Jump to Main Content
- Stephenson, Kyle B., et al. Show all 7 Authors
- Vaccine 2018 v.36 no.16 pp. 2181-2192
- CD8-positive T-lymphocytes; Maraba virus; Papillomaviridae; antigens; immune response; mice; models; neoplasm cells; neoplasms; peptides; sterilizing; vaccination; vaccines
- ... Human papilloma virus (HPV)-associated cancer is a significant global health burden and despite the presence of viral transforming antigens within neoplastic cells, therapeutic vaccinations are ineffective for advanced disease. HPV positive TC1 cells are susceptible to viral oncolysis by MG1-E6E7, a custom designed oncolytic Maraba virus. Epitope mapping of mice vaccinated with MG1-E6E7 enabled th ...