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- Yeung, John H. K., et al. Show all 2 Author
- Phytotherapy research 2011 v.25 no.11 pp. 1653-1659
- Salvia miltiorrhiza; cerebrovascular disorders; high performance liquid chromatography; humans; liver; liver microsomes; medicine; metabolism; rats
- ... Salvia miltiorrhiza (Danshen) is a famous Traditional Chinese medicine used widely in the treatment of cardiovascular and cerebrovascular diseases. This study explored the effects of Danshen capsules commonly used in clinical practice on the liver CYP3A activity in humans and rats. The effects of Danshen extract on liver CYP3A activity were determined by metabolism of model substrates in vitro in ...
- Yeung, John H.
K., et al. Show all 7 Authors
- Journal of natural products 2015 v.78 no.9 pp. 2266-2275
- P-glycoproteins; Salvia miltiorrhiza; active sites; antineoplastic activity; apoptosis; binding capacity; cell growth; cytotoxicity; diterpenoids; doxorubicin; drug resistance; flow cytometry; growth retardation; hepatoma; human cell lines; humans; median effective concentration; mitogen-activated protein kinase; molecular models; neoplasm cells; signal transduction; synergism
- ... Miltirone (1), an abietane-type diterpene quinone isolated from Salvia miltiorrhiza, possesses anticancer activity in p-glycoprotein (P-gp)-overexpressing human cancer cells. Results of the current study suggest a dual effect of miltirone on P-gp inhibition and apoptotic induction in a human hepatoma HepG2 cell line and its P-gp-overexpressing doxorubicin-resistant counterpart (R-HepG2). Miltirone ...