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- STRINGER, JAMES R.
- Journal of eukaryotic microbiology 2007 v.54 no.1 pp. 8-13
- Pneumocystis; antigenic variation; fungi; gene conversion; genes; glycoproteins; hosts; humans; parasitism; pneumonia; rats
- ... Pneumocystis is a genus containing many species of non-culturable fungi, each of which infects a different mammalian host. Pneumonia caused by Pneumocystis is a problem in immunodeficient humans, but not in normal humans. Nevertheless, it appears that Pneumocystis organisms cannot survive and proliferate outside of their mammalian hosts, suggesting that Pneumocystis parasitizes immunocompetent mam ...
- STRINGER, JAMES R., et al. Show all 6 Authors
- The journal of eukaryotic microbiology 2011 v.58 no.4 pp. 383-392
- Pneumocystis carinii; Saccharomyces cerevisiae; biosynthesis; complementary DNA; drugs; ergosterol; gas chromatography-mass spectrometry; genes; high performance liquid chromatography; mutants; nuclear magnetic resonance spectroscopy; pneumonia; quantitative analysis; rats; thin layer chromatography; yeasts
- ... Pneumocystis carinii is an unusual fungus that can cause pneumonitis in immunosuppressed laboratory rats. Reactions in sterol biosynthesis are attractive targets for development of antimycotic drugs. A key enzyme in sterol biosynthesis is sterol 14α-demethylase (14DM), which is coded by the erg11 gene. Here we describe detailed sterol analysis of wild-type Saccharomyces cerevisiae and in an erg11 ...
- Stringer, James R., et al. Show all 8 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.24 pp. 9454-9459
- DNA damage; DNA repair; actinomycin D; alpha-amanitin; chromosomes; free radicals; genes; genotoxicity; humans; intergenic DNA; interphase; ionizing radiation; proteins; somatic cells; transcription (genetics)
- ... Double-strand DNA breaks (DSBs) are continuously induced in cells by endogenously generated free radicals and exogenous genotoxic agents such as ionizing radiation. DSBs activate the kinase activity in sensor proteins such as ATM and DNA-PK, initiating a complex DNA damage response that coordinates various DNA repair pathways to restore genomic integrity. In this study, we report the unexpected fi ...
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