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1. Identification of unique key genes and miRNAs in latent tuberculosis infection by network analysis

Author:
Zhang, Yuwei,   et al.   ; Lin, Yan; Yu, Huiyuan; Tian, Ruonan; Wang, Guoqing; Li, Fan;     Show all 6 Authors
Source:
Molecular immunology 2019 v.112 pp. 103-114
ISSN:
0161-5890
Subject:
Mycobacterium tuberculosis; data collection; databases; disease transmission; gene expression regulation; genes; immune response; inflammation; messenger RNA; microRNA; microarray technology; mononuclear leukocytes; patients; protein-protein interactions; quantitative polymerase chain reaction; signal transduction; tuberculosis
Abstract:
... Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis (M.tb). New cases are now mainly caused by the progression of latent tuberculosis infection (LTBI). Thus, methods to diagnose and treat LTBI are urgently needed to prevent the development of active TB in infected individuals and the subsequent spread of the disease. In this study, a systems biology approach was ...
DOI:
10.1016/j.molimm.2019.04.032

2. Ultrasensitive peptide-based electrochemical detection of protein kinase activity amplified by RAFT polymerization

Author:
Zhang, Yuwei,   et al.   ; Hu, Qiong; Kong, Jinming; Han, Dongxue; Bao, Yu; Zhang, Xueji; Niu, Li;     Show all 7 Authors
Source:
Talanta 2019 pp. 120173
ISSN:
0039-9140
Subject:
biosensors; cAMP-dependent protein kinase; detection limit; electrochemistry; electrodes; enzyme activity; gold; human diseases; peptides; phosphorylation; polymerization; polymers; screening; therapeutics; thiols
Abstract:
... Since the oversecretion of protein kinases is indicative of multiple human diseases, the screening of their activities is quite important to clinical diagnosis and targeted therapy. In this work, an ultrasensitive peptide-based electrochemical biosensor was presented for the detection of protein kinase activity by using the reversible addition-fragmentation chain transfer (RAFT) polymerization tec ...
DOI:
10.1016/j.talanta.2019.120173

3. Polyurethane heat preservation materials: The significant sources of organophosphorus flame retardants

Author:
Zhang, Yuwei,   et al.   ; Wang, Yan; Yang, Ya; Tan, Feng; Li, Qilu; Zhao, Hongxia; Xie, Qing; Chen, Jingwen;     Show all 8 Authors
Source:
Chemosphere 2019 v.227 pp. 409-415
ISSN:
0045-6535
Subject:
X-ray photoelectron spectroscopy; additives; buildings; esters; flame retardants; foams; heat; humans; organophosphorus compounds; polystyrenes; polyurethanes; risk; China
Abstract:
... The concentrations and compositions of organophosphorus flame retardants (OPFRs) in various heat preservation materials from different brands and types in China were investigated, as well as their OPFR burdens and emission amounts. The average concentrations of ΣOPFRs were 41.4 ± 10.2, (7.1 ± 4.0) × 104, and 56.3 ± 19.3 μg/g in phenolic foams (PF), polyurethane foams (PUR), and extruded polystyren ...
DOI:
10.1016/j.chemosphere.2019.04.085

4. Characterizing the protein corona of sub-10 nm nanoparticles

Author:
Zhang, Yuwei,   et al.   ; Glancy, Dylan; Wu, Jamie L.Y.; Ouyang, Ben; Ohta, Seiichi; Chan, Warren C.W.;     Show all 6 Authors
Source:
Journal of controlled release 2019 v.304 pp. 102-110
ISSN:
0168-3659
Subject:
blood proteins; nanoparticles; protein corona
Abstract:
... Studies into the interactions of serum proteins with nanoparticles are typically performed using nanoparticles that are larger than the size of proteins. Due to this size discrepancy, adsorbed proteins are commonly depicted as a globular structure surrounding a nanoparticle. Here, we asked how we should view nanoparticle–protein complexes when the nanoparticles are of similar size or smaller than ...
DOI:
10.1016/j.jconrel.2019.04.023

5. Linifanib exerts dual anti-obesity effect by regulating adipocyte browning and formation

Author:
Zhang, Yuwei,   et al.   ; Zhao, Shiting; Chu, Yi; Zhou, Yulai; Jiang, Zhiwu; Wang, Zhengqi; Mao, Liufeng; Li, Kuai; Sun, Wei; Li, Peng; Jia, Shiqi; Wang, Cunchuan; Xu, Aimin; Loomes, Kerry; Tang, Shibing; Wu, Donghai; Hui, Xiaoyan; Nie, Tao;     Show all 18 Authors
Source:
Life sciences 2019 v.222 pp. 117-124
ISSN:
0024-3205
Subject:
adipocytes; adipogenesis; animal models; chemical compounds; drugs; energy expenditure; enzymes; hyperplasia; hypertrophy; mitosis; obesity; phosphorylation; screening; signal transduction
Abstract:
... Obesity is caused by energy imbalance and accompanied by adipocyte hypertrophy and hyperplasia. Therefore, both enhancement of adipocyte energy expenditure and inhibition of adipogenesis are viable ways to combat obesity. Using the Ucp1-2A-luciferase reporter animal model previously reported by us as a screening platform, a chemical compound Linifanib was identified as a potent inducer of UCP1 exp ...
DOI:
10.1016/j.lfs.2019.01.047

6. Effects of electron beam irradiation on storability of brown and milled rice

Author:
Zhang, Yuwei,   et al.   ; Luo, Xiaohu; Li, Yulin; Yang, Dan; Xing, Jiali; Li, Ke; Yang, Ming; Wang, Ren; Wang, Li; Chen, Zhengxing;     Show all 10 Authors
Source:
Journal of stored products research 2019 v.81 pp. 22-30
ISSN:
0022-474X
Subject:
amylose; brown rice; carboxylic ester hydrolases; color; enzyme activity; free fatty acids; freshness; irradiation; microstructure; plate count; scanning electron microscopy; storage quality; viscosity
Abstract:
... The effects of electron beam irradiation (EBI) treatment on the freshness and quality of brown and milled rice at different irradiation doses were investigated. The colors of brown rice (P > 0.05) and milled rice (P < 0.05) slightly changed after 5 kGy irradiation. After irradiation, the viscosities and amylose contents of the samples decreased (P < 0.05), crystal forms remained unchanged, but cry ...
DOI:
10.1016/j.jspr.2018.12.003

7. In vitro fermentation of arabinoxylan from oat (Avena sativa L.) by Pekin duck intestinal microbiota

Author:
Zhang, Yuwei,   et al.   ; Tian, Dandan; Xu, Xiaoqing; Peng, Qing; Wen, Zhiguo; Wei, Chenyang; Qiao, Yu; Shi, Bo;     Show all 8 Authors
Source:
3 Biotech 2019 v.9 no.2 pp. 54
ISSN:
2190-572X
Subject:
Avena sativa; Bifidobacterium; Megamonas; Pekin; animal health; arabinoxylan; bacteria; ducks; fermentation; genes; high-throughput nucleotide sequencing; intestinal microorganisms; intestines; isobutyric acid; oats; pH; ribosomal RNA
Abstract:
... Arabinoxylan (AX) is abundant in cereal grains used as feed for ducks. However, the duck intestinal microbes responsible for the degradation of AX are not fully understood. In this study, oat AX was degraded and utilized by different duck intestinal microbiota in vitro. Changes in short-chain fatty acids (SCFAs), branch-chain fatty acids, and the pH resulted from a 72-h AX fermentation in intestin ...
DOI:
10.1007/s13205-019-1571-5

8. Source apportionment of polycyclic aromatic hydrocarbons (PAHs) in the air of Dalian, China: Correlations with six criteria air pollutants and meteorological conditions

Author:
Zhang, Yuwei,   et al.   ; Wang, Yan; Zhang, Qiaonan; Zhao, Hongxia; Tan, Feng; Wu, Xiaowei; Chen, Jingwen;     Show all 7 Authors
Source:
Chemosphere 2019 v.216 pp. 516-523
ISSN:
0045-6535
Subject:
air; air pollutants; air pollution; autumn; biomass; burning; fuel combustion; heat; models; nitrogen dioxide; ozone; petroleum; photochemistry; polycyclic aromatic hydrocarbons; relative humidity; spring; suburban areas; sulfur dioxide; summer; temperature; temporal variation; traffic; winter; China
Abstract:
... Concentrations and temporal variations of priority polycyclic aromatic hydrocarbons (PAHs) in the air from a suburban area of Dalian, China were investigated for a 1-year period to assess their sources and potential correlations with six criteria air pollutants and meteorological parameters. The total concentrations of PAHs were in the range of 4.32–112.2 ng/m3 (Mean = 52.37 ± 23.99 ng/m3). Season ...
DOI:
10.1016/j.chemosphere.2018.10.184

9. Electrochemically Controlled RAFT Polymerization for Highly Sensitive Electrochemical Biosensing of Protein Kinase Activity

Author:
Zhang, Yuwei,   et al.   ; Hu, Qiong; Kong, Jinming; Han, Dongxue; Bao, Yu; Zhang, Xueji; Niu, Li;     Show all 7 Authors
Source:
Analytical chemistry 2019 v.91 no.3 pp. 1936-1943
ISSN:
1520-6882
Subject:
biosensors; blood serum; cAMP-dependent protein kinase; cyclic AMP; disease diagnosis; drugs; electrochemistry; electrodes; enzyme activity; gold; models; peptides; phosphorylation; polymerization; polymers; proteins; screening
Abstract:
... Phosphorylation of proteins catalyzed by protein kinases (PKs) is essential to many biological processes; the sensitive detection of PK activity and the screening of PK inhibitors are thus integral to disease diagnosis and drug discovery. Herein, a highly sensitive biosensor has been fabricated for the electrochemical detection of PK activity by exploiting the electrochemically controlled reversib ...
DOI:
10.1021/acs.analchem.8b04221

10. Preparation and characterization of D. opposita Thunb polysaccharide-zinc inclusion complex and evaluation of anti-diabetic activities

Author:
Zhang, Yuwei,   et al.   ; Zhang, Yun; Khan, M.Z.H.; Yuan, Tingting; Liu, Xiuhua; Du, Zuliang; Zhao, Yingyong;     Show all 7 Authors
Source:
International journal of biological macromolecules 2019 v.121 pp. 1029-1036
ISSN:
0141-8130
Subject:
Dioscorea oppositifolia; animal disease models; blood serum; diabetes; functional foods; glucose; glycemic effect; ingredients; insulin; liver; malondialdehyde; polysaccharides; rats; spectroscopy; streptozotocin; superoxide dismutase; zinc
Abstract:
... In the present work, Dioscorea opposita Thunb polysaccharide-zinc (DPS-zinc) inclusion complex was synthesized for the first time and its anti-diabetes activities against Streptozotocin (STZ)-induced diabetic rats were assayed. The detail structural and morphological analysis of as-prepared DPS-zinc complex was done by using different spectroscopic and microscopic methods. The pharmacological stud ...
DOI:
10.1016/j.ijbiomac.2018.10.068

11. Seasonal variation, air-water exchange, and multivariate source apportionment of polycyclic aromatic hydrocarbons in the coastal area of Dalian, China

Author:
Zhang, Yuwei,   et al.   ; Wu, Xiaowei; Wang, Yan; Zhang, Qiaonan; Zhao, Hongxia; Yang, Ya; Xie, Qing; Chen, Jingwen;     Show all 8 Authors
Source:
Environmental pollution 2019 v.244 pp. 405-413
ISSN:
0269-7491
Subject:
air; coasts; combustion; phenanthrenes; principal component analysis; seasonal variation; seawater; summer; temperature; volatilization; winter; China
Abstract:
... The concentrations and seasonal variations of polycyclic aromatic hydrocarbons (PAHs) in air and seawater dissolved samples from the coastal area of Dalian were investigated, as well as their air-water exchanges. The average concentrations of PAHs were 27.5 ± 14.6 ng/m3 and 49.5 ± 20.5 ng/L in the air and water, respectively. Phenanthrene was the dominant congener in both air and water dissolved p ...
DOI:
10.1016/j.envpol.2018.10.075

12. Design and Biosynthesis of Dimeric Alboflavusins with Biaryl Linkages via Regiospecific C–C Bond Coupling

Author:
Zhang, Yuwei,   et al.   ; Guo, Zhengyan; Li, Pengwei; Chen, Guozhu; Li, Chao; Cao, Zhenju; Ren, Jinwei; Xiang, Hua; Lin, Shuangjun; Ju, Jianhua; Chen, Yihua;     Show all 11 Authors
Source:
Journal of the American Chemical Society 2018 v.140 no.51 pp. 18009-18015
ISSN:
1520-5126
Subject:
Streptomyces alboflavus; antineoplastic activity; biosynthesis; chemical bonding; enzymes; in vitro studies; multigene family; mutants; peptides; regioselectivity; structure-activity relationships; tryptophan
Abstract:
... Alboflavusins (AFNs) are a group of cyclohexapeptides with moderate antibacterial and antitumor activities from Streptomyces alboflavus sp. 313. In vivo and in vitro studies proposed that AFNs are biosynthesized by a nonribosomal peptide synthetase machinery, and the 6-Cl-L-Trp precursor is supplied by a tryptophan halogenase gene located outside the afn gene cluster. Guided by the structure–activ ...
DOI:
10.1021/jacs.8b10136

13. Decursin inhibits the growth of HepG2 hepatocellular carcinoma cells via Hippo/YAP signaling pathway

Author:
Zhang, Yuwei,   et al.   ; Li, Jianchun; Wang, Honglian; Wang, Lu; Tan, Ruizhi; Zhu, Menglian; Zhong, Xia; Chen, Bo; Wang, Li;     Show all 9 Authors
Source:
Phytotherapy research 2018 v.32 no.12 pp. 2456-2465
ISSN:
0951-418X
Subject:
apoptosis; cell proliferation; hepatoma; human cell lines; mice; neoplasm cells; signal transduction; therapeutics
Abstract:
... Targeted therapy has a pivotal role for the treatment of liver cancer. The aim of this current study was to examine the effects of decursin on the growth of HepG2 cells and the underlying mechanisms. Our present study showed that treatment of HepG2 cells with decursin significantly inhibited the growth of HepG2 cells by suppressing cell proliferation, cell cycle arresting, and promoting apoptosis ...
DOI:
10.1002/ptr.6184

14. One-pot synthesis of the stable CdZnTeS quantum dots for the rapid and sensitive detection of copper-activated enzyme

Author:
Zhang, Yuwei,   et al.   ; Mao, Guobin; Liu, Chen; Du, Mingyuan; Ji, Xinghu; He, Zhike;     Show all 6 Authors
Source:
Talanta 2018 v.185 pp. 123-131
ISSN:
0039-9140
Subject:
blood; copper; fluorescence; galactose; galactosemia; ligands; metabolism; milk consumption; patients; quantum dots; reducing agents; synthesis
Abstract:
... Galactose oxidase is a copper-activated enzyme and have a vital role in metabolism of galactose. Much of the work is focused on determining the amount of galactose in the blood rather than measuring the amount of galactose oxidase to urge the galactosemia patients to restrict milk intake. Here, a simple and effective method was developed for Cu2+ and copper-activated enzyme detection based on homo ...
DOI:
10.1016/j.talanta.2018.03.054

15. Identification of long noncoding RNAs in Schistosoma mansoni and Schistosoma japonicum

Author:
Zhang, Yuwei,   et al.   ; Liao, Qi; Zhu, Yuchao; Chen, Jia; Dong, Changzheng; Tao, Yang; He, Ai; Liu, Jianfa; Wu, Zhongdao;     Show all 9 Authors
Source:
Experimental parasitology 2018 v.191 pp. 82-87
ISSN:
0014-4894
Subject:
Schistosoma japonicum; Schistosoma mansoni; gene expression regulation; genes; germplasm conservation; mammals; messenger RNA; microRNA; non-coding RNA; nucleotide sequences; parasites; proteins; schistosomiasis; sequence analysis; transcriptome
Abstract:
... Schistosomiasis is a major parasitic disease caused by 3 principal species of schistosome. Studies of schistosome transcriptomes have focused on protein-coding transcripts and although miRNAs are attracting increased attention, few reports have concerned the long noncoding RNAs (lncRNAs). These have been shown to play key roles in the regulation of gene expression through interactions with mRNAs, ...
DOI:
10.1016/j.exppara.2018.07.001

16. Regulatory network analysis of high expressed long non-coding RNA LINC00941 in gastric cancer

Author:
Zhang, Yuwei,   et al.   ; Luo, Cong; Tao, Yang; Zhu, Yinyin; Minyao, Derry Ng; Haleem, Maria; Dong, Changzheng; Zhang, Lina; Zhang, Xiaohong; Zhao, Jinshun; Liao, Qi;     Show all 11 Authors
Source:
Gene 2018 v.662 pp. 103-109
ISSN:
0378-1119
Subject:
biomarkers; carcinogenesis; cell communication; cell division; cell movement; gene expression regulation; immune system; metastasis; mortality; non-coding RNA; patients; reverse transcriptase polymerase chain reaction; stomach neoplasms; therapeutics; tissues
Abstract:
... Accumulating evidence suggests that the aberrant expression of long non-coding RNAs is closely related to the carcinogenesis and progression of gastric cancer (GC), which is a type of prevalent tumor with a high incidence and mortality rate. However, it is still a challenge to find reliable biomarkers and to understand their molecular mechanisms in GC. In this study, we first confirmed that LINC00 ...
DOI:
10.1016/j.gene.2018.04.023

17. Constructing a filler network for thermal conductivity enhancement in epoxy composites via reaction-induced phase separation Part A Applied science and manufacturing

Author:
Zhang, Yuwei,   et al.   ; Shen, Yucai; Shi, Kunxiang; Wang, Tingwei; Harkin-Jones, Eileen;     Show all 5 Authors
Source:
Composites 2018 v.110 pp. 62-69
ISSN:
1359-835X
Subject:
anhydrides; bisphenol A; composite materials; epoxides; ethers; graphene; impact strength; resins; separation; thermal conductivity
Abstract:
... Diglycidyl ethers of bisphenol-A (DGEBA)/methyl tetrahydrophthalic anhydride/polyethersulphone (PES) blends are prepared as matrix resins for thermally conductive composites using graphite nanoplatelets (GNPs) as the conductive component. The epoxy/PES blends form a network structure via reaction-induced phase separation (RIPS) during the curing process, and the GNPs are selectively localized in t ...
DOI:
10.1016/j.compositesa.2018.04.009

18. The regulatory network analysis of long noncoding RNAs in human colorectal cancer

Author:
Zhang, Yuwei,   et al.   ; Tao, Yang; Li, Yang; Zhao, Jinshun; Zhang, Lina; Zhang, Xiaohong; Dong, Changzheng; Xie, Yangyang; Dai, Xiaoyu; Zhang, Xinjun; Liao, Qi;     Show all 11 Authors
Source:
Functional & integrative genomics 2018 v.18 no.3 pp. 261-275
ISSN:
1438-793X
Subject:
DNA damage; RNA-binding proteins; bioinformatics; cell cycle; cell differentiation; colorectal neoplasms; gene expression regulation; genes; humans; messenger RNA; microRNA; non-coding RNA; transcription factors
Abstract:
... Colorectal cancer (CRC) is among one of the most prevalent and lethiferous diseases worldwide. Long noncoding RNAs (lncRNAs) are commonly accepted to function as a key regulatory factor in human cancer, but the potential regulatory mechanisms of CRC-associated lncRNA are largely obscure. Here, we integrated several expression profiles to obtain 55 differentially expressed (DE) lncRNAs. We first de ...
DOI:
10.1007/s10142-017-0588-2

19. Application of high‐speed counter‐current chromatography and HPLC to separate and purify of three polyacetylenes from Platycodon grandiflorum

Author:
Zhang, Yuwei,   et al.   ; Chen, Bao; Liu, Zhengbo; Li, Wei; Sun, Yanjun; Wang, Yufang; Wang, Yanhua; Sun, Yinshi;     Show all 8 Authors
Source:
Journal of separation science 2018 v.41 no.3 pp. 789-796
ISSN:
1615-9306
Subject:
Platycodon grandiflorum; chemical structure; countercurrent chromatography; ethyl acetate; hexane; high performance liquid chromatography; mass spectrometry; methanol; nuclear magnetic resonance spectroscopy; polyacetylenes; solvents
Abstract:
... Three polyacetylenes were isolated and purified from Platycodon grandiflorum A. DC for the first time by high‐speed counter‐current chromatography using a two‐phase solvent system composed of hexane/ethyl acetate/methanol/water (1:31:1:31, v/v/v/v) and high‐performance liquid chromatography with an Agilent ZORBAX® SB‐C18 column (4.6 mm × 150 mm, 5 μm). After separation by high‐speed counter‐curren ...
DOI:
10.1002/jssc.201700767

20. Single-Molecule Nanocatalysis of Pt Nanoparticles C

Author:
Zhang, Yuwei,   et al.   ; Liu, Xiaodong; Chen, Tao; Song, Ping; Xu, Weilin;     Show all 5 Authors
Source:
Journal of physical chemistry 2018 v.122 no.3 pp. 1746-1752
ISSN:
1932-7455
Subject:
catalysts; catalytic activity; desorption; nanoparticles
Abstract:
... Because of the inhomogeneous structure of nanoparticles, many underlying catalytic details of these catalysts are hidden in the ensemble-averaged measurements. The single-molecule approach enables studying the catalytic behavior of nanoparticles at the single-particle level in single-turnover resolution. Here, on the basis of such a method, we study the catalytic behaviors of individual Pt nanopar ...
DOI:
10.1021/acs.jpcc.7b11630