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1. microRNA-16–5p promotes 3T3-L1 adipocyte differentiation through regulating EPT1

Author:
Xu, Jingjing; Zhang, Liping; Shu, Guobin; Wang, Bin
Source:
Biochemical and biophysical research communications 2019 v.514 no.4 pp. 1251-1256
ISSN:
0006-291X
Subject:
adipogenesis,   etc   ; adipocytes; angiogenesis; apoptosis; cell proliferation; droplets; gene overexpression; genes;     Show all 8 Subjects
Abstract:
... Adipogenesis is an organized process of cellular differentiation by which pre-adipocytes differentiate towards mature adipocytes. miR-16–5p has been reported to be involved in cell proliferation, apoptosis, differentiation and angiogenesis. However little is known about miR-16–5p functional role in 3T3-L1 adipocyte differentiation. In this study, we found that miRNA-16–5p was significantly upregul ...
DOI:
10.1016/j.bbrc.2019.04.179

2. Lipid droplet growth and adipocyte development: mechanistically distinct processes connected by phospholipids Molecular and cell biology of lipids

Author:
Qi, Yanfei; Sun, Lei; Yang, Hongyuan
Source:
Biochimica et biophysica acta 2017 v.1862 no.10 pp. 1273-1283
ISSN:
1388-1981
Subject:
adipogenesis,   etc   ; adipocytes; mammals; phospholipids; proteins;     Show all 5 Subjects
Abstract:
... The differentiation of preadipocytes into mature adipocytes is accompanied by the growth and formation of a giant, unilocular lipid droplet (LD). Mechanistically however, LD growth and adipogenesis are two different processes. Recent studies have uncovered a number of proteins that are able to regulate both LD dynamics and adipogenesis, such as SEIPIN, LIPIN and CDP-Diacylglycerol Synthases. It ap ...
DOI:
10.1016/j.bbalip.2017.06.016

3. Hydrogen sulfide impacts on inflammation-induced adipocyte dysfunction

Author:
Comas, Ferran; Latorre, Jèssica; Cussó, Olaf; Ortega, Francisco; Lluch, Aina; Sabater, Mònica; Castells-Nobau, Anna; Ricart, Wifredo; Ribas, Xavier; Costas, Miquel; Fernández-Real, José Manuel; Moreno-Navarrete, José María
Source:
Food and chemical toxicology 2019 v.131 pp. 110543
ISSN:
0278-6915
Subject:
adipogenesis,   etc   ; adipocytes; culture media; exposure duration; gene expression; genes; hydrogen sulfide; inflammation; insulin; sodium sulfide; toxicology;     Show all 11 Subjects
Abstract:
... A dual role of hydrogen sulfide (H2S) in inflammation is well-reported and recent studies demonstrated adipogenic effects of H2S in 3T3-L1 cells. Here, we aimed to investigate the effects of H2S on adipocyte differentiation and inflammation. H2S concentration in 3T3-L1 culture media was increased during adipocyte differentiation in parallel to adipogenic and Cth gene expression, and its inhibition ...
DOI:
10.1016/j.fct.2019.05.051

4. Wnt3a regulates mitochondrial biogenesis through p38/CREB pathway

Author:
Ning, Xiaomin; He, Jingjing; Shi, Xin’e; Yu, Taiyong; Yang, Gongshe
Source:
Biochemical and biophysical research communications 2019 v.516 no.3 pp. 1019-1025
ISSN:
0006-291X
Subject:
adipogenesis,   etc   ; adipocytes; biogenesis; bone formation; cyclic AMP; genes; mitochondria; mitogen-activated protein kinase;     Show all 8 Subjects
Abstract:
... Wnt3a is established as an important regulator of various developmental processes, especially in osteogenesis, adipogenesis and mitochondrial biogenesis. Numerous studies reported Wnt3a regulates osteogenesis and adipogenesis, but the mechanisms by which Wnt3a regulates mitochondrial biogenesis are not well understood. In this study, results suggested that Wnt3a stimulates mitochondrial biogenesis ...
DOI:
10.1016/j.bbrc.2016.05.004

5. Pharmacological Notch pathway inhibition leads to cell cycle arrest and stimulates ascl1 and neurogenin2 genes expression in dental pulp stem cells-derived neurospheres

Author:
Niapour, Ali; Ghasemi Hamidabadi, Hatef; Niapour, Nazila; Mohammadi, Perham; Sharifi Pasandi, Marzieh; Malekzadeh, Vadoud
Source:
Biotechnology letters 2019 v.41 no.6-7 pp. 873-887
ISSN:
0141-5492
Subject:
adipogenesis,   etc   ; cell cycle checkpoints; genes; humans; lactic acid; neurons; stem cells; tooth pulp;     Show all 8 Subjects
Abstract:
... OBJECTIVE: Human dental pulp-derived stem cells (hDPSCs) are becoming an attractive source for cell-based neurorestorative therapies. As such, it is important to understand the molecular mechanisms that regulate the differentiation of hDPSCs toward the neuronal fate. Notch signaling plays key roles in neural stem/progenitor cells (NS/PCs) maintenance and prevention of their differentiation. The ai ...
DOI:
10.1007/s10529-019-02687-1

6. Spliceostatin A treatment inhibits mitotic clonal expansion and adipogenesis

Author:
Kaida, Daisuke
Source:
Biochemical and biophysical research communications 2019 v.514 no.3 pp. 848-852
ISSN:
0006-291X
Subject:
adipogenesis,   etc   ; adipocytes; cell proliferation; interphase; mesenchymal stromal cells; messenger RNA; mitosis; transcription (genetics);     Show all 8 Subjects
Abstract:
... Adipogenesis is a differentiation process from mesenchymal stem cells to adipocytes. It has been reported that adipogenesis is regulated by a highly orchestrated transcriptional cascade. However, the effects of modulation of mRNA splicing on adipogenesis remain unknown. To investigate these effects, 3T3-L1 preadipocyte were treated with the potent splicing inhibitor spliceostatin A, which revealed ...
DOI:
10.1016/j.bbrc.2019.04.180

7. Determinants of stem cell lineage differentiation toward chondrogenesis versus adipogenesis

Author:
Zhou, Sheng; Chen, Song; Jiang, Qing; Pei, Ming
Source:
Cellular and molecular life sciences 2019 v.76 no.9 pp. 1653-1680
ISSN:
1420-682X
Subject:
adipogenesis,   etc   ; adipose tissue; adult stem cells; bone formation; cartilage; chondrogenesis; signal transduction; transcription (genetics);     Show all 8 Subjects
Abstract:
... Adult stem cells, also termed as somatic stem cells, are undifferentiated cells, detected among differentiated cells in a tissue or an organ. Adult stem cells can differentiate toward lineage specific cell types of the tissue or organ in which they reside. They also have the ability to differentiate into mature cells of mesenchymal tissues, such as cartilage, fat and bone. Despite the fact that th ...
DOI:
10.1007/s00018-019-03017-4

8. A time-resolved proteomic analysis of transcription factors regulating adipogenesis of human adipose derived stem cells

Author:
Li, Sen; Xue, Ting; He, Feng; Liu, Zhuo; Ouyang, Shengrong; Cao, Dingding; Wu, Jianxin
Source:
Biochemical and biophysical research communications 2019 v.511 no.4 pp. 855-861
ISSN:
0006-291X
Subject:
adipogenesis,   etc   ; adipocytes; cell proliferation; chromatin; humans; lipids; obesity; oxygen; proteome; proteomics; stem cells; transcription factors;     Show all 12 Subjects
Abstract:
... Adipogenesis is one of the key processes during obesity development. Better understanding of this process could advance our knowledge on obesity and its treatment. Transcription factors (TFs) are master regulators during adipogenesis, however, a system-wide analysis of TFs dynamic proteome during adipogenesis is lacking. Here, we profiled 472 TFs and systematically elucidated their roles during th ...
DOI:
10.1016/j.bbrc.2019.02.134

9. Exosomal release through TRPML1-mediated lysosomal exocytosis is required for adipogenesis

Author:
Kim, Mi Seong; Muallem, Shmuel; Kim, Sung Hyun; Kwon, Kang Beom; Kim, Min Seuk
Source:
Biochemical and biophysical research communications 2019 v.510 no.3 pp. 409-415
ISSN:
0006-291X
Subject:
adipogenesis,   etc   ; adipocytes; calcium; cell membranes; endosomes; exocytosis; exosomes; genetic markers; lipids; lysosomes; obesity-related diseases;     Show all 11 Subjects
Abstract:
... The lysosomal Ca2+ permeable channel TRPML1 (MCOLN1) plays key roles in lysosomal membrane trafficking, including the fusion of late endosomes to lysosomes and lysosomal exocytosis, both of which are essential for release of exosomes into the extracellular milieu. Multiple lines of evidence indicate that the contents of adipocyte-derived exosomes mediate diverse cellular responses, including adipo ...
DOI:
10.1016/j.bbrc.2019.01.115

10. MiR-199a-3p mediates the adipogenic differentiation of bone marrow-derived mesenchymal stem cells by regulating KDM6A/WNT signaling

Author:
Shuai, Yi; Yang, Rui; Mu, Rui; Yu, Yang; Rong, Liang; Jin, Lei
Source:
Life sciences 2019 v.220 pp. 84-91
ISSN:
0024-3205
Subject:
adipogenesis,   etc   ; adipocytes; bone marrow; mesenchymal stromal cells; microRNA; stem cells; therapeutics;     Show all 7 Subjects
Abstract:
... A number of evidences suggest that microRNAs are involved in the adipogenic commitment of mesenchymal stem cells (MSCs). Recent studies have investigated that miR-199a-3p played a pivotal role in adipocyte differentiation. However, the detailed mechanism in this complex biological process remains largely unknown. In current study, we found that the expression of miR-199a-3p was gradually increased ...
DOI:
10.1016/j.lfs.2019.01.051

11. miR-107 inhibits CDK6 expression, differentiation, and lipid storage in human adipocytes

Author:
Ahonen, Maria A.; Haridas, P.A. Nidhina; Mysore, Raghavendra; Wabitsch, Martin; Fischer-Posovszky, Pamela; Olkkonen, Vesa M.
Source:
Molecular and cellular endocrinology 2019 v.479 pp. 110-116
ISSN:
0303-7207
Subject:
adipogenesis,   etc   ; adipocytes; fatty acids; glucose; glucose tolerance; humans; insulin resistance; obesity; triacylglycerols;     Show all 9 Subjects
Abstract:
... MicroRNA-107 (miR-107) plays a regulatory role in obesity and insulin resistance, but the mechanisms of its function in adipocytes have not been elucidated in detail. Here we show that overexpression of miR-107 in pre- and mature human Simpson-Golabi-Behmel syndrome (SGBS) adipocytes attenuates differentiation and lipid accumulation. Our results suggest that miR-107 controls adipocyte differentiat ...
DOI:
10.1016/j.mce.2018.09.007

12. Bisphenol a: A narrative review of prenatal exposure effects on adipogenesis and childhood obesity via peroxisome proliferator-activated receptor gamma

Author:
Hoepner, Lori A.
Source:
Environmental research 2019 v.173 pp. 54-68
ISSN:
0013-9351
Subject:
adipogenesis,   etc   ; bisphenol A; childhood obesity; cohort studies; maternal exposure; models; peroxisome proliferator-activated receptor gamma; stem cells;     Show all 8 Subjects
Abstract:
... There is significant evidence of globally ubiquitous prenatal exposures to bisphenol A (BPA). Childhood obesity as an epidemic has been a global concern for over a decade. Experimental models and epidemiological evidence suggest that BPA may act as an obesogen during adipogenesis. Results from stem cell models and birth cohort studies support the developmental origins of health and disease theory. ...
DOI:
10.1016/j.envres.2019.03.012

13. Substrate mechanics controls adipogenesis through YAP phosphorylation by dictating cell spreading

Author:
Oliver-De La Cruz, Jorge; Nardone, Giorgia; Vrbsky, Jan; Pompeiano, Antonio; Perestrelo, Ana Rubina; Capradossi, Francesco; Melajová, Katarína; Filipensky, Petr; Forte, Giancarlo
Source:
Biomaterials 2019 v.205 pp. 64-80
ISSN:
0142-9612
Subject:
adipogenesis,   etc   ; bioengineering; bone formation; cytoskeleton; focal adhesions; mechanics; mesenchymal stromal cells; neoplasms; orthopedics; phosphorylation; proteins; surgery; transcription (genetics);     Show all 13 Subjects
Abstract:
... The mechanoregulated proteins YAP/TAZ are involved in the adipogenic/osteogenic switch of mesenchymal stem cells (MSCs).MSC fate decision can be unbalanced by controlling substrate mechanics, in turn altering the transmission of tension through cell cytoskeleton. MSCs have been proposed for orthopedic and reconstructive surgery applications. Thus, a tight control of their adipogenic potential is r ...
DOI:
10.1016/j.biomaterials.2019.03.009

14. Thyroid receptor antagonism as a contributory mechanism for adipogenesis induced by environmental mixtures in 3T3-L1 cells

Author:
Kassotis, Christopher D.; Kollitz, Erin M.; Hoffman, Kate; Sosa, Julie Ann; Stapleton, Heather M.
Source:
The Science of the total environment 2019 v.666 pp. 431-444
ISSN:
0048-9697
Subject:
adipogenesis,   etc   ; agonists; antagonism; biomarkers; blood serum; body mass index; dust; flame retardants; health information; small interfering RNA; thyrotropin; triacylglycerols; triiodothyronine;     Show all 13 Subjects
Abstract:
... We previously demonstrated that indoor house dust extracts could induce adipogenesis in pre-adipocytes, suggesting a potential role for indoor contaminant mixtures in metabolic health. Herein, we investigated the potential role of thyroid receptor beta (TRβ) antagonism in adipogenic effects (dust-induced triglyceride accumulation and pre-adipocyte proliferation) following exposure to environmental ...
DOI:
10.1016/j.scitotenv.2019.02.273

15. Estradiol stimulates adipogenesis and Slc2a4/GLUT4 expression via ESR1-mediated activation of CEBPA

Author:
Fatima, Luciana A.; Campello, Raquel S.; Barreto-Andrade, João N.; Passarelli, Marisa; Santos, Roberta S.; Clegg, Deborah J.; Machado, Ubiratan F.
Source:
Molecular and cellular endocrinology 2019 pp. 110447
ISSN:
0303-7207
Subject:
adipogenesis,   etc   ; adipocytes; adipose tissue; cell membranes; estradiol; estrogen receptors; gene expression; genes; glucose; glucose transporters; glycemic control; lipids; messenger RNA;     Show all 13 Subjects
Abstract:
... The ability of adipose tissue to expand is dependent on adipocyte differentiation and adipose tissue glucose disposal. The CCAAT/enhancer-binding protein alpha (CEBPA) enhances the expression of the Slc2a4 gene and GLUT4 protein, which are markers of adipocyte differentiation/glucose disposal. We hypothesized estradiol (E2) facilitates adipocyte differentiation/glucose disposal by an estrogen rece ...
DOI:
10.1016/j.mce.2019.05.006

16. Long non-coding RNA lnc-OAD is required for adipocyte differentiation in 3T3-L1 preadipocytes

Author:
Wang, Zonggui; Luo, Zhicong; Dai, Zhong; Zhong, Yanting; Liu, Xinguang; Zuo, Changqing
Source:
Biochemical and biophysical research communications 2019 v.511 no.4 pp. 753-758
ISSN:
0006-291X
Subject:
adipogenesis,   etc   ; adipocytes; genes; mitosis; non-coding RNA; osteoblasts; peroxisome proliferator-activated receptors; protein synthesis; signal transduction; transcription (genetics);     Show all 10 Subjects
Abstract:
... Long non-coding RNAs (lncRNAs) have gained extensive attentions due to their significant roles in diverse biological process. However, the potential functions of lncRNAs participation in adipocyte differentiation have not been fully explored. Here we identified a long non-coding RNA called lnc-OAD (lncRNA associated with osteoblast and adipocyte differentiation, transcribed from 1700018A04Rik gene ...
DOI:
10.1016/j.bbrc.2019.02.133

17. Linifanib exerts dual anti-obesity effect by regulating adipocyte browning and formation

Author:
Zhao, Shiting; Chu, Yi; Zhang, Yuwei; Zhou, Yulai; Jiang, Zhiwu; Wang, Zhengqi; Mao, Liufeng; Li, Kuai; Sun, Wei; Li, Peng; Jia, Shiqi; Wang, Cunchuan; Xu, Aimin; Loomes, Kerry; Tang, Shibing; Wu, Donghai; Hui, Xiaoyan; Nie, Tao
Source:
Life sciences 2019 v.222 pp. 117-124
ISSN:
0024-3205
Subject:
adipogenesis,   etc   ; adipocytes; animal models; chemical compounds; drugs; energy expenditure; enzymes; hyperplasia; hypertrophy; mitosis; obesity; phosphorylation; screening; signal transduction;     Show all 14 Subjects
Abstract:
... Obesity is caused by energy imbalance and accompanied by adipocyte hypertrophy and hyperplasia. Therefore, both enhancement of adipocyte energy expenditure and inhibition of adipogenesis are viable ways to combat obesity. Using the Ucp1-2A-luciferase reporter animal model previously reported by us as a screening platform, a chemical compound Linifanib was identified as a potent inducer of UCP1 exp ...
DOI:
10.1016/j.lfs.2019.01.047

18. The role of phoenixin in behavior and food intake

Author:
Schalla, Martha A.; Stengel, Andreas
Source:
Peptides 2019 v.114 pp. 38-43
ISSN:
0196-9781
Subject:
adipogenesis,   etc   ; anxiety; cognition; databases; food intake; gonadotropin-releasing hormone; luteinizing hormone; pruritus; secretion; sensation; systematic review; vasopressin;     Show all 12 Subjects
Abstract:
... The recently discovered peptide phoenixin was initially implicated in reproduction as a regulator of gonadotropin-releasing hormone (GnRH)-stimulated luteinizing hormone (LH) release from the pituitary. Subsequently, various functions of phoenixin have been demonstrated including mediation of itching sensation, stimulation of vasopressin secretion, stimulation of white adipogenesis and hypothalami ...
DOI:
10.1016/j.peptides.2019.04.002

19. miR-10b-5p regulates 3T3-L1 cells differentiation by targeting Apol6

Author:
Tan, Ya; Gan, Mailin; Fan, Yuan; Li, Liang; Zhong, Zhijun; Li, Xuewei; Bai, Lin; Zhao, Ye; Niu, Lili; Shang, Yishun; Zhang, Shunhua; Zhu, Li
Source:
Gene 2019 v.687 pp. 39-46
ISSN:
0378-1119
Subject:
adipogenesis,   etc   ; adipocytes; adipose tissue; cell proliferation; gene expression regulation; humans; mice; microRNA; neoplasms; non-coding RNA; obesity; oncogenes; rats; therapeutics;     Show all 14 Subjects
Abstract:
... MicroRNAs (miRNAs) are small, non-coding RNAs that have been proposed to control or fine-tune complex genetic pathways by post-transcriptional regulation of target genes. It was proved that numerous miRNAs have influence on the biology of adipocytes as well as on the function of adipose tissues. This study shows that miR-10b-5p expression was decreased in mice, rats, and human under obesity. In ad ...
DOI:
10.1016/j.gene.2018.11.028

20. The Gata2 repression during 3T3-L1 preadipocyte differentiation is dependent on a rapid decrease in histone acetylation in response to glucocorticoid receptor activation

Author:
Ishijima, Yasushi; Ohmori, Shin'ya; Uneme, Ai; Aoki, Yusuke; Kobori, Miki; Ohida, Terutoshi; Arai, Momoko; Hosaka, Misa; Ohneda, Kinuko
Source:
Molecular and cellular endocrinology 2019 v.483 pp. 39-49
ISSN:
0303-7207
Subject:
adipogenesis,   etc   ; GATA transcription factors; acetylation; adipocytes; enzyme inhibition; gene expression regulation; genes; glucocorticoid receptors; histone deacetylase; histones; loci;     Show all 11 Subjects
Abstract:
... The transcription factor GATA2 is an anti-adipogenic factor whose expression is downregulated during adipocyte differentiation. The present study attempted to clarify the molecular mechanism underlying the GATA2 repression and found that the repression is dependent on the activation of the glucocorticoid receptor (GR) during 3T3-L1 preadipocyte differentiation. Although several recognition sequenc ...
DOI:
10.1016/j.mce.2019.01.002