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- Wilson, Brian M., et al. Show all 2 Author
- Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.7 pp. 2454-2459
- animal models; antagonists; cognition; glutamic acid; humans; knockout mutants; learning; mice; neocortex; neurons; patients
- ... Fragile X syndrome is a common heritable form of mental retardation in humans. Recent neuroanatomical studies indicate an apparent immature appearance of neurons in fragile X syndrome patients and fragile X mental retardation protein (FMRP)-knockout mice, an animal model of this condition. In this work, we investigated possible alterations in synaptic plasticity in the neocortex of FMRP-knockout m ...
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