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1. In vitro profiling of toxicity and endocrine disrupting effects of bisphenol analogues by employing MCF‐7 cells and two‐hybrid yeast bioassay

Author:
Wang, Yipei,   et al.   ; Lei, Bingli; Xu, Jie; Peng, Wei; Wen, Yu; Zeng, Xiangying; Yu, Zhiqiang; Chen, Tian;     Show all 8 Authors
Source:
Environmental toxicology 2017 v.32 no.1 pp. 278-289
ISSN:
1520-4081
Subject:
bioassays; bisphenol A; calcium; cell viability; cytotoxicity; genotoxicity; humans
Abstract:
... The potentially adverse health implications of bisphenol A (BPA) have led to increasing use of alternative bisphenols (BPs). However, little is known about the toxicity of alternative BPs. In this study, the cytotoxicity, genotoxicity, intracellular ROS formation, and Ca²⁺ fluctuation effects of BPs on MCF‐7 cells were evaluated. At the same time, the estrogenic and thyroidal hormone effect potent ...
DOI:
10.1002/tox.22234

2. In vitro toxicity assessment of sediment samples from Huangpu River and Suzhou River, Shanghai, China

Author:
Wang, Yipei,   et al.   ; Lou, Shufang; Lei, Bingli; Feng, Chenglian; Xu, Jie; Peng, Wei;     Show all 6 Authors
Source:
Environmental science and pollution research international 2016 v.23 no.15 pp. 15183-15192
ISSN:
0944-1344
Subject:
agonists; aquatic environment; bioassays; estradiol; estrogenic properties; hepatoma; pollutants; polycyclic aromatic hydrocarbons; rats; risk assessment; rivers; sediments; tetrachlorodibenzo-p-dioxin; toxicity; two hybrid system techniques; China
Abstract:
... Sediments are the ultimate sink for many toxic organic contaminants released into aquatic environment. The present study evaluated the toxicity effect of 13 surface sediment samples from Huangpu River and Suzhou River, East China using two-hybrid yeast bioassays for estrogenic and thyroidal effects and H4IIE rat hepatoma cell bioassay for ethoxyresorufin O-deethylase (EROD) activity. Toxicity was ...
DOI:
10.1007/s11356-016-6683-4

3. Diethylstilbestrol at environmental levels affects the development of early life stage and target gene expression in Japanese Medaka (Oryzias latipes)

Author:
Wang, Yipei,   et al.   ; Lei, Bingli; Peng, Wei; Li, Wei; Yu, Yingxin; Xu, Jie;     Show all 6 Authors
Source:
Ecotoxicology 2016 v.25 no.3 pp. 563-573
ISSN:
0963-9292
Subject:
Oryzias latipes; adults; adverse effects; diethylstilbestrol; early development; eggs; estrogen receptors; estrogenic properties; females; fish; gene expression; gene expression regulation; gonadosomatic index; hatching; larvae; liver; males; messenger RNA; mortality; scoliosis; tap water; toxicity; vitellogenin
Abstract:
... In this study, the biologic effects of DES on the early life and adult life stages of Japanese medaka (Oryzias latipes) were evaluated. At the early life stage, the fertilized eggs were exposed to 1–1000 ng/L diethylstilbestrol (DES) for 15 days and the hatched larvae were continually exposed to the same concentrations for an additional 25 days. Significant adverse effects on hatchability, time to ...
DOI:
10.1007/s10646-016-1615-0

4. Activation of G protein-coupled receptor 30 by thiodiphenol promotes proliferation of estrogen receptor α-positive breast cancer cells

Author:
Wang, Yipei,   et al.   ; Lei, Bingli; Peng, Wei; Xu, Gang; Wu, Minghong; Wen, Yu; Xu, Jie; Yu, Zhiqiang;     Show all 8 Authors
Source:
Chemosphere 2016
ISSN:
0045-6535
Subject:
G-protein coupled receptors; bisphenol A; breast neoplasms; calcium; cell proliferation; cell viability; estrogen receptors; estrogenic properties; neoplasm cells; phosphorylation; reactive oxygen species; signal transduction
Abstract:
... Many studies have been shown that environmental estrogen bisphenol A (BPA) can activate nuclear receptor (estrogen receptor alpha, ERα) or membrane receptor (G-protein-coupled receptor, GPR30) in breast cancer cells and exerts genomic or nongenomic actions inducing cell proliferation. 4,4′-thiodiphenol (TDP) as one of BPA derivatives exhibits more potent estrogenic activity than BPA does. However, ...
DOI:
10.1016/j.chemosphere.2016.11.066

5. Correlation between clothing air gap space and fabric mechanical properties

Author:
Wang, Yipei,   et al.   ; Yu, Miao; Wang, Yunyi; Li, Jun;     Show all 4 Authors
Source:
The journal of the Textile Institute 2013 v.104 no.1 pp. 67-77
ISSN:
1754-2340
Subject:
air; clothing; clothing design; computer graphics; correlation; fabrics; mechanical properties; models; prediction; process design
Abstract:
... To investigate the distribution of clothing air gap layers, clothes with the same pattern but different fabrics were put on a standard scan model. The [TC]² NX-16 three-dimensional (3D) body scanning technique was used to collect point cloud data and the overall 3D visualization model of clothing air gaps was represented in a novel way through computer graphics processing. The volumes of air gap s ...
DOI:
10.1080/00405000.2012.693274

6. The levels of PAHs and aryl hydrocarbon receptor effects in sediments of Taihu Lake, China

Author:
Wang, Yipei,   et al.   ; Lei, Bingli; Kang, Jia; Wang, Xuetong; Yu, Yingxin; Zhang, Xiaolan; Wen, Yu;     Show all 7 Authors
Source:
Environmental science and pollution research international 2014 v.21 no.10 pp. 6547-6557
ISSN:
0944-1344
Subject:
aquatic organisms; chemical analysis; chemical concentration; dioxins; environmental impact; lakes; polychlorinated biphenyls; polycyclic aromatic hydrocarbons; predators; rats; risk; risk assessment; sediments; China
Abstract:
... A total of 16 priority polycyclic aromatic hydrocarbons (PAHs) in sediment samples from Taihu Lake were analyzed by instruments, and sediment extracts were assayed for aryl hydrocarbon receptor (AhR)-mediated ethoxyresorufin-o-deethylase (EROD) induction using a rat hepatoma cell line (H4IIE). The cause–effect relationship between the observed EROD activity and chemical concentrations of PAHs was ...
DOI:
10.1007/s11356-014-2542-3
PubMed:
24497304

7. Long-term exposure investigating the estrogenic potency of estriol in Japanese medaka (Oryzias latipes)

Author:
Wang, Yipei,   et al.   ; Lei, Bingli; Kang, Jia; Yu, Yingxin; Zha, Jinmiao; Li, Wei; Wang, Zijian; Wen, Yu;     Show all 8 Authors
Source:
Comparative Biochemistry and Physiology, Part C 2014 v.160 pp. 86-92
ISSN:
1532-0456
Subject:
Oryzias latipes; adverse effects; chronic exposure; developmental stages; eggs; estriol; estrogen receptors; estrogenic properties; females; fish; gene expression regulation; genes; gonadosomatic index; hatching; hepatosomatic index; males; messenger RNA; reverse transcriptase polymerase chain reaction; sex reversal; transcription (genetics); vitellogenin
Abstract:
... The growth, development, and ERα and Vtg-I gene expressions of Japanese ricefish (Oryzias latipes; medaka) exposed to different concentrations of estriol (E3), including one environmentally relevant concentration, during embryo-adult life stages were evaluated. At the early life stage, fertilized eggs were exposed to 5, 50, 500, 5000ng/L E3 for 15days, and the hatched fry were exposed continuously ...
DOI:
10.1016/j.cbpc.2013.11.001

8. Effects of estrone on the early life stages and expression of vitellogenin and estrogen receptor genes of Japanese medaka (Oryzias latipes)

Author:
Wang, Yipei,   et al.   ; Lei, Bingli; Wen, Yu; Wang, Xuetong; Zha, Jinmiao; Li, Wei; Wang, Zijian; Sun, Yanfeng; Kang, Jia;     Show all 9 Authors
Source:
Chemosphere 2013 v.93 pp. 1104-1110
ISSN:
0045-6535
Subject:
Oryzias latipes; adverse effects; developmental stages; estrogen receptors; estrone; females; fish eggs; gene expression regulation; genes; hatching; hepatosomatic index; liver; males; reverse transcriptase polymerase chain reaction; sex reversal; tap water; vitellogenin
Abstract:
... The fertilized eggs of Japanese medaka (Oryzias latipes) were exposed to estrone (E1) at 5–5000ngL−1 for 15d, and the hatched fry were exposed continuously to the same concentrations for the additional 15d. Adverse effects on hatchability, time to hatching, and gross abnormalities occurred at 50ngL−1 or above. Then the fry were divided into a continual exposure group, and a water recovery group. W ...
DOI:
10.1016/j.chemosphere.2013.06.025
PubMed:
23830040

9. The cytotoxic effects of synthetic 6‐hydroxylated and 6‐methoxylated polybrominated diphenyl ether 47 (BDE47)

Author:
Wang, Yipei,   et al.   ; An, Jing; Li, Shuhui; Zhong, Yufang; Zhen, Kewen; Zhang, Xinyu; Wang, Yangjun; Wu, Minghong; Yu, Zhiqiang; Sheng, Guoying; Fu, Jiamo; Huang, Yuecheng;     Show all 12 Authors
Source:
Environmental toxicology 2011 v.26 no.6 pp. 591-599
ISSN:
1520-4081
Subject:
DNA; DNA damage; apoptosis; cell cycle; cell viability; cytotoxicity; fabrics; flame retardants; foams; free radicals; hepatoma; humans; liver; metabolites; oxidative stress; paints; plastics; polybrominated diphenyl ethers; stress response; superoxide dismutase
Abstract:
... Polybrominated diphenyl ethers (PBDE) have been widely applied as flame retardants in plastics, polyurethane foam, paints, and synthetic fabrics. The rising PBDE level in human tissues and environment has led to concern about the health impact of exposure to PBDE. The 2,2′,4,4′‐tetrabromodiphenyl ether (BDE47), the dominant PBDE congener found in the environment and human tissues, has been shown t ...
DOI:
10.1002/tox.20582
PubMed:
20549613