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- Wikberg, Jarl E.S., et al. Show all 8 Authors
- Biochemical and biophysical research communications 2013 v.434 pp. 767-772
- Dengue virus; X-radiation; models; peptides; proteinases
- ... A series of 45 peptide inhibitors was designed, synthesized, and evaluated against the NS2B–NS3 proteases of the four subtypes of dengue virus, DEN-1–4. The design was based on proteochemometric models for Michaelis (Km) and cleavage rate constants (kcat) of protease substrates. This led first to octapeptides showing submicromolar or low micromolar inhibitory activities on the four proteases. Step ...