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- T.Cuenco, Karen, et al. Show all 8 Authors
- Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.24 pp. 9454-9459
- DNA damage; DNA repair; actinomycin D; alpha-amanitin; chromosomes; free radicals; genes; genotoxicity; humans; intergenic DNA; interphase; ionizing radiation; proteins; somatic cells; transcription (genetics)
- ... Double-strand DNA breaks (DSBs) are continuously induced in cells by endogenously generated free radicals and exogenous genotoxic agents such as ionizing radiation. DSBs activate the kinase activity in sensor proteins such as ATM and DNA-PK, initiating a complex DNA damage response that coordinates various DNA repair pathways to restore genomic integrity. In this study, we report the unexpected fi ...
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