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1. Naphthenic Acid Mixtures and Acid-Extractable Organics from Oil Sands Process-Affected Water Impair Embryonic Development of Silurana (Xenopus) tropicalis

Author:
Trudeau, Vance L.,   et al.   ; Gutierrez-Villagomez, Juan M.; Peru, Kerry M.; Edington, Connor; Headley, John V.; Pauli, Bruce D.;     Show all 6 Authors
Source:
Environmental science & technology 2019 v.53 no.4 pp. 2095-2104
ISSN:
1520-5851
Subject:
Xenopus; abnormal development; amphibians; bitumen; body size; carboxylic acids; death; digestive system; edema; embryogenesis; guidelines; heart; lethal concentration 50; mass spectrometry; median effective concentration; mine tailings; mining; naphthenates; oil sands; oils; oxygen; petroleum; ponds; teratogenicity; toxic substances; wastewater
Abstract:
... Naphthenic acids (NAs) are carboxylic acids naturally occurring in crude oils and bitumen and are suspected to be the primary toxic substances in wastewaters associated with oil refineries and mining of oil sands. Oil sands process-affected water (OSPW) generated by the extraction of bitumen from oil sands are a major source of NAs and are currently stored in tailings ponds. We report on the acute ...
DOI:
10.1021/acs.est.8b04461

2. Can estrogens be considered as key elements of the challenge hypothesis? The case of intrasexual aggression in a cichlid fish

Author:
Trudeau, Vance L.,   et al.   ; Scaia, María Florencia; Morandini, Leonel; Noguera, CristobalAlejandro; Somoza, Gustavo Manuel; Pandolfi, Matías;     Show all 6 Authors
Source:
Physiology & behavior 2018 v.194 pp. 481-490
ISSN:
0031-9384
Subject:
Cichlasoma dimerus; aggression; aromatization; estrogens; females; males; physiological regulation; testosterone
Abstract:
... Territorial aggression has been widely studied in males and it has been historically suggested that androgens are key mediators of this behavior. However, more recent evidence suggests that it is the aromatization to estrogens, rather than androgens themselves, that is key to regulating this behavior. Females also display aggressive behaviors, but the physiological regulation of female aggression ...
DOI:
10.1016/j.physbeh.2018.06.028

3. Implication of microRNA deregulation in the response of vertebrates to endocrine disrupting chemicals

Author:
Trudeau, Vance L.,   et al.   ; Cameron, Brooke E.; Craig, Paul M.;     Show all 3 Authors
Source:
Environmental toxicology and chemistry 2016 v.35 no.4 pp. 788-793
ISSN:
0730-7268
Subject:
antidepressants; aquatic organisms; carcinogenesis; ecotoxicology; endocrine-disrupting chemicals; estrogens; gonadotropins; messenger RNA; microRNA; neoplasms; physiology; plants (botany); thyroid hormones; tissues; translation (genetics); vertebrates; wildlife
Abstract:
... Micro ribonucleic acids (miRNAs) are recently discovered small regulatory molecules that control messenger RNA (mRNA) translation in plants and animals and have been implicated in a variety of hormone‐related physiological pathways. Estrogens, thyroid hormones, and gonadotropins are all known to act on miRNA abundance to cause major shifts in cellular activity, physiology, and homeostatic control ...
DOI:
10.1002/etc.3063

4. Bioconcentration of polycyclic musks in fathead minnows caged in a wastewater effluent plume

Author:
Trudeau, Vance L.,   et al.   ; Lefebvre, Claudine; Kimpe, Linda E.; Metcalfe, Chris D.; Blais, Jules M.;     Show all 5 Authors
Source:
Environmental pollution 2017 v.231 pp. 1593-1600
ISSN:
0269-7491
Subject:
Oncorhynchus mykiss; air; bioaccumulation factor; biotransformation; females; fish; models; risk; rivers; sediments; vitellogenin; wastewater; wastewater treatment; Alberta; Saskatchewan
Abstract:
... The synthetic polycyclic musks HHCB (Galaxolide®) and AHTN (Tonalide®) were monitored in fathead minnows (FHMs) caged for a month at various locations in the North Saskatchewan River (NSR), upstream and downstream of the Gold Bar wastewater treatment plant that serves the city of Edmonton, AB, Canada. In addition, the distribution of these musk compounds in the river was predicted using the fugaci ...
DOI:
10.1016/j.envpol.2017.09.062

5. Endocrine disrupting effects of waterborne fluoxetine exposure on the reproductive axis of female goldfish, Carassius auratus Toxicology & pharmacology

Author:
Trudeau, Vance L.,   et al.   ; Mennigen, Jan A.; Zamora, Jacob M.; Chang, John P.;     Show all 4 Authors
Source:
Comparative biochemistry and physiology 2017 v.202 pp. 70-78
ISSN:
1532-0456
Subject:
Carassius auratus; animal ovaries; aromatase; drugs; endocrine-disrupting chemicals; estradiol; experimental design; females; goldfish; gonadosomatic index; gonadotropin receptors; homeostasis; luteinizing hormone; males; messenger RNA; pituitary gland; reproduction; serotonin; somatotropin; testosterone; vasotocin
Abstract:
... Evidence suggests that pharmaceuticals and personal care products reach urban watersheds, bioconcentrate in fish, and potentially disrupt physiological homeostasis. These impairments often affect hormone functions. Selective serotonin reuptake inhibitors (SRRIs) are increasingly studied with regards to their endocrine disrupting effects on teleost physiological processes, including reproduction. T ...
DOI:
10.1016/j.cbpc.2017.08.003

6. Analysis of naphthenic acid mixtures as pentafluorobenzyl derivatives by gas chromatography-electron impact mass spectrometry

Author:
Trudeau, Vance L.,   et al.   ; Gutierrez-Villagomez, Juan Manuel; Vázquez-Martínez, Juan; Ramírez-Chávez, Enrique; Molina-Torres, Jorge;     Show all 5 Authors
Source:
Talanta 2017 v.162 pp. 440-452
ISSN:
0039-9140
Subject:
additives; carboxylic acids; derivatization; distillation; emulsifiers; gas chromatography; hexane; industry; infrastructure; mass spectrometry; methanol; naphthenates; oil sands; oils; preservatives; surfactants; toxicity
Abstract:
... In this study, we report for the first time the efficiency of pentafluorobenzyl bromide (PFBBr) for naphthenic acid (NA) mixtures derivatization, and the comparison in the optimal conditions to the most common NAs derivatization reagents, BF3/MeOH and N-(t-butyldimethylsilyl)-N-methyltrifluoroacetamide (MTBSTFA). Naphthenic acids are carboxylic acid mixtures of petrochemical origin. These compound ...
DOI:
10.1016/j.talanta.2016.10.057

7. Dehydroabietic acid cytotoxicity in goldfish radial glial cells in vitro

Author:
Trudeau, Vance L.,   et al.   ; Xing, Lei; Gutierrez-Villagomez, Juan Manuel; Da Fonte, Dillon F.; Venables, Maddie J.;     Show all 5 Authors
Source:
Aquatic toxicology 2016 v.180 pp. 78-83
ISSN:
0166-445X
Subject:
aquatic environment; central nervous system; cytotoxicity; death; gene expression; goldfish; lactate dehydrogenase; neurogenesis; neuroglia; steroidogenesis
Abstract:
... Dehydroabietic acid (DHAA) is a resin acid present in aquatic environments shown to induce cellular and molecular damage in aquatic animals. In this study, the cytotoxicity of DHAA on primary cultured goldfish radial glial cells (RGCs), an important component of the central nervous system, was evaluated. Here, it is reported that a concentration of 20mg/L DHAA affected cellular morphology and expr ...
DOI:
10.1016/j.aquatox.2016.09.009

8. Characterization of multiple nestin isoforms in the goldfish brain Part D Genomics and proteomics

Author:
Trudeau, Vance L.,   et al.   ; Venables, Maddie J.; Navarro-Martín, Laia; Basak, Ajoy; Baum, Bernard R.; Zhang, Dapeng;     Show all 6 Authors
Source:
Comparative biochemistry and physiology 2016 v.19 pp. 8-17
ISSN:
1744-117X
Subject:
Western blotting; alternative splicing; amino acids; antibodies; brain; complementary DNA; goldfish; humans; intermediate filaments; mass spectrometry; mice; molecular weight; neurogenesis; nucleotides; protein isoforms; proteins; rapid amplification of cDNA ends; sequence analysis
Abstract:
... Nestin is an intermediate filament protein involved in neurogenesis in fish, mice, and humans. In this study we used rapid amplification of cDNA ends PCR to isolate goldfish nestin (nes). PCR analysis and sequencing revealed three different nes transcripts of 4003, 2446, and 2126 nucleotides, which are predicted to generate proteins of 860, 274, and 344 amino acids in length. Sequence analysis sug ...
DOI:
10.1016/j.cbd.2016.05.002

9. Proteomic profiling reveals dopaminergic regulation of progenitor cell functions of goldfish radial glial cells in vitro

Author:
Trudeau, Vance L.,   et al.   ; Xing, Lei; Martyniuk, Christopher J.; Esau, Crystal; Da Fonte, Dillon F.;     Show all 5 Authors
Source:
Journal of proteomics 2016 v.144 pp. 123-132
ISSN:
1874-3919
Subject:
Western blotting; actin; adenosine monophosphate; adenosine triphosphate; adults; agonists; biomarkers; brain; calcium; cell cycle; cyclic AMP; dopamine; dopamine receptors; estrogen receptors; females; glucose; goldfish; hormones; muscles; neurogenesis; neuroglia; neurons; neurotransmitters; phosphoglycerate dehydrogenase; protein synthesis; proteome; proteomics; quantitative polymerase chain reaction; signal transduction; stem cells; steroids; triose-phosphate isomerase
Abstract:
... Radial glial cells (RGCs) are stem-like cells found in the developing and adult central nervous system. They function as both a scaffold to guide neuron migration and as progenitor cells that support neurogenesis. Our previous study revealed a close anatomical relationship between dopamine neurons and RGCs in the telencephalon of female goldfish. In this study, label-free proteomics was used to id ...
DOI:
10.1016/j.jprot.2016.05.003

10. Exploring Antipredator Mechanisms: New Findings in Ceratophryid Tadpoles

Author:
Trudeau, Vance L.,   et al.   ; Salgado Costa, Carolina; Ronco, Alicia E.; Natale, Guillermo S.;     Show all 4 Authors
Source:
Journal of Herpetology 2016 v.50 no.2 pp. 233-238
ISSN:
0022-1511
Subject:
cannibalism; frogs; hunger; ingestion; predation; tadpoles
Abstract:
... Previous studies found that two larvae of the family Ceratophryidae, Ceratophrys ornata (Ornate Horned Frogs) and Ceratophrys cranwelli (Cranwell's Horned Frogs), are able to produce underwater sounds as an antipredator strategy. Here, we determined whether tadpoles of another ceratophryid, Lepidobatrachus llanensis (Llanos Frogs), also produce underwater sounds in similar contexts of intraspecifi ...
DOI:
10.1670/14-179

11. Silver nanoparticles stimulate glycogenolysis in rainbow trout (Oncorhynchus mykiss) hepatocytes

Author:
Trudeau, Vance L.,   et al.   ; Massarsky, Andrey; Labarre, Justine; Moon, Thomas W.;     Show all 4 Authors
Source:
Aquatic toxicology 2014 v.147 pp. 68-75
ISSN:
0166-445X
Subject:
Oncorhynchus mykiss; bioactive properties; glucocorticoid receptors; gluconeogenesis; glucose; glycogenolysis; hepatocytes; nanosilver; signal transduction; stress response; trout
Abstract:
... Silver nanoparticles (AgNPs) are found in many consumer products yet their biological effects on non-target aquatic organisms are yet to be fully understood. This research aimed to investigate the effects of AgNPs on cell signaling in rainbow trout (Oncorhynchus mykiss) hepatocytes. We focused on the β-adrenoreceptor (AR), which mediates glycogenolysis, and the glucocorticoid receptor (GCR), which ...
DOI:
10.1016/j.aquatox.2013.11.026

12. Sublethal effects on wood frogs chronically exposed to environmentally relevant concentrations of two neonicotinoid insecticides

Author:
Trudeau, Vance L.,   et al.   ; Robinson, Stacey A.; Richardson, Sarah D.; Dalton, Rebecca L.; Maisonneuve, France; Pauli, Bruce D.; Lee‐Jenkins, Stacey S.Y.;     Show all 7 Authors
Source:
Environmental toxicology and chemistry 2017 v.36 no.4 pp. 1101-1109
ISSN:
0730-7268
Subject:
Rana sylvatica; amphibians; aquatic ecosystems; chronic exposure; crops; imidacloprid; metamorphosis; population dynamics; sublethal effects; tadpoles; thiamethoxam
Abstract:
... Neonicotinoids are prophylactically used globally on a variety of crops, and there is concern for the potential impacts of neonicotinoids on aquatic ecosystems. The intensive use of pesticides on crops has been identified as a contributor to population declines of amphibians, but currently little is known regarding the sublethal effects of chronic neonicotinoid exposure on amphibians. The objectiv ...
DOI:
10.1002/etc.3739

13. Effects of hormonal stimulation on the concentration and quality of excreted spermatozoa in the critically endangered Panamanian golden frog (Atelopus zeteki)

Author:
Trudeau, Vance L.,   et al.   ; Della Togna, Gina; Gratwicke, Brian; Evans, Matthew; Augustine, Lauren; Chia, Han; Bronikowski, Edward J.; Murphy, James B.; Comizzoli, Pierre;     Show all 9 Authors
Source:
Theriogenology 2017 v.91 pp. 27-35
ISSN:
0093-691X
Subject:
Atelopus; DNA; acrosome; agonists; body weight; cryopreservation; frogs; germplasm; gonadotropin-releasing hormone; human chorionic gonadotropin; intraperitoneal injection; males; metoclopramide; mitochondria; pH; sperm concentration; urine
Abstract:
... Knowledge of basic gamete biology is critical to better protect and propagate endangered amphibian species and also to develop reproductive technologies combined with germplasm cryopreservation. The objectives of the study were to test different hormonal stimulations and then characterize the quantity and quality of Panamanian golden frog (Atelopus zeteki) spermatozoa. Following intraperitoneal in ...
DOI:
10.1016/j.theriogenology.2016.12.033

14. A botanical extract of Souroubea sympetala and its active principle, betulinic acid, attenuate the cortisol response to a stressor in rainbow trout, Oncorhynchus mykiss

Author:
Trudeau, Vance L.,   et al.   ; Mullally, Martha; Mimeault, Caroline; Otárola Rojas, Marco; Sanchez Vindas, Pablo; Garcia, Mario; Poveda Alvarez, Luis; Moon, Thomas W.; Gilmour, Kathleen M.; Arnason, John Thor;     Show all 10 Authors
Source:
Aquaculture 2017 v.468 pp. 26-31
ISSN:
0044-8486
Subject:
Oncorhynchus mykiss; aquaculture; betulinic acid; corticotropin; cortisol; cytotoxicity; diet; humans; kidneys; trout
Abstract:
... The capacity of the traditional anxiolytic plant, Souroubea sympetala, and its bioactive principle, betulinic acid (BA), to lower cortisol levels in rainbow trout, Oncorhynchus mykiss, was investigated. Effects at the level of the cortisol-producing interrenal cells were investigated using an in vitro head kidney preparation. Head kidney tissue incubated with S. sympetala extract or BA produced si ...
DOI:
10.1016/j.aquaculture.2016.09.040

15. Growth, development and incidence of deformities in amphibian larvae exposed as embryos to naphthenic acid concentrations detected in the Canadian oil sands region

Author:
Trudeau, Vance L.,   et al.   ; Melvin, Steven D.;     Show all 2 Author
Source:
Environmental pollution 2012 v.167 pp. 178-183
ISSN:
0269-7491
Subject:
Lithobates; Xenopus tropicalis; amphibians; hatching; lethal concentration 50; mortality; naphthenates; oil sands; pollution; tadpoles; wildlife
Abstract:
... Naphthenic acids (NA) have been identified as harmful environmental contaminants that influence survival, growth and development of wildlife. Amphibian larvae are particularly susceptible to waterborne contaminants, but little information exists regarding exposure of amphibian embryos or tadpoles to NA. Our results demonstrate that embryos of Lithobates pipiens and Silurana tropicalis exposed to 2 ...
DOI:
10.1016/j.envpol.2012.04.002
PubMed:
22575099

16. Transcript profiles and triiodothyronine regulation of sex steroid- and thyroid hormone-related genes in the gonad–mesonephros complex of Silurana tropicalis

Author:
Trudeau, Vance L.,   et al.   ; Duarte-Guterman, Paula;     Show all 2 Author
Source:
Molecular and cellular endocrinology 2011 v.331 no.1 pp. 143-149
ISSN:
0303-7207
Subject:
Xenopus tropicalis; amphibians; bioactive properties; estrogen receptors; gene expression; genes; masculinization; metamorphosis; reverse transcriptase polymerase chain reaction; sex hormones; tadpoles; triiodothyronine
Abstract:
... In amphibians, the main role of thyroid hormones (THs) is to regulate metamorphosis; however, there is evidence that THs also affect gonadal sexual differentiation. In this study, Silurana (Xenopus) tropicalis tadpoles were exposed to triiodothyronine (T3; 0, 0.5, 5 and 50nM), the bioactive form of THs for 48h. Real-time RT-PCR analyses in the gonad–mesonephros complex (GMC) revealed that TH- and ...
DOI:
10.1016/j.mce.2010.09.004

17. Genotype–environment interactions for survival at low and sub-zero temperatures at varying salinity for channel catfish, hybrid catfish and transgenic channel catfish

Author:
Trudeau, Vance L.,   et al.   ; Abass, Nermeen Y.; Elwakil, Houssam E.; Hemeida, Alaa A.; Abdelsalam, Nader R.; Ye, Zhi; Su, Baofeng; Alsaqufi, Ahmed S.; Weng, Chia-Chen; Dunham, Rex A.;     Show all 10 Authors
Source:
Aquaculture 2016 v.458 pp. 140-148
ISSN:
0044-8486
Subject:
Ictalurus furcatus; Ictalurus punctatus; actin; antifreeze proteins; aquaculture; catfish; climate change; fingerlings; freezing; genotype-environment interaction; glutamate decarboxylase; goldfish; gonadotropin-releasing hormone; heterosis; hybrids; males; natural resource management; osmoregulation; pleiotropy; risk; salinity; somatotropin; survival rate; temperature; transgenes; transgenic animals; weather
Abstract:
... Organisms exposed to sub-zero temperatures are at risk of freezing damage. Fingerling channel catfish, Ictalurus punctatus, hybrid catfish (channel catfish female×blue catfish, Ictalurus furcatus, male), channel catfish transgenic for the goldfish glutamate decarboxylase 65 gene driven by the carp β-actin promoter (βA-GAD65), and channel catfish transgenic for the catfish growth hormone gene drive ...
DOI:
10.1016/j.aquaculture.2016.02.031

18. Acute embryonic exposure to nanosilver or silver ion does not disrupt the stress response in zebrafish (Danio rerio) larvae and adults

Author:
Trudeau, Vance L.,   et al.   ; Massarsky, Andrey; Strek, Laura; Craig, Paul M.; Eisa-Beygi, Shahram; Moon, Thomas W.;     Show all 6 Authors
Source:
The Science of the total environment 2014 v.478 pp. 133-140
ISSN:
0048-9697
Subject:
Danio rerio; adulthood; adults; antibacterial properties; aquatic environment; corticotropin; cortisol; fish; larvae; nanosilver; silver; stress response; toxicity
Abstract:
... The antibacterial properties of silver nanoparticles (AgNPs) are widely exploited in a variety of medical and consumer products. AgNPs in these products can be released into the aquatic environment, however, the potential toxicity of AgNPs to organisms, including fish, is yet to be fully understood. The present study aimed to investigate the effects of the early life exposure to AgNPs on the hypot ...
DOI:
10.1016/j.scitotenv.2014.01.077

19. Extracts from hardwood trees used in commercial paper mills contain biologically active neurochemical disruptors

Author:
Trudeau, Vance L.,   et al.   ; Basu, Niladri; Waye, Andrew; Arnason, John T.;     Show all 4 Authors
Source:
The Science of the total environment 2012 v.414 pp. 205-209
ISSN:
0048-9697
Subject:
Juglans cinerea; acetylcholinesterase; amine oxidase (flavin-containing); cholinergic receptors; enzyme activity; fish; gamma-aminobutyric acid; glutamic acid; hardwood; juglone; paper; paper pulp; pulp and paper mill effluents; trees; wood extractives
Abstract:
... Following on our discovery that pulp and paper mill effluents can interact with, and disrupt, various neurotransmitter receptors and enzymes important to fish reproduction, we tested wood and bark extracts of 14 Eastern North American hardwood trees used in pulp and paper production. Radioligand binding to neurotransmitter receptors, including the dopamine-2 receptor (D2), the gamma aminobutyric a ...
DOI:
10.1016/j.scitotenv.2011.10.061
PubMed:
22137476

20. Mercury-induced reproductive impairment in fish

Author:
Trudeau, Vance L.,   et al.   ; Crump, Kate L.;     Show all 2 Author
Source:
Environmental toxicology and chemistry 2009 v.28 no.5 pp. 895-907
ISSN:
0730-7268
Subject:
mercury; animal reproduction; endocrine-disrupting chemicals; neurotoxins; fish; hypothalamic regulation; neurotransmitters; pituitary hormones; spermatogenesis; testes; sperm motility; oogenesis; steroidogenesis; vitellogenesis; lipids; ovulation; spawning; eggs; embryo (animal); hatching
Abstract:
... Mercury is a potent neurotoxin, and increasing levels have led to concern for human and wildlife health in many regions of the world. During the past three decades, studies in fish have examined the effects of sublethal mercury exposure on a range of endpoints within the reproductive axis. Mercury studies have varied from highly concentrated aqueous exposures to ecologically relevant dietary expos ...
DOI:
10.1897/08-151.1
PubMed:
19102578