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- Wiedmann, Silke, et al. Show all 3 Authors
- Journal of nutrition 2003 v.133 no.3 pp. 716-719
- adults; antigens; apoptosis; biotin; cell proliferation; concanavalin A; cultured cells; gene expression; gene expression regulation; genes; homeostasis; humans; immune response; interferon-gamma; interleukin-4; messenger RNA; metabolism; microarray technology; mononuclear leukocytes; reverse transcriptase polymerase chain reaction; secretion; signal transduction; stress response
- ... Stimulation of immune cells by antigens triggers changes in the transcription of genes encoding cytokines and other proteins; these changes in gene expression are part of the normal immune response. Previous studies have provided evidence that biotin status may affect secretion of cytokines by immune cells. Here we determined whether biotin supplementation affects gene expression in human immune c ...