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1. Harmane ameliorates obesity though inhibiting lipid accumulation and inducing adipocyte browning

Author:
Li, Yanwen; Li, Chanjuan; Wu, Jiaqiang; Liu, Wenfeng; Li, Dongli; Xu, Jun
Source:
RSC advances 2020 v.10 no.8 pp. 4397-4403
ISSN:
2046-2069
Subject:
adipogenesis,   etc   ; Peganum harmala; adipocytes; lipogenesis; obesity; signal transduction; triacylglycerols;     Show all 7 Subjects
Abstract:
... Harmane, a compound derived from Peganum harmala L., was discovered as a lipid accumulation inhibitor with our triglyceride (TG) assay. To investigate the molecular mechanism underlying the role of harmane in the prevention of lipid accumulation, a number of biological experiments have been designed to determine if harmane reduces lipid accumulation by suppressing adipogenesis, lipogenesis, and re ...
DOI:
10.1039/c9ra09383d

2. The transcriptomes from two adipocyte progenitor cell types provide insight into the differential functions of MSTN

Author:
Deng, Bing; Zhang, Feng; Wen, Jianghui; Shen, Wenjun; Gao, Qishuang; Peng, Xia; Tan, Junjun; Pu, Zhenyu; Ye, Shengqiang; Wang, Lixia; Liu, Wu; Jiang, Siwen
Source:
Genomics 2020 v.112 no.5 pp. 3826-3836
ISSN:
0888-7543
Subject:
adipogenesis,   etc   ; adipocytes; gene expression regulation; genes; muscles; myostatin; peroxisome proliferator-activated receptor gamma; stem cells; transcriptome;     Show all 9 Subjects
Abstract:
... Myostatin (MSTN) was previously shown to differentially regulate the adipogenesis of adipose-derived stem cells (ADSCs) and muscle satellite cells (MSCs), both of which can serve as progenitor cells for intramuscular adipocytes. We previously showed that MSTN mediates the differential regulation of MyoD and PPARγ in ADSCs and MSCs. Here, we analyzed the effects of MSTN on whole-transcriptome expre ...
DOI:
10.1016/j.ygeno.2020.01.024

3. Chlorantraniliprole induces adipogenesis in 3T3-L1 adipocytes via the AMPKα pathway but not the ER stress pathway

Author:
Yuan, Li; Lin, Jie; Peng, Ye; Gao, Ruichang; Sun, Quancai
Source:
Food chemistry 2020 v.311 pp. 125953
ISSN:
0308-8146
Subject:
adipogenesis,   etc   ; adipocytes; endoplasmic reticulum stress; flubendiamide; insecticides; peroxisome proliferator-activated receptor gamma; phosphorylation;     Show all 7 Subjects
Abstract:
... Flubendiamide, a ryanoid family insecticide, has been linked to elevated adipogenesis. However, the influence on adipogenesis of chlorantraniliprole, another widely-used ryanoid-class insecticide in agriculture, remains unknown. Therefore, the influence of chlorantraniliprole on adipogenesis was studied in 3T3-L1 cells. Chlorantraniliprole enhanced TG content and upregulated the expression of C/EB ...
DOI:
10.1016/j.foodchem.2019.125953

4. Carotenoids and carotenoid conversion products in adipose tissue biology and obesity: Pre-clinical and human studies

Author:
Bonet, M. Luisa; Ribot, Joan; Galmés, Sebastiá; Serra, Francisca; Palou, Andreu
Source:
Biochimica et biophysica acta 2020 v.1865 no.11 pp. 158676
ISSN:
1388-1981
Subject:
adipogenesis,   etc   ; adipose tissue; biochemical pathways; dietary recommendations; energy; genetic variation; humans; metabolism; molecular biology; obesity; oxidation; oxidative stress; vitamin A;     Show all 13 Subjects
Abstract:
... Antiobesity activities of carotenoids and carotenoid conversion products (CCPs) have been demonstrated in pre-clinical studies, and mechanisms behind have begun to be unveiled, thus suggesting these compounds may help obesity prevention and management. The antiobesity action of carotenoids and CCPs can be traced to effects in multiple tissues, notably the adipose tissues. Key aspects of the biolog ...
DOI:
10.1016/j.bbalip.2020.158676

5. Bisphenols B, E, F, and S and 4‐cumylphenol induce lipid accumulation in mouse adipocytes similarly to bisphenol A

Author:
Ramskov Tetzlaff, Cecilie N.; Svingen, Terje; Vinggaard, Anne M.; Rosenmai, Anna K.; Taxvig, Camilla
Source:
Environmental toxicology 2020 v.35 no.5 pp. 543-552
ISSN:
1520-4081
Subject:
adipogenesis,   etc   ; adipocytes; bisphenol A; bisphenol B; bisphenol E; bisphenol F; bisphenol S; human health; leptin; lipids; mice;     Show all 11 Subjects
Abstract:
... Bisphenol A (BPA) has been widely reported to exert endocrine disrupting effects, including the induction of adipogenesis in cultured preadipocytes and intact animals. Because of the potential harm to human health, BPA is being substituted by structurally related bisphenols. Whether or not such BPA analogues are safe substitutes, however, remains largely unknown. Here, we investigated the potentia ...
DOI:
10.1002/tox.22889

6. Cytological and functional characteristics of fascia adipocytes in rats: A unique population of adipocytes

Author:
Zhang, Yanfei; Su, Xueying; Dong, Yingyue; Chen, Tongsheng; Zhang, Yuanyuan; Wu, Bihan; Li, Hanxiao; Sun, Xiaozhe; Xia, Lisha; Zhang, Dandan; Wang, Huamin; Xu, Guoheng
Source:
Biochimica et biophysica acta 2020 v.1865 no.2 pp. 158585
ISSN:
1388-1981
Subject:
adipogenesis,   etc   ; adipocytes; adipose tissue; catecholamines; dermis; droplets; fascia; functional properties; lipids; lipolysis; models; neonates; phosphorylation; rats; triacylglycerol lipase;     Show all 15 Subjects
Abstract:
... The dermal adipocytes, superficial fascia and subcutaneous adipose tissue (SAT) exist in the interspaces between the dermis and muscular fascia. They are adjacent to each other and traditionally recognized as one SAT. Recently, the dermal adipocyte was redefined as a unique population independent from the SAT. Also, we identified a novel type of adipogenic progenitors in rat superficial fascia. Th ...
DOI:
10.1016/j.bbalip.2019.158585

7. Effects of the proportion of two different cross-linkers on the material and biological properties of enzymatically degradable PEG hydrogels

Author:
Liu, Siju; Cao, Hong; Guo, Renqi; Li, Heling; Lu, Cuifen; Yang, Guichun; Nie, Junqi; Wang, Feiyi; Dong, Nianguo; Shi, Jiawei; Shi, Feng
Source:
Polymer degradation and stability 2020 v.172 pp. 109067
ISSN:
0141-3910
Subject:
adipogenesis,   etc   ; adipocytes; biocompatibility; bone formation; calcium; cytotoxicity; hydrogels; mechanical properties; metalloproteinases; osteoblasts; peptides; staining; thiols; tissue engineering;     Show all 14 Subjects
Abstract:
... A series of enzymatically degradable PEG hydrogels with tunable degradability were prepared by changing the proportions of two cross-linkers, enzymatically degradable cross-linker matrix metalloproteinase (MMP) degradable peptide and non-degradable cross-linker PEG-dithiol, and the effects of the proportion of two cross-linkers on the other properties of PEG hydrogels were also investigated. As th ...
DOI:
10.1016/j.polymdegradstab.2019.109067

8. microRNA-16–5p promotes 3T3-L1 adipocyte differentiation through regulating EPT1

Author:
Xu, Jingjing; Zhang, Liping; Shu, Guobin; Wang, Bin
Source:
Biochemical and biophysical research communications 2019 v.514 no.4 pp. 1251-1256
ISSN:
0006-291X
Subject:
adipogenesis,   etc   ; adipocytes; angiogenesis; apoptosis; cell proliferation; droplets; gene overexpression; genes;     Show all 8 Subjects
Abstract:
... Adipogenesis is an organized process of cellular differentiation by which pre-adipocytes differentiate towards mature adipocytes. miR-16–5p has been reported to be involved in cell proliferation, apoptosis, differentiation and angiogenesis. However little is known about miR-16–5p functional role in 3T3-L1 adipocyte differentiation. In this study, we found that miRNA-16–5p was significantly upregul ...
DOI:
10.1016/j.bbrc.2019.04.179

9. Kurozu melanoidin, a novel oligoglucan-melanoidin complex from Japanese black vinegar, suppresses adipogenesis in vitro

Author:
Suzuki, Eriko; Otake, Shinya; Hamadate, Naobumi; Hasumi, Keiji
Source:
Journal of functional foods 2020 v.72 pp. 104046
ISSN:
1756-4646
Subject:
adipogenesis,   etc   ; chemical analysis; gel chromatography; glucans; matrix-assisted laser desorption-ionization mass spectrometry; melanoidins; moieties; molecular weight; polyethylene glycol; solvents; vinegars;     Show all 11 Subjects
Abstract:
... The black vinegar “kurozu” has an anti-obesity potential, but its active principle is unknown. Here, we isolate and characterize a novel oligoglucan-melanoidin complex, designated kurozu melanoidin (KZM), that suppresses adipogenesis in vitro. KZM was isolated by organic solvent extraction, followed by size-exclusion chromatography. Its average molecular mass was estimated to be 1,090 ± 30 Da usin ...
DOI:
10.1016/j.jff.2020.104046

10. Catalase is required for peroxisome maintenance during adipogenesis

Author:
Nitta, Yuuki; Muraoka-Hirayama, Sanae; Sakurai, Koichi
Source:
Biochimica et biophysica acta 2020 v.1865 no.8 pp. 158726
ISSN:
1388-1981
Subject:
adipogenesis,   etc   ; adipocytes; autophagy; catalase; enzyme activity; enzyme inhibition; enzyme inhibitors; hydrogen peroxide; lipid metabolism; lipids; metabolic diseases; obesity; pathogenesis; peroxisomes; small interfering RNA; triazoles;     Show all 16 Subjects
Abstract:
... Although obesity contributes to the onset and pathogenesis of metabolic diseases, it has been repeatedly demonstrated that being overweight or mildly obese carries a survival advantage compared with being thin or normal-weight. This relationship is called the obesity paradox. Hence, it is necessary to clarify the underlying mechanism of obesity onset for the prevention and treatment of these disea ...
DOI:
10.1016/j.bbalip.2020.158726

11. New insights into potential nutritional effects of dietary saponins in protecting against the development of obesity

Author:
Jeepipalli, Syam P.K.; Du, Bin; Sabitaliyevich, Uteuliyev Y.; Xu, Baojun
Source:
Food chemistry 2020 v.318 pp. 126474
ISSN:
0308-8146
Subject:
adipogenesis,   etc   ; antioxidants; appetite suppressants; bile acids; diosgenin; energy intake; enzyme inhibitors; epigenetics; epithelium; excretion; exercise; fatty liver; intestinal absorption; lipogenesis; obesity; toxicity; triacylglycerol lipase; triacylglycerols;     Show all 18 Subjects
Abstract:
... Excessive energy intake, poor physical exercise and genetics/epigenetics are instrumental for the development of obesity. Because of rapidly emerging evidences related to off-target effects and toxicity of anti-obesity drugs, there is a need to search for more effective and targeted drugs for treatment of obesity. Substantial studies have found the nutritional effects of dietary saponins (bio-dete ...
DOI:
10.1016/j.foodchem.2020.126474

12. Induction of DEAD Box helicase 5 in early adipogenesis is regulated by Ten-eleven translocation 2

Author:
Cho, Minyoung; Lee, Eunbi; Shon, Jinyoung; Choi, Moon Jung; Park, Joo Hyun; Park, Yoon Jung
Source:
Biochimica et biophysica acta 2020 v.1865 no.7 pp. 158684
ISSN:
1388-1981
Subject:
adipogenesis,   etc   ; DNA replication; RNA helicases; RNA splicing; cell cycle; epigenetics; gene overexpression; genes; loci; microarray technology; precipitin tests; ribosomes; screening; small interfering RNA; transcription (genetics);     Show all 15 Subjects
Abstract:
... Dead box helicase 5 (DDX5) is an RNA helicase that is has cellular function on RNA splicing and transcriptional regulation. It has been reported to be involved in cell differentiation including adipogenesis. However, it is not clear how DDX5 is regulated during adipogenesis. Our previous report demonstrated that the Ten-eleven translocation methyl-cytosine dioxygenase 2 (TET2) is required for adip ...
DOI:
10.1016/j.bbalip.2020.158684

13. MiR-145 reduces the activity of PI3K/Akt and MAPK signaling pathways and inhibits adipogenesis in bovine preadipocytes

Author:
Wang, Li; Zhang, Song; Cheng, Gong; Mei, Chugang; Li, Shijun; Zhang, Wenzhen; Junjvlieke, Zainaguli; Zan, Linsen
Source:
Genomics 2020 v.112 no.4 pp. 2688-2694
ISSN:
0888-7543
Subject:
adipogenesis,   etc   ; adipose tissue; cattle; enzyme activity; insulin; microRNA; mitogen-activated protein kinase; phosphatidylinositol 3-kinase; phosphorylation; proteins; sequence analysis; signal transduction;     Show all 12 Subjects
Abstract:
... Adipose tissue is the largest metabolic organ because of adipogenesis controlled by numerous miRNAs. MiR-145 is classified into the same cluster with famous miR-143. However, few studies have investigated the role of miR-145 in adipogenesis. In the current study, we observed that the expression of miR-145 was downregulated during bovine adipogenesis in vivo and in vitro. The results of RNA-Seq ana ...
DOI:
10.1016/j.ygeno.2020.02.020

14. Pelargonidin suppresses adipogenesis in 3T3-L1 cells through inhibition of PPAR-γ signaling pathway

Author:
Guo, Lu; Kang, Jum Soon; Kang, Nam Jun; Je, Byoung Il; Lee, Yong Jae; Park, Young Hoon; Choi, Young Whan
Source:
Archives of biochemistry and biophysics 2020 v.686 pp. 108365
ISSN:
0003-9861
Subject:
adipogenesis,   etc   ; Western blotting; anti-obesity agents; antioxidants; dimethyl sulfoxide; droplets; fruits; glucose; glycemic effect; luciferase; oils; pelargonidin; peroxisome proliferator-activated receptor gamma; signal transduction; triacylglycerols;     Show all 15 Subjects
Abstract:
... Pelargonidin is a natural compound that exists widely in fruits, and exerts antioxidant, anti-atherosclerotic, anti-inflammatory, anti-hyperglycemic, and anti-diabetic activities. However, there have not been any studies concerning its anti-obesity potential to date. Therefore, we evaluated the anti-obesity potential of pelargonidin via inhibition of adipogenesis in 3T3-L1 cells. The cellular oil ...
DOI:
10.1016/j.abb.2020.108365

15. Biocatalytic Production of a Potent Inhibitor of Adipocyte Differentiation from Phloretin Using Engineered CYP102A1

Author:
Nguyen, Ngoc Anh; Jang, Jin; Le, Thien-Kim; Nguyen, Thi Huong Ha; Woo, Su-Min; Yoo, Su-Kyoung; Lee, Young Ju; Park, Ki Deok; Yeom, Soo-Jin; Kim, Geun-Joong; Kang, Hyung-Sik; Yun, Chul-Ho
Source:
Journal of agricultural and food chemistry 2020 v.68 no.24 pp. 6683-6691
ISSN:
1520-5118
Subject:
adipogenesis,   etc   ; adipocytes; almonds; apple pomace; beta-glucosidase; biocatalysis; gene expression regulation; glucose; glucosides; hydroxylation; lipids; metabolites; moieties; regioselectivity; regulator genes; site-directed mutagenesis;     Show all 16 Subjects
Abstract:
... In this study, we investigated an efficient enzymatic strategy for producing potentially valuable phloretin metabolites from phlorizin, a glucoside of phloretin that is rich in apple pomace. Almond β-glucosidase efficiently removed phlorizin’s glucose moiety to produce phloretin. CYP102A1 engineered by site-directed mutagenesis, domain swapping, and random mutagenesis catalyzed the highly regiosel ...
DOI:
10.1021/acs.jafc.0c03156

16. Targeted Proteomic Analysis of Small GTPases in Murine Adipogenesis

Author:
Yang, Yen-Yu; Huang, Ming; Wang, Yinsheng
Source:
Analytical chemistry 2020 v.92 no.9 pp. 6756-6763
ISSN:
1520-6882
Subject:
adipogenesis,   etc   ; Western blotting; adipocytes; adipose tissue; blood glucose; cell lines; gene expression regulation; glucose; guanosinetriphosphatase; insulin; isotope labeling; mice; monitoring; peptides; proteins; proteome; proteomics;     Show all 17 Subjects
Abstract:
... Small GTPases are essential signaling molecules for regulating glucose uptake in adipose tissues upon insulin stimulation, and this regulation maintains an appropriate range of glycemia. The involvement of small GTPases in adipogenesis, however, has not been systemically investigated. In this study, we applied a high-throughput scheduled multiple-reaction monitoring (MRM) method, along with the us ...
DOI:
10.1021/acs.analchem.0c00974

17. Angiopoietin-1 protects 3T3-L1 preadipocytes from saturated fatty acid–induced cell death

Author:
Son, Yura; Cox, Jaclyn M.; Stevenson, Jada L.; Cooper, Jamie A.; Paton, Chad M.
Source:
Nutrition research 2020 v.76 pp. 20-28
ISSN:
0271-5317
Subject:
adipogenesis,   etc   ; adipocytes; angiogenesis; angiopoietin-1; apoptosis; cell viability; endoplasmic reticulum stress; endothelial cells; endothelium; genes; polyunsaturated fatty acids; saturated fatty acids;     Show all 12 Subjects
Abstract:
... Cross talk between endothelial cells and adipocytes is vital to adipocyte functions, but little is known about the mechanisms or factors controlling the process. Angiogenesis is a critical component linking the endothelium to healthy adipogenesis, yet it is not known if or how it is involved in adipocyte physiology. Therefore, the purpose of this study was to determine the effect of angiopoietin-1 ...
DOI:
10.1016/j.nutres.2020.02.007

18. Inhibition of class I HDACs imprints adipogenesis toward oxidative and brown-like phenotype

Author:
Ferrari, Alessandra; Longo, Raffaella; Peri, Carolina; Coppi, Lara; Caruso, Donatella; Mai, Antonello; Mitro, Nico; De Fabiani, Emma; Crestani, Maurizio
Source:
Biochimica et biophysica acta 2020 v.1865 no.4 pp. 158594
ISSN:
1388-1981
Subject:
adipogenesis,   etc   ; acetylation; adipose tissue; epigenetics; genes; histone deacetylase; histones; hyperplasia; hypertrophy; metabolism; obesity; peroxisome proliferator-activated receptor gamma; phenotype; white adipocytes;     Show all 14 Subjects
Abstract:
... Obesity is characterized by uncontrolled expansion of adipose tissue mass, resulting in adipocyte hypertrophy (increased adipocyte size) and hyperplasia (increased number of adipocytes). The number of adipose cells is directly related to adipocyte differentiation process from stromal vascular cells to mature adipocytes. It is known that epigenetic factors influence adipose differentiation program. ...
DOI:
10.1016/j.bbalip.2019.158594

19. Identification of a prolonged action molecular GLP-1R agonist for the treatment of femoral defects

Author:
Wang, Ning; Liu, Xuanchen; Shi, Lei; Liu, Yanwu; Guo, Shuo; Liu, Wenwen; Li, Xiaokang; Meng, Jingru; Ma, Xue; Guo, Zheng
Source:
Biomaterials science 2020 v.8 no.6 pp. 1604-1614
ISSN:
2047-4849
Subject:
adipogenesis,   etc   ; agonists; autografting; bone formation; bone marrow; endothelial cells; macrophages; mesenchymal stromal cells; mice; models; pain; patients; polymers; signal transduction; transforming growth factor beta 1;     Show all 15 Subjects
Abstract:
... Autografts are still regarded as the gold standard treatment for bone defects but they require additional surgery that causes pain for the patient. Thus, alternatives that can substitute for grafts are required. In the present study, a novel poly-GLP-1 molecule was developed using a polymeric pro-drug strategy which was found to accelerate bone healing in a mouse femoral defect model. Furthermore, ...
DOI:
10.1039/c9bm01426h

20. Tripeptide-induced modulation of mesenchymal stem cell biomechanics stimulates proliferation and wound healing

Author:
Sharma, Swati; Kulkarni, Chirag; Kulkarni, Manish M.; Ali, Rafat; Porwal, Konica; Chattopadhyay, Naibedya; Tewari, Deepshikha; Verma, Sandeep
Source:
Chemical communications 2020 v.56 no.20 pp. 3043-3046
ISSN:
1364-548X
Subject:
adipogenesis,   etc   ; biomechanics; bone formation; chemical compounds; chemical reactions; humans; mechanical properties; mesenchymal stromal cells; modulus of elasticity; tissue engineering; tissue repair; tripeptides;     Show all 12 Subjects
Abstract:
... We demonstrate the ability of two tripeptides to promote proliferation and modulate the mechanical properties of human mesenchymal stem cells (hMSCs). Notably, Young's modulus of peptide-treated hMSCs was found to be ∼2 fold higher compared to the control group. These peptides promoted wound healing in hMSCs, without stimulating osteogenic and adipogenic differentiation, thus showing high potentia ...
DOI:
10.1039/c9cc10043a