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- Tariq, Zia, et al. Show all 2 Author
- International journal of biological macromolecules 2018 v.120 pp. 1965-1974
- DNA; Tetrahymena; absorbance; anthracyclines; antineoplastic agents; circular dichroism spectroscopy; computer simulation; enzyme inhibitors; fluorescence; guanine; mechanism of action; neoplasm cells; neoplasms; nuclear magnetic resonance spectroscopy; nucleotide sequences; oncogenes; telomerase; telomeres; thermal stability; wavelengths
- ... Guanine rich DNA sequences form four stranded G-quadruplex structures found in telomeric DNA and oncogene promoters. Small molecules binding and stabilizing the G-quadruplex disrupt telomere maintenance and gene regulation, thereby limiting the proliferation of cancer cells. The anti-cancer drug daunomycin binds to both G-quadruplex DNA and duplex DNA. We have undertaken a study of interaction of ...