboratories; decontamination; heat; models; in vitro studies; temperature; mortality; Turkey astrovirus; heat inactivation; buffers; turkeys; Influenza A virus; margin of safety; animal viruses; Mardivirus; avian influenza; disinfection; bacteria
Abstract:
... Avian influenza (AI) virus, avian paramyxovirus Type 1 (APMV-1 or NDV), reovirus, rotavirus, turkey astrovirus (TAst), avian metapneumovirus (aMPV), Marek’s disease virus (MDV-1), avian parvovirus (ChPV), and Salmonella enterica serovar Enteritidis are significant biosafety level 2 (BSL-2) or biosafety level 3 enhanced (BSL-3E) pathogens of poultry that are studied in veterinary medical research l ...
Handle:
10113/61304