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- Veniant, M.M., et al. Show all 7 Authors
- Proceedings of the National Academy of Sciences of the United States of America 1998 v.95 no.15 pp. 8686-8691
- yolk sac; high fat diet; animal proteins; apolipoproteins; immunohistochemistry; intestines; messenger RNA; blood lipids; mutagenesis; mice; protein secretion; lethal genes; hepatocytes; liver; very low density lipoprotein; heterozygosity; cholesterol; low density lipoprotein; homozygosity
- ... Abetalipoproteinemia, an inherited human disease characterized by a near-complete absence of the apolipoprotein (apo) B-containing lipoproteins in the plasma, is caused by mutations in the gene for microsomal triglyceride transfer protein (MTP). We used gene targeting to knock out the mouse MTP gene (Mttp). In heterozygous knockout mice (Mttp+/-), the MTP mRNA, protein, and activity levels were re ...
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- Veniant, M.M., et al. Show all 10 Authors
- Proceedings of the National Academy of Sciences of the United States of America 1996 v.93 no.13 pp. 6393-6398
- blood lipids; phenotype; structural genes; blood proteins; apolipoproteins; very low density lipoprotein; triacylglycerols; mice; homologous recombination; low density lipoprotein; cholesterol; mutants; gene targeting; blood plasma; site-directed mutagenesis; embryogenesis
- ... Apolipoprotein (apo)-B is found in two forms in mammals: apo-B100, which is made in the liver and the yolk sac, and apo-B48, a truncated protein made in the intestine. To provide models for understanding the physiologic purpose for the two forms of apo-B, we used targeted mutagenesis of the apo-B gene to generate mice that synthesize exclusively apo-B48 (apo-B48-only mice) and mice that synthesize ...
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