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- Valabhoju, Vishalini, et al. Show all 7 Authors
- Molecular cell 2018 v.70 no.2 pp. 297-311.e4
- amino acids; genes; genomics; messenger RNA; mutational analysis; transactivators; yeasts
- ... Gcn4 is a yeast transcriptional activator induced by amino acid starvation. ChIP-seq analysis revealed 546 genomic sites occupied by Gcn4 in starved cells, representing ∼30% of Gcn4-binding motifs. Surprisingly, only ∼40% of the bound sites are in promoters, of which only ∼60% activate transcription, indicating extensive negative control over Gcn4 function. Most of the remaining ∼300 Gcn4-bound si ...