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- Stokowski, R.S., et al. Show all 10 Authors
- Proceedings of the National Academy of Sciences of the United States of America 1996 v.93 no.13 pp. 6393-6398
- blood lipids; phenotype; structural genes; blood proteins; apolipoproteins; very low density lipoprotein; triacylglycerols; mice; homologous recombination; low density lipoprotein; cholesterol; mutants; gene targeting; blood plasma; site-directed mutagenesis; embryogenesis
- ... Apolipoprotein (apo)-B is found in two forms in mammals: apo-B100, which is made in the liver and the yolk sac, and apo-B48, a truncated protein made in the intestine. To provide models for understanding the physiologic purpose for the two forms of apo-B, we used targeted mutagenesis of the apo-B gene to generate mice that synthesize exclusively apo-B48 (apo-B48-only mice) and mice that synthesize ...
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