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1. VPS32, a member of the ESCRT complex, modulates adherence to host cells in the parasite Trichomonas vaginalis by affecting biogenesis and cargo sorting of released extracellular vesicles

Author:
Nehuén Salas; Veronica M. Coceres; Tuanne dos Santos Melo; Antonio Pereira-Neves; Vanina G. Maguire; Tania M. Rodriguez; Bruna Sabatke; Marcel I. Ramirez; Jihui Sha; James A. Wohlschlegel; Natalia de Miguel
Source:
Cellular and molecular life sciences 2022 v.79 no.1 pp. 11
ISSN:
1420-682X
Subject:
Trichomonas vaginalis,   etc   ; RNA; biogenesis; cell communication; epithelium; humans; parasites; pathogenesis;     Show all 8 Subjects
Abstract:
... Trichomonas vaginalis is a common sexually transmitted extracellular parasite that adheres to epithelial cells in the human urogenital tract. Extracellular vesicles (EVs) have been described as important players in the pathogenesis of this parasite as they deliver proteins and RNA into host cells and modulate parasite adherence. EVs are heterogeneous membrane vesicles released from virtually all c ...
DOI:
10.1007/s00018-021-04083-3

2. A systematic review of the correlation between Trichomonas vaginalis infection and infertility

Author:
Zhenchao Zhang; Yuhua Li; Haoran Lu; Dongxian Li; Rui Zhang; Xianghuan Xie; Lihua Guo; Lixia Hao; Xiaowei Tian; Zhenke Yang; Shuai Wang; Xuefang Mei
Source:
Acta tropica 2022 v.236 pp. 106693
ISSN:
0001-706X
Subject:
Trichomonas vaginalis,   etc   ; humans; immune response; meta-analysis; pathogenesis; sperm quality; systematic review;     Show all 7 Subjects
Abstract:
... Trichomonas vaginalis (T. vaginalis) is an extracellular flagellated protozoan parasitizing the human genital and urinary tracts. T. vaginalis infection impacts human reproductive function, but whether it causes infertility is still a matter of debate. In this work, we consulted 205 relevant articles, which were classified into three categories: epidemiological investigations (100), review article ...
DOI:
10.1016/j.actatropica.2022.106693

3. Molecular typing of the actin gene of Trichomonas vaginalis isolates in Tehran, Iran

Author:
Farah Bokharaei-Salim; Neda Hedayati; Khadijeh Khanaliha; Maryam Esghaei; Sara Minaeian; Mojgan Oshaghi; Borna Salemi
Source:
Journal of parasitic diseases 2022 v.46 no.3 pp. 764-770
ISSN:
0971-7196
Subject:
Trichomonas vaginalis,   etc   ; actin; ancestry; digestion; genes; genotype; mixed infection; parasites; phylogeny; sequence analysis; trichomoniasis; Iran;     Show all 12 Subjects
Abstract:
... Trichomonas vaginalis is a protozoan parasite that causes trichomoniasis with worldwide distribution. This study evaluated actin genotypes of T. vaginalis isolates using PCR–RFLP and sequence analysis in Tehran, Iran. Overall, 850 vaginal samples were collected from women admitted to hospitals affiliated with the Iran University of Medical Sciences in Tehran from 2020-to 2021. The samples were exa ...
DOI:
10.1007/s12639-022-01496-0

4. In vitro activity of amixicile against T. vaginalis from clinical isolates

Author:
Eisha Jain; Edna I. Zaenker; Paul S. Hoffman; Cirle A. Warren
Source:
Parasitology research 2022 v.121 no.8 pp. 2453-2455
ISSN:
0932-0113
Subject:
Trichomonas vaginalis,   etc   ; etiological agents; metronidazole; minimum inhibitory concentration; parasitology; research; sexually transmitted diseases; tinidazole; trichomoniasis; vaginitis;     Show all 10 Subjects
Abstract:
... Trichomoniasis is a sexually transmitted infection in humans caused by the protozoan Trichomonas vaginalis, the leading causative agent of vaginitis in women and urethritis in men worldwide. Metronidazole is the standard treatment for trichomoniasis, with tinidazole as the second line. There are currently no FDA-approved non-nitroimidazole alternative treatments for resistant strains. This study c ...
DOI:
10.1007/s00436-022-07567-8

5. Trichomonas infection in pregnant women: a nationwide cohort study

Author:
Ruei-Ting Li; Hsin-Chung Lin; Chi Hsiang Chung; Hsin-An Lin; Jui-Yang Wang; Lih-Chyang Chen; Kuo-Yang Huang; Chien-An Sun; Wu-Chien Chien; Chien-Chou Chen
Source:
Parasitology research 2022 v.121 no.7 pp. 1973-1981
ISSN:
0932-0113
Subject:
Trichomonas vaginalis,   etc   ; cohort studies; databases; health insurance; medical facilities; parasitology; public health; research; risk; sexually transmitted diseases; trichomoniasis; Taiwan;     Show all 12 Subjects
Abstract:
... Trichomoniasis is the most prevalent sexually transmitted infection worldwide, and is associated with adverse pregnancy outcomes. However, Trichomonas vaginalis (TV) has received little public health attention, and only limited data are available on prevalence of TV and other Trichomonas-associated syndromes in pregnant women. This study aimed to determine associations between pregnancy and incide ...
DOI:
10.1007/s00436-022-07498-4

6. Effects of amiodarone, amioder, and dronedarone on Trichomonas vaginalis

Author:
Tatiana Guinancio de Souza; Gustavo Benaim; Wanderley de Souza; Marlene Benchimol
Source:
Parasitology research 2022 v.121 no.6 pp. 1761-1773
ISSN:
0932-0113
Subject:
Trichomonas vaginalis,   etc   ; biosynthesis; calcium; glycogen; homeostasis; humans; inhibitory concentration 50; metronidazole; parasites; parasitology; pregnancy; research; sexually transmitted diseases; sterols; trichomoniasis;     Show all 15 Subjects
Abstract:
... Trichomonas vaginalis is a protozoan that causes human trichomoniasis, the most common non-viral sexually transmitted infection (STI) affecting approximately 278 million people worldwide. The current treatment for trichomoniasis is based on 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole, known as metronidazole (MTZ). Although effective in clearing the parasite infection, MTZ is related to provoking ...
DOI:
10.1007/s00436-022-07521-8

7. Prevalence and spatial heterogeneity of Trichomonas vaginalis infection among the female population and association with climate in Guangxi Zhuang autonomous region, Southern China

Author:
Huaxiang Lu; Haoyu He; Xijia He; Qiumei Liu; Chunbao Mo; Min Li; Mingjian Chen; Jian Qin; Zhiyong Zhang
Source:
Acta tropica 2022 v.225 pp. 106204
ISSN:
0001-706X
Subject:
Trichomonas vaginalis,   etc   ; at-risk population; autocorrelation; climate; females; models; mountains; odds ratio; risk; rivers; spatial variation; temperature; uterine cervical neoplasms; China;     Show all 14 Subjects
Abstract:
... : Two cervical cancer screening (CCS) projects have been ongoing for years in Guangxi Zhuang autonomous region (Guangxi), and some Trichomonas vaginalis infection (TVI) cases have been found as an opportunistic finding. This study aimed to identify the high-risk population and expound the spatial epidemiological features of TVI in Guangxi.: This study was based on CCS from 2012 to 2019. Adjusted o ...
DOI:
10.1016/j.actatropica.2021.106204

8. Detection of metronidazole resistance in Trichomonas vaginalis using uncultured vaginal swabs

Author:
Bongekile Ngobese; Ravesh Singh; Khine Swe Swe- Han; Partson Tinarwo; Nonkululeko Mabaso; Nathlee S. Abbai
Source:
Parasitology research 2022 v.121 no.8 pp. 2421-2432
ISSN:
0932-0113
Subject:
Trichomonas vaginalis,   etc   ; Human immunodeficiency virus; metronidazole; monitoring; mutation; nitroreductases; parasitology; phenotype; quantitative polymerase chain reaction; research; sexually transmitted diseases; South Africa;     Show all 12 Subjects
Abstract:
... Trichomonas vaginalis (T. vaginalis) is the most prevalent sexually transmitted infection (STI) globally. Metronidazole is the drug of choice for treating T. vaginalis infections although metronidazole-resistant T. vaginalis has been reported in clinical isolates. The purpose of this study was to determine the presence of mutations in nitroreductase genes associated with metronidazole resistance i ...
DOI:
10.1007/s00436-022-07548-x

9. Structure-Guided Insight into the Specificity and Mechanism of a Parasitic Nucleoside Hydrolase

Author:
Samantha N. Muellers; Mattias M. Nyitray; Nicholas Reynarowych; Edina Saljanin; Annie Laurie Benzie; Alan R. Schoenfeld; Brian J. Stockman; Karen N. Allen
Source:
Biochemistry 2022 v.61 no.17 pp. 1853-1861
ISSN:
1520-4995
Subject:
Trichomonas vaginalis,   etc   ; X-radiation; adenosine; bioinformatics; catalysts; catalytic activity; genome; guanosine; hydrolases; inosine; parasites; scaffolding proteins; sequence homology; sexually transmitted diseases; trichomoniasis;     Show all 15 Subjects
Abstract:
... Trichomonas vaginalis is the causative parasitic protozoan of the disease trichomoniasis, the most prevalent, nonviral sexually transmitted disease in the world. T. vaginalis is a parasite that scavenges nucleosides from the host organism via catalysis by nucleoside hydrolase (NH) enzymes to yield purine and pyrimidine bases. One of the four NH enzymes identified within the genome of T. vaginalis ...
DOI:
10.1021/acs.biochem.2c00361

10. Innovative Hybrid-Alignment Annotation Method for Bioinformatics Identification and Functional Verification of a Novel Nitric Oxide Synthase in Trichomonas vaginalis

Author:
Hung-Che Lin; Hao-Ai Shui; Kuo-Yang Huang; Wei-Zhi Lin; Hsin-Yi Chang; Hwei-Jen Lee; Ying-Chih Lin; Yuahn-Sieh Huang; Guan-Ru Chen; Ya-Ting Yang; Hsiu-Lin Liu; Yi-Syuan Wu; Chia-Shiang Cheng; Ching-Lung Ko; Yu-Tien Chang; Jih-Chin Lee; Chen-Shien Lin; Chih-Hung Wang; Chi-Ming Chu
Source:
Biology 2022 v.11 no.8 pp. -
ISSN:
2079-7737
Subject:
Trichomonas vaginalis,   etc   ; bioinformatics; computer simulation; databases; enzyme activity; flavin-adenine dinucleotide; genes; heme; ligands; mass spectrometry; nitric oxide; nitric oxide synthase; protein structure; virulence;     Show all 14 Subjects
Abstract:
... Both the annotation and identification of genes in pathogenic parasites are still challenging. Although, as a survival factor, nitric oxide (NO) has been proven to be synthesized in Trichomonas vaginalis (TV), nitric oxide synthase (NOS) has not yet been annotated in the TV genome. We developed a witness-to-suspect strategy to identify incorrectly annotated genes in TV via the Smith–Waterman and N ...
DOI:
10.3390/biology11081210

11. Discovery of a Novel Species of Trichomonasvirus in the Human Parasite Trichomonas vaginalis Using Transcriptome Mining

Author:
Austin R. Manny; Carrie A. Hetzel; Arshan Mizani; Max L. Nibert
Source:
Viruses 2022 v.14 no.3 pp. -
ISSN:
1999-4915
Subject:
Trichomonas vaginalis; Trichomonas vaginalis virus 1,   etc   ; animal pathogens; genome; humans; parasites; phylogeny; sequence analysis; transcriptome; trichomoniasis; viruses;     Show all 11 Subjects
Abstract:
... Trichomonas vaginalis is the most common non-viral cause of sexually transmitted infections globally. Infection by this protozoan parasite results in the clinical syndrome trichomoniasis, which manifests as an inflammatory disease with acute and chronic consequences. Half or more isolates of this parasite are themselves infected with one or more dsRNA viruses that can exacerbate the inflammatory s ...
DOI:
10.3390/v14030548

12. Molecular characterization of Trichomonas infections in women of Ilam City, southwestern Iran

Author:
Maryam Alikhani; Mohammad Akhoundi; Denis Sereno; Jahangir Abdi; Razi Naserifar; Mohammad Reza Mahmoudi; Asad Mirzaei
Source:
Parasitology research 2022 v.121 no.6 pp. 1631-1638
ISSN:
0932-0113
Subject:
Trichomonas vaginalis,   etc   ; Philippines; chronic diseases; diabetes; epidemiology; erythema; genetic similarity; genetic variation; immune system; microscopy; parasitology; phylogeny; research; sexually transmitted diseases; trichomoniasis; urination; urine; Austria; Iran;     Show all 19 Subjects
Abstract:
... Trichomoniasis is a sexually transmitted infection (STI) caused by the flagellated protozoan Trichomonas vaginalis. Little information is available on the epidemiology and genetic diversity of T. vaginalis in Ilam City, southwestern Iran. A descriptive cross-sectional investigation was carried out between July 2017 and December 2018 on the suspected women patients referred to eight gynecology clin ...
DOI:
10.1007/s00436-022-07492-w

13. Biogenic Nanocopper: Eco-Friendly Synthesis, Characterization, and Their Anti-Trichomonas vaginalis, Anticancer, and Antimicrobial Effects

Author:
Beyza Duran; Eda Perçin; Ali Aydın; Ali Destegül; Davut Aydin; Necati Özpınar; Ahmet Karadağ
Source:
Journal of medicinal food 2022 v.25 no.7 pp. 787-792
ISSN:
1557-7600
Subject:
Trichomonas vaginalis,   etc   ; Fourier transform infrared spectroscopy; absorption; antiparasitic agents; ascorbic acid; chlorides; copper; copper nanoparticles; excretion; functional foods; medicinal properties; metabolism; particle size distribution; therapeutics; thermogravimetry; toxicity;     Show all 16 Subjects
Abstract:
... Biogenic nanocopper (BNC) agents exhibit strong anticancer, antimicrobial, and antiparasitic effects. Their fewer side effects to normal cells cause them to be preferred to treat various diseases. Metal nanoparticles, particularly copper nanoparticles, are attracting more significant interest as therapeutic agents with the improvement of green synthesis methods. Studies to reduce the side effects ...
DOI:
10.1089/jmf.2021.0151

14. Identification of Endosymbiotic Virus in Small Extracellular Vesicles Derived from Trichomonas vaginalis

Author:
Seow-Chin Ong; Wei-Hung Cheng; Fu-Man Ku; Chih-Yu Tsai; Po-Jung Huang; Chi-Ching Lee; Yuan-Ming Yeh; Petr Rada; Ivan Hrdý; Ravi Kumar Narayanasamy; Tamara Smutná; Rose Lin; Hong-Wei Luo; Cheng-Hsun Chiu; Jan Tachezy; Petrus Tang
Source:
Genes 2022 v.13 no.3 pp. -
ISSN:
2073-4425
Subject:
Trichomonas vaginalis,   etc   ; Trichomonasvirus; capsid; data collection; drugs; epithelium; exosomes; humans; immune response; liquid chromatography; pathogenesis; pathogenicity; reverse transcriptase polymerase chain reaction; tandem mass spectrometry; transmission electron microscopy; viruses;     Show all 16 Subjects
Abstract:
... Accumulated evidence suggests that the endosymbiotic Trichomonasvirus (TVV) may play a role in the pathogenesis and drug susceptibility of Trichomonas vaginalis. Several reports have shown that extracellular vesicles (EVs) released from TVV-positive (TVV+) trichomonads can modulate the immune response in human vaginal epithelial cells and animal models. These results prompted us to examine whether ...
DOI:
10.3390/genes13030531

15. Establishment and application of a CRISPR-Cas12a-based RPA-LFS and fluorescence for the detection of Trichomonas vaginalis

Author:
Shan Li; Xiaocen Wang; Yanhui Yu; Songgao Cao; Juan Liu; Panpan Zhao; Jianhua Li; Xichen Zhang; Xin Li; Nan Zhang; Min Sun; Lili Cao; Pengtao Gong
Source:
Parasites & vectors 2022 v.15 no.1 pp. 350
ISSN:
1756-3305
Subject:
Trichomonas vaginalis,   etc   ; Candida albicans; Cryptosporidium parvum; Escherichia coli; Mycoplasma hominis; Neisseria gonorrhoeae; Toxoplasma gondii; actin; ancillary equipment; biosensors; cross reaction; detection limit; fluorescence; genes; humans; polymerase chain reaction; prostatitis; risk;     Show all 18 Subjects
Abstract:
... BACKGROUND: Infection with Trichomonas vaginalis can lead to cervicitis, urethritis, pelvic inflammatory disease, prostatitis and perinatal complications and increased risk of HIV transmission. Here, we used an RPA-based CRISPR-Cas12a assay system in combination with a lateral flow strip (LFS) (referred to as RPA-CRISPR-Cas12a) to establish a highly sensitive and field-ready assay and evaluated it ...
DOI:
10.1186/s13071-022-05475-5

16. Antibacterial and anti-trichomunas characteristics of local landraces of Lawsonia inermis L.

Author:
M. Fatahi Bafghi; S. Salary; F. Mirzaei; H. Mahmoodian; H. Meftahizade; R. Zareshahi
Source:
BMC complementary medicine and therapies 2022 v.22 no.1 pp. 203
ISSN:
2662-7671
Subject:
Trichomonas vaginalis,   etc   ; Gram-negative bacteria; Gram-positive bacteria; Lawsonia inermis; Pseudomonas aeruginosa; Streptococcus agalactiae; alternative medicine; antibacterial properties; drug resistance; growth retardation; inhibitory concentration 50; landraces; minimum inhibitory concentration; oils; phenols; traditional medicine; Iran;     Show all 17 Subjects
Abstract:
... BACKGROUND: Henna (Lawsonia inermis) with anti-bacterial properties has been widely used in traditional medicine especially Persian medicine. Henna oil is suggested for diseases of infectious origin, such as cervical ulcers. Group B Streptococcus agalactiae, Pseudomonas aeruginosa and, Trichomonas vaginalis are involved in the infection of women especially cervicitis. Henna grows in dry and tropic ...
DOI:
10.1186/s12906-022-03676-0

17. The Natural Course of Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and Mycoplasma genitalium in Pregnant and Post-Delivery Women in Pemba Island, Tanzania

Author:
Naomi C. A. Juliana; Abdulla Mbaruk Omar; Jolein Pleijster; Fahad Aftab; Nina B. Uijldert; Said M. Ali; Sander Ouburg; Sunil Sazawal; Servaas A. Morré; Saikat Deb; Elena Ambrosino
Source:
Microorganisms 2021 v.9 no.6 pp. -
ISSN:
2076-2607
Subject:
Trichomonas vaginalis,   etc   ; Chlamydia trachomatis; Mycoplasma genitalium; Neisseria gonorrhoeae; natural history; pregnancy; Tanzania;     Show all 7 Subjects
Abstract:
... This study aimed to determine the persistence of Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Trichomonas vaginalis (TV) and Mycoplasma genitalium (MG) infections during pregnancy and after delivery in vaginal swabs of women from Pemba Island, Tanzania. In the context of an earlier biobanking effort, vaginal swabs were collected at two timepoints during pregnancy and once post-delivery. ...
DOI:
10.3390/microorganisms9061180

18. Promising effects of parasite-derived compounds on tumor regression: a systematic review of in vitro and in vivo studies

Author:
Ali Asghari; Hassan Nourmohammadi; Hamidreza Majidiani; Seyyed Ali Shariatzadeh; Davood Anvari; Sadegh Shamsinia; Ezatollah Ghasemi; Morteza Shams; Gholam Basati
Source:
Environmental science and pollution research 2022 v.29 no.22 pp. 32383-32396
ISSN:
0944-1344
Subject:
Trichomonas vaginalis,   etc   ; Acanthamoeba castellanii; Besnoitia; Echinococcus granulosus; Leishmania major; Plasmodium yoelii; Schistosoma mansoni; Taenia crassiceps; Toxocara canis; Toxoplasma gondii; Trichinella spiralis; Trypanosoma cruzi; antineoplastic activity; cancer therapy; data collection; helminths; pollution; remission; research; systematic review;     Show all 20 Subjects
Abstract:
... The parasites are repeatedly confronting their host to take advantage of nutrients for multiplication and survival. In this sense, a wide spectrum of molecules is released from both sides, with immune-regulatory activity, accompanying this biological battle. Such parasites and their valuable molecules can be directed toward microbial-based cancer therapy. Herein, we contrived a systematic review t ...
DOI:
10.1007/s11356-021-17090-5

19. Trichomonas vaginalis triggers neutrophil extracellular traps reducing parasite integrity and growth

Author:
María G. Ramírez-Ledesma; Yordan J. Romero-Contreras; Mayra C. Rodríguez; Ruth Reyes-Cortes; Patricia Cuéllar-Mata; Eva E. Avila
Source:
Parasitology research 2022 v.121 no.5 pp. 1355-1367
ISSN:
0932-0113
Subject:
Trichomonas vaginalis,   etc   ; DNA; antibodies; glycoconjugates; humans; micrococcal nuclease; neutrophils; parasites; parasitology; research; risk; trichomoniasis; trophozoites;     Show all 13 Subjects
Abstract:
... Trichomoniasis—caused by the parasite Trichomonas vaginalis—is associated with a high inflammatory process that may contribute to the risk of suffering from other medical complications. Our study focused on the in vitro interaction of T. vaginalis with human neutrophils because these are the most abundant cells implicated in the characteristic inflammatory process of trichomoniasis. This study sho ...
DOI:
10.1007/s00436-022-07475-x

20. Omics Analyses of Trichomonas vaginalis Actin and Tubulin and Their Participation in Intercellular Interactions and Cytokinesis

Author:
Sebastián Lorenzo-Benito; Luis Alberto Rivera-Rivas; Lizbeth Sánchez-Ayala; Jaime Ortega-López; Octavio Montes-Flores; Daniel Talamás-Lara; Rossana Arroyo
Source:
Genes 2022 v.13 no.6 pp. -
ISSN:
2073-4425
Subject:
Trichomonas vaginalis,   etc   ; Escherichia coli; actin; cytokinesis; flagellum; fluorescent antibody technique; mitosis; morphogenesis; nanotubes; parasites; pseudopodia; tubulin;     Show all 12 Subjects
Abstract:
... Actin and tubulin proteins from Trichomonas vaginalis are crucial for morphogenesis and mitosis. This parasite has 10 and 11 genes coding bonafide actin and tubulin proteins, respectively. Hence, the goal of this work was to analyze these actin and tubulin genes, their expression at the mRNA and protein levels, and their parasite localization in intercellular interaction and cytokinesis. Represent ...
DOI:
10.3390/genes13061067