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- Author:
- James T. Caldwell, et al. ; Daniel J. Mermelstein; Ross C. Walker; Sanford I. Bernstein; Tom Huxford; Show all 5 Authors
- Source:
- Journal of molecular biology 2020 v.432 no.2 pp. 427-447
- ISSN:
- 0022-2836
- Subject:
- Drosophila melanogaster; X-ray diffraction; amino acid substitution; binding sites; citrates; contractile proteins; crystal structure; crystallization; exons; flight muscles; fruit flies; molecular dynamics; muscular diseases; myosin heavy chains; proteolysis; simulation models; skeletal muscle; transgenic insects
- Abstract:
- ... Drosophila melanogaster is a powerful system for characterizing alternative myosin isoforms and modeling muscle diseases, but high-resolution structures of fruit fly contractile proteins have not been determined. Here we report the first x-ray crystal structure of an insect myosin: the D melanogaster skeletal muscle myosin II embryonic isoform (EMB). Using our system for recombinant expression of ...
- DOI:
- 10.1016/j.jmb.2019.11.013
- PubMed:
- 31786266
- PubMed Central:
- PMC6995774
- https://doi.org/10.1016/j.jmb.2019.11.013
- Author:
- Stuart T. Caldwell, et al. ; Sean N. O'Byrne; Calum Wilson; Filip Cvetko; Michael P. Murphy; John G. McCarron; Richard C. Hartley; Show all 7 Authors
- Source:
- Chemical communications 2021 v.57 no.32 pp. 3917-3920
- ISSN:
- 1364-548X
- Subject:
- anions; chemical communication; photoirradiation; sulfonates; trapping; traps
- Abstract:
- ... Photouncaging delivers compounds with high spatial and temporal control to induce or inhibit biological processes but the released compounds may diffuse out. We here demonstrate that sulfonate anions can be photocaged so that a membrane impermeable compound can enter cells, be uncaged by photoirradiation and trapped within the cell. ...
- DOI:
- 10.1039/d0cc07713e
- https://doi.org/10.1039/d0cc07713e
- Author:
- Stuart T. Caldwell, et al. ; Kishore K. Gaddale Devanna; Justyna M. Gawel; Tracy A. Prime; Filip Cvetko; Cristiane Benincá; Alexander Negoda; Andrew Harrison; Andrew M. James; Evgeny V. Pavlov; Michael P. Murphy; Richard C. Hartley; Show all 12 Authors
- Source:
- Chemical communications 2021 v.57 no.25 pp. 3147-3150
- ISSN:
- 1364-548X
- Subject:
- lipophilicity; lysosomes; membrane potential; mitochondria
- Abstract:
- ... Tetraphenylborate (TPB) anions traverse membranes but are excluded from mitochondria by the membrane potential (Δψ). TPB-conjugates also distributed across membranes in response to Δψ, but surprisingly, they rapidly entered cells. They accumulated within lysosomes following endocystosis. This pH-independent targeting of lysosomes makes possible new classes of probe and bioactive molecules. ...
- DOI:
- 10.1039/d0cc07924c
- https://doi.org/10.1039/d0cc07924c
- Author:
- Stuart T. Caldwell, et al. ; Sih Min Tan; Runa S. J. Lindblom; Mark Ziemann; Adrienne Laskowski; Cesare Granata; Matthew Snelson; Vicki Thallas-Bonke; Assam El-Osta; Carlos D. Baeza-Garza; Richard C. Hartley; Thomas Krieg; Mark E. Cooper; Michael P. Murphy; Melinda T. Coughlan; Show all 15 Authors
- Source:
- Nutrients 2021 v.13 no.5 pp. -
- ISSN:
- 2072-6643
- Subject:
- albuminuria; blood glucose; body composition; diabetes; electron transfer; fibrosis; glycemic control; heterozygosity; immune system; kidney diseases; kidneys; males; mitochondria; models; pathogenesis; phenotype; post-translational modification; therapeutics; transcriptomics
- Abstract:
- ... Diabetic kidney disease (DKD) remains the number one cause of end-stage renal disease in the western world. In experimental diabetes, mitochondrial dysfunction in the kidney precedes the development of DKD. Reactive 1,2-dicarbonyl compounds, such as methylglyoxal, are generated from sugars both endogenously during diabetes and exogenously during food processing. Methylglyoxal is thought to impair ...
- DOI:
- 10.3390/nu13051457
- https://doi.org/10.3390/nu13051457
- Author:
- Julia T. Caldwell, et al. ; Haena Lee; Kathleen A. Cagney; Show all 3 Authors
- Source:
- Journal of rural health 2017 v.33 no.4 pp. 409-418
- ISSN:
- 0890-765X
- Subject:
- Blacks; Whites; elderly; health services; oral hygiene; regression analysis; rural areas; rural health; urban areas; United States
- Abstract:
- ... CONTEXT: Rural populations often have restricted access to dental care and poor oral health. These problems may disproportionately affect older blacks in rural areas. Little is known about how access to primary health care may improve the oral health of rural seniors. PURPOSE: This study examines whether the relationship between having a usual source of health care and oral health varies for white ...
- DOI:
- 10.1111/jrh.12269
- https://doi.org/10.1111/jrh.12269
- Author:
- Jacob T. Caldwell, et al. ; Shelbi L. Sutterfield; Hunter K. Post; Garrett M. Lovoy; Heather R. Banister; Vanessa-Rose G. Turpin; Trenton D. Colburn; Stephen S. Hammond; Steven W. Copp; Carl J. Ade; Show all 10 Authors
- Source:
- Applied physiology, nutrition and metabolism 2020 v.45 no.6 pp. 613-620
- ISSN:
- 1715-5320
- Subject:
- arms (limbs); blood flow; blood pressure; excretion; exercise; females; heart rate; humans; hypertension; males; metabolism; nutrition; pressure; risk factors; sodium; testing; ultrasonography; urine; vasoconstriction
- Abstract:
- ... High dietary sodium intake is a risk factor for arterial hypertension; given that the ability to overcome sympathetically mediated vasoconstriction (functional sympatholysis) is attenuated in individuals with hypertension, we investigated the cardiovascular responses to high salt (HS) intake in healthy humans. We hypothesized that a HS intake of 15 g/day for 7 days would attenuate functional sympa ...
- DOI:
- 10.1139/apnm-2019-0445
- https://doi.org/10.1139/apnm-2019-0445
- Author:
- T. Caldwell, et al. ; T.C. Bruinjé; P. Ponce-Barajas; A. Dourey; M.G. Colazo; Z. Wang; S.P. Miller; D.J. Ambrose; Show all 8 Authors
- Source:
- Canadian journal of animal science 2018 v.99 no.3 pp. 456-464
- ISSN:
- 1918-1825
- Subject:
- acrosome; beef bulls; crossbreds; feed conversion; feed intake; flow cytometry; membrane potential; microscopy; mitochondria; mitochondrial membrane; viability; yearlings
- Abstract:
- ... The objectives of this study were to compare morphology, plasma and acrosome membrane integrities, and mitochondrial function in sperm of bulls selected for low- vs. high-residual feed intake (RFI). Semen samples obtained from 10 low- and 8 high-RFI yearling crossbred beef bulls were evaluated. Assessment of sperm morphology was performed by microscopy, and sperm membrane integrity and mitochondri ...
- DOI:
- 10.1139/cjas-2018-0103
- https://doi.org/10.1139/cjas-2018-0103
- Author:
- T. Caldwell, et al. ; J. Kolassa; R.H. Reichle; Q. Liu; S.H. Alemohammad; P. Gentine; K. Aida; J. Asanuma; S. Bircher; A. Colliander; M. Cosh; C. Holifield Collins; T.J. Jackson; J. Martínez-Fernández; H. McNairn; A. Pacheco; M. Thibeault; J.P. Walker; Show all 18 Authors
- Source:
- Remote sensing of environment 2018 v.204 pp. 43-59
- ISSN:
- 0034-4257
- Subject:
- Earth Observing System; algorithms; climatology; image analysis; microwave radiometers; neural networks; remote sensing; satellites; soil temperature; soil water; vegetation; water content
- Abstract:
- ... A Neural Network (NN) algorithm was developed to estimate global surface soil moisture for April 2015 to March 2017 with a 2–3day repeat frequency using passive microwave observations from the Soil Moisture Active Passive (SMAP) satellite, surface soil temperatures from the NASA Goddard Earth Observing System Model version 5 (GEOS-5) land modeling system, and Moderate Resolution Imaging Spectrorad ...
- DOI:
- 10.1016/j.rse.2017.10.045
- PubMed:
- 29290638
- PubMed Central:
- PMC5744888
- https://doi.org/10.1016/j.rse.2017.10.045
- Author:
- Stuart T. Caldwell, et al. ; Andrew G. Cairns; Marnie Olson; Susan Chalmers; Mairi Sandison; William Mullen; John G. McCarron; Richard C. Hartley; Show all 8 Authors
- Source:
- Tetrahedron 2015 v.71 pp. 9571-9578
- ISSN:
- 0040-4020
- Subject:
- calcium; cell communication; chemical bonding; chemical reactions; chemical structure; endoplasmic reticulum; ions; organic compounds
- Abstract:
- ... Changes in high localised concentrations of Ca2+ ions are fundamental to cell signalling. The synthesis of a dual excitation, ratiometric calcium ion sensor with a Kd of 90 μM, is described. It is tagged with an azido group for bioconjugation, and absorbs in the blue/green and emits in the red region of the visible spectrum with a large Stokes shift. The binding modulating nitro group is introduce ...
- DOI:
- 10.1016/j.tet.2015.10.052
- PubMed:
- 26709317
- PubMed Central:
- PMC4660056
- https://doi.org/10.1016/j.tet.2015.10.052
- Author:
- James T. Caldwell, et al. ; Girish C. Melkani; Tom Huxford; Sanford I. Bernstein; Show all 4 Authors
- Source:
- Methods 2012 v.56 no.1 pp. 25-32
- ISSN:
- 1046-2023
- Subject:
- Drosophila melanogaster; adenosinetriphosphatase; cardiomyopathy; cell culture; crystallization; flight muscles; fruit flies; gene expression; genes; integument; muscular diseases; mutants; myosin heavy chains; recombinant proteins; skeletal muscle; striated muscle
- Abstract:
- ... Biophysical and structural studies on muscle myosin rely upon milligram quantities of extremely pure material. However, many biologically interesting myosin isoforms are expressed at levels that are too low for direct purification from primary tissues. Efforts aimed at recombinant expression of functional striated muscle myosin isoforms in bacterial or insect cell culture have largely met with fai ...
- DOI:
- 10.1016/j.ymeth.2011.12.002
- PubMed:
- 22178692
- PubMed Central:
- PMC3308726
- https://doi.org/10.1016/j.ymeth.2011.12.002
- Author:
- Stuart T. Caldwell, et al. ; Niall A. McDonald; Chandramouleeswaran Subramani; Nada Y. Zainalabdeen; Graeme Cooke; Vincent M. Rotello; Show all 6 Authors
- Source:
- Tetrahedron letters 2011 v.52 no.17 pp. 2107-2110
- ISSN:
- 0040-4039
- Subject:
- chemical reactions; chemical structure; hydrogen bonding; porphyrins
- Abstract:
- ... In this Letter, we describe the formation of complexes between flavin and diamidopyridine functionalized porphyrin systems via hydrogen bonding and π-stacking interactions. ...
- DOI:
- 10.1016/j.tetlet.2010.11.004
- https://doi.org/10.1016/j.tetlet.2010.11.004
- Author:
- T. Caldwell, et al. ; A. Colliander; T.J. Jackson; S.K. Chan; P. O'Neill; R. Bindlish; M.H. Cosh; J.P. Walker; A. Berg; H. McNairn; M. Thibeault; J. Martínez-Fernández; K.H. Jensen; J. Asanuma; M.S. Seyfried; D.D. Bosch; P.J. Starks; C. Holifield Collins; J.H. Prueger; Z. Su; E. Lopez-Baeza; S.H. Yueh; Show all 22 Authors
- Source:
- Remote sensing of environment 2018 v.207 pp. 65-70
- ISSN:
- 0034-4257
- Subject:
- data collection; remote sensing; satellites; soil water
- Abstract:
- ... Satellite-based passive microwave remote sensing typically involves a scanning antenna that makes measurements at irregularly spaced locations. These locations can change on a day to day basis. Soil moisture products derived from satellite-based passive microwave remote sensing are usually resampled to a fixed Earth grid that facilitates their use in applications. In many cases the grid size is fi ...
- Handle:
- 10113/5906746
- DOI:
- 10.1016/j.rse.2018.02.006
- https://doi.org/10.1016/j.rse.2018.02.006
- Author:
- Patricia T. Caldwell, et al. ; Christopher A. Tipple; Brian M. Kile; Douglas J. Beussman; Blake Rushing; Natalie J. Mitchell; Christian J. Whitchurch; Martin Grime; Rex Stockham; Brian A. Eckenrode; Show all 10 Authors
- Source:
- Forensic science international 2014 v.242 pp. 242-254
- ISSN:
- 0379-0738
- Subject:
- cadaverine; desorption; dogs; headspace analysis; humans; law enforcement; nose; odors; putrescine; solid phase microextraction; teams; volatile compounds
- Abstract:
- ... Effective and reliable training aids for victim recovery canine teams is essential for law enforcement and investigative purposes. Without adequate training aids, the rate of recovery for sub surface or surface human remains deposition using canine teams may be adversely affected and result in confusing information. The composition of three commercially available canine training aids that purporte ...
- DOI:
- 10.1016/j.forsciint.2014.06.033
- https://doi.org/10.1016/j.forsciint.2014.06.033
- Author:
- T. Caldwell, et al. ; B. J. Awda; S. P. Miller; Y. R. Montanholi; G. Vander Voort; M. M. Buhr; K. C. Swanson; Show all 7 Authors
- Source:
- Canadian journal of plant science 2013 v.93 no.2 pp. 185-192
- ISSN:
- 1918-1833
- Subject:
- animal fertility; backfat; beef bulls; crossbreds; dry matter intake; feed conversion; models; multiple trait selection; nitrogen; semen; sperm motility; spermatozoa; viability
- Abstract:
- ... Awda, B. J., Miller, S. P., Montanholi, Y. R., Vander Voort, G., Caldwell, T., Buhr, M. M. and Swanson, K. C. 2013. The relationship between feed efficiency traits and fertility in young beef bulls. Can. J. Anim. Sci. 93: 185–192. Great efforts have been taken in recent years for improving feed efficiency in beef cattle. Despite there being several studies on biological factors associated with thi ...
- DOI:
- 10.4141/cjas2012-092
- https://doi.org/10.4141/cjas2012-092
- Author:
- Stuart T. Caldwell, et al. ; Louis J. Farrugia; Shanika Gunatilaka Hewage; Nadiya Kryvokhyzha; Vincent M. Rotello; Graeme Cooke; Show all 6 Authors
- Source:
- Chemical communications 2009 v. no.11 pp. 1350-1352
- ISSN:
- 1364-548X
- Subject:
- chemical communication; chemical compounds; chemical reactions; electrochemistry; models
- Abstract:
- ... We describe the role functionality attached to the C(7) position of a family of flavin derivatives has in tuning their redox and recognition properties and the subsequent exploitation of two of these derivatives as a three-component electrochemically controllable molecular switch. ...
- DOI:
- 10.1039/b900269n
- https://doi.org/10.1039/b900269n
- Author:
- Mark T. Caldwell, et al. ; Kimberly A. Edgel; Timothy S. McMillen; Hao Wei; Nathalie Pamir; Barbara A. Houston; Phuong-Oanh T. Mai; John F. Oram; Chongren Tang; Renée C. LeBoeuf; Show all 10 Authors
- Source:
- Biochimica et biophysica acta 2012 v.1821 no.3 pp. 425-434
- ISSN:
- 1388-1981
- Subject:
- adipocytes; adipose tissue; atherosclerosis; cell death; cholelithiasis; cholesterol; diabetes; genes; high density lipoprotein; hyperlipidemia; inflammation; insulin resistance; leukocytes; lipolysis; low calorie diet; macrophages; messenger RNA; mice; obesity; weight loss
- Abstract:
- ... The prevalence of obesity has reached epidemic proportions and is associated with several co-morbid conditions including diabetes, dyslipidemia, cancer, atherosclerosis and gallstones. Obesity is associated with low systemic inflammation and an accumulation of adipose tissue macrophages (ATMs) that are thought to modulate insulin resistance. ATMs may also modulate adipocyte metabolism and take up ...
- DOI:
- 10.1016/j.bbalip.2011.11.012
- PubMed:
- 22179025
- PubMed Central:
- PMC3293702
- https://doi.org/10.1016/j.bbalip.2011.11.012
- Author:
- Stuart T. Caldwell, et al. ; Graeme Cooke; Brian Fitzpatrick; De-Liang Long; Gouher Rabani; Vincent M. Rotello; Show all 6 Authors
- Source:
- Chemical communications 2008 v. no.45 pp. 5912-5914
- ISSN:
- 1364-548X
- Subject:
- catenanes; chemical reactions; flavins; solid state culture; synthesis
- Abstract:
- ... We report the synthesis, solid-state and preliminary solution properties of a flavin-based [2]catenane. ...
- DOI:
- 10.1039/b813779j
- https://doi.org/10.1039/b813779j
- Author:
- Stuart T. Caldwell, et al. ; Graeme Cooke; Alan Cooper; Margaret Nutley; Gouher Rabani; Vincent Rotello; Brian O. Smith; Patrice Woisel; Show all 8 Authors
- Source:
- Chemical communications 2008 v. no.23 pp. 2650-2652
- ISSN:
- 1364-548X
- Subject:
- avidin; binding sites; chemical reactions; rotaxanes
- Abstract:
- ... A biotinylated 1,5-dialkoxynaphthalene derivative has been shown to have the ability to bind strongly to avidin and thus act as an artificial binding site for cyclobis(paraquat-p-phenylene) thereby facilitating the formation of a tuneable pseudorotaxane-based bioconjugate. ...
- DOI:
- 10.1039/b803856b
- https://doi.org/10.1039/b803856b
- Author:
- Stuart T. Caldwell, et al. ; Debabrata Patra; Chiara Pagliuca; Chandramouleeswaran Subramani; Bappaditya Samanta; Sarit S. Agasti; Nada Zainalabdeen; Graeme Cooke; Vincent M. Rotello; Show all 9 Authors
- Source:
- Chemical communications 2009 v. no.28 pp. 4248-4250
- ISSN:
- 1364-548X
- Subject:
- chemical compounds; chemical reactions; crosslinking; liquid-liquid interface
- Abstract:
- ... Dithiocarbamate chemistry is used as a crosslinking tool to fabricate FePt colloidal microcapsules which provide a versatile scaffold for “host–guest” recognition at the liquid–liquid interface. ...
- DOI:
- 10.1039/b906458c
- https://doi.org/10.1039/b906458c
- Author:
- T. Caldwell, et al. ; S.K. Chan; R. Bindlish; P. O'Neill; T. Jackson; E. Njoku; S. Dunbar; J. Chaubell; J. Piepmeier; S. Yueh; D. Entekhabi; A. Colliander; F. Chen; M.H. Cosh; J. Walker; A. Berg; H. McNairn; M. Thibeault; J. Martínez-Fernández; F. Uldall; M. Seyfried; D. Bosch; P. Starks; C. Holifield Collins; J. Prueger; R. van der Velde; J. Asanuma; M. Palecki; E.E. Small; M. Zreda; J. Calvet; W.T. Crow; Y. Kerr; Show all 33 Authors
- Source:
- Remote sensing of environment 2018 v.204 pp. 931-941
- ISSN:
- 0034-4257
- Subject:
- National Aeronautics and Space Administration; algorithms; correlation; ecosystems; freeze-thaw cycles; radar; remote sensing; satellites; soil water; temperature; uncertainty
- Abstract:
- ... Launched in January 2015, the National Aeronautics and Space Administration (NASA) Soil Moisture Active Passive (SMAP) observatory was designed to provide frequent global mapping of high-resolution soil moisture and freeze-thaw state every two to three days using a radar and a radiometer operating at L-band frequencies. Despite a hardware mishap that rendered the radar inoperable shortly after lau ...
- Handle:
- 10113/5819699
- DOI:
- 10.1016/j.rse.2017.08.025
- https://doi.org/10.1016/j.rse.2017.08.025