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1. Synthesis of the hexasaccharide from Trypanosoma cruzi mucins with the Galp(1 → 2)Galf unit constructed with a superarmed thiogalactopyranosyl donor

Author:
Kashiwagi, Gustavo A.; Cori, Carmen R.; de Lederkremer, Rosa M.; Gallo-Rodriguez, Carola
Source:
Carbohydrate research 2019 v.482 pp. 107734
ISSN:
0008-6215
Subject:
Trypanosoma cruzi,   etc   ; epimastigotes; insects; mucins; trisaccharides;     Show all 5 Subjects
Abstract:
... Hexasaccharide β-D-Galp-(1→ 2)-[β-D-Galp-(1 → 3)]-β-D-Galp-(1 → 6)-[β-D-Galp-(1 → 2)-β-D-Galf-(1 → 4)]-D-GlcNAc (1) was found O-linked in mucins of Trypanosoma cruzi epimastigotes and metacyclic trypomatigotes. Studies on the biological pathways and functionalities of the mucin oligosaccharides are prompted in order to understand the interactions of these molecules with the insect host. Trisacchar ...
DOI:
10.1016/j.carres.2019.06.013

2. Synthesis and Characterization of Sialylated Lactose- and Lactulose-Derived Oligosaccharides by Trypanosoma cruzi Trans-sialidase

Author:
Pham, Hien T. T.; ten Kate, Geert A.; Dijkhuizen, Lubbert; van Leeuwen, Sander S.
Source:
Journal of agricultural and food chemistry 2019 v.67 no.12 pp. 3469-3479
ISSN:
1520-5118
Subject:
Trypanosoma cruzi,   etc   ; breast milk; enzymes; prebiotics; sialic acid; virulent strains;     Show all 6 Subjects
Abstract:
... Sialylated oligosaccharides contribute 12.6–21.9% of total free oligosaccharides in human milk (hMOS). These acidic hMOS possess prebiotic properties and display antiadhesive effects against pathogenic bacteria. Only limited amounts of sialylated hMOS are currently available. The aim of our work is to enzymatically synthesize sialylated oligosaccharides mimicking hMOS functionality. In this study, ...
DOI:
10.1021/acs.jafc.8b06974

3. More than Microtubules: The Structure and Function of the Subpellicular Array in Trypanosomatids

Author:
Sinclair, Amy N.; de Graffenried, Christopher L.
Source:
Trends in parasitology 2019
ISSN:
1471-4922
Subject:
Trypanosoma cruzi,   etc   ; Leishmania; Trypanosoma brucei; biogenesis; humans; livestock; longevity; microtubules;     Show all 8 Subjects
Abstract:
... The subpellicular microtubule array defines the wide range of cellular morphologies found in parasitic kinetoplastids (trypanosomatids). Morphological studies have characterized array organization, but little progress has been made towards identifying the molecular mechanisms that are responsible for array differentiation during the trypanosomatid life cycle, or the apparent stability and longevit ...
DOI:
10.1016/j.pt.2019.07.008

4. Occurrence of domestic and intrusive triatomines (Hemiptera: Reduviidae) in sylvatic habitats of the temperate Monte Desert ecoregion of Argentina

Author:
Carbajal-de-la-Fuente, Ana Laura; Fernández, María del Pilar; Piccinali, Romina Valeria; Rodríguez-Planes, Lucía Inés; Duarte, Rosemere; Gürtler, Ricardo Esteban
Source:
Acta tropica 2019 v.196 pp. 37-41
ISSN:
0001-706X
Subject:
Trypanosoma cruzi,   etc   ; Triatoma infestans; ecoregions; habitats; light traps; males; monitoring; risk; Argentina;     Show all 9 Subjects
Abstract:
... The eco-epidemiology of Triatominae and Trypanosoma cruzi transmission has been little studied in the Argentinean Monte ecoregion. Herein, we provide a comprehensive description of domestic and intrusive triatomines to evaluate the risk of reinfestation of rural dwellings. Triatoma infestans, T. patagonica, T. garciabesi and T. eratyrusiformis were collected by active searches or light traps. None ...
DOI:
10.1016/j.actatropica.2019.04.028

5. Vaccines and the regulatory arm of the immune system. An overview from the Trypanosoma cruzi infection model

Author:
Cabrera, Gabriel; Marcipar, Iván
Source:
Vaccine 2019 v.37 no.28 pp. 3628-3637
ISSN:
0264-410X
Subject:
Trypanosoma cruzi,   etc   ; autoimmune diseases; immune response; models; neoplasms; parasites; pathogens; suppressor cells; vaccine development; vaccines;     Show all 10 Subjects
Abstract:
... The knowledge that the immune system is composed of a regulatory/suppressor arm added a new point of view to better understand the nature of several pathologies including cancer, transplants, infections and autoimmune diseases. The striking discoveries concerning molecules and cells involved in this kind of regulation were followed by the elucidation of equally notable mechanisms used by several p ...
DOI:
10.1016/j.vaccine.2019.05.015

6. Trypanosoma cruzi trans-sialidase. A tool for the synthesis of sialylated oligosaccharides

Author:
Agusti, Rosalía; Gallo-Rodriguez, Carola; de Lederkremer, Rosa M.
Source:
Carbohydrate research 2019 v.479 pp. 48-58
ISSN:
0008-6215
Subject:
Trypanosoma cruzi,   etc   ; adhesion; enzymatic treatment; fetuins; glycoproteins; oligosaccharides; sialic acid; sialidase; stereospecificity; synthesis;     Show all 10 Subjects
Abstract:
... Cells are covered by a complex array of carbohydrates. Among them, sialosides are of key importance in intracellular adhesion, recognition and signaling. The need for structurally diverse sialosides impelled the search for efficient synthetic methods since their isolation from natural sources is a difficult task. The enzymatic approach obviates the need of a chemical synthesis for protecting or pa ...
DOI:
10.1016/j.carres.2019.05.004

7. Synthesis and characterization of α-d-Galp-(1 → 3)-β-d-Galp epitope-containing neoglycoconjugates for chagas disease serodiagnosis

Author:
Lopez, Rosana; Giorgi, M. Eugenia; Melgarejo, Linda Toro; Ducrey, Ivana; Balouz, Virginia; González-Salas, Diego; Cámara, María de los Milagros; Buscaglia, Carlos A.; de Lederkremer, Rosa M.; Marino, Carla
Source:
Carbohydrate research 2019 v.478 pp. 58-67
ISSN:
0008-6215
Subject:
Trypanosoma cruzi,   etc   ; Chagas disease; antibodies; blood serum; glucose; glycosides; immunodominant epitopes; mucins; neoplasms; serodiagnosis; trisaccharides; xenotransplantation;     Show all 12 Subjects
Abstract:
... The immunodominant epitope α-d-Galp-(1 → 3)-β-d-Galp-(1 → 4)-d-GlcNAc, expressed in the mucins of the infective trypomastigote stage of Trypanosoma cruzi has been proposed for multiple clinical applications, from serodiagnosis of protozoan caused diseases to xenotransplantation or cancer vaccinology. It was previously shown that the analogue trisaccharide, with glucose in the reducing end instead ...
DOI:
10.1016/j.carres.2019.04.007

8. The Dynamics of Replication in Trypanosoma cruzi Parasites by Single‐Molecule Analysis

Author:
de Araujo, Christiane B.; Calderano, Simone G.; Elias, Maria Carolina
Source:
Thejournal of eukaryotic microbiology 2019 v.66 no.3 pp. 514-518
ISSN:
1066-5234
Subject:
Trypanosoma cruzi,   etc   ; DNA damage; DNA-directed DNA polymerase; chromatin; epimastigotes; frequency distribution; parasites; transcription (genetics);     Show all 8 Subjects
Abstract:
... Here, we investigated the features of replication in Trypanosoma cruzi epimastigotes based on fork speed progression, which is influenced by distinct features such as DNA polymerase rate, susceptibility to DNA damage and repair, secondary structures, transcription and chromatin state. Although T. cruzi exhibits a mean fork speed (2.05 ± 0.10 kb/min) very similar to other trypanosomatids, we found ...
DOI:
10.1111/jeu.12676

9. Cordycepin (3′-deoxyadenosine) and pentostatin (deoxycoformycin) against Trypanosoma cruzi

Author:
do Carmo, Guilherme M.; de Sá, Mariângela F.; Grando, Thirssa H.; Gressler, Lucas T.; Baldissera, Matheus D.; Monteiro, Silvia G.; Henker, Luan C.; Mendes, Ricardo E.; Stefani, Lenita M.; Da Silva, Aleksandro S.
Source:
Experimental parasitology 2019 v.199 pp. 47-51
ISSN:
0014-4894
Subject:
Trypanosoma cruzi,   etc   ; benznidazole; cordycepin; epimastigotes; lethal dose 50; mice; parasites; therapeutics; trypomastigotes;     Show all 9 Subjects
Abstract:
... The aim of this study was to evaluate in vitro the efficacy of cordycepin and pentostatin (alone or combined) against Trypanosoma cruzi, as well as the therapeutic efficiency of protocols of cordycepin and pentostatin combinations in mice experimentally infected with T. cruzi. In vitro, the cordycepin (3′-deoxyadenosine) and pentostatin (deoxycoformycin) exerted potent trypanocidal effect against ...
DOI:
10.1016/j.exppara.2019.02.016

10. A systematic review of the Trypanosoma cruzi genetic heterogeneity, host immune response and genetic factors as plausible drivers of chronic chagasic cardiomyopathy

Author:
Jiménez, Paula; Jaimes, Jesús; Poveda, Cristina; Ramírez, Juan David
Source:
Parasitology 2019 v.146 no.3 pp. 269-283
ISSN:
1469-8161
Subject:
Trypanosoma cruzi,   etc   ; Chagas disease; cardiomyopathy; cytokines; genetic factors; genetic heterogeneity; immune response; parasites; systematic review; virulence;     Show all 10 Subjects
Abstract:
... Chagas disease is a complex tropical pathology caused by the kinetoplastid Trypanosoma cruzi. This parasite displays massive genetic diversity and has been classified by international consensus in at least six Discrete Typing Units (DTUs) that are broadly distributed in the American continent. The main clinical manifestation of the disease is the chronic chagasic cardiomyopathy (CCC) that is letha ...
DOI:
10.1017/S0031182018001506
PubMed:
30210012

11. Haematological alterations in non-human hosts infected with Trypanosoma cruzi: a systematic review

Author:
Villalba-Alemán, Evaristo; Justinico, David L.; Sarandy, Mariáurea M.; Novaes, Rômulo D.; Freitas, Mariella B.; Gonçalves, Reggiani V.
Source:
Parasitology 2019 v.146 no.2 pp. 142-160
ISSN:
1469-8161
Subject:
Trypanosoma cruzi,   etc   ; Chagas disease; anemia; databases; hosts; mammals; systematic review; tropical diseases;     Show all 8 Subjects
Abstract:
... American trypanosomiasis is a neglected tropical disease whose spectrum has not been quite understood, including the impact of Trypanosoma cruzi infection on the haematological parameters of different vertebrate hosts. Thus, this study was designed to compare the pattern of haematological changes induced by T. cruzi infection in order to identify possible species-specific differences among taxons. ...
DOI:
10.1017/S0031182018001294
PubMed:
30070181 30070181

12. Tridimensional Electron Microscopy Analysis of the Early Endosomes and Endocytic Traffic in Trypanosoma cruzi Epimastigotes

Author:
Alcantara, Carolina de Lima; de Souza, Wanderley; da Cunha e Silva, Narcisa L.
Source:
Protist 2018 v.169 no.6 pp. 887-910
ISSN:
1434-4610
Subject:
Trypanosoma cruzi,   etc   ; electron microscopy; endocytosis; endosomes; epimastigotes; microtubules; temperature;     Show all 7 Subjects
Abstract:
... Trypanosoma cruzi epimastigotes internalize macromolecules avidly by endocytosis. Previously, we identified a tubule-vesicular network likely to correspond to the early-endosomes. However, a detailed ultrastructural characterization of these endosomes was missing. Here, we combined endocytosis assays with ultrastructural data from high-resolution electron microscopy to produce a 3D analysis of epi ...
DOI:
10.1016/j.protis.2018.09.004

13. D-Proline: Comment to “An overview on D-amino acids”

Author:
König, Simone; Marco, Heather; Gäde, Gerd
Source:
Amino acids 2018 v.50 no.2 pp. 359-361
ISSN:
0939-4451
Subject:
Trypanosoma cruzi,   etc   ; Cicadidae; bacteria; neuropeptides; parasites; prokaryotic cells; proline; surveys;     Show all 8 Subjects
Abstract:
... An excellent 2017 review in this journal about D-amino acids by Genchi aims for a comprehensive representation of the current state of knowledge. Unfortunately, information about both D-proline and proline racemase is almost entirely missing. In our investigations into D/L-Pro-containing neuropeptides in cicadas, we have performed literature surveys in this context. Proline racemases in bacteria a ...
DOI:
10.1007/s00726-017-2511-5

14. A reduction in ecological niche for Trypanosoma cruzi-infected triatomine bugs

Author:
Villalobos, Guiehdani; Nava-Bolaños, Angela; De Fuentes-Vicente, José A.; Téllez-Rendón, Juan Luis; Huerta, Herón; Martínez-Hernández, Fernando; Rocha-Ortega, Maya; Gutiérrez-Cabrera, Ana E.; Ibarra-Cerdeña, Carlos N.; Córdoba-Aguilar, Alex
Source:
Parasites & vectors 2019 v.12 no.1 pp. 240
ISSN:
1756-3305
Subject:
Trypanosoma cruzi,   etc   ; Chagas disease; Triatoma dimidiata; geographical distribution; hosts; insects; models; niches; parasites; prediction; vector-borne diseases; Mexico;     Show all 12 Subjects
Abstract:
... BACKGROUND: Theory predicts that parasites can affect and thus drive their hosts’ niche. Testing this prediction is key, especially for vector-borne diseases including Chagas disease. Here, we examined the niche use of seven triatomine species that occur in Mexico, based on whether they are infected or not with Trypanosoma cruzi, the vectors and causative parasites of Chagas disease, respectively. ...
DOI:
10.1186/s13071-019-3489-5

15. Drug discovery for chagas disease: A viewpoint

Author:
Kratz, Jadel Müller
Source:
Acta tropica 2019 v.198 pp. 105107
ISSN:
0001-706X
Subject:
Trypanosoma cruzi,   etc   ; Chagas disease; benznidazole; host-parasite relationships; new drugs; parasites; pathophysiology; patients; people; public health; tropical diseases;     Show all 11 Subjects
Abstract:
... Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. It is a significant public health problem, affecting millions of people worldwide. And although it was described 110 years ago, only two old nitroheterocyclic drugs, benznidazole and nifurtimox, are currently available for the treatment of Chagas disease and both have several limitations. Besides the ...
DOI:
10.1016/j.actatropica.2019.105107

16. Experimental evidences that P21 protein controls Trypanosoma cruzi replication and modulates the pathogenesis of infection

Author:
Teixeira, Thaise L.; Castilhos, Patrícia; Rodrigues, Cassiano C.; da Silva, Aline A.; Brígido, Rebecca TS.; Teixeira, Samuel C.; Borges, Bruna C.; Dos Santos, Marlus A.; Martins, Flávia A.; Santos, Paulo César F.; Servato, João Paulo S.; Silva, M.S.; da Silva, M.J.B.; Elias, M.C.; da Silva, Claudio V.
Source:
Microbial pathogenesis 2019 v.135 pp. 103618
ISSN:
0882-4010
Subject:
Trypanosoma cruzi,   etc   ; amastigotes; angiogenesis; bioactive properties; cell cycle; chemotaxis; epimastigotes; fibrosis; leukocytes; mice; parasite load; parasites; pathogenesis; phagocytosis;     Show all 14 Subjects
Abstract:
... P21 is a protein secreted by Trypanosoma cruzi (T. cruzi). Previous studies have shown a spectrum of biological activities performed by P21 such as induction of phagocytosis, leukocyte chemotaxis and inhibition of angiogenesis. However, the activity of P21 in T. cruzi infection remains unknown. Here, we reported the role of P21 in mice harboring late T. cruzi infection. Treatment with recombinant ...
DOI:
10.1016/j.micpath.2019.103618

17. Hedyosulide, a novel trypanosomicidal sesterterpene lactone from Hedyosmum brasiliense Mart. ex Miq

Author:
Murakami, Cynthia; Cabral, Rodrigo Sant’Ana; Gomes, Kaio S.; Costa-Silva, Thais A.; Amaral, Maiara; Romanelli, Maiara; Tempone, Andre G.; Lago, João Henrique G.; da S. Bolzani, Vanderlan; Moreno, Paulo Roberto H.; Young, Maria Cláudia M.
Source:
Phytochemistry letters 2019 v.33 pp. 6-11
ISSN:
1874-3900
Subject:
Trypanosoma cruzi,   etc   ; Chloranthaceae; antiprotozoal properties; inhibitory concentration 50; leaves; nuclear magnetic resonance spectroscopy; parasites; sesquiterpenoid lactones; vertebrates;     Show all 9 Subjects
Abstract:
... A new sesterterpene lactone, Hedyosulide, together with five previously described sesquiterpene lactones were isolated from the leaves of Hedyosmum brasiliense Mart. ex Miq. (Chloranthaceae). Their structures were established by NMR analysis and HRESIMS data. The isolated compounds were evaluated for antiprotozoal activity against trypomastigote and amastigote forms of Trypanosoma cruzi. Hedyosuli ...
DOI:
10.1016/j.phytol.2019.06.005

18. Physical training improves exercise tolerance, cardiac function and promotes changes in neurotrophins levels in chagasic mice

Author:
Alves, Rafael Leite; Cardoso, Bárbara Ramalho Ladeira; Ramos, Isalira Peroba Rezende; Oliveira, Bruna da Silva; dos Santos, Mara Lívia; de Miranda, Aline Silva; de Almeida, Tatiane Cristine Silva; Vieira, Maria Aparecida Ribeiro; Machado, Fabiana Simão; Ferreira, Anderson José; de Avelar, Gleide Fernandes
Source:
Life sciences 2019 v.232 pp. 116629
ISSN:
0024-3205
Subject:
Trypanosoma cruzi,   etc   ; biomarkers; brain; cardiac output; exercise; exercise test; heart; intraperitoneal injection; males; mice; nerve growth factor;     Show all 11 Subjects
Abstract:
... To investigate the effects of moderate aerobic physical training on cardiac function and morphology as well as on the levels of glial cell-derived neurotrophic factor (GDNF), nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) of animals infected with the Y strain of Trypanosoma cruzi.Twenty-eight male C57BL/6 mice were distributed into 4 groups: sedentary control (SC), trained ...
DOI:
10.1016/j.lfs.2019.116629

19. Messenger RNA levels of the Polo-like kinase gene (PLK) correlate with cytokinesis in the Trypanosoma rangeli cell cycle

Author:
Prestes, Elisa Beatriz; Stoco, Patrícia Hermes; de Moraes, Milene Höehr; Moura, Hércules; Grisard, Edmundo Carlos
Source:
Experimental parasitology 2019 v.204 pp. 107727
ISSN:
0014-4894
Subject:
Trypanosoma cruzi,   etc   ; DNA; Trypanosoma rangeli; blood flow; cytokinesis; enzymes; epimastigotes; flagellum; genes; genetic markers; mammals; messenger RNA; parasites; staining; trypomastigotes;     Show all 15 Subjects
Abstract:
... Trypanosoma rangeli is a protozoan parasite that is non-virulent to the mammalian host and is morphologically and genomically related to Trypanosoma cruzi, whose proliferation within the mammalian host is controversially discussed.We aimed to investigate the T. rangeli cell cycle in vitro and in vivo by characterizing the timespan of the parasite life cycle and by proposing a molecular marker to a ...
DOI:
10.1016/j.exppara.2019.107727

20. Direct determination of anaerobe contributions to the energy metabolism of Trypanosoma cruzi by chip calorimetry

Author:
Lerchner, Johannes; Sartori, Marina R.; Volpe, Pedro O. L.; Lander, Noelia; Mertens, Florian; Vercesi, Anibal E.
Source:
Analytical and bioanalytical chemistry 2019 v.411 no.17 pp. 3763-3768
ISSN:
1618-2642
Subject:
Trypanosoma cruzi,   etc   ; anaerobic conditions; antimycin A; calorimetry; energy metabolism; glycolysis; heat production; mitochondria; oligomycin; oxygen; oxygen partial pressure;     Show all 11 Subjects
Abstract:
... We describe a chip calorimetric technique that allows the investigation of biological material under anoxic conditions in a micro-scale and in real time. Due to the fast oxygen exchange through the sample flow channel wall, the oxygen concentration inside the samples could be switched between atmospheric oxygen partial pressure to an oxygen concentration of 0.5% within less than 2 h. Using this te ...
DOI:
10.1007/s00216-019-01882-3