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albumins, etc ; lead; metabolites; occupational exposure; regression analysis; Kuwait; Show all 6 Subjects
Abstract:
... A negative association between blood Pb level (BPbL) and vitamin D metabolites in occupationally exposed populations has been reported, but data from the general population are scarce. Furthermore, the association between BPbL and vitamin D binding protein (DBP) and free 25-hydroxyvitamin D (25(OH)D) has not been reported. We investigated the association of BPbL with DBP, total and free 25(OH)D in ...
albumins, etc ; centrifugation; chromatography; doxorubicin; exosomes; nanomedicine; oligonucleotides; pH; silica; therapeutics; Show all 10 Subjects
Abstract:
... Nanoparticles are widely used in the medical field for diagnosis and therapy. In particular, the use of nanoparticles containing vaccines has spread rapidly; hence, ensuring nanoparticle safety and minimizing their side effects have become important concerns worldwide. In this study, we used three types (NH₂, poly-Lys, and trimethylaminopropyl) of cationic modified silica monoliths with cylindrica ...
albumins, etc ; DNA; Orthomyxoviridae; anion exchange chromatography; hemagglutinins; immunization; influenza; purification methods; viruses; Show all 9 Subjects
Abstract:
... Immunization is the most effective way to respond to an influenza epidemic. To produce Vero cell-derived influenza vaccines, a more efficient, stable and economical purification process is required. In this study, we purified the H7N9 influenza virus grown in Vero cells that were cultured in a serum-free medium by using a combination of anion exchange chromatography (AEC) and ligand-activated core ...
albumins, etc ; carboxylic ester hydrolases; color; colorimetry; detection limit; nanospheres; oleic acid; polymers; protonation; Show all 9 Subjects
Abstract:
... Colorimetric detection of fatty acids during biological interactions is extremely difficult since they are optically silent. Here, fatty acids are found to function as ion-exchangers in ultrasmall polymeric nanospheres to facilitate the protonation of chromoionophores, causing a vivid color change between red and blue. With an excellent detection limit of 1.8 μg mL⁻¹ for oleic acid, colorimetric a ...
albumins, etc ; cholesterol; drug therapy; hospitals; lymphocyte count; nutrition assessment; nutritional status; ovarian neoplasms; Show all 8 Subjects
Abstract:
... This study aimed to investigate the association between preoperative prognostic nutritional index (PNI) and controlling nutritional status (CONUT) scores on the stage of ovarian cancer (OC), chemotherapeutic response, and overall survival (OS) in patients with OC. The data of the patients who operated due to OC between January 2015 and January 2020 in a tertiary referral hospital were recorded. Th ...
albumins, etc ; blood; blood lipids; genes; high fat diet; hyperlipidemia; kidneys; lipid metabolism; proteinuria; research; Show all 10 Subjects
Abstract:
... The molecular mechanism of in hyperlipidemia-induced renal injury has not been elucidated. Angiogenin-like protein 4 (ANGPTL4) is a key regulator of lipid metabolism. The role of ANGPTL4 hyperlipidemia-induced renal injury has not been reported. Wild type C57 mice and gene angptl4 knockout mice were fed with 60% high fat diet or normal diet respectively. The serum lipid, urinary albumin and renal ...
albumins, etc ; Fasciola; enzymes; fascioliasis; fecal egg count; globulins; levamisole; liver; protein content; therapeutics; triclabendazole; Show all 11 Subjects
Abstract:
... Fascioliasis is an important parasitic disease which affects productivity of ruminants, and imposes significant economic losses. Benzimidazoles are effective in the treatment of fascioliasis; however, there are several reports on benzimidazoles resistant flukes. Combinational therapy is an approach to delay the emergence of resistant flukes. The present study aimed to compare the efficacy of tricl ...
Ana Fernández-Araque; Andrea Giaquinta-Aranda; Carmelo Moreno-Sainz; María Cruz Martínez-Martínez; Verónica Velasco-González; María Sainz-Gil; Luis H. Martín-Arias; Silvia Carretero-Molinero; Miguel García-Hidalgo; Zoraida Verde
albumins, etc ; biomarkers; blood serum; bone metabolism; calcium; creatinine; gender; genes; haplotypes; mineral metabolism; models; phosphorus; Show all 12 Subjects
Abstract:
... Candidate gene studies have analyzed the effect of specific vitamin D pathway genes on vitamin D availability; however, it is not clear whether genetic variants also affect overall bone metabolism. This study evaluated the association between genetic polymorphisms in GC, CYP2R1 and CYP24A1 and serum levels of total 25(OH)D, iPTH and other mineral metabolism biomarkers (albumin, total calcium and p ...
... Radiotheranostics has attracted attention as a powerful strategy for treating cancer patients with precision medicine. We designed and synthesized a novel DOTA-based trifunctional agent, ADIBO-DOTADG-ALB (ADA), which allowed compounds with targeting ligands, radiometals, and an albumin binder to be readily prepared. ADA exhibited promising properties as a theranostic platform. ...
albumins, etc ; animal research; blood serum; enteritis; haptoglobins; interleukin-6; necrosis; neoplasms; pneumonia; protein content; veterinary medicine; Show all 11 Subjects
Abstract:
... This study aims to determine the concentration of serum haptoglobin (Hp), interleukin 1 (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) in cases of Pneumonia, Pneumoenteritis and Enteritis. 60 calves were subjected to the study and they were divided into four groups. The study group consisted of the claves diagnosed with clinical pneumonia (Group P; n=15), pneumoenteritis (Group ...
Morten Seirup; Srikumar Sengupta; Scott Swanson; Brian E. McIntosh; Mike Collins; Li-Fang Chu; Zhang Cheng; David U. Gorkin; Bret Duffin; Jennifer M. Bolin; Cara Argus; Ron Stewart; James A. Thomson
... Primary hepatocytes are widely used in the pharmaceutical industry to screen drug candidates for hepatotoxicity, but hepatocytes quickly dedifferentiate and lose their mature metabolic function in culture. Attempts have been made to better recapitulate the in vivo liver environment in culture, but the full spectrum of signals required to maintain hepatocyte function ex vivo remains elusive. To elu ...
Filip Janjić; Anđelo Beletić; Milena Radaković; Kristina Spariosu; Miloš Diklić; Jelena Francuski Andrić; Vladimir Radonjić; Jelena Ajtić; Milica Kovačević Filipović
... The highest number of acute Babesia canis cases in dogs is recorded over the February–May (Feb–May) period, which also represents the optimal climate conditions for tick activity in Belgrade, Serbia. A possibility that the acute phase response is more intense in dogs developing the disease in the Feb–May period compared with the response in other time periods of the year was tested. A total of 63 ...
Sergey A. Miroshnikov; Svetlana V. Notova; Margarita G. Skalnaya; Elena A. Sizova; Olga V. Marshinskaia; Tatiana V. Kazakova; Anatoly V. Skalny; Bernhard Michalke; Olga P. Ajsuvakova; Alexey A. Tinkov
... The objective of the present study was assessment of the major copper and zinc species in dairy cow blood serum using a hybrid high-performance liquid chromatography-inductively coupled plasma-mass spectrometry (HPLC-ICP-MS) technique. A total of seventeen 5–6-year-old female Simmental cows, cultivated in the Southern Ural region, were examined. Speciation of serum Cu and Zn was performed using ch ...
Guillem Pascual-Pasto; Helena Castillo-Ecija; Nora Unceta; Rosario Aschero; Claudia Resa-Pares; Alberto Gómez-Caballero; Monica Vila-Ubach; Oscar Muñoz-Aznar; Mariona Suñol; Victor Burgueño; Soledad Gomez-Gonzalez; Alejandro Sosnik; Manuel Ibarra; Paula Schaiquevich; Enrique de Álava; Oscar M. Tirado; Jaume Mora; Angel M. Carcaboso
albumins, etc ; acetylation; antineoplastic agents; cysteine; drug therapy; genes; glycoproteins; histones; immunoblotting; lysine; osteosarcoma; paclitaxel; protein secretion; xenotransplantation; Show all 14 Subjects
Abstract:
... Secreted protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein overexpressed by several cancers. Because SPARC shows high binding affinity to albumin, we reasoned that pediatric sarcoma xenografts expressing SPARC would show enhanced uptake and accumulation of nanoparticle albumin-bound (nab)-paclitaxel, a potent anticancer drug formulation. We first evaluated the expression ...
albumins, etc ; alcohols; analysis of covariance; body mass index; diabetes mellitus; drug therapy; gender; hemoglobin; pteridines; regression analysis; risk; Show all 11 Subjects
Abstract:
... Presented here are the supplemental data of the research article “Urinary pteridines as a discriminator of atherosclerotic risk in patients with diabetes” [1]. These data provide the first information on variables that affect urinary levels of pteridines (oxidized-form pteridine derivatives) in patients with diabetes mellitus. In linear regression analysis, gender (women vs. men), current history ...
albumins, etc ; brittleness; confocal microscopy; denaturation; egg albumen; fluorescent dyes; food chemistry; hydrocolloids; microstructure; modulus of elasticity; rheology; texture; Show all 12 Subjects
Abstract:
... Nowadays, food materials can be well characterized at their molecular level (food chemistry) and macroscopic level (texture and rheology) thanks to the advances in these areas in the last decades. However, there is a gap in the understanding of how food materials organize at microscopic level. This article shows how an optical super-resolution microscopy technique can be used to gain more informat ...
... In this work, the interfacial rheological properties and the quantitative changes of proteins at interfacial protein layers of emulsions stabilized by soy protein isolates (SPI) and heat-treated soy protein isolates (HSPI) were investigated. The quantification results showed that the relative quantities of albumin (2S) and glycinin (11S) in SPI decreased at the oil-water interface, suggesting that ...
albumins, etc ; erbB-2 receptor; ligands; photothermotherapy; Show all 4 Subjects
Abstract:
... The successful development of targeted nanoparticle (NP)-based therapeutics depends on the effective conjugation of targeting ligands to the NP. However, conventional methods based on chemical reactive groups such as N-hydroxysuccinimide, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide, and maleimide have several limitations, including low binding efficiency, complex reaction methods, long reaction ...
albumins, etc ; 2,4-dinitrophenol; nitroaromatic compounds; therapeutics; Show all 4 Subjects
Abstract:
... Therapeutic antibodies should cover particular physicochemical and functional requirements for successful entry into clinical practice. Numerous experimental and computational approaches have been developed for early identification of different unfavourable features of antibodies. Immune repertoires of healthy humans contain a fraction of antibodies that recognize nitroarenes. These antibodies hav ...
albumins, etc ; Aeromonas hydrophila; Cyprinus carpio; Scrophularia; antibodies; complement; fish; growth performance; hematocrit; immune response; lysozyme; monocytes; protein content; shellfish; Show all 14 Subjects
Abstract:
... This study was conducted to investigate the effect of figwort on the growth and immunohematological parameters of common carp (14.20 ± 0.53 g). Four experimental diets were developed to feed fish for eight weeks: control, Figw10 (10 g/kg figwort), Figw20 (20 g/kg figwort), and Figw30 (30 g/kg figwort). The results showed that fish fed dietary Figw10 gained more weight (38.25 g) than control (P < 0 ...