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- Author:
- Barbosa, Rosicler L.; da Cunha, Julia Pinheiro Chagas; Menezes, Arthur T.; Melo, Raíssa de F.P.; Elias, Maria Carolina; Silber, Ariel M.; Coltri, Patricia P.
- Source:
- Journal of proteomics 2020 v.223 pp. 103822
- ISSN:
- 1874-3919
- Subject:
- Trypanosoma cruzi, etc ; proteomics; spliceosomes; Show all 3 Subjects
- Abstract:
- ... The unicellular protists of the group Kinetoplastida include the genera Leishmania and Trypanosoma, which are pathogens of invertebrate and vertebrate animals. Despite their medical and economical importance, critical aspects of their biology such as specific molecular characteristics of gene expression regulation are just beginning to be deciphered. Gene expression regulation also depends on post ...
- DOI:
- 10.1016/j.jprot.2020.103822
-
https://dx.doi.org/10.1016/j.jprot.2020.103822
- Author:
- Sánchez-Vega, José Trinidad; Almanza-Mackintoy, Angélica; Luna-Santillán, Alejandra Victoria; De La Sancha-Solares, Tania
- Source:
- Parasitology international 2020 v.77 pp. 102121
- ISSN:
- 1383-5769
- Subject:
- Trypanosoma cruzi, etc ; Chagas disease; Triatoma; blood; case studies; feces; hosts; patients; trypomastigotes; xenodiagnosis; zoonoses; Show all 11 Subjects
- Abstract:
- ... Chagas disease is a serious problem of parasitic disease in the American continent, this zoonosis is caused by the flagellated protozoan known as Trypanosoma cruzi and transmitted through trypomastigotes present in the blood of sick hosts or in the faeces of the triatomines.Metacyclic trypomastigotes were detected in the faeca material of Triatoma pallidepennis maintained in the laboratory after t ...
- DOI:
- 10.1016/j.parint.2020.102121
-
https://dx.doi.org/10.1016/j.parint.2020.102121
- Author:
- Ghartey-Kwansah, George; Aboagye, Benjamin; Adu-Nti, Frank; Opoku, Yeboah Kwaku; Abu, Emmanuel Kwasi
- Source:
- Life sciences 2020 v.247 pp. 117453
- ISSN:
- 0024-3205
- Subject:
- Trypanosoma cruzi, etc ; Leishmania; Plasmodium; Toxoplasma; autophagy; humans; macrophages; parasites; pathogens; proteins; protozoal infections; public health; therapeutics; Show all 13 Subjects
- Abstract:
- ... The protozoan parasites are evolutionarily divergent, unicellular eukaryotic pathogens representing one of the essential sources of parasitic diseases. These parasites significantly affect the economy and cause public health burdens globally. Protozoan parasites share many cellular features and pathways with their respective host cells. This includes autophagy, a process responsible for self-degra ...
- DOI:
- 10.1016/j.lfs.2020.117453
-
https://dx.doi.org/10.1016/j.lfs.2020.117453
- Author:
- Chung, Jonathan H.; Tang, Arthur H.; Geraghty, Kieran; Corcilius, Leo; Kaiser, Marcel; Payne, Richard J.
- Source:
- Organic letters 2020 v.22 no.8 pp. 3089-3093
- ISSN:
- 1523-7052
- Subject:
- Trypanosoma cruzi, etc ; Okeania; Suzuki reaction; Trypanosoma rhodesiense; antitrypanosomal properties; chemical structure; enantioselectivity; parasites; polyketides; Show all 9 Subjects
- Abstract:
- ... Janadolide is a cyclic depsipeptide natural product isolated from the marine cyanobacterium Okeania sp. Herein, we describe the total synthesis of janadolide, along with eight simplified analogues, via an efficient solid-phase strategy. Crucial to the synthesis of the natural product was the construction of a key polyketide fragment via an enantioselective (−)-B-chlorodiisopinocampheylborane-media ...
- DOI:
- 10.1021/acs.orglett.0c00840
-
http://dx.doi.org/10.1021/acs.orglett.0c00840
- Author:
- Boreiko, Sheila; Silva, Marcio; de F. P. Melo, Raíssa; Silber, Ariel M.; Iulek, Jorge
- Source:
- International journal of biological macromolecules 2020 v.146 pp. 716-724
- ISSN:
- 0141-8130
- Subject:
- Trypanosoma cruzi, etc ; Bacillus kaustophilus; Bacillus subtilis; Pseudomonas putida; biochemical pathways; enzymes; histidine; humans; mutation; Show all 9 Subjects
- Abstract:
- ... The enzyme Urocanate Hydratase (UH) participates in the catabolic pathway of L-histidine. Trypanosoma cruzi Urocanate Hydratase (TcUH) is identified as a therapeutic molecular target in the WHO/TDR Targets Database. We report the 3D structure determination and number of features of TcUH, and compared it to other few available bacterial UH structures. Each monomer presents two domains and one NAD⁺ ...
- DOI:
- 10.1016/j.ijbiomac.2019.12.101
-
https://dx.doi.org/10.1016/j.ijbiomac.2019.12.101
- Author:
- Perin, Luísa; Fonseca, Kátia da Silva; de Carvalho, Thaís Vieira; Carvalho, Lívia Mendes; Madeira, João Vitor; Medeiros, Luciana da Fonseca; Molina, Israel; Correa-Oliveira, Rodrigo; Carneiro, Cláudia Martins; Vieira, Paula Melo de Abreu
- Source:
- Experimental parasitology 2020 v.210 pp. 107834
- ISSN:
- 0014-4894
- Subject:
- Trypanosoma cruzi, etc ; Chagas disease; animal models; benznidazole; blood; colon; heart; mice; parasitism; therapeutics; Show all 10 Subjects
- Abstract:
- ... Studies suggest that the dose of the standard benznidazole (BNZ) treatment regimen might be too high. We investigated the efficacy of BNZ 20 and 40 mg/kg/day compared with standard dose (100 mg/kg/day) to induce cure in mice infected with Trypanosoma cruzi Y strain in the acute and chronic phases of Chagas' disease. Our findings indicate that an experimental treatment with a BNZ low-dose (40 mg/kg ...
- DOI:
- 10.1016/j.exppara.2020.107834
-
https://dx.doi.org/10.1016/j.exppara.2020.107834
- Author:
- Ferreira Cura das Neves, Roberta; Marques Adade, Camila; Silva Fernandes, Anne Cristine; Hampshire Lopes, Angela; Souto-Padrón, Thaïs
- Source:
- Parasitology 2020 v.147 no.3 pp. 310-321
- ISSN:
- 1469-8161
- Subject:
- Trypanosoma cruzi, etc ; antibodies; concanavalin A; ferritin; immune system; ligands; lysine; parasites; trypomastigotes; Show all 9 Subjects
- Abstract:
- ... Capping and shedding of ectodomains in Trypanosoma cruzi may be triggered by different ligands. Here, we analysed the mobility and shedding of cell surface components of living trypomastigotes of the Y strain and the CL Brener clone in the presence of poly-L-lysine, cationized ferritin (CF) and Concanavalin A (Con A). Poly-L-lysine and CF caused intense shedding in Y strain parasites. Shedding was ...
- DOI:
- 10.1017/S0031182019001616
-
http://dx.doi.org/10.1017/S0031182019001616
- Author:
- Kashiwagi, Gustavo A.; Cori, Carmen R.; de Lederkremer, Rosa M.; Gallo-Rodriguez, Carola
- Source:
- Carbohydrate research 2019 v.482 pp. 107734
- ISSN:
- 0008-6215
- Subject:
- Trypanosoma cruzi, etc ; epimastigotes; insects; mucins; trisaccharides; Show all 5 Subjects
- Abstract:
- ... Hexasaccharide β-D-Galp-(1→ 2)-[β-D-Galp-(1 → 3)]-β-D-Galp-(1 → 6)-[β-D-Galp-(1 → 2)-β-D-Galf-(1 → 4)]-D-GlcNAc (1) was found O-linked in mucins of Trypanosoma cruzi epimastigotes and metacyclic trypomatigotes. Studies on the biological pathways and functionalities of the mucin oligosaccharides are prompted in order to understand the interactions of these molecules with the insect host. Trisacchar ...
- DOI:
- 10.1016/j.carres.2019.06.013
-
https://dx.doi.org/10.1016/j.carres.2019.06.013
- Author:
- Meyers, Alyssa C.; Ellis, Megan M.; Purnell, Julia C.; Auckland, Lisa D.; Meinders, Marvin; Saunders, Ashley B.; Hamer, Sarah A.
- Source:
- BMC veterinary research 2020 v.16 no.1 pp. 101
- ISSN:
- 1746-6148
- Subject:
- Trypanosoma cruzi, etc ; Chagas disease; Triatominae; arrhythmia; biomarkers; blood serum; death; dogs; humans; immunologic techniques; troponin I; vaccines; wildlife; zoonoses; Show all 14 Subjects
- Abstract:
- ... BACKGROUND: Chagas disease is increasingly recognized in the southern U.S., where triatomine vectors transmit Trypanosoma cruzi among wildlife and domestic dogs with occasional vector spillover to humans. As in humans, clinical outcome in dogs is variable, ranging from acute death to asymptomatic infections or chronic heart disease. In order to characterize cardiac manifestations of T. cruzi infec ...
- DOI:
- 10.1186/s12917-020-02322-6
- PubMed:
- 32228593
- PubMed Central:
- PMC7106864
-
https://dx.doi.org/10.1186/s12917-020-02322-6
- Author:
- Majeau, Alicia; Pronovost, Henry; Sanford, Anna; Cloherty, Erin; Anderson, A. Nikki; Balsamo, Gary; Gee, Laura; Straif-Bourgeois, Susanne C.; Herrera, Claudia
- Source:
- Vector borne and zoonotic diseases 2020 v.20 no.7 pp. 535-540
- ISSN:
- 1557-7759
- Subject:
- Trypanosoma cruzi, etc ; Procyon lotor; animal diseases; human health; metropolitan areas; parasitemia; polymerase chain reaction; risk; tissues; Louisiana; Show all 10 Subjects
- Abstract:
- ... Raccoons are an important reservoir for Trypanosoma cruzi infection, having been reported to maintain a high and lengthy parasitemia. Although raccoon populations have historically been abundant in Louisiana, the prevalence rate of T. cruzi infection in raccoons in this state is unknown. Here, we tested raccoon tissues from two urban areas in Louisiana, namely Orleans Parish (OP) and East Baton Ro ...
- DOI:
- 10.1089/vbz.2019.2559
-
https://dx.doi.org/10.1089/vbz.2019.2559
- Author:
- da Silva, Marcelo S.; O. Vitarelli, Marcela; F. Souza, Bruno; Elias, Maria Carolina
- Source:
- Genes 2020 v.11 no.5
- ISSN:
- 2073-4425
- Subject:
- Trypanosoma cruzi, etc ; Internet; Leishmania major; Saccharomyces cerevisiae; Schizosaccharomyces pombe; Trypanosoma brucei; chromosomes; eukaryotic cells; genome; interphase; replication origin; yeasts; Show all 12 Subjects
- Abstract:
- ... Single-celled eukaryote genomes predominantly replicate through multiple origins. Although origin usage during the S-phase has been elucidated in some of these organisms, few studies have comparatively approached this dynamic. Here, we developed a user-friendly website able to calculate the length of the cell cycle phases for any organism. Next, using a formula developed by our group, we showed a ...
- DOI:
- 10.3390/genes11050523
-
https://dx.doi.org/10.3390/genes11050523
- Author:
- Parra, Federico L.; Frank, Fernanda M.; Alliani, Bruno F.; Romero, Eder L.; Petray, Patricia B.
- Source:
- Colloids and surfaces 2020 v.189 pp. 110850
- ISSN:
- 0927-7765
- Subject:
- Trypanosoma cruzi, etc ; Chagas disease; acute course; animal models; immunotherapy; infectious diseases; lipids; mice; mortality; musculoskeletal system; parasitemia; Show all 11 Subjects
- Abstract:
- ... The purpose of this study was to evaluate the efficacy of imiquimod-containing nanovesicles prepared with lipids extracted from the hyperhalophile archaebacterium Halorubrum tebenquichense (nanoARC-IMQ) to induce protection against Trypanosoma cruzi infection. The therapeutic efficacy of archaeolipid nanovesicles was assessed in an experimental murine model of acute infection with T. cruzi. The ad ...
- DOI:
- 10.1016/j.colsurfb.2020.110850
-
https://dx.doi.org/10.1016/j.colsurfb.2020.110850
- Author:
- de Carvalho, Renan V.H.; Zamboni, Dario S.
- Source:
- Trends in parasitology 2020 v.36 no.5 pp. 459-472
- ISSN:
- 1471-4922
- Subject:
- Trypanosoma cruzi, etc ; Leishmania; Plasmodium; Toxoplasma gondii; caspase-1; cytokines; fungi; host-pathogen relationships; inflammasomes; inflammation; parasites; parasitoses; pyroptosis; Show all 13 Subjects
- Abstract:
- ... Inflammasomes are cytosolic complexes that assemble in response to cellular stress or upon sensing microbial molecules, culminating in cytokine processing and an inflammatory form of cell death called pyroptosis. Inflammasomes are usually composed of a sensor molecule, an adaptor protein, and an inflammatory caspase, such as Caspase-1, which cleaves and activates multiple substrates, including Gas ...
- DOI:
- 10.1016/j.pt.2020.02.006
-
https://dx.doi.org/10.1016/j.pt.2020.02.006
- Author:
- Mosquera, Katherine D.; Lorenzo, Marcelo G.
- Source:
- Acta tropica 2020 v.205 pp. 105433
- ISSN:
- 0001-706X
- Subject:
- Trypanosoma cruzi, etc ; Chagas disease; Rhodnius prolixus; etiological agents; health services; insect vectors; lighting; photoperiod; phototaxis; sensory ecology; thigmotaxis; Latin America; Show all 12 Subjects
- Abstract:
- ... Triatomines are insect vectors of Trypanosoma cruzi¸ the etiological agent of Chagas disease. Several species belonging to the genus Rhodnius (Hemiptera: Reduviidae) have been reported inhabiting domestic and peridomestic environments in different regions of Latin America. However, behavioral and sensory ecology aspects related to their use of shelters have been poorly studied. The objective of th ...
- DOI:
- 10.1016/j.actatropica.2020.105433
-
https://dx.doi.org/10.1016/j.actatropica.2020.105433
- Author:
- Santos, Renato Elias Rodrigues de Souza; Naves, Lucila Langoni; Fajardo, Emanuella Francisco; Ramirez, Luis Eduardo; Lages-Silva, Eliane; Pedrosa, André Luiz; Ferreira, Keila Adriana Magalhães
- Source:
- Vector borne and zoonotic diseases 2020 v.20 no.2 pp. 117-124
- ISSN:
- 1557-7759
- Subject:
- Trypanosoma cruzi, etc ; Chagas disease; Leishmania braziliensis; Trypanosoma brucei; Trypanosoma rangeli; etiological agents; genes; genotyping; restriction fragment length polymorphism; ribosomal DNA; Show all 10 Subjects
- Abstract:
- ... Trypanosoma rangeli is an avirulent flagellate protozoan that could mislead correct diagnosis of Trypanosoma cruzi infection, the causative agent of Chagas' disease, given their high similarity. Besides, T. rangeli presents two genetic groups, whose differentiation is achieved mainly by molecular approaches. In this context, ribosomal DNA (rDNA) is a useful target for intra and interspecific molec ...
- DOI:
- 10.1089/vbz.2019.2496
-
https://dx.doi.org/10.1089/vbz.2019.2496
- Author:
- Pereyra, N.; Lobbia, P.A.; Mougabure-Cueto, G.
- Source:
- Bulletin of entomological research 2020 v.110 no.1 pp. 169-176
- ISSN:
- 1475-2670
- Subject:
- Trypanosoma cruzi, etc ; Triatoma infestans; ad libitum feeding; defecation; excretion; feces; feeding patterns; insects; mammals; mucosa; nymphs; probability; urine; vector competence; Show all 14 Subjects
- Abstract:
- ... Transmission of Trypanosma cruzi (Kinetoplastida: Trypanosomatidae) occurs when feces/urine of infected triatomines come into contact with mucous membranes or damaged skin, and this occurs mainly when insects defecate while feeding on the host. Thus, the vector competence of the triatomines is associated with their feeding and excretion/defecation behavior. This work studied for the first time the ...
- DOI:
- 10.1017/S0007485319000464
-
http://dx.doi.org/10.1017/S0007485319000464
- Author:
- Pérez-Antón, Elena; Egui, Adriana; Thomas, Mª Carmen; Simón, Marina; Segovia, Manuel; López, Manuel Carlos
- Source:
- Acta tropica 2020 v.202 pp. 105242
- ISSN:
- 0001-706X
- Subject:
- Trypanosoma cruzi, etc ; CD8-positive T-lymphocytes; Chagas disease; benznidazole; biomarkers; cytokines; cytotoxicity; interferon-gamma; monitoring; patients; phenotype; receptors; therapeutics; Show all 13 Subjects
- Abstract:
- ... The lack of useful tools for detection the impact of treatment during the follow-up of chronic Chagas disease treated patients difficult the adequate care to the affected population. The objective of this study was to evaluate the functional response of CD8⁺ T lymphocyte population, critical for the control of Trypanosoma cruzi infection, as a possible cellular biomarker of treated Chagas disease ...
- DOI:
- 10.1016/j.actatropica.2019.105242
-
https://dx.doi.org/10.1016/j.actatropica.2019.105242
- Author:
- Breyner, Natália Martins; Hecht, Mariana; Nitz, Nadjar; Rose, Ester; Carvalho, Juliana Lott
- Source:
- Acta tropica 2020 v.202 pp. 105262
- ISSN:
- 0001-706X
- Subject:
- Trypanosoma cruzi, etc ; Chagas disease; animal organs; ethics; host-parasite relationships; in vitro studies; in vivo studies; intestines; pathophysiology; Show all 9 Subjects
- Abstract:
- ... Chagas disease (CD), caused by Trypanosoma cruzi, is the main parasitic disease in the Western Hemisphere, with an increasing number of cases, especially in non-endemic regions. The disease is characterized by cardiomegaly and mega viscera, nevertheless, the clinical outcome is hard to predict, underscoring the need for further research into the pathophysiology of CD. Even though most basic and tr ...
- DOI:
- 10.1016/j.actatropica.2019.105262
-
https://dx.doi.org/10.1016/j.actatropica.2019.105262
- Author:
- Martínez-Ibarra, J Alejandro; Meraz-Medina, Tzintli; Nogueda-Torres, Benjamin; Villagrán-Herrera, María E; de Diego-Cabrera, Jose A; Rust, Michael
- Source:
- Journal of medical entomology 2020 v.57 no.1 pp. 33-38
- ISSN:
- 1938-2928
- Subject:
- Trypanosoma cruzi, etc ; Triatoma; adults; defecation; geographical distribution; hematophagy; humans; instars; life history; molting; monitoring; mortality; nymphs; vectorial capacity; Mexico; Show all 15 Subjects
- Abstract:
- ... This study reports the third collection of Triatoma nitida Usinger in Mexico, with a brief description of the collection area and an investigation of parameters related to its vectorial capacity. Whether a triatomine (Hemiptera: Reduviidae) species is a primary or secondary vector is determined by factors that include vectorial capacity, anthropophilic habits, geographic distribution, and capacity ...
- DOI:
- 10.1093/jme/tjz163
-
https://dx.doi.org/10.1093/jme/tjz163
- Author:
- Sinclair, Amy N.; de Graffenried, Christopher L.
- Source:
- Trends in parasitology 2019 v.35 no.10 pp. 760-777
- ISSN:
- 1471-4922
- Subject:
- Trypanosoma cruzi, etc ; Leishmania; Trypanosoma brucei; biogenesis; humans; livestock; longevity; microtubules; Show all 8 Subjects
- Abstract:
- ... The subpellicular microtubule array defines the wide range of cellular morphologies found in parasitic kinetoplastids (trypanosomatids). Morphological studies have characterized array organization, but little progress has been made towards identifying the molecular mechanisms that are responsible for array differentiation during the trypanosomatid life cycle, or the apparent stability and longevit ...
- DOI:
- 10.1016/j.pt.2019.07.008
- PubMed:
- 31471215
- PubMed Central:
- PMC6783356
-
https://dx.doi.org/10.1016/j.pt.2019.07.008