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1. Proteomic analysis of Trypanosoma cruzi spliceosome complex

Author:
Barbosa, Rosicler L.; da Cunha, Julia Pinheiro Chagas; Menezes, Arthur T.; Melo, Raíssa de F.P.; Elias, Maria Carolina; Silber, Ariel M.; Coltri, Patricia P.
Source:
Journal of proteomics 2020 v.223 pp. 103822
ISSN:
1874-3919
Subject:
Trypanosoma cruzi,   etc   ; proteomics; spliceosomes;     Show all 3 Subjects
Abstract:
... The unicellular protists of the group Kinetoplastida include the genera Leishmania and Trypanosoma, which are pathogens of invertebrate and vertebrate animals. Despite their medical and economical importance, critical aspects of their biology such as specific molecular characteristics of gene expression regulation are just beginning to be deciphered. Gene expression regulation also depends on post ...
DOI:
10.1016/j.jprot.2020.103822

2. A case report of Chagas disease in acute phase diagnosed by xenodiagnosis

Author:
Sánchez-Vega, José Trinidad; Almanza-Mackintoy, Angélica; Luna-Santillán, Alejandra Victoria; De La Sancha-Solares, Tania
Source:
Parasitology international 2020 v.77 pp. 102121
ISSN:
1383-5769
Subject:
Trypanosoma cruzi,   etc   ; Chagas disease; Triatoma; blood; case studies; feces; hosts; patients; trypomastigotes; xenodiagnosis; zoonoses;     Show all 11 Subjects
Abstract:
... Chagas disease is a serious problem of parasitic disease in the American continent, this zoonosis is caused by the flagellated protozoan known as Trypanosoma cruzi and transmitted through trypomastigotes present in the blood of sick hosts or in the faeces of the triatomines.Metacyclic trypomastigotes were detected in the faeca material of Triatoma pallidepennis maintained in the laboratory after t ...
DOI:
10.1016/j.parint.2020.102121

3. Clearing or subverting the enemy: Role of autophagy in protozoan infections

Author:
Ghartey-Kwansah, George; Aboagye, Benjamin; Adu-Nti, Frank; Opoku, Yeboah Kwaku; Abu, Emmanuel Kwasi
Source:
Life sciences 2020 v.247 pp. 117453
ISSN:
0024-3205
Subject:
Trypanosoma cruzi,   etc   ; Leishmania; Plasmodium; Toxoplasma; autophagy; humans; macrophages; parasites; pathogens; proteins; protozoal infections; public health; therapeutics;     Show all 13 Subjects
Abstract:
... The protozoan parasites are evolutionarily divergent, unicellular eukaryotic pathogens representing one of the essential sources of parasitic diseases. These parasites significantly affect the economy and cause public health burdens globally. Protozoan parasites share many cellular features and pathways with their respective host cells. This includes autophagy, a process responsible for self-degra ...
DOI:
10.1016/j.lfs.2020.117453

4. Total Synthesis and Antitrypanosomal Activity of Janadolide and Simplified Analogues

Author:
Chung, Jonathan H.; Tang, Arthur H.; Geraghty, Kieran; Corcilius, Leo; Kaiser, Marcel; Payne, Richard J.
Source:
Organic letters 2020 v.22 no.8 pp. 3089-3093
ISSN:
1523-7052
Subject:
Trypanosoma cruzi,   etc   ; Okeania; Suzuki reaction; Trypanosoma rhodesiense; antitrypanosomal properties; chemical structure; enantioselectivity; parasites; polyketides;     Show all 9 Subjects
Abstract:
... Janadolide is a cyclic depsipeptide natural product isolated from the marine cyanobacterium Okeania sp. Herein, we describe the total synthesis of janadolide, along with eight simplified analogues, via an efficient solid-phase strategy. Crucial to the synthesis of the natural product was the construction of a key polyketide fragment via an enantioselective (−)-B-chlorodiisopinocampheylborane-media ...
DOI:
10.1021/acs.orglett.0c00840

5. Structure of Urocanate Hydratase from the protozoan Trypanosoma cruzi

Author:
Boreiko, Sheila; Silva, Marcio; de F. P. Melo, Raíssa; Silber, Ariel M.; Iulek, Jorge
Source:
International journal of biological macromolecules 2020 v.146 pp. 716-724
ISSN:
0141-8130
Subject:
Trypanosoma cruzi,   etc   ; Bacillus kaustophilus; Bacillus subtilis; Pseudomonas putida; biochemical pathways; enzymes; histidine; humans; mutation;     Show all 9 Subjects
Abstract:
... The enzyme Urocanate Hydratase (UH) participates in the catabolic pathway of L-histidine. Trypanosoma cruzi Urocanate Hydratase (TcUH) is identified as a therapeutic molecular target in the WHO/TDR Targets Database. We report the 3D structure determination and number of features of TcUH, and compared it to other few available bacterial UH structures. Each monomer presents two domains and one NAD⁺ ...
DOI:
10.1016/j.ijbiomac.2019.12.101

6. Low-dose of benznidazole promotes therapeutic cure in experimental chronic Chagas' disease with absence of parasitism in blood, heart and colon

Author:
Perin, Luísa; Fonseca, Kátia da Silva; de Carvalho, Thaís Vieira; Carvalho, Lívia Mendes; Madeira, João Vitor; Medeiros, Luciana da Fonseca; Molina, Israel; Correa-Oliveira, Rodrigo; Carneiro, Cláudia Martins; Vieira, Paula Melo de Abreu
Source:
Experimental parasitology 2020 v.210 pp. 107834
ISSN:
0014-4894
Subject:
Trypanosoma cruzi,   etc   ; Chagas disease; animal models; benznidazole; blood; colon; heart; mice; parasitism; therapeutics;     Show all 10 Subjects
Abstract:
... Studies suggest that the dose of the standard benznidazole (BNZ) treatment regimen might be too high. We investigated the efficacy of BNZ 20 and 40 mg/kg/day compared with standard dose (100 mg/kg/day) to induce cure in mice infected with Trypanosoma cruzi Y strain in the acute and chronic phases of Chagas' disease. Our findings indicate that an experimental treatment with a BNZ low-dose (40 mg/kg ...
DOI:
10.1016/j.exppara.2020.107834

7. Trypanosoma cruzi: cell surface dynamics in trypomastigotes of different strains

Author:
Ferreira Cura das Neves, Roberta; Marques Adade, Camila; Silva Fernandes, Anne Cristine; Hampshire Lopes, Angela; Souto-Padrón, Thaïs
Source:
Parasitology 2020 v.147 no.3 pp. 310-321
ISSN:
1469-8161
Subject:
Trypanosoma cruzi,   etc   ; antibodies; concanavalin A; ferritin; immune system; ligands; lysine; parasites; trypomastigotes;     Show all 9 Subjects
Abstract:
... Capping and shedding of ectodomains in Trypanosoma cruzi may be triggered by different ligands. Here, we analysed the mobility and shedding of cell surface components of living trypomastigotes of the Y strain and the CL Brener clone in the presence of poly-L-lysine, cationized ferritin (CF) and Concanavalin A (Con A). Poly-L-lysine and CF caused intense shedding in Y strain parasites. Shedding was ...
DOI:
10.1017/S0031182019001616

8. Synthesis of the hexasaccharide from Trypanosoma cruzi mucins with the Galp(1 → 2)Galf unit constructed with a superarmed thiogalactopyranosyl donor

Author:
Kashiwagi, Gustavo A.; Cori, Carmen R.; de Lederkremer, Rosa M.; Gallo-Rodriguez, Carola
Source:
Carbohydrate research 2019 v.482 pp. 107734
ISSN:
0008-6215
Subject:
Trypanosoma cruzi,   etc   ; epimastigotes; insects; mucins; trisaccharides;     Show all 5 Subjects
Abstract:
... Hexasaccharide β-D-Galp-(1→ 2)-[β-D-Galp-(1 → 3)]-β-D-Galp-(1 → 6)-[β-D-Galp-(1 → 2)-β-D-Galf-(1 → 4)]-D-GlcNAc (1) was found O-linked in mucins of Trypanosoma cruzi epimastigotes and metacyclic trypomatigotes. Studies on the biological pathways and functionalities of the mucin oligosaccharides are prompted in order to understand the interactions of these molecules with the insect host. Trisacchar ...
DOI:
10.1016/j.carres.2019.06.013

9. Selected cardiac abnormalities in Trypanosoma cruzi serologically positive, discordant, and negative working dogs along the Texas-Mexico border

Author:
Meyers, Alyssa C.; Ellis, Megan M.; Purnell, Julia C.; Auckland, Lisa D.; Meinders, Marvin; Saunders, Ashley B.; Hamer, Sarah A.
Source:
BMC veterinary research 2020 v.16 no.1 pp. 101
ISSN:
1746-6148
Subject:
Trypanosoma cruzi,   etc   ; Chagas disease; Triatominae; arrhythmia; biomarkers; blood serum; death; dogs; humans; immunologic techniques; troponin I; vaccines; wildlife; zoonoses;     Show all 14 Subjects
Abstract:
... BACKGROUND: Chagas disease is increasingly recognized in the southern U.S., where triatomine vectors transmit Trypanosoma cruzi among wildlife and domestic dogs with occasional vector spillover to humans. As in humans, clinical outcome in dogs is variable, ranging from acute death to asymptomatic infections or chronic heart disease. In order to characterize cardiac manifestations of T. cruzi infec ...
DOI:
10.1186/s12917-020-02322-6
PubMed:
32228593
PubMed Central:
PMC7106864

10. Raccoons As an Important Reservoir for Trypanosoma cruzi: A Prevalence Study from Two Metropolitan Areas in Louisiana

Author:
Majeau, Alicia; Pronovost, Henry; Sanford, Anna; Cloherty, Erin; Anderson, A. Nikki; Balsamo, Gary; Gee, Laura; Straif-Bourgeois, Susanne C.; Herrera, Claudia
Source:
Vector borne and zoonotic diseases 2020 v.20 no.7 pp. 535-540
ISSN:
1557-7759
Subject:
Trypanosoma cruzi,   etc   ; Procyon lotor; animal diseases; human health; metropolitan areas; parasitemia; polymerase chain reaction; risk; tissues; Louisiana;     Show all 10 Subjects
Abstract:
... Raccoons are an important reservoir for Trypanosoma cruzi infection, having been reported to maintain a high and lengthy parasitemia. Although raccoon populations have historically been abundant in Louisiana, the prevalence rate of T. cruzi infection in raccoons in this state is unknown. Here, we tested raccoon tissues from two urban areas in Louisiana, namely Orleans Parish (OP) and East Baton Ro ...
DOI:
10.1089/vbz.2019.2559

11. Comparative Analysis of the Minimum Number of Replication Origins in Trypanosomatids and Yeasts

Author:
da Silva, Marcelo S.; O. Vitarelli, Marcela; F. Souza, Bruno; Elias, Maria Carolina
Source:
Genes 2020 v.11 no.5
ISSN:
2073-4425
Subject:
Trypanosoma cruzi,   etc   ; Internet; Leishmania major; Saccharomyces cerevisiae; Schizosaccharomyces pombe; Trypanosoma brucei; chromosomes; eukaryotic cells; genome; interphase; replication origin; yeasts;     Show all 12 Subjects
Abstract:
... Single-celled eukaryote genomes predominantly replicate through multiple origins. Although origin usage during the S-phase has been elucidated in some of these organisms, few studies have comparatively approached this dynamic. Here, we developed a user-friendly website able to calculate the length of the cell cycle phases for any organism. Next, using a formula developed by our group, we showed a ...
DOI:
10.3390/genes11050523

12. Imiquimod-loaded nanoarchaeosomes as a promising immunotherapy against Trypanosoma cruzi infection

Author:
Parra, Federico L.; Frank, Fernanda M.; Alliani, Bruno F.; Romero, Eder L.; Petray, Patricia B.
Source:
Colloids and surfaces 2020 v.189 pp. 110850
ISSN:
0927-7765
Subject:
Trypanosoma cruzi,   etc   ; Chagas disease; acute course; animal models; immunotherapy; infectious diseases; lipids; mice; mortality; musculoskeletal system; parasitemia;     Show all 11 Subjects
Abstract:
... The purpose of this study was to evaluate the efficacy of imiquimod-containing nanovesicles prepared with lipids extracted from the hyperhalophile archaebacterium Halorubrum tebenquichense (nanoARC-IMQ) to induce protection against Trypanosoma cruzi infection. The therapeutic efficacy of archaeolipid nanovesicles was assessed in an experimental murine model of acute infection with T. cruzi. The ad ...
DOI:
10.1016/j.colsurfb.2020.110850

13. Inflammasome Activation in Response to Intracellular Protozoan Parasites

Author:
de Carvalho, Renan V.H.; Zamboni, Dario S.
Source:
Trends in parasitology 2020 v.36 no.5 pp. 459-472
ISSN:
1471-4922
Subject:
Trypanosoma cruzi,   etc   ; Leishmania; Plasmodium; Toxoplasma gondii; caspase-1; cytokines; fungi; host-pathogen relationships; inflammasomes; inflammation; parasites; parasitoses; pyroptosis;     Show all 13 Subjects
Abstract:
... Inflammasomes are cytosolic complexes that assemble in response to cellular stress or upon sensing microbial molecules, culminating in cytokine processing and an inflammatory form of cell death called pyroptosis. Inflammasomes are usually composed of a sensor molecule, an adaptor protein, and an inflammatory caspase, such as Caspase-1, which cleaves and activates multiple substrates, including Gas ...
DOI:
10.1016/j.pt.2020.02.006

14. Species-specific patterns of shelter exploitation in Chagas disease vectors of the genus Rhodnius

Author:
Mosquera, Katherine D.; Lorenzo, Marcelo G.
Source:
Acta tropica 2020 v.205 pp. 105433
ISSN:
0001-706X
Subject:
Trypanosoma cruzi,   etc   ; Chagas disease; Rhodnius prolixus; etiological agents; health services; insect vectors; lighting; photoperiod; phototaxis; sensory ecology; thigmotaxis; Latin America;     Show all 12 Subjects
Abstract:
... Triatomines are insect vectors of Trypanosoma cruzi¸ the etiological agent of Chagas disease. Several species belonging to the genus Rhodnius (Hemiptera: Reduviidae) have been reported inhabiting domestic and peridomestic environments in different regions of Latin America. However, behavioral and sensory ecology aspects related to their use of shelters have been poorly studied. The objective of th ...
DOI:
10.1016/j.actatropica.2020.105433

15. Trypanosoma rangeli 28Sβ Ribosomal Gene Allows Intra and Interspecific Molecular Differentiation

Author:
Santos, Renato Elias Rodrigues de Souza; Naves, Lucila Langoni; Fajardo, Emanuella Francisco; Ramirez, Luis Eduardo; Lages-Silva, Eliane; Pedrosa, André Luiz; Ferreira, Keila Adriana Magalhães
Source:
Vector borne and zoonotic diseases 2020 v.20 no.2 pp. 117-124
ISSN:
1557-7759
Subject:
Trypanosoma cruzi,   etc   ; Chagas disease; Leishmania braziliensis; Trypanosoma brucei; Trypanosoma rangeli; etiological agents; genes; genotyping; restriction fragment length polymorphism; ribosomal DNA;     Show all 10 Subjects
Abstract:
... Trypanosoma rangeli is an avirulent flagellate protozoan that could mislead correct diagnosis of Trypanosoma cruzi infection, the causative agent of Chagas' disease, given their high similarity. Besides, T. rangeli presents two genetic groups, whose differentiation is achieved mainly by molecular approaches. In this context, ribosomal DNA (rDNA) is a useful target for intra and interspecific molec ...
DOI:
10.1089/vbz.2019.2496

16. Effects of the infection with Trypanosoma cruzi on the feeding and excretion/defecation patterns of Triatoma infestans

Author:
Pereyra, N.; Lobbia, P.A.; Mougabure-Cueto, G.
Source:
Bulletin of entomological research 2020 v.110 no.1 pp. 169-176
ISSN:
1475-2670
Subject:
Trypanosoma cruzi,   etc   ; Triatoma infestans; ad libitum feeding; defecation; excretion; feces; feeding patterns; insects; mammals; mucosa; nymphs; probability; urine; vector competence;     Show all 14 Subjects
Abstract:
... Transmission of Trypanosma cruzi (Kinetoplastida: Trypanosomatidae) occurs when feces/urine of infected triatomines come into contact with mucous membranes or damaged skin, and this occurs mainly when insects defecate while feeding on the host. Thus, the vector competence of the triatomines is associated with their feeding and excretion/defecation behavior. This work studied for the first time the ...
DOI:
10.1017/S0007485319000464

17. Immunological exhaustion and functional profile of CD8+ T lymphocytes as cellular biomarkers of therapeutic efficacy in chronic Chagas disease patients

Author:
Pérez-Antón, Elena; Egui, Adriana; Thomas, Mª Carmen; Simón, Marina; Segovia, Manuel; López, Manuel Carlos
Source:
Acta tropica 2020 v.202 pp. 105242
ISSN:
0001-706X
Subject:
Trypanosoma cruzi,   etc   ; CD8-positive T-lymphocytes; Chagas disease; benznidazole; biomarkers; cytokines; cytotoxicity; interferon-gamma; monitoring; patients; phenotype; receptors; therapeutics;     Show all 13 Subjects
Abstract:
... The lack of useful tools for detection the impact of treatment during the follow-up of chronic Chagas disease treated patients difficult the adequate care to the affected population. The objective of this study was to evaluate the functional response of CD8⁺ T lymphocyte population, critical for the control of Trypanosoma cruzi infection, as a possible cellular biomarker of treated Chagas disease ...
DOI:
10.1016/j.actatropica.2019.105242

18. In vitro models for investigation of the host-parasite interface - possible applications in acute Chagas disease

Author:
Breyner, Natália Martins; Hecht, Mariana; Nitz, Nadjar; Rose, Ester; Carvalho, Juliana Lott
Source:
Acta tropica 2020 v.202 pp. 105262
ISSN:
0001-706X
Subject:
Trypanosoma cruzi,   etc   ; Chagas disease; animal organs; ethics; host-parasite relationships; in vitro studies; in vivo studies; intestines; pathophysiology;     Show all 9 Subjects
Abstract:
... Chagas disease (CD), caused by Trypanosoma cruzi, is the main parasitic disease in the Western Hemisphere, with an increasing number of cases, especially in non-endemic regions. The disease is characterized by cardiomegaly and mega viscera, nevertheless, the clinical outcome is hard to predict, underscoring the need for further research into the pathophysiology of CD. Even though most basic and tr ...
DOI:
10.1016/j.actatropica.2019.105262

19. Life-History Data of a Mexican Population of Triatoma nitida (Hemiptera: Reduviidae)

Author:
Martínez-Ibarra, J Alejandro; Meraz-Medina, Tzintli; Nogueda-Torres, Benjamin; Villagrán-Herrera, María E; de Diego-Cabrera, Jose A; Rust, Michael
Source:
Journal of medical entomology 2020 v.57 no.1 pp. 33-38
ISSN:
1938-2928
Subject:
Trypanosoma cruzi,   etc   ; Triatoma; adults; defecation; geographical distribution; hematophagy; humans; instars; life history; molting; monitoring; mortality; nymphs; vectorial capacity; Mexico;     Show all 15 Subjects
Abstract:
... This study reports the third collection of Triatoma nitida Usinger in Mexico, with a brief description of the collection area and an investigation of parameters related to its vectorial capacity. Whether a triatomine (Hemiptera: Reduviidae) species is a primary or secondary vector is determined by factors that include vectorial capacity, anthropophilic habits, geographic distribution, and capacity ...
DOI:
10.1093/jme/tjz163

20. More than Microtubules: The Structure and Function of the Subpellicular Array in Trypanosomatids

Author:
Sinclair, Amy N.; de Graffenried, Christopher L.
Source:
Trends in parasitology 2019 v.35 no.10 pp. 760-777
ISSN:
1471-4922
Subject:
Trypanosoma cruzi,   etc   ; Leishmania; Trypanosoma brucei; biogenesis; humans; livestock; longevity; microtubules;     Show all 8 Subjects
Abstract:
... The subpellicular microtubule array defines the wide range of cellular morphologies found in parasitic kinetoplastids (trypanosomatids). Morphological studies have characterized array organization, but little progress has been made towards identifying the molecular mechanisms that are responsible for array differentiation during the trypanosomatid life cycle, or the apparent stability and longevit ...
DOI:
10.1016/j.pt.2019.07.008
PubMed:
31471215
PubMed Central:
PMC6783356