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- Yang, Jung-Mou, et al. Show all 9 Authors
- Toxicology 2018 v.410 pp. 65-72
- Parkinson disease; agonists; apoptosis; beta catenin; brain; clinical trials; cytotoxicity; etiology; glycogen synthase kinases; humans; mitochondria; models; neoplasms; neurogenesis; neurons; paraquat; patients; therapeutics
- ... Paraquat (PQ) as an herbicide has been demonstrated to impair dopaminergic (DAergic) neurons and highly correlate with the etiology of Parkinson’s disease (PD). WNT/β-CATENIN signaling is known for the specification and neurogenesis of midbrain DAergic neurons and implicated as a therapeutic target in treating many diseases, such as cancer and degenerative diseases. LGK974, a WNT pathway inhibitor ...
- Yang, Jung-Mou, et al. Show all 4 Authors
- European journal of nutrition 2012 v.51 no.8 pp. 987-995
- anaerobic conditions; animal injuries; calcium; coronary vessels; cytokines; docosahexaenoic acid; enzyme-linked immunosorbent assay; esters; hypoxia; myocardial infarction; myocytes; nitric oxide; omega-3 fatty acids; reactive oxygen species; smooth muscle
- ... PURPOSE: Hypoxia and reoxygenation (H/R) occur in a wide variety of important clinical conditions such as myocardial infarction. H/R injury is a complex phenomenon involving not only intracellular damage processes but also an injurious inflammatory response. Docosahexaenoic acid (DHA), an n-3 polyunsaturated fatty acid, has long been proved to be protective against several types of cardiovascular ...
- Yang, Jung-Mou, et al. Show all 7 Authors
- Journal of ethnopharmacology 2011 v.138 no.1 pp. 162-168
- Gastrodia elata; adenosine; antagonists; cAMP-dependent protein kinase; epilepsy; filters; headache; herbal medicines; image analysis; microscopes; models; monitoring; neuroprotective effect; proteasome endopeptidase complex; receptors; tetanus; transfection; ubiquitin
- ... ETHNOPHARMACOLOGICAL RELEVANCE: Gastrodia elata Blume (Fam. Orchidaceae) is a traditional Chinese herbal medicine for treating headaches, dizziness, tetanus, epilepsy, and numbness of the limbs, which suggests that it has neuroprotective effect. AIM OF THE STUDY: To validate the neuroprotection of Gastrodia elata in preventing neurodegenerations, such as Huntington's disease (HD). MATERIALS AND ME ...