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You searched for: Subject "adaptive immunity" Remove constraint Subject: "adaptive immunity"
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1. Novel model for chronic intestinal inflammation in chickens: (2) Immunologic mechanism behind the inflammatory response

Author:
Gabriela Cardoso Dal Pont; A. Lee; C. Bortoluzzi; Y.Z. Farnell; C. Gougoulias; M.H. Kogut
Source:
Developmental and comparative immunology 2023 v.138 no. pp. 104524
ISSN:
0145-305X
Subject:
adaptive immunity,   etc   ; T-lymphocytes; broiler chickens; chemokines; diet; histology; ileum; inflammation; interferon-alpha; interleukin-10; interleukin-21; interleukin-6; jejunum; models; monocytes; polysaccharides; vascular endothelial growth factors;     Show all 17 Subjects
Abstract:
... Intestinal inflammation in poultry is a complex response that involves immune and intestinal cells which is still not fully understood. Thus, to better understand the mechanisms that drive the chronic intestinal inflammation in fowl we conducted an experiment applying a previously established nutritional model of low-grade chronic intestinal inflammation to evaluate cytokine and chemokine profiles ...
DOI:
10.1016/j.dci.2022.104524

2. Methods for the directed evolution of biomolecular interactions

Author:
Victoria Cochran Xie; Matthew J. Styles; Bryan C. Dickinson
Source:
Trends in biochemical sciences 2022 v.47 no.5 pp. 403-416
ISSN:
0968-0004
Subject:
adaptive immunity,   etc   ; directed evolution; evolution;     Show all 3 Subjects
Abstract:
... Noncovalent interactions between biomolecules such as proteins and nucleic acids coordinate all cellular processes through changes in proximity. Tools that perturb these interactions are and will continue to be highly valuable for basic and translational scientific endeavors. By taking cues from natural systems, such as the adaptive immune system, we can design directed evolution platforms that ca ...
DOI:
10.1016/j.tibs.2022.01.001

3. The Relevance of TLR8 in Viral Infections

Author:
Iván Martínez-Espinoza; Antonieta Guerrero-Plata
Source:
Pathogens 2022 v.11 no.2 pp. -
ISSN:
2076-0817
Subject:
adaptive immunity,   etc   ; cytokines; immune system; vaccines;     Show all 4 Subjects
Abstract:
... Toll-like receptors (TLRs) are the largest pattern recognition receptors responsible for activating the innate and adaptive immune response against viruses through the release of inflammatory cytokines and antiviral mediators. Viruses are recognized by several TLRs, including TLR8, which is known to bind ssRNA structures. However, the similarities between TLR8 and TLR7 have obscured the distinctiv ...
DOI:
10.3390/pathogens11020134

4. Viral manipulation of host cell necroptosis and pyroptosis

Author:
Simon Verdonck; Josephine Nemegeer; Peter Vandenabeele; Jonathan Maelfait
Source:
Trends in microbiology 2022 v.30 no.6 pp. 593-605
ISSN:
0966-842X
Subject:
adaptive immunity,   etc   ; immune response; necroptosis; pyroptosis;     Show all 4 Subjects
Abstract:
... Cell death forms an essential component of the antiviral immune response. Viral infection elicits different forms of host cell death, including the lytic and inflammatory cell death modes necroptosis or pyroptosis. The induction of both types of cell death not only eliminates virus-infected cells but also contributes to the development of innate and adaptive immunity through the release of inflamm ...
DOI:
10.1016/j.tim.2021.11.011

5. Deep Learning of Morphologic Correlations To Accurately Classify CD4+ and CD8+ T Cells by Diffraction Imaging Flow Cytometry

Author:
Lin Zhao; Liwen Tang; Marion S. Greene; Yu Sa; Wenjin Wang; Jiahong Jin; Heng Hong; Jun Q. Lu; Xin-Hua Hu
Source:
Analytical chemistry 2022 v.94 no.3 pp. 1567-1574
ISSN:
1520-6882
Subject:
adaptive immunity,   etc   ; algorithms; analytical chemistry; flow cytometry; humans; splenocytes;     Show all 6 Subjects
Abstract:
... The two major subtypes of human T cells, CD4+ and CD8+, play important roles in adaptive immune response by their diverse functions. To understand the structure–function relation at the single cell level, we isolated 2483 CD4+ and 2450 CD8+ T cells from fresh human splenocytes by immunofluorescent sorting and investigated their morphologic relations to the surface CD markers by acquisition and ana ...
DOI:
10.1021/acs.analchem.1c03337

6. Microbiota regulation of viral infections through interferon signaling

Author:
Nurul I. Wirusanti; Megan T. Baldridge; Vanessa C. Harris
Source:
Trends in microbiology 2022 v.30 no.8 pp. 778-792
ISSN:
0966-842X
Subject:
adaptive immunity,   etc   ; digestive system; humans; innate immunity; interferons; intestinal microorganisms;     Show all 6 Subjects
Abstract:
... The interferon (IFN) response is the major early innate immune response against invading viral pathogens and is even capable of mediating sterilizing antiviral immunity without the support of the adaptive immune system. Cumulative evidence suggests that the gut microbiota can modulate IFN responses, indirectly determining virological outcomes. This review outlines our current knowledge of the inte ...
DOI:
10.1016/j.tim.2022.01.007

7. The Impact of Short-Chain Fatty Acids on Neonatal Regulatory T Cells

Author:
Jessica Chun; Gergely Toldi
Source:
Nutrients 2022 v.14 no.18 pp. -
ISSN:
2072-6643
Subject:
adaptive immunity,   etc   ; digestive tract; immune system; intestinal mucosa; metabolism; microbial colonization;     Show all 6 Subjects
Abstract:
... Over the first weeks of life, the neonatal gastrointestinal tract is rapidly colonised by a diverse range of microbial species that come to form the ‘gut microbiota’. Microbial colonisation of the neonatal gut is a well-established regulator of several physiological processes that contribute to immunological protection in postnatal life, including the development of the intestinal mucosa and adapt ...
DOI:
10.3390/nu14183670

8. The double life of CRISPR–Cas13

Author:
Jorik F Bot; John van der Oost; Niels Geijsen
Source:
Current opinion in biotechnology 2022 v.78 pp. 102789
ISSN:
0958-1669
Subject:
adaptive immunity,   etc   ; RNA; biomedical research; biotechnology; eukaryotic cells; mammals; nucleases; toxicity;     Show all 8 Subjects
Abstract:
... Since the discovery of RNA-programmable nucleases from the prokaryotic adaptive immune system CRISPR–Cas, these proteins have seen rapid and widespread adoption for biotechnological and clinical research. A recently discovered system, CRISPR–Cas13, uses CRISPR RNA guides to target RNA. Interestingly, RNA targeting by Cas13 results in cleavage of both target RNA and bystander RNA. This feature has ...
DOI:
10.1016/j.copbio.2022.102789

9. Characterization of the variable lymphocyte receptor B genes of a freshwater nonparasitic lamprey species, Lampetra hubbsi

Author:
Kyle L. Rekedal; Khan MA. Hassan; Chris T. Amemiya
Source:
Developmental and comparative immunology 2022 v.126 pp. 104241
ISSN:
0145-305X
Subject:
adaptive immunity,   etc   ; Lampetra; Petromyzon marinus; freshwater; immunoglobulins; leucine; organogenesis; rivers; California;     Show all 9 Subjects
Abstract:
... Agnathans possess a convergent adaptive immune system in comparison to that of jawed vertebrates. In lieu of immunoglobulins, agnathans deploy variable lymphocyte receptors (VLRs), single chain protein effector molecules consisting of leucine rich repeat modules. Foundational work for this discovery utilized the parasitic sea lamprey, Petromyzon marinus. However, for several reasons, it is desirab ...
DOI:
10.1016/j.dci.2021.104241

10. How many post-translationally proteasomal spliced HLA-I peptides can be confidently identified in large scale MS/MS data?

Author:
Markus Müller; Zach Rolfs; Roman Mylonas; Michael R. Shortreed; Loyd M. Smyth; Michal Bassani-Sternberg
Source:
Molecular immunology 2022 v.150 no. pp. -
ISSN:
0161-5890
Subject:
adaptive immunity,   etc   ; HLA antigens; bioinformatics; databases; filtration; hydrophobicity; mass spectrometry; peptides;     Show all 8 Subjects
Abstract:
... Mass spectrometry-based immunopeptidomics is the method of choice for characterizing human leukocyte antigen binding peptides (HLAp) which play a key role in adaptive immunity. Recently two studies [1,2] reported that a large portion (20-40%) of HLAp’s originate from proteasomal splicing events. Both studies used large-scale mass spectrometry measurements of HLAp’s and bioinformatics analysis: the ...
DOI:
10.1016/j.molimm.2022.05.048

11. Reactivity of selected markers of innate and adaptive immunity in rabbits experimentally infected with antigenic variants of RHD (Lagovirus europaeus/GI.1a)

Author:
Paulina Niedźwiedzka-Rystwej; Beata Tokarz-Deptuła; Wiesław Deptuła
Source:
Veterinary research communications 2022 v.46 no.1 pp. 233-242
ISSN:
0165-7380
Subject:
adaptive immunity,   etc   ; Lagovirus; coagulation; hemagglutination; microscopy; phagocytosis; spectroscopy; veterinary medicine; viral hepatitis;     Show all 9 Subjects
Abstract:
... Lagovirus europaeus/GI.1 causes a fatal viral condition in rabbits characterized by acute viral hepatitis and disseminated intravascular coagulation. Due to rapid viral and environmental changes variants (Lagovirus europaeus/GI.1a and GI.2) have appeared and few immunological studies were performed. The aim of the study was to determine innate and adaptive immunity parameters in rabbits infected w ...
DOI:
10.1007/s11259-021-09851-x

12. Attenuated T cell activation and rearrangement of T cell receptor β repertoire in silica nanoparticle-induced pulmonary fibrosis of mice

Author:
Lei Bao; Zihan Geng; Juan Wang; Liyi He; Aijuan Kang; Jianshi Song; Xiaoyan Huang; Yaling Zhang; Qingping Liu; Tao Jiang; Yaxian Pang; Yujie Niu; Rong Zhang
Source:
Environmental research 2022 v.213 pp. 113678
ISSN:
0013-9351
Subject:
adaptive immunity,   etc   ; coculture; genes; immune response; lungs; macrophages; mice; pulmonary fibrosis; research; silica;     Show all 10 Subjects
Abstract:
... Silica nanoparticles (SiNPs) cause pulmonary fibrosis through a complex immune response, but the underlying mechanisms by which SiNPs interact with T cells and affect their functions remain unclear. The T cell receptor (TCR) repertoire is closely related to T cell activation and proliferation and mediates innate and adaptive immunity. High-throughput sequencing of the TCR enables comprehensive mon ...
DOI:
10.1016/j.envres.2022.113678

13. Comparison of Propionibacterium genomes: CRISPR-Cas systems, phage/plasmid diversity, and insertion sequences

Author:
Özge Kahraman-Ilıkkan
Source:
Archives of microbiology 2022 v.204 no.7 pp. 434
ISSN:
0302-8933
Subject:
adaptive immunity,   etc   ; CRISPR-Cas systems; Propionibacterium; bacteriocins; bacteriophages; bioinformatics; phylogeny; plasmids; prokaryotic cells;     Show all 9 Subjects
Abstract:
... The clustered regularly interspaced short palindromic repeats (CRISPR)-Cas systems constitute the adaptive immune system in prokaryotes that provide resistance against invasive genetic elements. The genus Propionibacterium comprises gram-positive, facultative anaerobe, non-spore-forming bacteria, and is the source of some B group vitamins such as B12 as well as bacteriocins. Some of the selected s ...
DOI:
10.1007/s00203-022-03062-x

14. Preoperative Stereotactic Radiosurgery for Glioblastoma

Author:
Eric J. Lehrer; Henry Ruiz-Garcia; Anthony D. Nehlsen; Kunal K. Sindhu; Rachel Sarabia Estrada; Gerben R. Borst; Jason P. Sheehan; Alfredo Quinones-Hinojosa; Daniel M. Trifiletti
Source:
Biology 2022 v.11 no.2 pp. -
ISSN:
2079-7737
Subject:
adaptive immunity,   etc   ; adjuvants; brain neoplasms; central nervous system; glioblastoma; necrosis; prognosis; risk; therapeutics;     Show all 9 Subjects
Abstract:
... Glioblastoma is a devastating primary brain tumor with a median overall survival of approximately 15 months despite the use of optimal modern therapy. While GBM has been studied for decades, modern therapies have allowed for a reduction in treatment-related toxicities, while the prognosis has largely been unchanged. Adjuvant stereotactic radiosurgery (SRS) was previously studied in GBM; however, t ...
DOI:
10.3390/biology11020194

15. APOBEC3, TRIM5α, and BST2 polymorphisms in healthy individuals of various populations with special references to its impact on HIV transmission

Author:
HariOm Singh; Sushama Jadhav; Abdul Arif Khan; Shubham K. Aggarwal; Ranjana Choudhari; Sheetal Verma; Sumit Aggarwal; Vivek Gupta; Amita Singh; Sumitra Nain; Harjeet Singh Maan
Source:
Microbial pathogenesis 2022 v.162 pp. 105326
ISSN:
0882-4010
Subject:
adaptive immunity,   etc   ; cytokines; disease progression; gene expression regulation; genetic polymorphism; humans; inflammation; pathogenesis;     Show all 8 Subjects
Abstract:
... AIDS restriction genes (ARGs) like APOBEC3, TRIM5α, and BST2 can act as immunological detectors of the innate protective mechanism of the body. ARGs influence the course of viral pathogenesis and progression of the disease. The infection caused by different viruses including HIV activates the innate immune receptors leading to production of proinflammatory cytokines, interferons and signals that r ...
DOI:
10.1016/j.micpath.2021.105326

16. Characterisation of dendritic cell frequency and phenotype in bovine afferent lymph reveals kinetic changes in costimulatory molecule expression

Author:
Sara Marzo; Mark Gray; Waywen Loh; Lindsey A. Waddell; C. Irene McGuinnes; Jayne C. Hope; Heather A. Mathie
Source:
Veterinary immunology and immunopathology 2022 v.243 pp. 110363
ISSN:
0165-2427
Subject:
adaptive immunity,   etc   ; T-lymphocytes; cattle; dendritic cells; flow cytometry; immunopathology; lymph; models; phenotype;     Show all 9 Subjects
Abstract:
... The bovine afferent lymphatic cannulation model allows collection of large volumes of afferent lymph and provides an opportunity to study lymphatic cells trafficking from the periphery directly ex-vivo. The technique requires surgical intervention, but influence of the procedure or time post-surgery on cells trafficking in the lymph has not been well documented. Here, we measured the volume of lym ...
DOI:
10.1016/j.vetimm.2021.110363

17. Binding of Orysata lectin induces an immune response in insect cells

Author:
Pengyu Chen; Kristof De Schutter; Jarne Pauwels; Kris Gevaert; Els J. M. Van Damme; Guy Smagghe
Source:
Insect science 2022 v.29 no.3 pp. 717-729
ISSN:
1672-9609
Subject:
adaptive immunity,   etc   ; Atta; Drosophila melanogaster; antimicrobial peptides; encapsulation; immune response; insects; lectins; proteomics; transferrin;     Show all 10 Subjects
Abstract:
... In mammals, plant lectinshave been shown to possess immunomodulatory properties, acting in both the innate and adaptive immune system to modulate the production of mediators of the immune response, ultimately improving host defences. At present, knowledge of immunomodulatory effects of plant lectins in insects is scarce. Treatment of insect cells with the Orysa sativa lectin, Orysata, was previous ...
DOI:
10.1111/1744-7917.12968

18. Genomic and transcriptomic identification of the cathepsin superfamily in the Mediterranean mussel Mytilus galloprovincialis

Author:
Alejandro Romero; Beatriz Novoa; Antonio Figueras
Source:
Developmental and comparative immunology 2022 v.127 pp. 104286
ISSN:
0145-305X
Subject:
adaptive immunity,   etc   ; Mytilus galloprovincialis; Vibrio splendidus; cathepsins; genomics; immune response; larval development; mussels; transcriptomics;     Show all 9 Subjects
Abstract:
... Cathepsins are lysosomal enzymes that participate in important physiological processes, such as development, tissue remodelling, senescence and innate and adaptive immunity. The description of these proteins in molluscs is fragmented and incomplete. In the present work, we identified most of the cathepsin family members in the bivalve Mytilus galloprovincialis by screening published genomic and tr ...
DOI:
10.1016/j.dci.2021.104286

19. Reproducibility of 10x Genomics single cell RNA sequencing method in the immune cell environment

Author:
Gloria Kraus; Marc Weigelt; Susanne Reinhardt; Andreas Petzold; Andreas Dahl; Ezio Bonifacio
Source:
Journal of immunological methods 2022 v.502 pp. 113227
ISSN:
0022-1759
Subject:
adaptive immunity,   etc   ; RNA; T-lymphocytes; cellular microenvironment; gene expression; gene expression regulation; genes; genomics;     Show all 8 Subjects
Abstract:
... 10x Genomics is a highly accessible single cell RNA sequencing platform that allows for simultaneous gene expression analysis and identification of receptor chain combinations in cells of the adaptive immune system. Here, we asked whether the gene and receptor expression measurements in peripheral blood mononuclear cells (PBMC) are influenced by technical, cell freezing, FACS-processing, and day t ...
DOI:
10.1016/j.jim.2022.113227

20. A20 and ABIN-1 cooperate in balancing CBM complex-triggered NF-κB signaling in activated T cells

Author:
Hongli Yin; Ozge Karayel; Ying-Yin Chao; Thomas Seeholzer; Isabel Hamp; Oliver Plettenburg; Torben Gehring; Christina Zielinski; Matthias Mann; Daniel Krappmann
Source:
Cellular and molecular life sciences 2022 v.79 no.2 pp. 112
ISSN:
1420-682X
Subject:
adaptive immunity,   etc   ; T-lymphocytes; homeostasis; humans; mass spectrometry; proteinases; signalosome; ubiquitin; zinc finger motif;     Show all 9 Subjects
Abstract:
... T cell activation initiates protective adaptive immunity, but counterbalancing mechanisms are critical to prevent overshooting responses and to maintain immune homeostasis. The CARD11-BCL10-MALT1 (CBM) complex bridges T cell receptor engagement to NF-κB signaling and MALT1 protease activation. Here, we show that ABIN-1 is modulating the suppressive function of A20 in T cells. Using quantitative ma ...
DOI:
10.1007/s00018-022-04154-z