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- Yao, Jin-Feng, et al. Show all 6 Authors
- Journal of chromatography 2014 v.962 pp. 94-101
- acetonitrile; antagonists; drugs; formic acid; gonadotropin-releasing hormone; hormone antagonists; intravenous injection; liquid chromatography; liquid-liquid extraction; luteinization; mass spectrometry; models; monitoring; pharmacokinetics; rapid methods; rats; screening
- ... Long acting luteinizing hormone-releasing hormone (LHRH) antagonists designed to be protease-resistant were a series of novel decapeptides structurally similar to LHRH. In the present work, a high-throughput method based on a LC–MS/MS has been developed for the simultaneous determination of pharmacokinetics of five LHRH antagonists in rat via cassette dosing. The method was performed under selecte ...