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- Tong, Yulong, et al. Show all 9 Authors
- Biochemical and biophysical research communications 2018 v.504 no.4 pp. 679-685
- Western blotting; blood serum; bone resorption; collagen; enzyme-linked immunosorbent assay; flow cytometry; histopathology; humans; immunization; immunogenicity; inflammation; interleukin-1beta; mice; micro-computed tomography; mitogen-activated protein kinase; models; osteoclasts; rheumatoid arthritis; staining
- ... Wnt5a signalling plays pathological roles in synovial inflammation and bone destruction. In the present study, we designed four human Wnt5a-based DNA recombinants and detected their effects on immunogenicity and anti-rheumatism in a collagen-induced arthritis (CIA) model. Histomorphometry and micro-CT scanning showed that the phWnt5a-NL was superior to other recombinants because it resulted in dec ...