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1. Association of blood lead level with vitamin D binding protein, total and free 25-hydroxyvitamin D levels in middle-school children

Author:
Abdur Rahman; Reem Al-Sabah; Reem Jallad; Muddanna S. Rao
Source:
British journal of nutrition 2022 v.127 no.7 pp. 982-992
ISSN:
1475-2662
Subject:
albumins,   etc   ; lead; metabolites; occupational exposure; regression analysis; Kuwait;     Show all 6 Subjects
Abstract:
... A negative association between blood Pb level (BPbL) and vitamin D metabolites in occupationally exposed populations has been reported, but data from the general population are scarce. Furthermore, the association between BPbL and vitamin D binding protein (DBP) and free 25-hydroxyvitamin D (25(OH)D) has not been reported. We investigated the association of BPbL with DBP, total and free 25(OH)D in ...
DOI:
10.1017/S0007114521001823

2. A method for purifying nanoparticles using cationic modified monoliths and aqueous elution

Author:
Masaru Kato; Misa Yamaguchi; Tomoka Morita; Noriko Watanabe; Shigenori Ota; Eiichi Yamamoto
Source:
Journal of chromatography 2022 v.1664 pp. 462802
ISSN:
0021-9673
Subject:
albumins,   etc   ; centrifugation; chromatography; doxorubicin; exosomes; nanomedicine; oligonucleotides; pH; silica; therapeutics;     Show all 10 Subjects
Abstract:
... Nanoparticles are widely used in the medical field for diagnosis and therapy. In particular, the use of nanoparticles containing vaccines has spread rapidly; hence, ensuring nanoparticle safety and minimizing their side effects have become important concerns worldwide. In this study, we used three types (NH₂, poly-Lys, and trimethylaminopropyl) of cationic modified silica monoliths with cylindrica ...
DOI:
10.1016/j.chroma.2021.462802

3. A flow-through chromatography purification process for Vero cell-derived influenza virus (H7N9)

Author:
ChengRui Fei; JingXia Gao; ChengHua Fei; Lei Ma; WenYong Zhu; LingYu He; YaNan Wu; ShaoHui Song; WeiDong Li; Jian Zhou; GuoYang Liao
Source:
Journal of virological methods 2022 v.301 pp. 114408
ISSN:
0166-0934
Subject:
albumins,   etc   ; DNA; Orthomyxoviridae; anion exchange chromatography; hemagglutinins; immunization; influenza; purification methods; viruses;     Show all 9 Subjects
Abstract:
... Immunization is the most effective way to respond to an influenza epidemic. To produce Vero cell-derived influenza vaccines, a more efficient, stable and economical purification process is required. In this study, we purified the H7N9 influenza virus grown in Vero cells that were cultured in a serum-free medium by using a combination of anion exchange chromatography (AEC) and ligand-activated core ...
DOI:
10.1016/j.jviromet.2021.114408

4. Phase transfer of fatty acids into ultrasmall nanospheres for colorimetric detection of lipase and albumin

Author:
Chao Guo; Jingying Zhai; Qinghan Chen; Xinfeng Du; Xiaojiang Xie
Source:
Chemical communications 2022 v.58 no.32 pp. 5037-5040
ISSN:
1364-548X
Subject:
albumins,   etc   ; carboxylic ester hydrolases; color; colorimetry; detection limit; nanospheres; oleic acid; polymers; protonation;     Show all 9 Subjects
Abstract:
... Colorimetric detection of fatty acids during biological interactions is extremely difficult since they are optically silent. Here, fatty acids are found to function as ion-exchangers in ultrasmall polymeric nanospheres to facilitate the protonation of chromoionophores, causing a vivid color change between red and blue. With an excellent detection limit of 1.8 μg mL⁻¹ for oleic acid, colorimetric a ...
DOI:
10.1039/d2cc01089e

5. The Association between the Preoperative Prognostic Nutritional Index and the Controlling Nutritional Status Score on Tumor Stage, Chemotherapeutic Response and Overall Survival in Ovarian Cancer

Author:
Sema Karakaş; Gökhan Demirayak; Ayşe Büşra Önder; İsa Aykut Özdemir; Cihan Comba; Sema Süzen Çaypınar; Şükrü Yıldız; Selim Avşar; Sema Bağhaki; Güneş Özlem Yıldız; Şakir Volkan Erdoğan
Source:
Nutrition and cancer 2022 v.74 no.5 pp. 1770-1779
ISSN:
1532-7914
Subject:
albumins,   etc   ; cholesterol; drug therapy; hospitals; lymphocyte count; nutrition assessment; nutritional status; ovarian neoplasms;     Show all 8 Subjects
Abstract:
... This study aimed to investigate the association between preoperative prognostic nutritional index (PNI) and controlling nutritional status (CONUT) scores on the stage of ovarian cancer (OC), chemotherapeutic response, and overall survival (OS) in patients with OC. The data of the patients who operated due to OC between January 2015 and January 2020 in a tertiary referral hospital were recorded. Th ...
DOI:
10.1080/01635581.2021.2022170

6. Angiopoietin-like protein 4 promotes hyperlipidemia-induced renal injury by down-regulating the expression of ACTN4

Author:
Yue Li; Wangqiu Gong; Jing Liu; Xingxing Chen; Yanhong Suo; Huabing Yang; Xia Gao
Source:
Biochemical and biophysical research communications 2022 v.595 pp. 69-75
ISSN:
0006-291X
Subject:
albumins,   etc   ; blood; blood lipids; genes; high fat diet; hyperlipidemia; kidneys; lipid metabolism; proteinuria; research;     Show all 10 Subjects
Abstract:
... The molecular mechanism of in hyperlipidemia-induced renal injury has not been elucidated. Angiogenin-like protein 4 (ANGPTL4) is a key regulator of lipid metabolism. The role of ANGPTL4 hyperlipidemia-induced renal injury has not been reported. Wild type C57 mice and gene angptl4 knockout mice were fed with 60% high fat diet or normal diet respectively. The serum lipid, urinary albumin and renal ...
DOI:
10.1016/j.bbrc.2022.01.061

7. Therapeutic efficacy of triclabendazole in comparison to combination of triclabendazole and levamisole in sheep naturally infected with Fasciola sp.

Author:
Mohaddeseh Abouhosseini Tabari; Seyed Aria Fallah Vahdati; Shohre Alian Samakkhah; Atefeh Araghi; Mohammad Reza Youssefi
Source:
Journal of parasitic diseases 2022 v.46 no.1 pp. 80-86
ISSN:
0971-7196
Subject:
albumins,   etc   ; Fasciola; enzymes; fascioliasis; fecal egg count; globulins; levamisole; liver; protein content; therapeutics; triclabendazole;     Show all 11 Subjects
Abstract:
... Fascioliasis is an important parasitic disease which affects productivity of ruminants, and imposes significant economic losses. Benzimidazoles are effective in the treatment of fascioliasis; however, there are several reports on benzimidazoles resistant flukes. Combinational therapy is an approach to delay the emergence of resistant flukes. The present study aimed to compare the efficacy of tricl ...
DOI:
10.1007/s12639-021-01422-w

8. Haplotypes in the GC, CYP2R1 and CYP24A1 Genes and Biomarkers of Bone Mineral Metabolism in Older Adults

Author:
Ana Fernández-Araque; Andrea Giaquinta-Aranda; Carmelo Moreno-Sainz; María Cruz Martínez-Martínez; Verónica Velasco-González; María Sainz-Gil; Luis H. Martín-Arias; Silvia Carretero-Molinero; Miguel García-Hidalgo; Zoraida Verde
Source:
Nutrients 2022 v.14 no.2 pp. -
ISSN:
2072-6643
Subject:
albumins,   etc   ; biomarkers; blood serum; bone metabolism; calcium; creatinine; gender; genes; haplotypes; mineral metabolism; models; phosphorus;     Show all 12 Subjects
Abstract:
... Candidate gene studies have analyzed the effect of specific vitamin D pathway genes on vitamin D availability; however, it is not clear whether genetic variants also affect overall bone metabolism. This study evaluated the association between genetic polymorphisms in GC, CYP2R1 and CYP24A1 and serum levels of total 25(OH)D, iPTH and other mineral metabolism biomarkers (albumin, total calcium and p ...
DOI:
10.3390/nu14020259

9. Development of a novel radiotheranostic platform with a DOTA-based trifunctional chelating agent

Author:
Kazuma Nakashima; Shimpei Iikuni; Hiroyuki Watanabe; Masahiro Ono
Source:
Chemical communications 2021 v.57 no.52 pp. 6432-6435
ISSN:
1364-548X
Subject:
albumins,   etc   ; ligands; precision medicine;     Show all 3 Subjects
Abstract:
... Radiotheranostics has attracted attention as a powerful strategy for treating cancer patients with precision medicine. We designed and synthesized a novel DOTA-based trifunctional agent, ADIBO-DOTADG-ALB (ADA), which allowed compounds with targeting ligands, radiometals, and an albumin binder to be readily prepared. ADA exhibited promising properties as a theranostic platform. ...
DOI:
10.1039/d1cc00823d

10. Determining Serum Haptoglobin and Proinflammatory Cytokines Concentration in the Calves Clinically Diagnosed with Pneumonitis, Pneumoenteritis and Enteritis

Author:
M. Kabu; C. Uyarlar
Source:
Indian journal of animal research 2022 v.56 no.4 pp. 498-501
ISSN:
0976-0555
Subject:
albumins,   etc   ; animal research; blood serum; enteritis; haptoglobins; interleukin-6; necrosis; neoplasms; pneumonia; protein content; veterinary medicine;     Show all 11 Subjects
Abstract:
... This study aims to determine the concentration of serum haptoglobin (Hp), interleukin 1 (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) in cases of Pneumonia, Pneumoenteritis and Enteritis. 60 calves were subjected to the study and they were divided into four groups. The study group consisted of the claves diagnosed with clinical pneumonia (Group P; n=15), pneumoenteritis (Group ...
DOI:
10.18805/IJAR.B-1376

11. Rapid changes in chromatin structure during dedifferentiation of primary hepatocytes in vitro

Author:
Morten Seirup; Srikumar Sengupta; Scott Swanson; Brian E. McIntosh; Mike Collins; Li-Fang Chu; Zhang Cheng; David U. Gorkin; Bret Duffin; Jennifer M. Bolin; Cara Argus; Ron Stewart; James A. Thomson
Source:
Genomics 2022 v.114 no.3 pp. 110330
ISSN:
0888-7543
Subject:
albumins,   etc   ; biochemical pathways; chromatin; drugs; gene expression; genes; genomics; hepatocytes; hepatotoxicity; liver; pharmaceutical industry; sequence analysis;     Show all 12 Subjects
Abstract:
... Primary hepatocytes are widely used in the pharmaceutical industry to screen drug candidates for hepatotoxicity, but hepatocytes quickly dedifferentiate and lose their mature metabolic function in culture. Attempts have been made to better recapitulate the in vivo liver environment in culture, but the full spectrum of signals required to maintain hepatocyte function ex vivo remains elusive. To elu ...
DOI:
10.1016/j.ygeno.2022.110330

12. Seasonal differences in the intensity of acute phase response in dogs infected with Babesia canis

Author:
Filip Janjić; Anđelo Beletić; Milena Radaković; Kristina Spariosu; Miloš Diklić; Jelena Francuski Andrić; Vladimir Radonjić; Jelena Ajtić; Milica Kovačević Filipović
Source:
International journal of biometeorology 2022 v.66 no.4 pp. 691-698
ISSN:
0020-7128
Subject:
albumins,   etc   ; Babesia canis; acute course; amyloid; bioclimatology; creatinine; ferroxidase; hematology; iron; parasitemia; regression analysis; ticks; Serbia;     Show all 13 Subjects
Abstract:
... The highest number of acute Babesia canis cases in dogs is recorded over the February–May (Feb–May) period, which also represents the optimal climate conditions for tick activity in Belgrade, Serbia. A possibility that the acute phase response is more intense in dogs developing the disease in the Feb–May period compared with the response in other time periods of the year was tested. A total of 63 ...
DOI:
10.1007/s00484-021-02228-4

13. Speciation of Serum Copper and Zinc-Binding High- and Low-Molecular Mass Ligands in Dairy Cows Using HPLC-ICP-MS Technique

Author:
Sergey A. Miroshnikov; Svetlana V. Notova; Margarita G. Skalnaya; Elena A. Sizova; Olga V. Marshinskaia; Tatiana V. Kazakova; Anatoly V. Skalny; Bernhard Michalke; Olga P. Ajsuvakova; Alexey A. Tinkov
Source:
Biological trace element research 2022 v.200 no.2 pp. 591-599
ISSN:
0163-4984
Subject:
albumins,   etc   ; Simmental; blood serum; copper; dairy cows; ferroxidase; hybrids; ligands; molecular weight; research; spectrometers; spectroscopy; zinc;     Show all 13 Subjects
Abstract:
... The objective of the present study was assessment of the major copper and zinc species in dairy cow blood serum using a hybrid high-performance liquid chromatography-inductively coupled plasma-mass spectrometry (HPLC-ICP-MS) technique. A total of seventeen 5–6-year-old female Simmental cows, cultivated in the Southern Ural region, were examined. Speciation of serum Cu and Zn was performed using ch ...
DOI:
10.1007/s12011-021-02666-6

14. SPARC-mediated long-term retention of nab-paclitaxel in pediatric sarcomas

Author:
Guillem Pascual-Pasto; Helena Castillo-Ecija; Nora Unceta; Rosario Aschero; Claudia Resa-Pares; Alberto Gómez-Caballero; Monica Vila-Ubach; Oscar Muñoz-Aznar; Mariona Suñol; Victor Burgueño; Soledad Gomez-Gonzalez; Alejandro Sosnik; Manuel Ibarra; Paula Schaiquevich; Enrique de Álava; Oscar M. Tirado; Jaume Mora; Angel M. Carcaboso
Source:
Journal of controlled release 2022 v.342 pp. 81-92
ISSN:
0168-3659
Subject:
albumins,   etc   ; acetylation; antineoplastic agents; cysteine; drug therapy; genes; glycoproteins; histones; immunoblotting; lysine; osteosarcoma; paclitaxel; protein secretion; xenotransplantation;     Show all 14 Subjects
Abstract:
... Secreted protein acidic and rich in cysteine (SPARC) is a matricellular glycoprotein overexpressed by several cancers. Because SPARC shows high binding affinity to albumin, we reasoned that pediatric sarcoma xenografts expressing SPARC would show enhanced uptake and accumulation of nanoparticle albumin-bound (nab)-paclitaxel, a potent anticancer drug formulation. We first evaluated the expression ...
DOI:
10.1016/j.jconrel.2021.12.035

15. Data on urinary pteridines as a discriminator of atherosclerotic risk in patients with diabetes

Author:
Mikio Marumo; Kazumi Ekawa; Ichiro Wakabayashi
Source:
Data in Brief 2022 v.41 pp. 107897
ISSN:
2352-3409
Subject:
albumins,   etc   ; alcohols; analysis of covariance; body mass index; diabetes mellitus; drug therapy; gender; hemoglobin; pteridines; regression analysis; risk;     Show all 11 Subjects
Abstract:
... Presented here are the supplemental data of the research article “Urinary pteridines as a discriminator of atherosclerotic risk in patients with diabetes” [1]. These data provide the first information on variables that affect urinary levels of pteridines (oxidized-form pteridine derivatives) in patients with diabetes mellitus. In linear regression analysis, gender (women vs. men), current history ...
DOI:
10.1016/j.dib.2022.107897

16. Super-resolution microscopy to visualize and quantify protein microstructural organization in food materials and its relation to rheology: Egg white proteins

Author:
Jose C. Bonilla; Mathias P. Clausen
Source:
Food hydrocolloids 2022 v.124 pp. 107281
ISSN:
0268-005X
Subject:
albumins,   etc   ; brittleness; confocal microscopy; denaturation; egg albumen; fluorescent dyes; food chemistry; hydrocolloids; microstructure; modulus of elasticity; rheology; texture;     Show all 12 Subjects
Abstract:
... Nowadays, food materials can be well characterized at their molecular level (food chemistry) and macroscopic level (texture and rheology) thanks to the advances in these areas in the last decades. However, there is a gap in the understanding of how food materials organize at microscopic level. This article shows how an optical super-resolution microscopy technique can be used to gain more informat ...
DOI:
10.1016/j.foodhyd.2021.107281

17. The Effects of Thermal Treatment on Emulsifying Properties of Soy Protein Isolates: Interfacial Rheology and Quantitative Proteomic Analysis

Author:
Qian Shen; Ting Xiong; Wei Zheng; Yilun Luo; Weiting Peng; Jun Dai; Rong Song; Yan Li; Shilin Liu; Bin Li; Yijie Chen
Source:
Food research international 2022 pp. 111326
ISSN:
0963-9969
Subject:
albumins,   etc   ; adsorption; amino acid sequences; food research; globulins; glycinin; heat treatment; hydrophilicity; hydrophobicity; oil-water interface; proteomics; rheology;     Show all 12 Subjects
Abstract:
... In this work, the interfacial rheological properties and the quantitative changes of proteins at interfacial protein layers of emulsions stabilized by soy protein isolates (SPI) and heat-treated soy protein isolates (HSPI) were investigated. The quantification results showed that the relative quantities of albumin (2S) and glycinin (11S) in SPI decreased at the oil-water interface, suggesting that ...
DOI:
10.1016/j.foodres.2022.111326

18. Development of HER2-Targeting-Ligand-Modified Albumin Nanoparticles Based on the SpyTag/SpyCatcher System for Photothermal Therapy

Author:
Changkyu Lee; Sebyung Kang
Source:
Biomacromolecules 2021 v.22 no.6 pp. 2649-2658
ISSN:
1526-4602
Subject:
albumins,   etc   ; erbB-2 receptor; ligands; photothermotherapy;     Show all 4 Subjects
Abstract:
... The successful development of targeted nanoparticle (NP)-based therapeutics depends on the effective conjugation of targeting ligands to the NP. However, conventional methods based on chemical reactive groups such as N-hydroxysuccinimide, 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide, and maleimide have several limitations, including low binding efficiency, complex reaction methods, long reaction ...
DOI:
10.1021/acs.biomac.1c00336

19. Interaction with 2,4-dinitrophenol correlates with polyreactivity, self-binding, and stability of clinical-stage therapeutic antibodies

Author:
Valentin Dietlin-Auril; Maxime Lecerf; Stephanie Depinay; Rémi Noé; Jordan D. Dimitrov
Source:
Molecular immunology 2021 v.140 pp. 233-239
ISSN:
0161-5890
Subject:
albumins,   etc   ; 2,4-dinitrophenol; nitroaromatic compounds; therapeutics;     Show all 4 Subjects
Abstract:
... Therapeutic antibodies should cover particular physicochemical and functional requirements for successful entry into clinical practice. Numerous experimental and computational approaches have been developed for early identification of different unfavourable features of antibodies. Immune repertoires of healthy humans contain a fraction of antibodies that recognize nitroarenes. These antibodies hav ...
DOI:
10.1016/j.molimm.2021.10.019

20. Remarkable positive effects of figwort (Scrophularia striata) on improving growth performance, and immunohematological parameters of fish

Author:
Hossein Hosseini; Mehrdad Pooyanmehr; Azadeh Foroughi; Moha Esmaeili; Farzad Ghiasi; Reza Lorestany
Source:
Fish & shellfish immunology 2022 v.120 pp. 111-121
ISSN:
1050-4648
Subject:
albumins,   etc   ; Aeromonas hydrophila; Cyprinus carpio; Scrophularia; antibodies; complement; fish; growth performance; hematocrit; immune response; lysozyme; monocytes; protein content; shellfish;     Show all 14 Subjects
Abstract:
... This study was conducted to investigate the effect of figwort on the growth and immunohematological parameters of common carp (14.20 ± 0.53 g). Four experimental diets were developed to feed fish for eight weeks: control, Figw10 (10 g/kg figwort), Figw20 (20 g/kg figwort), and Figw30 (30 g/kg figwort). The results showed that fish fed dietary Figw10 gained more weight (38.25 g) than control (P < 0 ...
DOI:
10.1016/j.fsi.2021.11.020