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1. The galloyl moiety enhances inhibitory activity of polyphenols against adipogenic differentiation in 3T3-L1 preadipocytes

Author:
Jinming Peng; Wenjun Wen; Ruifeng Wang; Kaikai Li; Gengsheng Xiao; Chunmei Li
Source:
Food & function 2022 v.13 no.9 pp. 5275-5286
ISSN:
2042-650X
Subject:
adipogenesis,   etc   ; adipocytes; moieties; polyphenols;     Show all 4 Subjects
Abstract:
... Previous studies have proved that the characteristic galloyl moiety in polyphenols is crucial for their biological activities. However, whether the presence of the galloyl moiety in the structure of polyphenols has a great contribution to their inhibition of adipogenic differentiation is not clear. Therefore, in this study, seven polyphenols with different galloylation degrees were chosen for expl ...
DOI:
10.1039/d1fo04179g

2. MiR-144 regulates adipogenesis by mediating formation of C/EBPα-FOXO1 protein complex

Author:
Weimin Lin; Xianyu Wen; Xuexin Li; Lei Chen; Wei Wei; Lifan Zhang; Jie Chen
Source:
Biochemical and biophysical research communications 2022 v.612 pp. 126-133
ISSN:
0006-291X
Subject:
adipogenesis,   etc   ; microRNA; research; transcription (genetics);     Show all 4 Subjects
Abstract:
... CeRNA effect was an important regulation mode of miRNA mediated bio-activities, however, most of the researches of ceRNA were on ncRNAs synergetic with mRNAs, the exploration of ceRNA effect regulated mRNA interaction was still lack of. Besides, C/EBPα was one of the most crucial adipogenic regulators, which has been demonstrated to form a protein complex with FOXO1 to mediate AdipoQ expression. S ...
DOI:
10.1016/j.bbrc.2022.04.093

3. Characterization of a Read-through Fusion Transcript, BCL2L2-PABPN1, Involved in Porcine Adipogenesis

Author:
Jiyuan Zhu; Zewei Yang; Wanjun Hao; Jiaxin Li; Liang Wang; Jiqiao Xia; Dongjie Zhang; Di Liu; Xiuqin Yang
Source:
Genes 2022 v.13 no.3 pp. -
ISSN:
2073-4425
Subject:
adipogenesis,   etc   ; humans; microRNA; obesity; sequence analysis; swine;     Show all 6 Subjects
Abstract:
... cis-Splicing of adjacent genes (cis-SAGe) has been involved in multiple physiological and pathological processes in humans. However, to the best of our knowledge, there is no report of cis-SAGe in adipogenic regulation. In this study, a cis-SAGe product, BCL2L2–PABPN1 (BP), was characterized in fat tissue of pigs with RT-PCR and RACE method. BP is an in-frame fusion product composed of 333 aa and ...
DOI:
10.3390/genes13030445

4. Construction of miRNA-mRNA network in the differentiation of chicken preadipocytes

Author:
T. Zhang; L. Chen; H. Ding; P. Wu; G. Zhang; Z. Pan; K. Xie; G. Dai; J. Wang
Source:
British poultry science 2022 v.63 no.3 pp. 298-306
ISSN:
1466-1799
Subject:
adipogenesis,   etc   ; chickens; gene expression; lipid metabolism; microRNA;     Show all 5 Subjects
Abstract:
... 1. MicroRNAs (miRNAs) play key roles in regulating lipid metabolism, adipogenesis and fat deposition in chicken. To date, there are only a few miRNAs that have been confirmed to be involved in chicken adipogenesis. The detailed mechanisms by which miRNAs regulate chicken adipogenesis remain largely unknown. 2. To identify candidate miRNAs involved in chicken preadipocyte differentiation and explor ...
DOI:
10.1080/00071668.2021.2000585

5. Ajuba functions as a co-activator of C/EBPβ to induce expression of PPARγ and C/EBPα during adipogenesis

Author:
Han Yan; Qi Li; Mengying Li; Xiuqun Zou; Ningning Bai; Zichao Yu; Jie Zhang; Dan Zhang; Qun Zhang; Jiamin Wang; Hao Jia; Yingjie Wu; Zhaoyuan Hou
Source:
Molecular and cellular endocrinology 2022 v.539 pp. 111485
ISSN:
0303-7207
Subject:
adipogenesis,   etc   ; acetylation; adipocytes; endocrinology; histones; lipids; phenotype; therapeutics;     Show all 8 Subjects
Abstract:
... Adipogenesis is regulated by a complicated network of transcription factors among which PPARγ and C/EBP family members are the major regulators. During adipogenesis, C/EBPβ is induced early and then transactivates PPARγ and C/EBPα, which cooperatively induce genes whose expressions give rise to the mature adipocyte phenotype. Identifying the factors that influence the expression and activity of C/ ...
DOI:
10.1016/j.mce.2021.111485

6. The curious case of TMEM120A: Mechanosensor, fat regulator, or antiviral defender?

Author:
Nianchao Qian; Shuo Li; Xu Tan
Source:
BioEssays 2022 v.44 no.6 pp. e2200045
ISSN:
0265-9247
Subject:
adipogenesis,   etc   ; adipocytes; fatty acid metabolism; genome; innate immunity; pain; transmembrane proteins;     Show all 7 Subjects
Abstract:
... Mechanical pain sensing, adipogenesis, and STING‐dependent innate immunity seem three distinct biological processes without substantial relationships. Intriguingly, TMEM120A, a transmembrane protein, has been shown to detect mechanical pain stimuli as a mechanosensitive channel, contribute to adipocyte differentiation/function by regulating genome organization and promote STING trafficking to acti ...
DOI:
10.1002/bies.202200045

7. Tamarixetin Abrogates Adipogenesis Through Inhibiting p300/CBP-Associated Factor Acetyltransferase Activity in 3T3-L1 Preadipocyte Cells

Author:
Hyo-Jin Kim; Jangho Lee; Min-Yu Chung; Soo Hyun Park; Jae Ho Park; Hyo-Kyoung Choi; Jin-Taek Hwang
Source:
Journal of medicinal food 2022 v.25 no.3 pp. 272-280
ISSN:
1557-7600
Subject:
adipogenesis,   etc   ; acetylation; adipocytes; functional foods; gene expression; histone acetyltransferase; histones; lipids; quercetin;     Show all 9 Subjects
Abstract:
... Tamarixetin (TX) is an O-methylated flavonoid naturally derived from quercetin. TX has bioactive properties; however, whether it shows antilipogenic activity remains unknown. Therefore, in the present study, we aimed to determine the antilipogenic effects of TX using 3T3-L1 adipocytes. The 3T3-L1 adipocytes were cultured in a differentiation medium with or without TX. Lipid accumulation was dimini ...
DOI:
10.1089/jmf.2021.K.0126

8. Drosophila Keap1 xenobiotic response factor regulates developmental transcription through binding to chromatin

Author:
Jennifer Carlson; Lindsey Price; Isabel Cook; Huai Deng
Source:
Developmental biology 2022 v.481 pp. 139-147
ISSN:
0012-1606
Subject:
adipogenesis,   etc   ; Drosophila; adipose tissue; adults; chromatin; death; humans; models; mutants; transcription (genetics); xenobiotics;     Show all 11 Subjects
Abstract:
... The Keap1-Nrf2 complex is a central regulator that mediates transcriptional responses to xenobiotic stimuli and is highly related with multiple human diseases. The molecular mechanisms and biological functions of Keap1 and Nrf2 are not fully understood. The Drosophila Keap1 homolog (dKeap1) is conserved with mammalian Keap1 except that dKeap1 contains a 156 aa C-terminal tail (CTD). A dKeap1 trunc ...
DOI:
10.1016/j.ydbio.2021.10.003

9. Vitamin D and Visceral Obesity in Humans: What Should Clinicians Know?

Author:
Prapimporn Chattranukulchai Shantavasinkul; Hataikarn Nimitphong
Source:
Nutrients 2022 v.14 no.15 pp. -
ISSN:
2072-6643
Subject:
adipogenesis,   etc   ; adipocytes; adipokines; adipose tissue; energy metabolism; humans; obesity; vitamin D; weight loss;     Show all 9 Subjects
Abstract:
... The extraskeletal effect of vitamin D on adipose tissue biology and modulation in human obesity is of great interest and has been extensively investigated. Current evidence from preclinical and clinical studies in human adipose tissue suggests that the anti-inflammatory effects of vitamin D are evident and consistent, whereas the effects of vitamin D on adipocyte differentiation, adipogenesis, and ...
DOI:
10.3390/nu14153075

10. Genome-wide survey and functional analysis reveal TCF21 promotes chicken preadipocyte differentiation by directly upregulating HTR2A

Author:
Xinyang Zhang; Bohan Cheng; Yanyan Ma; Yumeng Liu; Ning Wang; Hui Zhang; Yumao Li; Yuxiang Wang; Peng Luan; Zhiping Cao; Hui Li
Source:
Biochemical and biophysical research communications 2022 v.587 pp. 131-138
ISSN:
0006-291X
Subject:
adipogenesis,   etc   ; adipose tissue; luciferase; oils; research; sequence analysis; serotonin receptors; surveys; transcription factors;     Show all 9 Subjects
Abstract:
... Previously, we showed that transcription factor 21 (TCF21) promotes chicken preadipocyte differentiation. However, the genome-wide TCF21 binding sites and its downstream target genes in chicken adipogenesis were unknown. ChIP-Seq and RNA-Seq were used to screen candidate targets of TCF21. qPCR and luciferase reporter assay were applied to verify the sequencing results. Western blotting, oil red-O ...
DOI:
10.1016/j.bbrc.2021.11.103

11. Recent insights into vitamin D, adipocyte, and adipose tissue biology

Author:
Imene Bennour; Nicole Haroun; Flavie Sicard; Lourdes Mounien; Jean‐François Landrier
Source:
Obesity reviews 2022 v.23 no.8 pp. e13453
ISSN:
1467-7881
Subject:
adipogenesis,   etc   ; adipocytes; adipose tissue; adulthood; bioactive properties; energy metabolism; inflammation; metabolites; obesity; progeny;     Show all 10 Subjects
Abstract:
... Several studies bring strong evidence for an active role of vitamin D and its metabolites in physiological adipocyte and adipose tissue processes in adulthood. This role includes effects of vitamin D on key adipose tissue and adipocyte biology parameters, including adipogenesis, energy metabolism, and inflammation. Interestingly, recent data also point to a role of maternal vitamin D deficiency in ...
DOI:
10.1111/obr.13453

12. Comparative Effects of Sulforaphane and Allyl Isothiocyanate on 3T3-L1 Adipogenesis

Author:
Satoru Sakuma; Kana Yasuda; Risa Kitahara; Kaho Tsujimoto; Kishiko Yamashita; Naohiro Hoshino; Yohko Fujimoto; Keiichiro Okuhira
Source:
Journal of nutrition and metabolism 2022 v.2022 pp. -
ISSN:
2090-0732
Subject:
adipogenesis,   etc   ; adipocytes; allyl isothiocyanate; dexamethasone; insulin; mechanism of action; metabolism; nutrition; obesity; sulforaphane; triacylglycerols;     Show all 11 Subjects
Abstract:
... Sulforaphane and allyl isothiocyanate, naturally occurring isothiocyanates, have been reported to inhibit adipocyte differentiation, but little is known about how they compare in terms of their potency and mechanism of action. In the present study, we compared the effects of sulforaphane and allyl isothiocyanate on the differentiation of 3T3-L1 preadipocytes. A mixture of insulin, dexamethasone, a ...
DOI:
10.1155/2022/8705163

13. Suppression of Adipogenesis and Fat Accumulation by Vitexin Through Activation of Hedgehog Signaling in 3T3-L1 Adipocytes

Author:
Shuai Qiu; Jing Chen; Jin Tae Kim; Yimeng Zhou; Ji Hyun Moon; Seung Beom Lee; Ho Jin Park; Hong Jin Lee
Source:
Journal of medicinal food 2022 v.25 no.3 pp. 313-323
ISSN:
1557-7600
Subject:
adipogenesis,   etc   ; AMP-activated protein kinase; Erinaceidae; adipocytes; functional foods; lipids; obesity; phosphorylation; transcription (genetics);     Show all 9 Subjects
Abstract:
... Many studies have demonstrated that adipogenesis is associated with obesity, and the Hedgehog (Hh) signaling pathway regulates adipogenesis and obesity. Following the screening study of the chemical library evaluating the effect of vitexin on Gli1 transcriptional activity, vitexin was chosen as a candidate for antiadipogenic efficacy. Vitexin significantly reduced lipid accumulation and suppressed ...
DOI:
10.1089/jmf.2021.K.0163

14. Relationship of matrix stiffness and cell morphology in regulation of osteogenesis and adipogenesis of BMSCs

Author:
Yutong Guo; Yini Qiao; Shuqi Quan; Cai Yang; Juan Li
Source:
Molecular biology reports 2022 v.49 no.4 pp. 2677-2685
ISSN:
0301-4851
Subject:
adipogenesis,   etc   ; actin; bone formation; bone marrow; cytoskeleton; fibronectins; fluorescent antibody technique; molecular biology; tissue culture;     Show all 9 Subjects
Abstract:
... BACKGROUNDS: Matrix stiffness has been found to regulate cell morphology, while both cell morphology and matrix stiffness are verified as important factors directing BMSCs (bone marrow mesenchymal stem cells) differentiation. This study aimed to investigate whether matrix stiffness depended on cell morphology to regulate osteogenesis and adipogenesis of BMSCs on 2D substrates. METHODS AND RESULTS: ...
DOI:
10.1007/s11033-021-07075-5

15. C/EBPα promotes porcine pre-adipocyte proliferation and differentiation via mediating MSTRG.12568.2/FOXO3 trans-activation for STYX

Author:
Weimin Lin; Lei Chen; Wenjing Meng; Kai Yang; Shengjuan Wei; Wei Wei; Jie Chen; Lifan Zhang
Source:
Biochimica et biophysica acta 2022 v.1867 no.10 pp. 159206
ISSN:
1388-1981
Subject:
adipogenesis,   etc   ; cell proliferation; genes; non-coding RNA; sequence analysis; serine; swine; threonine; transcriptional activation; tyrosine;     Show all 10 Subjects
Abstract:
... As a key adipogenic marker, C/EBPα (CCAAT/enhancer binding protein α) is also an important factor in regulating targets containing CCAAT element for transcription, whose products include coding and non-coding RNAs (ncRNAs). However, knowledge of the mechanism of C/EBPα affecting pre-adipocyte proliferation and adipogenesis through regulating ncRNA is still limited. In this study, we firstly conduc ...
DOI:
10.1016/j.bbalip.2022.159206

16. Genetic and pharmacologic suppression of PPARγ enhances NELL-1-stimulated bone regeneration

Author:
Justine Tanjaya; Pin Ha; Yulong Zhang; Chenchao Wang; Yash Shah; Emily Berthiaume; Hsin Chuan Pan; Jiayu Shi; Jinny Kwak; Benjamin Wu; Kang Ting; Xinli Zhang; Chia Soo
Source:
Biomaterials 2022 v.287 pp. 121609
ISSN:
0142-9612
Subject:
adipogenesis,   etc   ; adiposity; antagonists; apoptosis; biocompatible materials; bone density; bone formation; bone resorption; mice; osteoporosis; therapeutics;     Show all 11 Subjects
Abstract:
... Recent investigations into mechanisms behind the development of osteoporosis suggest that suppressing PPARγ-mediated adipogenesis can improve bone formation and bone mineral density. In this study, we investigated a co-treatment strategy to enhance bone formation by combining NELL-1, an osteogenic molecule that has been extensively studied for its potential use as a therapeutic for osteoporosis, w ...
DOI:
10.1016/j.biomaterials.2022.121609

17. MiR-218-5p Affects Subcutaneous Adipogenesis by Targeting ACSL1, a Novel Candidate for Pig Fat Deposition

Author:
Baosen Shan; Mengting Yan; Kai Yang; Weimin Lin; Jiayu Yan; Shengjuan Wei; Wei Wei; Jie Chen; Lifan Zhang
Source:
Genes 2022 v.13 no.2 pp. -
ISSN:
2073-4425
Subject:
adipogenesis,   etc   ; fatty acids; homeostasis; long-chain-fatty-acid-CoA ligase; luciferase; subcutaneous fat; swine; triacylglycerols;     Show all 8 Subjects
Abstract:
... As a centre enzyme in fatty acid activation, acyl-CoA synthetase long-chain family member 1 (ACSL1) plays an important role in body lipid homeostasis. However, the functions of ACSL1 in the subcutaneous adipogenesis of pigs are largely unknown. In the present study, we found that the expression of ACSL1 significantly increased during the process of porcine preadipocyte differentiation. Moreover, s ...
DOI:
10.3390/genes13020260

18. Perspectives on scaling production of adipose tissue for food applications

Author:
John S.K. Yuen Jr; Andrew J. Stout; N. Stephanie Kawecki; Sophia M. Letcher; Sophia K. Theodossiou; Julian M. Cohen; Brigid M. Barrick; Michael K. Saad; Natalie R. Rubio; Jaymie A. Pietropinto; Hailey DiCindio; Sabrina W. Zhang; Amy C. Rowat; David L. Kaplan
Source:
Biomaterials 2022 v.280 pp. 121273
ISSN:
0142-9612
Subject:
adipogenesis,   etc   ; adipocytes; adipose tissue; animals; biocompatible materials; cell proliferation; environmental impact; flavor; meat; meat production;     Show all 10 Subjects
Abstract:
... With rising global demand for food proteins and significant environmental impact associated with conventional animal agriculture, it is important to develop sustainable alternatives to supplement existing meat production. Since fat is an important contributor to meat flavor, recapitulating this component in meat alternatives such as plant based and cell cultured meats is important. Here, we discus ...
DOI:
10.1016/j.biomaterials.2021.121273

19. Transcriptional regulation of adipogenic marker genes for the improvement of intramuscular fat in Qinchuan beef cattle

Author:
Guo Hongfang; Rajwali Khan; Sayed Haidar Abbas Raza; Kaster Nurgulsim; Syed Muhammad Suhail; Abdur Rahman; Ijaz Ahmed; Asim Ijaz; Iftikhar Ahmad; Zan Linsen
Source:
Animal biotechnology 2022 v.33 no.4 pp. 776-795
ISSN:
1532-2378
Subject:
adipogenesis,   etc   ; beef cattle; biochemical pathways; biotechnology; intramuscular fat; meat production; meat quality; synergism; transcription (genetics);     Show all 9 Subjects
Abstract:
... The intramuscular fat content plays a crucial role in meat quality traits. Increasing the degree of adipogenesis in beef cattle leads to an increase in the content of intramuscular fat. Adipogenesis a complex biochemical process which is under firm genetic control. Over the last three decades, the Qinchuan beef cattle have been extensively studied for the improvement of meat production and quality ...
DOI:
10.1080/10495398.2020.1837847

20. The Combined Partial Knockdown of CBS and MPST Genes Induces Inflammation, Impairs Adipocyte Function-Related Gene Expression and Disrupts Protein Persulfidation in Human Adipocytes

Author:
Jessica Latorre; Angeles Aroca; José Manuel Fernández-Real; Luis C. Romero; José María Moreno-Navarrete
Source:
Antioxidants 2022 v.11 no.6 pp. -
ISSN:
2076-3921
Subject:
adipogenesis,   etc   ; adipocytes; adipose tissue; biogenesis; gene expression; gene targeting; humans; inflammation; lipogenesis; mass spectrometry; mitochondria; proteomics;     Show all 12 Subjects
Abstract:
... Recent studies in mice and humans demonstrated the relevance of H₂S synthesising enzymes, such as CTH, CBS, and MPST, in the physiology of adipose tissue and the differentiation of preadipocyte into adipocytes. Here, our objective was to investigate the combined role of CTH, CBS, and MPST in the preservation of adipocyte protein persulfidation and adipogenesis. Combined partial CTH, CBS, and MPST ...
DOI:
10.3390/antiox11061095