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- Yang, Jiang-Nan, et al. Show all 28 Authors
- Cell 2019 v.177 no.3 pp. 622-638.e22
- DNA repair; accelerated aging; amino acids; evolution; longevity; mice; mutants; phenotype; solar radiation
- ... DNA repair has been hypothesized to be a longevity determinant, but the evidence for it is based largely on accelerated aging phenotypes of DNA repair mutants. Here, using a panel of 18 rodent species with diverse lifespans, we show that more robust DNA double-strand break (DSB) repair, but not nucleotide excision repair (NER), coevolves with longevity. Evolution of NER, unlike DSB, is shaped prim ...