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- Sun, S.C.C., et al. Show all 8 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2000 v.97 no.14 pp. 7981-7986
- Bovine viral diarrhea virus; Border disease virus; Classical swine fever virus; antiviral agents; mechanism of action; virus replication; DNA-directed RNA polymerase; enzyme inhibitors; enzyme activity; mutants; drug resistance; RNA; antiviral properties
- ... We report here the discovery of a small molecule inhibitor of pestivirus replication. The compound, designated VP32947, inhibits the replication of bovine viral diarrhea virus (BVDV) in cell culture at a 50% inhibitory concentration of approximately 20 nM. VP32947 inhibits both cytopathic and noncytopathic pestiviruses, including isolates of BVDV-1, BVDV-2, border disease virus, and classical swin ...
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