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... Previous studies have proved that the characteristic galloyl moiety in polyphenols is crucial for their biological activities. However, whether the presence of the galloyl moiety in the structure of polyphenols has a great contribution to their inhibition of adipogenic differentiation is not clear. Therefore, in this study, seven polyphenols with different galloylation degrees were chosen for expl ...
adipogenesis, etc ; microRNA; research; transcription (genetics); Show all 4 Subjects
Abstract:
... CeRNA effect was an important regulation mode of miRNA mediated bio-activities, however, most of the researches of ceRNA were on ncRNAs synergetic with mRNAs, the exploration of ceRNA effect regulated mRNA interaction was still lack of. Besides, C/EBPα was one of the most crucial adipogenic regulators, which has been demonstrated to form a protein complex with FOXO1 to mediate AdipoQ expression. S ...
adipogenesis, etc ; humans; microRNA; obesity; sequence analysis; swine; Show all 6 Subjects
Abstract:
... cis-Splicing of adjacent genes (cis-SAGe) has been involved in multiple physiological and pathological processes in humans. However, to the best of our knowledge, there is no report of cis-SAGe in adipogenic regulation. In this study, a cis-SAGe product, BCL2L2–PABPN1 (BP), was characterized in fat tissue of pigs with RT-PCR and RACE method. BP is an in-frame fusion product composed of 333 aa and ...
adipogenesis, etc ; chickens; gene expression; lipid metabolism; microRNA; Show all 5 Subjects
Abstract:
... 1. MicroRNAs (miRNAs) play key roles in regulating lipid metabolism, adipogenesis and fat deposition in chicken. To date, there are only a few miRNAs that have been confirmed to be involved in chicken adipogenesis. The detailed mechanisms by which miRNAs regulate chicken adipogenesis remain largely unknown. 2. To identify candidate miRNAs involved in chicken preadipocyte differentiation and explor ...
adipogenesis, etc ; acetylation; adipocytes; endocrinology; histones; lipids; phenotype; therapeutics; Show all 8 Subjects
Abstract:
... Adipogenesis is regulated by a complicated network of transcription factors among which PPARγ and C/EBP family members are the major regulators. During adipogenesis, C/EBPβ is induced early and then transactivates PPARγ and C/EBPα, which cooperatively induce genes whose expressions give rise to the mature adipocyte phenotype. Identifying the factors that influence the expression and activity of C/ ...
adipogenesis, etc ; adipocytes; fatty acid metabolism; genome; innate immunity; pain; transmembrane proteins; Show all 7 Subjects
Abstract:
... Mechanical pain sensing, adipogenesis, and STING‐dependent innate immunity seem three distinct biological processes without substantial relationships. Intriguingly, TMEM120A, a transmembrane protein, has been shown to detect mechanical pain stimuli as a mechanosensitive channel, contribute to adipocyte differentiation/function by regulating genome organization and promote STING trafficking to acti ...
adipogenesis, etc ; acetylation; adipocytes; functional foods; gene expression; histone acetyltransferase; histones; lipids; quercetin; Show all 9 Subjects
Abstract:
... Tamarixetin (TX) is an O-methylated flavonoid naturally derived from quercetin. TX has bioactive properties; however, whether it shows antilipogenic activity remains unknown. Therefore, in the present study, we aimed to determine the antilipogenic effects of TX using 3T3-L1 adipocytes. The 3T3-L1 adipocytes were cultured in a differentiation medium with or without TX. Lipid accumulation was dimini ...
adipogenesis, etc ; Drosophila; adipose tissue; adults; chromatin; death; humans; models; mutants; transcription (genetics); xenobiotics; Show all 11 Subjects
Abstract:
... The Keap1-Nrf2 complex is a central regulator that mediates transcriptional responses to xenobiotic stimuli and is highly related with multiple human diseases. The molecular mechanisms and biological functions of Keap1 and Nrf2 are not fully understood. The Drosophila Keap1 homolog (dKeap1) is conserved with mammalian Keap1 except that dKeap1 contains a 156 aa C-terminal tail (CTD). A dKeap1 trunc ...
adipogenesis, etc ; adipocytes; adipokines; adipose tissue; energy metabolism; humans; obesity; vitamin D; weight loss; Show all 9 Subjects
Abstract:
... The extraskeletal effect of vitamin D on adipose tissue biology and modulation in human obesity is of great interest and has been extensively investigated. Current evidence from preclinical and clinical studies in human adipose tissue suggests that the anti-inflammatory effects of vitamin D are evident and consistent, whereas the effects of vitamin D on adipocyte differentiation, adipogenesis, and ...
adipogenesis, etc ; adipose tissue; luciferase; oils; research; sequence analysis; serotonin receptors; surveys; transcription factors; Show all 9 Subjects
Abstract:
... Previously, we showed that transcription factor 21 (TCF21) promotes chicken preadipocyte differentiation. However, the genome-wide TCF21 binding sites and its downstream target genes in chicken adipogenesis were unknown. ChIP-Seq and RNA-Seq were used to screen candidate targets of TCF21. qPCR and luciferase reporter assay were applied to verify the sequencing results. Western blotting, oil red-O ...
adipogenesis, etc ; adipocytes; adipose tissue; adulthood; bioactive properties; energy metabolism; inflammation; metabolites; obesity; progeny; Show all 10 Subjects
Abstract:
... Several studies bring strong evidence for an active role of vitamin D and its metabolites in physiological adipocyte and adipose tissue processes in adulthood. This role includes effects of vitamin D on key adipose tissue and adipocyte biology parameters, including adipogenesis, energy metabolism, and inflammation. Interestingly, recent data also point to a role of maternal vitamin D deficiency in ...
adipogenesis, etc ; adipocytes; allyl isothiocyanate; dexamethasone; insulin; mechanism of action; metabolism; nutrition; obesity; sulforaphane; triacylglycerols; Show all 11 Subjects
Abstract:
... Sulforaphane and allyl isothiocyanate, naturally occurring isothiocyanates, have been reported to inhibit adipocyte differentiation, but little is known about how they compare in terms of their potency and mechanism of action. In the present study, we compared the effects of sulforaphane and allyl isothiocyanate on the differentiation of 3T3-L1 preadipocytes. A mixture of insulin, dexamethasone, a ...
adipogenesis, etc ; AMP-activated protein kinase; Erinaceidae; adipocytes; functional foods; lipids; obesity; phosphorylation; transcription (genetics); Show all 9 Subjects
Abstract:
... Many studies have demonstrated that adipogenesis is associated with obesity, and the Hedgehog (Hh) signaling pathway regulates adipogenesis and obesity. Following the screening study of the chemical library evaluating the effect of vitexin on Gli1 transcriptional activity, vitexin was chosen as a candidate for antiadipogenic efficacy. Vitexin significantly reduced lipid accumulation and suppressed ...
adipogenesis, etc ; actin; bone formation; bone marrow; cytoskeleton; fibronectins; fluorescent antibody technique; molecular biology; tissue culture; Show all 9 Subjects
Abstract:
... BACKGROUNDS: Matrix stiffness has been found to regulate cell morphology, while both cell morphology and matrix stiffness are verified as important factors directing BMSCs (bone marrow mesenchymal stem cells) differentiation. This study aimed to investigate whether matrix stiffness depended on cell morphology to regulate osteogenesis and adipogenesis of BMSCs on 2D substrates. METHODS AND RESULTS: ...
adipogenesis, etc ; cell proliferation; genes; non-coding RNA; sequence analysis; serine; swine; threonine; transcriptional activation; tyrosine; Show all 10 Subjects
Abstract:
... As a key adipogenic marker, C/EBPα (CCAAT/enhancer binding protein α) is also an important factor in regulating targets containing CCAAT element for transcription, whose products include coding and non-coding RNAs (ncRNAs). However, knowledge of the mechanism of C/EBPα affecting pre-adipocyte proliferation and adipogenesis through regulating ncRNA is still limited. In this study, we firstly conduc ...
adipogenesis, etc ; adiposity; antagonists; apoptosis; biocompatible materials; bone density; bone formation; bone resorption; mice; osteoporosis; therapeutics; Show all 11 Subjects
Abstract:
... Recent investigations into mechanisms behind the development of osteoporosis suggest that suppressing PPARγ-mediated adipogenesis can improve bone formation and bone mineral density. In this study, we investigated a co-treatment strategy to enhance bone formation by combining NELL-1, an osteogenic molecule that has been extensively studied for its potential use as a therapeutic for osteoporosis, w ...
adipogenesis, etc ; fatty acids; homeostasis; long-chain-fatty-acid-CoA ligase; luciferase; subcutaneous fat; swine; triacylglycerols; Show all 8 Subjects
Abstract:
... As a centre enzyme in fatty acid activation, acyl-CoA synthetase long-chain family member 1 (ACSL1) plays an important role in body lipid homeostasis. However, the functions of ACSL1 in the subcutaneous adipogenesis of pigs are largely unknown. In the present study, we found that the expression of ACSL1 significantly increased during the process of porcine preadipocyte differentiation. Moreover, s ...
John S.K. Yuen Jr; Andrew J. Stout; N. Stephanie Kawecki; Sophia M. Letcher; Sophia K. Theodossiou; Julian M. Cohen; Brigid M. Barrick; Michael K. Saad; Natalie R. Rubio; Jaymie A. Pietropinto; Hailey DiCindio; Sabrina W. Zhang; Amy C. Rowat; David L. Kaplan
... With rising global demand for food proteins and significant environmental impact associated with conventional animal agriculture, it is important to develop sustainable alternatives to supplement existing meat production. Since fat is an important contributor to meat flavor, recapitulating this component in meat alternatives such as plant based and cell cultured meats is important. Here, we discus ...
... The intramuscular fat content plays a crucial role in meat quality traits. Increasing the degree of adipogenesis in beef cattle leads to an increase in the content of intramuscular fat. Adipogenesis a complex biochemical process which is under firm genetic control. Over the last three decades, the Qinchuan beef cattle have been extensively studied for the improvement of meat production and quality ...
adipogenesis, etc ; adipocytes; adipose tissue; biogenesis; gene expression; gene targeting; humans; inflammation; lipogenesis; mass spectrometry; mitochondria; proteomics; Show all 12 Subjects
Abstract:
... Recent studies in mice and humans demonstrated the relevance of H₂S synthesising enzymes, such as CTH, CBS, and MPST, in the physiology of adipose tissue and the differentiation of preadipocyte into adipocytes. Here, our objective was to investigate the combined role of CTH, CBS, and MPST in the preservation of adipocyte protein persulfidation and adipogenesis. Combined partial CTH, CBS, and MPST ...