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1. A novel defective recombinant porcine enterovirus G virus carrying a porcine torovirus papain-like cysteine protease gene and a putative anti-apoptosis gene in place of viral structural protein genes

Author:
Ujike, Makoto,   et al.   ; Imai, Ryo; Nagai, Makoto; Oba, Mami; Sakaguchi, Shoichi; Kimura, Ruka; Kida, Moeko; Masuda, Tsuneyuki; Kuroda, Moegi; Wen, Rongduo; Li, Kaixin; Katayama, Yukie; Naoi, Yuki; Tsuchiaka, Shinobu; Omatsu, Tsutomu; Yamazato, Hiroshi; Makino, Shinji; Mizutani, Tetsuya;     Show all 18 Authors
Source:
Infection, genetics, and evolution 2019 pp. 103975
ISSN:
1567-1348
Subject:
Enterovirus G; Porcine enterovirus; Porcine torovirus; amino acid sequences; apoptosis; cysteine proteinases; farms; feces; helper viruses; phylogeny; sequence homology; structural genes; structural proteins; swine; Belgium; Japan; United States
Abstract:
... Enterovirus G (EV-G) belongs to the family of Picornaviridae. Two types of recombinant porcine EV-Gs carrying papain-like cysteine protease (PLCP) gene of porcine torovirus, a virus in Coronaviridae, are reported. Type 1 recombinant EV-Gs are detected in pig feces in Japan, USA, and Belgium and carry the PLPC gene at the junction site of 2C/3A genes, while PLPC gene replaces the viral structural g ...
DOI:
10.1016/j.meegid.2019.103975

2. Identification of CCL2, RARRES2 and EFNB2 as host cell factors that influence the multistep replication of respiratory syncytial virus

Author:
Ujike, Makoto,   et al.   ; Shirato, Kazuya; Kawase, Miyuki; Matsuyama, Shutoku;     Show all 4 Authors
Source:
Virus research 2015 v.210 pp. 213-226
ISSN:
0168-1702
Subject:
risk; human cell lines; complementary DNA; humans; microarray technology; respiratory tract diseases; ligands; Human orthopneumovirus; retinoic acid receptors; tight junctions; children; chemokine CCL2; genes; cDNA libraries; lungs; small interfering RNA
Abstract:
... Human respiratory syncytial virus (RSV) is a major causative agent of respiratory tract infections in children worldwide. Preterm children or those with underlying cardiopulmonary disorders are at particularly high risk of developing severe and lethal RSV respiratory tract infections; however, there are currently no effective vaccines or anti-viral drugs. To identify targets for the development of ...
DOI:
10.1016/j.virusres.2015.08.006

3. Phylogenetic and antigenic characterization of newly isolated porcine epidemic diarrhea viruses in Japan

Author:
Ujike, Makoto,   et al.   ; Islam, Md. Taimur; Kubota, Tomoe; Yahara, Yoshiriro; Taguchi, Fumihiro;     Show all 5 Authors
Source:
Virus research 2016 v.222 pp. 113-119
ISSN:
0168-1702
Subject:
Porcine epidemic diarrhea virus; diarrhea; farms; intestines; neutralization tests; phylogeny; piglets; sows; vaccination; vaccines; viral antigens; virulence; viruses; Japan; United States
Abstract:
... To evaluate the mechanism by which a large outbreak of porcine epidemic diarrhea (PED) occurred in Japan, where the majority of sows are vaccinated, we isolated two new strains of PED virus (PEDV) from the intestines of piglets and found that they showed greater similarity to US isolates (group II PEDV) than to the Japanese vaccine strain (group I PEDV). We compared the antigenicity of the vaccine ...
DOI:
10.1016/j.virusres.2016.06.006

4. Hemagglutination mediated by the spike protein of cell-adapted bovine torovirus

Author:
Ujike, Makoto,   et al.   ; Shimabukuro, Kozue; Ito, Toshihiro; Tsunemitsu, Hiroshi; Oshitani, Hitoshi; Taguchi, Fumihiro;     Show all 6 Authors
Source:
Archives of virology 2013 v.158 no.7 pp. 1561-1566
ISSN:
0304-8608
Subject:
Bovine torovirus; antiserum; cultured cells; genes; hemagglutination; viral proteins; viruses
Abstract:
... Bovine torovirus (BToV)-Aichi, recently isolated in cultured cells, showed hemagglutination (HA) activity, although the virus has a truncated hemagglutinin-esterase (HE) protein, judging from its gene structure, indicating the existence of another viral protein with HA activity. We examined whether the spike (S) protein possesses HA activity. A BToV antiserum used in this study, reactive to S but ...
DOI:
10.1007/s00705-013-1636-4
PubMed:
23420207

5. Two palmitylated cysteine residues of the severe acute respiratory syndrome coronavirus spike (S) protein are critical for S incorporation into virus-like particles, but not for M–S co-localization

Author:
Ujike, Makoto,   et al.   ; Huang, Cheng; Shirato, Kazuya; Matsuyama, Shutoku; Makino, Shinji; Taguchi, Fumihiro;     Show all 6 Authors
Source:
TheJournal of general virology 2012 v.93 no.Pt Pt_4 pp. 823-828
ISSN:
1465-2099
Subject:
Murine hepatitis virus; Severe acute respiratory syndrome coronavirus; cysteine; fluorescent antibody technique; mutants; proteins; virion; virus-like particles
Abstract:
... The endodomain of several coronavirus (CoV) spike (S) proteins contains palmitylated cysteine residues and enables co-localization and interaction with the CoV membrane (M) protein. Depalmitylation of mouse hepatitis virus S proteins abolished this interaction, resulting in the failure of S incorporation into virions. In contrast, an immunofluorescence assay (IFA) showed that depalmitylated severe ...
DOI:
10.1099/vir.0.038091-0

6. Mutation in the cytoplasmic retrieval signal of porcine epidemic diarrhea virus spike (S) protein is responsible for enhanced fusion activity

Author:
Ujike, Makoto,   et al.   ; Shirato, Kazuya; Maejima, Madoka; Matsuyama, Shutoku; Miyazaki, Ayako; Takeyama, Natsumi; Ikeda, Hidetoshi; Taguchi, Fumihiro;     Show all 8 Authors
Source:
Virus research 2011 v.161 no.2 pp. 188-193
ISSN:
0168-1702
Subject:
Porcine epidemic diarrhea virus; mutation; proteins; viruses
Abstract:
... Murine-adapted porcine epidemic diarrhea virus (PEDV), MK-p10, shows high neurovirulence and increased fusion activity compared with a non-adapted MK strain. MK-p10 S protein had four mutations relative to the original virus S, and one of these (H→R at position 1381, H1381R) in the cytoplasmic tail (CT) was suggested to be responsible for the increased fusion activity. To explore this, we examined ...
DOI:
10.1016/j.virusres.2011.07.019

7. Mumefural and related HMF derivatives from Japanese apricot fruit juice concentrate show multiple inhibitory effects on pandemic influenza A (H1N1) virus

Author:
Ujike, Makoto,   et al.   ; Sriwilaijaroen, Nongluk; Kadowaki, Akio; Onishi, Yuriko; Gato, Nobuki; Odagiri, Takato; Tashiro, Masato; Suzuki, Yasuo;     Show all 8 Authors
Source:
Food chemistry 2011 v.127 no.1 pp. 1-9
ISSN:
0308-8146
Subject:
Prunus mume; citric acid; esters; fruit juices; hemagglutination; hydrogen; hydroxymethylfurfural; influenza; juice concentrates; microbial growth; pandemic; propane; sialidase; viruses
Abstract:
... Fruit-juice concentrate of Japanese apricot (Prunus mume Sieb. et Zucc.) has been shown to be effective against influenza A infection in MDCK cells. In this study, we isolated five components from the fruit-juice concentrate of Japanese apricot, 5-(hydroxymethyl)-2-formylfuran (HMF), 1-[5-(2-formylfuryl)methyl]dihydrogen 2-hydroxypropane-1,2,3-tricarboxylate (mumefural, MF), 2-[5-(2-formylfuryl)me ...
DOI:
10.1016/j.foodchem.2010.12.031