Jump to Main Content
- Warwas, Mark L., et al. Show all 4 Authors
- Glycobiology 2007 v.17 no.4 pp. 401-410
- Aspergillus fumigatus; Micromonospora viridifaciens; acetic acid; acid hydrolysis; aspergillosis; conidia; fibronectins; fungi; galactose; high performance liquid chromatography; immunocompromised population; lectins; ligands; macrophages; mice; neuraminic acid; oligosaccharides; pathogenesis; pathogens; phagocytosis; pneumocytes; sialic acid; sialidase
- ... Aspergillus fumigatus is an opportunistic fungal pathogen that causes a life-threatening invasive fungal disease (invasive aspergillosis, IA) in immunocompromised individuals. The first step of pathogenesis is thought to be the attachment of conidia to proteins in lung tissue. Previous studies in our laboratory have shown that conidia adhere to basal lamina proteins via negatively charged sugars o ...
- Warwas, Mark L., et al. Show all 5 Authors
- Infection and immunity 2005 v.73 no.9 pp. 5493-5503
- Aspergillus fumigatus; amino acids; animal models; aspergillosis; biosynthesis; blood serum; fungi; genes; humans; immunocompromised population; iron; secretion; siderophores; transferrin; virulence
- ... Aspergillus fumigatus is the leading cause of invasive mold infection and is a serious problem in immunocompromised populations worldwide. We have previously shown that survival of A. fumigatus in serum may be related to secretion of siderophores. In this study, we identified and characterized the sidA gene of A. fumigatus, which encodes L-ornithine N⁵-oxygenase, the first committed step in hydrox ...