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- Wouters, Emiel F.M., et al. Show all 5 Authors
- The international journal of biochemistry & cell biology 2016 v.81 pp. 403-418
- advanced glycation end products; animals; biomarkers; cardiovascular diseases; clinical trials; inflammation; noninsulin-dependent diabetes mellitus; osteoporosis; oxidative stress; pathogenesis; respiratory tract diseases; risk factors
- ... Age-related, non-communicable chronic inflammatory diseases represent the major 21st century health problem. Especially in Western countries, the prevalence of non-communicable diseases like chronic obstructive pulmonary disease, cardiovascular disease, type 2 diabetes and osteoporosis are exponentially rising as the population ages. These diseases are determined by common risk factors and share a ...
- Wouters, Emiel F.M., et al. Show all 9 Authors
- Journal of nutrition 2009 v.139 no.5 pp. 952-957
- human nutrition; NAD ADP-ribosyltransferase; enzyme inhibition; flavonoids; cytokines; blood chemistry; men; patients; chronic diseases; noninsulin-dependent diabetes mellitus; inflammation; anti-inflammatory activity; tumor necrosis factor-alpha; interleukins
- ... Recently, we identified several flavonoids as inhibitors of the nuclear enzyme poly(ADP-ribose) polymerase (PARP)-1 in vitro and in vivo. PARP-1 is recognized as coactivator of nuclear factor-κB and plays a role in the pathophysiology of diseases with low-grade systemic inflammation, such as chronic obstructive pulmonary disease (COPD) and type 2 diabetes (T2D). In this study, we assessed the anti ...
- Wouters, Emiel F.M., et al. Show all 7 Authors
- American journal of clinical nutrition 2002 v.76 no.1 pp. 113-119
- atrophy; bioelectrical impedance; biopsy; correlation; cytochrome-c oxidase; dual-energy X-ray absorptiometry; enzyme activity; fat free mass; muscle fibers; patients; phosphorylase; skeletal muscle; succinate dehydrogenase
- ... Background: Although the loss of peripheral muscle mass has been shown convincingly in chronic obstructive pulmonary disease (COPD), the underlying pathogenesis remains unclear. Objective: The aim of the present study was to determine the relations between skeletal muscle fiber types, fiber cross-sectional area (CSA), enzyme activities, and fat-free mass (FFM) in patients with COPD and in control ...