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- Author:
- Tracy L. Nicholson, et al. ; Karen B. Register; Brian W. Brunelle; Show all 3 Authors
- Source:
- Journal of Microbiological Methods 2016 v.129 no. pp. 117-126
- ISSN:
- 0167-7012
- Subject:
- Bordetella bronchiseptica; DNA fingerprinting; birds; genes; genotyping; hosts; mammals; molecular epidemiology; population structure; ribotypes; sequence analysis; Australia; Europe; Israel; United States
- Abstract:
- ... PvuII ribotyping and MLST are each highly discriminatory methods for genotyping Bordetella bronchiseptica, but a direct comparison between these approaches has not been undertaken. The goal of this study was to directly compare the discriminatory power of PvuII ribotyping and MLST, using a single set of geographically and genetically diverse strains, and to determine whether subtyping based on rep ...
- Handle:
- 10113/5430224
- DOI:
- 10.1016/j.mimet.2016.08.008
- https://doi.org/10.1016/j.mimet.2016.08.008
- Author:
- Tracy L. Nicholson, et al. ; Susan L. Brockmeier; Crystal L. Loving; Mitchel V. Palmer; Allyn Spear; Kay S. Faaberg; Kelly M. Lager; Show all 7 Authors
- Source:
- Veterinary microbiology 2017 v.203 pp. 6-17
- ISSN:
- 0378-1135
- Subject:
- Actinobacillus suis; Haemophilus parasuis; Porcine reproductive and respiratory syndrome virus; Streptococcus suis; bacteria; bacterial pneumonia; blood serum; cytokines; disease severity; fever; immune response; pathogenesis; swine; swine diseases; virulence; viruses; Asia; United States
- Abstract:
- ... Epidemiologic data from Asian outbreaks of highly-pathogenic (HP) porcine reproductive and respiratory syndrome virus (PRRSV) suggest that disease severity was associated with both the virulence of the PRRSV isolates and secondary bacterial infections. Previous reports have indicated that U.S. isolates of PRRSV predispose to secondary bacterial infections as well, but the severity of disease that ...
- DOI:
- 10.1016/j.vetmic.2017.02.003
- https://doi.org/10.1016/j.vetmic.2017.02.003
- Author:
- Tracy L. Nicholson, et al. ; Samantha J. Hau; Shi-Lu Luan; Crystal L. Loving; Jinhong Wang; Sarah E. Peters; David Seilly; Lucy A. Weinert; Paul R. Langford; Andrew N. Rycroft; Brendan W. Wren; Duncan J. Maskell; Alexander W. Tucker; Susan L. Brockmeier; on behalf of the BRaDP1T Consortium; Show all 15 Authors
- Source:
- BMC veterinary research 2020 v.16 no.1 pp. 167
- ISSN:
- 1746-6148
- Subject:
- antibodies; antibody binding sites; cell viability; disease control; host range; hosts; immunity; in vitro studies; interferon-gamma; mutagenesis; organ culture; outer membrane proteins; recombinant proteins; serotypes; subunit vaccines; swine; swine diseases; vaccination; vaccine development
- Abstract:
- ... BACKGROUND: Glaesserella parasuis, the causative agent of Glӓsser’s disease, is widespread in swine globally resulting in significant economic losses to the swine industry. Prevention of Glӓsser’s disease in pigs has been plagued with an inability to design broadly protective vaccines, as many bacterin based platforms generate serovar or strain specific immunity. Subunit vaccines are of interest t ...
- Handle:
- 10113/6965730
- DOI:
- 10.1186/s12917-020-02377-5
- https://doi.org/10.1186/s12917-020-02377-5
- Author:
- Tracy L. Nicholson, et al. ; Sarah M. Shore; Karen B. Register; Darrell O. Bayles; Robert A. Kingsley; Brian W. Brunelle; Show all 6 Authors
- Source:
- Veterinary microbiology 2016 v.182 pp. 87-94
- ISSN:
- 0378-1135
- Subject:
- Bordetella bronchiseptica; burden of disease; disease models; disease prevalence; gene expression; genes; genetic relationships; genomics; hosts; humans; nucleotide sequences; pathogens; quantitative polymerase chain reaction; rhinitis; swine; vaccine development; virulence
- Abstract:
- ... The well-characterized Bordetella bronchiseptica strain KM22, originally isolated from a pig with atrophic rhinitis, has been used to develop a reproducible swine respiratory disease model. The goal of this study was to identify genetic features unique to KM22 by comparing the genome sequence of KM22 to the laboratory reference strain RB50. To gain a broader perspective of the genetic relationship ...
- DOI:
- 10.1016/j.vetmic.2015.10.026
- PubMed:
- 26711033
- PubMed Central:
- PMC7117204
- https://doi.org/10.1016/j.vetmic.2015.10.026
- Author:
- Tracy L. Nicholson, et al. ; Matt S. Conover; Rajendar Deora; Roy Martin Roop II; Show all 4 Authors
- Source:
- PloS one v.7 no.11 pp. -
- ISSN:
- 1932-6203
- Subject:
- Bordetella bronchiseptica; biofilm; developmental stages; flagellum; gene expression; genes; microarray technology; pathogens; phenotype; transcriptomics
- Abstract:
- ... We have used microarray analysis to study the transcriptome of the bacterial pathogen Bordetella bronchiseptica over the course of five time points representing distinct stages of biofilm development. The results suggest that B. bronchiseptica undergoes a coordinately regulated gene expression program similar to a bacterial developmental process. Expression and subsequent production of the genes e ...
- Handle:
- 10113/57494
- DOI:
- 10.1371/journal.pone.0049166
- PubMed:
- 23152870
- PubMed Central:
- PMC3495763
- https://doi.org/10.1371/journal.pone.0049166
- Author:
- Tracy L. Nicholson, et al. ; Sarah M. Shore; Darrell O. Bayles; Karen B. Register; Robert A. Kingsley; Show all 5 Authors
- Source:
- Genome announcements 2014 v.2 no.4 pp. e00670-14
- ISSN:
- 2169-8287
- Subject:
- Bordetella bronchiseptica; bacterial infections; genome; herds; models; nucleotide sequences; swine; swine diseases
- Abstract:
- ... Bordetella bronchiseptica swine isolate KM22 has been used in experimental infections of swine as a model of clinical B. bronchiseptica infections within swine herds and to study host-to-host transmission. Here we report the draft genome sequence of KM22. ...
- Handle:
- 10113/61254
- DOI:
- 10.1128/genomeA.00670-14
- PubMed:
- 25013141
- PubMed Central:
- PMC4110755
- https://doi.org/10.1128/genomeA.00670-14
- Author:
- Tracy L. Nicholson, et al. ; Susan L. Brockmeier; Crystal L. Loving; Karen B. Register; Marcus E. Kehrli Jr.; Sarah M. Shore; Show all 6 Authors
- Source:
- Infection and Immunity 2014 v.82 no.3 pp. 1092-1103
- ISSN:
- 0019-9567
- Subject:
- Bordetella bronchiseptica; adaptive immunity; antibodies; blood serum; colonizing ability; disease severity; disease transmission; hosts; immune response; lesions (animal); models; mutants; nasal cavity; pathogenesis; pneumonia; rodents; swine; type III secretion system; virulence
- Abstract:
- ... Bordetella bronchiseptica is pervasive in swine populations and plays multiple roles in respiratory disease. Most studies addressing virulence factors of B. bronchiseptica utilize isolates derived from hosts other than pigs in conjunction with rodent infection models. Based on previous in vivo mouse studies, we hypothesized that the B. bronchiseptica type III secretion system (T3SS) would be requi ...
- Handle:
- 10113/61364
- DOI:
- 10.1128/IAI.01115-13
- PubMed:
- 24366249
- PubMed Central:
- PMC3957984
- https://doi.org/10.1128/IAI.01115-13
- Author:
- Tracy L. Nicholson, et al. ; Sarah M. Shore; Tara C. Smith; Timothy S. Fraena; Michael Otto; Show all 5 Authors
- Source:
- PloS one v.8 no.8 pp. -
- ISSN:
- 1932-6203
- Subject:
- DNA; Staphylococcus aureus; antibiotic resistance; biofilm; herds; humans; methicillin; peptidase K; polysaccharides; proteins; swine
- Abstract:
- ... Methicillin-resistant Staphylococcus aureus (MRSA) colonization of livestock animals is common and prevalence rates for pigs have been reported to be as high as 49%. Mechanisms contributing to the persistent carriage and high prevalence rates of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) strains in swine herds and production facilities have not been investigated. On ...
- DOI:
- 10.1371/journal.pone.0073376
- PubMed:
- 23951352
- PubMed Central:
- PMC3739819
- https://doi.org/10.1371/journal.pone.0073376
- Author:
- Tracy L. Nicholson, et al. ; Randy E. Sacco; Theresa E. Waters; Susan L. Brockmeier; Show all 4 Authors
- Source:
- Veterinary immunology and immunopathology 2011 v.142 no.1-2 pp. 57-63
- ISSN:
- 0165-2427
- Subject:
- Bordetella bronchiseptica; Influenza A virus; amino acids; immune response; lungs; swine
- Abstract:
- ... We have provided a detailed structural analysis of porcine alveolar macrophage TLR3 extracellular domain (ECD). The porcine TLR3-ECD contains 18 leucine-rich repeats (LRRs) consisting of blocks of consensus motifs and non-consensus motifs containing insertions. Excluding the N-terminal and C-terminal LRRs, porcine TLR3 has two LRRs with insertions, resulting in one LRR of 39 amino acids and anothe ...
- Handle:
- 10113/49879
- DOI:
- 10.1016/j.vetimm.2011.04.008
- https://doi.org/10.1016/j.vetimm.2011.04.008
- Author:
- Tracy L. Nicholson, et al. ; Bodo Linz; Yury V. Ivanov; Andrew Preston; Lauren Brinkac; Julian Parkhill; Maria Kim; Simon R. Harris; Laura L. Goodfield; Norman K. Fry; Andrew R. Gorringe; Karen B. Register; Liliana Losada; Eric T. Harvill; Show all 14 Authors
- Source:
- BMC genomics 2016 v.17 no.1 pp. 767-784
- ISSN:
- 1471-2164
- Subject:
- Bordetella; antigens; bacterial toxins; birds; coevolution; gene deletion; genes; nucleotide sequences; pathogens; phylogeny; protein secretion; sequence diversity; vaccines; virulence
- Abstract:
- ... Background The genus Bordetella consists of nine species that include important respiratory pathogens such as the ‘classical’ species B. bronchiseptica, B. pertussis and B. parapertussis and six more distantly related and less extensively studied species. Here we analyze sequence diversity and gene content of 128 genome sequences from all nine species with focus on the evolution of virulence-assoc ...
- Handle:
- 10113/5642523
- DOI:
- 10.1186/s12864-016-3112-5
- PubMed:
- 27716057
- PubMed Central:
- PMC5045587
- https://doi.org/10.1186/s12864-016-3112-5
- Author:
- Tracy L. Nicholson, et al. ; Susan L. Brockmeier; Karen B. Register; Joanna S. Kuehn; Crystal L. Loving; Darrell O. Bayles; Sarah M. Shore; Gregory J. Phillips; Show all 8 Authors
- Source:
- Plos One 2014 v.9 no.8 pp. e103787
- ISSN:
- 1932-6203
- Subject:
- DNA; Haemophilus parasuis; adhesins; animal pathogenic bacteria; arthritis; bacterial infections; disease severity; genes; genomic libraries; genomics; genotype; meningitis; metabolism; models; morbidity; mortality; nucleotide sequences; phenotype; sequence analysis; swine; swine diseases; vaccines; virulence
- Abstract:
- ... Haemophilus parasuis is the cause of Glässer’s disease in swine, which is characterized by systemic infection resulting in polyserositis, meningitis, and arthritis. Characterization of this animal disease is complicated by the enormous differences in the severity of disease caused by H. parasuis strains, ranging from lethal systemic disease to subclinical carriage. To identify differences in genot ...
- Handle:
- 10113/61244
- DOI:
- 10.1371/journal.pone.0103787
- PubMed:
- 25137096
- PubMed Central:
- PMC4138102
- https://doi.org/10.1371/journal.pone.0103787
- Author:
- Tracy L. Nicholson, et al. ; Susan L. Brockmeier; Crystal L. Loving; Michael A. Mullins; Karen B. Register; Barry S. Wiseman; Rodney B. Baker; Marcus E. Kehrli Jr.; Show all 8 Authors
- Source:
- Clinical and diagnostic laboratory immunology 2013 v.20 no.9 pp. 1466-1472
- ISSN:
- 1098-6588
- Subject:
- Haemophilus parasuis; animal models; arthritis; disease transmission; live vaccines; meningitis; strains; swine; vaccination; virulence
- Abstract:
- ... Haemophilus parasuis causes Glässer's disease, a syndrome of polyserositis, meningitis, and arthritis in swine. Previous studies with H. parasuis have revealed virulence disparity among isolates and inconsistent heterologous protection. In this study, virulence, direct transmission, and heterologous protection of 4 isolates of H. parasuis (SW114, 12939, MN-H, or 29755) were evaluated using a highl ...
- Handle:
- 10113/61365
- DOI:
- 10.1128/CVI.00168-13
- PubMed:
- 23885030
- PubMed Central:
- PMC3889593
- https://doi.org/10.1128/CVI.00168-13
- Author:
- Tracy L Nicholson, et al. ; Brian W Brunelle; Richard S Stephens; Show all 3 Authors
- Source:
- Genome biology 2004 v.5 no.6 pp. 846
- ISSN:
- 1474-760X
- Subject:
- sequence analysis; Chlamydia trachomatis; virulence; DNA microarrays; genes; pathogenesis; genetic polymorphism
- Abstract:
- ... By comparing two fully sequenced genomes of Chlamydia trachomatis using competitive hybridization on DNA microarrays, a logarithmic correlation was demonstrated between the signal ratio of the arrays and the 75-99% range of nucleotide identities of the genes. Variable genes within 14 uncharacterized strains of C. trachomatis were identified by array analysis and verified by DNA sequencing. These g ...
- DOI:
- 10.1186/gb-2004-5-6-r42
- PubMed:
- 15186493
- PubMed Central:
- PMC463075
- https://doi.org/10.1186/gb-2004-5-6-r42
- Author:
- Tracy L. Nicholson, et al. ; Baoqing Guo; Kelly M. Lager; Jamie N. Henningson; Laura C. Miller; Sarah N. Schlink; Matthew A. Kappes; Marcus E. Kehrli; Susan L. Brockmeier; Han-Chun Yang; Kay S. Faaberg; Show all 11 Authors
- Source:
- Virology 2013 v.435 no.2 pp. 372-384
- ISSN:
- 0042-6822
- Subject:
- Porcine reproductive and respiratory syndrome virus; atrophy; bacterial infections; cytokines; disease transmission; histopathology; immunity; lesions (animal); lungs; lymph nodes; pathogenesis; pathogenicity; sepsis (infection); swine; thymus gland; virus replication; weight loss; China; United States
- Abstract:
- ... The pathogenesis of Type 2 highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) in 10-week old swine in the United States was investigated. rJXwn06, rescued from an infectious clone of Chinese HP-PRRSV, replicated in swine with at least 100-fold increased kinetics over U.S. strain VR-2332. rJXwn06 caused significant weight loss, exacerbated disease due to bacterial seps ...
- Handle:
- 10113/57566
- DOI:
- 10.1016/j.virol.2012.09.013
- PubMed:
- 23079105
- PubMed Central:
- PMC7111980
- https://doi.org/10.1016/j.virol.2012.09.013
- Author:
- Tracy L. Nicholson, et al. ; Susan L. Brockmeier; Crystal L. Loving; Eric A. Nelson; Laura C. Miller; Karen B. Register; Marvin J. Grubman; Douglas E. Brough; Marcus E. Kehrli Jr.; Show all 9 Authors
- Source:
- Clinical and diagnostic laboratory immunology 2012 v.19 no.4 pp. 508-514
- ISSN:
- 1098-6588
- Subject:
- neutralization; porcine reproductive and respiratory syndrome; Porcine reproductive and respiratory syndrome virus; antibodies; hosts; cell-mediated immunity; vaccines; viremia; Human mastadenovirus C; viruses; seroconversion; immune response; lungs; virus replication; interferons; swine
- Abstract:
- ... Porcine reproductive and respiratory syndrome (PRRS) is one of the most devastating and costly diseases to the swine industry worldwide. Overall, the adaptive immune response to PRRS virus (PRRSV) is weak, which results in delayed elimination of virus from the host and inferior vaccine protection. PRRSV has been shown to induce a meager alpha interferon (IFN-α) response, and we hypothesized that e ...
- Handle:
- 10113/54499
- DOI:
- 10.1128/CVI.05490-11
- PubMed:
- 22301694
- PubMed Central:
- PMC3318278
- https://doi.org/10.1128/CVI.05490-11