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- Wang, Luman, et al. Show all 8 Authors
- Molecular immunology 2019 v.111 pp. 162-171
- B-lymphocytes; animal models; autoimmune diseases; colitis; dextran sulfate; hypoxia-inducible factor 1; immunosuppression; interleukin-10; messenger RNA; mice; mitogen-activated protein kinase; mucosal immunity; protein content; secretion; signal transduction; small interfering RNA; spleen; transcription (genetics); transfection
- ... B cells have been reported to have a suppressive function in autoimmune diseases, which appears to require an increase of CD11b expression on B cells. However, little is known how CD11b is induced in B cells to play the function. In this study, we found that the high expression of CD11b in B cells occurred not only in the mucosal immune organs, but also in systemically immune organs such as the sp ...
- Wang, Luman, et al. Show all 10 Authors
- In vitro cellular & developmental biology 2013 v.49 no.9 pp. 679-688
- biosynthesis; cystathionine gamma-lyase; hydrogen sulfide; inflammation; lipopolysaccharides; macrophages; mice; mitogen-activated protein kinase
- ... Hydrogen sulfide (H₂S), formed mainly by the enzyme cystathionine γ-lyase (CSE) in macrophages, is emerging as a novel regulator in inflammation. Although elevated production of H₂S has been shown in inflammatory processes, the underlying molecular mechanism remains to be further elucidated. In this study, we compared parallel TLR4 knockout (TLR4⁻/⁻) mice with their wild-type counterparts followin ...