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1. Carboxylated graphene oxide functionalized with β-cyclodextrin—Engineering of a novel nanohybrid drug carrier

Author:
Zhou, Ninglin,   et al.   ; Meng, Na; Su, YuTian; Zhang, Ming; Shao, Maoni; Fan, Yunting; Zhu, Haomiao; Yuan, Ping; Chi, Cheng; Xiao, Yinghong;     Show all 10 Authors
Source:
International journal of biological macromolecules 2016 v.93 pp. 117-122
ISSN:
0141-8130
Subject:
Fourier transform infrared spectroscopy; X-ray diffraction; cyclodextrins; dispersibility; drug carriers; esterification; graphene oxide; hydrogen bonding; medicine; scanning electron microscopy; solubility; thermogravimetry; transmission electron microscopy
Abstract:
... In this paper, we selected biocompatible carboxylated graphene oxide (GeneO-COOH) as a base material. The nanohybrid drug carriers composed of GeneO-COOH and cyclodextrin (β-CD), have been successfully synthesized through esterification and self-assembly technique. The nanohybrid drug carriers of GeneO-COO-β-CD were characterized by X-ray diffraction (XRD), fourier infrared spectroscopy (FTIR), th ...
DOI:
10.1016/j.ijbiomac.2016.08.051

2. Graphene oxide and adenosine triphosphate as a source for functionalized carbon dots with applications in pH-triggered drug delivery and cell imaging

Author:
Zhou, Ninglin,   et al.   ; Zhang, Ming; Yuan, Ping; Su, Yutian; Shao, Maoni; Chi, Cheng;     Show all 6 Authors
Source:
RSC advances 2017 v.7 no.15 pp. 9284-9293
ISSN:
2046-2069
Subject:
adenosine triphosphate; biocompatibility; carbon quantum dots; cytotoxicity; doxorubicin; electrostatic interactions; graphene oxide; hemolysis; human cell lines; humans; image analysis; intravenous injection; nanocarriers; neoplasm cells; pH; particle size; photoluminescence; uterine cervical neoplasms
Abstract:
... A folate-functionalized carbon dot-based nanocarrier system has been successfully synthesized for cancer cell targeted drug delivery. We hydrothermally synthesized blue photoluminescent N,P-CDs using adenosine triphosphate and graphene oxide as the starting materials. The particle size of the N,P-CDs was ca. 3.8 nm. An anticancer drug, doxorubicin (DOX), was grafted onto the carbon dots via electr ...
DOI:
10.1039/c6ra27887f

3. pH-Sensitive N-doped carbon dots–heparin and doxorubicin drug delivery system: preparation and anticancer research

Author:
Zhou, Ninglin,   et al.   ; Zhang, Ming; Yuan, Ping; Su, Yutian; Shao, Maoni; Chi, Cheng;     Show all 6 Authors
Source:
RSC advances 2017 v.7 no.15 pp. 9347-9356
ISSN:
2046-2069
Subject:
Fourier transform infrared spectroscopy; biocompatibility; carbon quantum dots; chemical bonding; confocal laser scanning microscopy; doxorubicin; drug carriers; electrostatic interactions; heparin; in vivo studies; medicine; neoplasm cells; nuclear magnetic resonance spectroscopy; toxicity; toxicity testing
Abstract:
... In this study, doxorubicin (DOX) hydrochloride as a model drug, N-doped carbon dots as a drug carrier, and heparin as an auxiliary medicine were selected to design and prepare a multi-functional drug delivery system with pH-triggered drug release. The CDs were anchored onto heparin via chemical bonds and DOX was then loaded on CDs–Hep by taking advantage of the electrostatic interactions between D ...
DOI:
10.1039/c6ra28345d

4. Near-infrared light triggered photo-therapy, in combination with chemotherapy using magnetofluorescent carbon quantum dots for effective cancer treating

Author:
Zhou, Ninglin,   et al.   ; Zhang, Ming; Wang, Wentao; Yuan, Ping; Su, Yutian; Shao, Maoni; Chi, Cheng; Pan, Feiyan;     Show all 8 Authors
Source:
Carbon 2017 v.118 pp. 752-764
ISSN:
0008-6223
Subject:
carbon quantum dots; confocal laser scanning microscopy; crosslinking; doxorubicin; folic acid; in vivo studies; irradiation; magnetic properties; nanospheres; neoplasm cells; neoplasms; photochemotherapy; photoluminescence; polymers; riboflavin; toxicity
Abstract:
... Magnetofluorescent carbon quantum dots (MCQDs) have attracted significant attention in biomedical studies due to their major role in cancer photothermal therapeutics. We synthesized the FeN@CQDs with intrinsic photoluminescent and magnetic properties with a green, hydrothermal method. These magnetofluorescent FeN@CQDs were conjugated with a folic acid and riboflavin (Rf-FA-FeN@CQDs) as the light-t ...
DOI:
10.1016/j.carbon.2017.03.085

5. Magnetic and fluorescent carbon nanotubes for dual modal imaging and photothermal and chemo-therapy of cancer cells in living mice

Author:
Zhou, Ninglin,   et al.   ; Zhang, Ming; Wang, Wentao; Wu, Fan; Yuan, Ping; Chi, Cheng;     Show all 6 Authors
Source:
Carbon 2017 v.123 pp. 70-83
ISSN:
0008-6223
Subject:
absorbance; carbon nanotubes; carbon quantum dots; doxorubicin; image analysis; irradiation; mice; nanocomposites; neoplasm cells; neoplasms; pH; therapeutics
Abstract:
... Multi-walled carbon nanotubes (MWCNTs) have drawn increasing attention in biomedical fields because of their unique structures and properties, including good photothermal performance, large surface areas, strong near-infrared (NIR) absorbance, and size stability on the nanoscale. However, big challenge for this platform is to achieve fluorescence/magnetic resonance (MR) imaging and photothermal th ...
DOI:
10.1016/j.carbon.2017.07.032

6. Anticoagulant polyurethane substrates modified with poly(2-methacryloyloxyethyl phosphorylcholine) via SI-RATRP

Author:
Zhou, Ninglin,   et al.   ; Chi, Cheng; Sun, Baohong; Zhang, Ming; Chu, Xiaohong; Yuan, Ping; shen, Jian;     Show all 7 Authors
Source:
Colloids and surfaces 2018 v.163 pp. 301-308
ISSN:
0927-7765
Subject:
X-ray photoelectron spectroscopy; acetates; adhesion; antibacterial properties; anticoagulants; biocompatibility; blood platelets; catalysts; cell adhesion; chlorhexidine; colloids; contact angle; copper; ethanol; lanthanum; ligands; phosphorylcholine; polymerization; polyurethanes; silane
Abstract:
... A novel catalyst system of Reverse Atom Transfer Radical Polymerization (RATRP) to prepare Polyurethane (PU) films modified by poly(2-methacryloyloxyethyl phosphorylcholine) (pMPC) was studied in this article. In this system, PU film was pretreated by LaCl3/CA ethanol solution to obtain a hydrated surface allowing more initiators to be immobilized on it. Moreover, complexes composed of silane coup ...
DOI:
10.1016/j.colsurfb.2018.01.005

7. Study on montmorillonite–chlorhexidine acetate–terbinafine hydrochloride intercalation composites as drug release systems

Author:
Zhou, Ninglin,   et al.   ; Sun, Baohong; Zhang, Ming; Chu, Xiaohong; Yuan, Ping; Chi, Cheng; Wu, Fan; Shen, Jian;     Show all 8 Authors
Source:
RSC advances 2018 v.8 no.38 pp. 21369-21377
ISSN:
2046-2069
Subject:
Fourier transform infrared spectroscopy; X-ray diffraction; acetates; adsorption; cation exchange capacity; chlorhexidine; clay; crosslinking; drug carriers; drugs; electrostatic interactions; ions; kinetics; montmorillonite; sodium chloride; thermogravimetry
Abstract:
... This paper focuses on the intercalation of chlorhexidine acetate (CA) and terbinafine hydrochloride (TBH) into montmorillonite as sustained release drug carriers. The intercalation compounds were characterized by X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, and thermogravimetric analysis (TGA). The basal spacing of montmorillonite increased from 1.23 to 2.97 nm. It was ...
DOI:
10.1039/c8ra03651a

8. Synthesis and characterization of a novel antibacterial material containing poly(sulfobetaine) using reverse atom transfer radical polymerization

Author:
Zhou, Ninglin,   et al.   ; Chu, Xiaohong; Zhang, Ming; Wu, Fan; Sun, Baohong; Shen, Jian;     Show all 6 Authors
Source:
RSC advances 2018 v.8 no.58 pp. 33000-33009
ISSN:
2046-2069
Subject:
Fourier transform infrared spectroscopy; X-ray photoelectron spectroscopy; adsorption; antibacterial properties; antibiotics; bacterial adhesion; contact angle; humans; hydrophilicity; kidney cells; nuclear magnetic resonance spectroscopy; pollution; polymerization; polyurethanes; sodium; sulfobetaine; survival rate
Abstract:
... A novel antibacterial agent was synthesized using 2-(dimethylamino)ethyl methacrylate (DM) and sodium 3-chloro-2-hydroxypropane sulfonate (CHPS). It was characterized by Fourier transform infrared spectroscopy (FTIR), NMR Spectroscopy (¹H NMR), and X-ray photoelectron spectroscopy (XPS). This new agent DMCHPS was then grafted onto a polyurethane (PU) substrate via surface-initiated reverse atom tr ...
DOI:
10.1039/c8ra05793a

9. Novel controlled drug release system engineered with inclusion complexes based on carboxylic graphene

Author:
Zhou, Ninglin,   et al.   ; Xiao, Yinghong; Zhang, Ming; Fan, Yunting; Zhang, Qicheng; Wang, Yuli; Yuan, Wenwen; Che, Jianfei;     Show all 8 Authors
Source:
Colloids and surfaces 2019 v.175 pp. 18-25
ISSN:
0927-7765
Subject:
Fourier transform infrared spectroscopy; atomic force microscopy; biocompatibility; blood coagulation; carboxylation; chemical bonding; colloids; cross-linking reagents; dexamethasone; drug carriers; glutaraldehyde; graphene; heat tolerance; hemolysis; hydrophilicity; intravenous injection; models; nanospheres; toxicity; water solubility
Abstract:
... A novel drug carrier is constructed by compositing hydrophilic hydroxypropyl-β-cyclodextrins (HP-β-CD) and carboxylated graphene nanomaterial (GO-COOH). Fourier transform infrared spectroscopy confirms that the two materials are successfully combined via chemical bonds. Further, a crosslinking agent of glutaraldehyde is applied to fabricate composite GO-COO-HP-β-CD nanospheres, as demonstrated by ...
DOI:
10.1016/j.colsurfb.2018.11.058