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1. The effects of reward and loss anticipation on attentional bias for reward-related stimuli

Author:
Jędras, Paweł; Jones, Andrew; Stancak, Andrej; Field, Matt
Source:
Appetite 2019 v.133 pp. 93-100
ISSN:
0195-6663
Subject:
alcohols,   etc   ; chocolate; eyes; uncertainty;     Show all 4 Subjects
Abstract:
... Attentional biases for reward-related (e.g., food, alcohol) cues are moderated by the expectation of imminent reward availability, but the psychological mechanisms that underlie this effect are unclear. We report two studies in which we investigated if effects of reward gain anticipation are specific to the type of reward that is anticipated, and if anticipation of loss has comparable effects to a ...
DOI:
10.1016/j.appet.2018.10.007

2. Ruthenium-Catalyzed Redox Isomerizations inside Living Cells

Author:
Vidal, Cristian; Tomás-Gamasa, María; Gutiérrez-González, Alejandro; Mascareñas, José L.
Source:
Journal of the American Chemical Society 2019 v.141 no.13 pp. 5125-5129
ISSN:
1520-5126
Subject:
alcohols,   etc   ; fluorescence; isomerization; mammals; ruthenium;     Show all 5 Subjects
Abstract:
... Tailored ruthenium(IV) complexes can catalyze the isomerization of allylic alcohols into saturated carbonyl derivatives under physiologically relevant conditions, and even inside living mammalian cells. The reaction, which involves ruthenium-hydride intermediates, is bioorthogonal and biocompatible, and can be used for the “in cellulo” generation of fluorescent and bioactive probes. Overall, our r ...
DOI:
10.1021/jacs.9b00837

3. Cascade reaction including a formal [5 + 2] cycloaddition by use of alkyne-Co2(CO)6 complex

Author:
Sakata, Yuki; Yasui, Eiko; Mizukami, Megumi; Nagumo, Shinji
Source:
Tetrahedron letters 2019 v.60 no.11 pp. 755-759
ISSN:
0040-4039
Subject:
alcohols,   etc   ; chemical structure; cycloaddition reactions;     Show all 3 Subjects
Abstract:
... A new cascade reaction including formal [5 + 2] cycloaddition was developed. Treatment of homocinnamyl alcohol and Co2(CO)6-complexed arylpropynal with BF3·OEt2 resulted in the generation of hydrobenzocycloheptafuran having an alkyne-Co2(CO)6 complex. The reaction consists of 5-membered ring selective Prins cyclization and subsequent Friedel-Crafts cyclization. The cascade reaction was applied to ...
DOI:
10.1016/j.tetlet.2019.01.045

4. Adjustable pervaporation performance of Zr‐MOF/poly(vinyl alcohol) mixed matrix membranes

Author:
Wu, Guorong; Li, Yongliang; Geng, Yanzi; Lu, Xiaoyu; Jia, Zhiqian
Source:
Journal of chemical technology and biotechnology 2019 v.94 no.3 pp. 973-981
ISSN:
0268-2575
Subject:
polyvinyl alcohol,   etc   ; ethanol; permeability; pervaporation;     Show all 4 Subjects
Abstract:
... BACKGROUND: Polymer membranes often display trade‐off effects between permeation flux and separation factor in pervaporation, and exploring the strategies for breaking the effects is crucial. In this study, by altering the organic linkers (1,4‐benzenedicarboxylate acid, 2‐hydroxyterephthalic acid, 2,5‐dihydroxyterephthalic acid and biphenyl‐4,4‐dicarboxylate), UiO‐66, UiO‐66‐OH, UiO‐66‐(OH)₂ and U ...
DOI:
10.1002/jctb.5846

5. Sex differences in incentive motivation and the relationship to the development and maintenance of alcohol use disorders

Author:
Barker, Jacqueline M.; Taylor, Jane R.
Source:
Physiology & behavior 2019 v.203 pp. 91-99
ISSN:
0031-9384
Subject:
alcohol abuse; alcohol drinking; alcohols,   etc   ; animal models; behavior disorders; drugs; gender differences; humans; males; men; motivation; risk; women;     Show all 13 Subjects
Abstract:
... Despite considerable evidence of higher rates of alcohol use disorders (AUDs) in men than in women, there is a dearth of research into the underlying causes of this disparity. As the gap in high risk drinking between men and women closes, it is critical to disentangle the biological factors that may place men and women at different risk for the development of AUDs as well as AUD-associated health ...
DOI:
10.1016/j.physbeh.2017.09.027

6. Kinetic inhibition effect of Type I and III antifreeze proteins on unidirectional tetrahydrofuran hydrate crystal growth

Author:
Muraoka, Michihiro; Ohtake, Michika; Yamamoto, Yoshitaka
Source:
RSC advances 2019 v.9 no.20 pp. 11530-11537
ISSN:
2046-2069
Subject:
polyvinyl alcohol,   etc   ; antifreeze proteins; crystals; polyvinylpyrrolidone; tetrahydrofuran;     Show all 5 Subjects
Abstract:
... Experiments were performed to evaluate the kinetic inhibition effect of Type I and Type III antifreeze proteins (AFPs), polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) on the growth of tetrahydrofuran (THF) clathrate hydrate crystals using the unidirectional growth technique. The crystal growth interface shifted under an applied temperature gradient over a given time. Type I AFP was the mos ...
DOI:
10.1039/c9ra00627c

7. Enantioselective syntheses of (E)-γ,δ-disubstituted homoallylic alcohols via BF3·OEt2-catalyzed aldehyde allylboration and analysis of the origin of E-selectivity: A1,2 allylic strain vs. syn-pentane interaction

Author:
Liu, Jiaming; Gao, Shang; Chen, Ming
Source:
Tetrahedron 2019
ISSN:
0040-4020
Subject:
alcohols,   etc   ; boron; catalysts; chemical reactions; enantioselectivity; moieties;     Show all 6 Subjects
Abstract:
... Enantioselective allylboration of aldehydes with α-substituted β-methyl allylboronate was reported. By using BF3·OEt2 as the catalyst, γ,δ-disubstituted homoallylic alcohols were obtained in good yields with high E-selectivities and enantioselectivities. Transition state analysis revealed that the disfavored transition state suffers from a syn-pentane interaction between the BF3 catalyst and axial ...
DOI:
10.1016/j.tet.2019.04.019

8. Electrochemical Semipinacol Rearrangements of Allylic Alcohols: Construction of All-Carbon Quaternary Stereocenters

Author:
Kang, Jun-Chen; Tu, Yong-Qiang; Dong, Jia-Wei; Chen, Chao; Zhou, Jia; Ding, Tong-Mei; Zai, Jian-Tao; Chen, Zhi-Min; Zhang, Shu-Yu
Source:
Organic letters 2019 v.21 no.8 pp. 2536-2540
ISSN:
1523-7052
Subject:
alcohols,   etc   ; chemical structure; electrochemistry; ketones; sulfonylation;     Show all 5 Subjects
Abstract:
... The first examples of electrochemical trifluoromethylation and sulfonylation/semipinacol rearrangements of allylic alcohols were developed using cheap and stable RSO₂Na (R = CF₃, Ph) as reagents. Various β-trifluoromethyl and sulfonated ketones were obtained in moderate to excellent yields. This strategy provides a facile, direct, and complementary approach to construct all-carbon quaternary stere ...
DOI:
10.1021/acs.orglett.9b00263

9. Reprint of: Acid-mediated four-component tandem cyclization: Access to multifused 1,3-benzoxazine frameworks

Author:
Wang, Jungang; Zhou, Rongrong; Zhuang, Shiyi; Wu, Anxin
Source:
Tetrahedron 2019 v.75 no.12 pp. 1590-1596
ISSN:
0040-4020
Subject:
alcohols,   etc   ; chemical bonding; chemical structure; cyclization reactions;     Show all 4 Subjects
Abstract:
... An acid-mediated multicomponent reaction has been developed for the direct synthesis of multifused 1,3-benzoxazine derivatives from simple and readily available arylglyoxal monohydrates and 2-aminobenzyl alcohols under mild conditions. This novel protocol is proposed to proceed through intramolecular poly-heterocyclizations, thus leading to the formation of three new rings and six new chemical bon ...
DOI:
10.1016/j.tet.2019.02.058

10. Cobalt(II)–catalyzed C8H alkoxylation of 1-naphthylamine derivatives with alcohols

Author:
Zhang, Tingfang; Zhu, Hongmei; Yang, Fan; Wu, Yusheng; Wu, Yangjie
Source:
Tetrahedron 2019 v.75 no.11 pp. 1541-1547
ISSN:
0040-4020
Subject:
alcohols,   etc   ; chemical reactions; cobalt; moieties; protocols; regioselectivity;     Show all 6 Subjects
Abstract:
... An efficient protocol for cobalt (II)-catalyzed regioselective aryl C8H bond alkoxylation of 1-naphthylamine derivatives with readily available alcohols has been developed, demonstrating an efficient approach to 8-alkoxy-1-naphthylamine derivatives with good functional group tolerance. Note that the picolinamide moiety as a bidentate directing group may play a key role in this regioselective trans ...
DOI:
10.1016/j.tet.2019.02.002

11. Total Synthesis of (-)-Haploscleridamine

Author:
Singha Roy, Moumita; Meng, Xiaofeng; Koda, Karuna; Rasapalli, Sivappa; Gout, Delphine; Lovely, Carl J.
Source:
Tetrahedron letters 2019
ISSN:
0040-4039
Subject:
alcohols,   etc   ; alkaloids; chemical reactions; histidine; moieties;     Show all 5 Subjects
Abstract:
... Asymmetric total synthesis of the imidazole containing β–carboline natural product, haploscleridamine, from histidine is described. Key to the successful assembly of this alkaloid is a ring-closing metathesis reaction of an imidazole derived allylic alcohol to construct a 3-piperidinone. Application of the Buchwald-modification of the classical Fischer indolization and deprotection of the N-tosyl ...
DOI:
10.1016/j.tetlet.2019.03.004

12. Solvent-free lipase-catalyzed production of (meth)acrylate monomers: Experimental results and kinetic modeling

Author:
Heeres, Arjan; Vanbroekhoven, Karolien; Van Hecke, Wouter
Source:
Biochemical engineering journal 2019 v.142 pp. 162-169
ISSN:
1369-703X
Subject:
alcohols,   etc   ; boiling; esters; methylmethacrylate; models; reaction kinetics;     Show all 6 Subjects
Abstract:
... This paper gives detailed insight in the solventless synthesis of (meth)acrylate esters catalysed by Novozym 435 with a focus on the quantitative understanding of the reaction kinetics. The (meth)acrylate esters were formed from various (heavy boiling) alcohols by applying methyl (meth)acrylate in excess. Attractive ester titers were obtained (up to 800 g.kg−1 for citronellyl acrylate) combined wi ...
DOI:
10.1016/j.bej.2018.11.011

13. Preparation of 2′-Deoxy-2′-spirocyclopropylcytidine via an Alternative Cyclopropanation Reaction

Author:
Lemaire, Sébastien; Diène, Coura; Gavryushin, Andrei; Du Jourdin, Xavier Mollat; Paolini, Léa; Jusseau, Xavier; Knochel, Paul; Farina, Vittorio
Source:
Journal of organic chemistry 2019 v.84 no.8 pp. 4910-4914
ISSN:
1520-6904
Subject:
alcohols,   etc   ; cyclization reactions; moieties; organic chemistry; uracil;     Show all 5 Subjects
Abstract:
... Herein we report the preparation of 2′-deoxy-2′-spirocyclopropylcytidine via an alternative cyclopropanation reaction starting from γ-silyl tertiary alcohols. Activation of the hydroxyl function with thionyl chloride in the presence of 4-DMAP allows the ring-closing step under mild conditions. Participation of the uracil moiety in the cyclization step is proposed. ...
DOI:
10.1021/acs.joc.8b02784

14. Enantioselective iridium-catalyzed carbonyl isoprenylation via alcohol-mediated hydrogen transfer

Author:
XiangThese authors contributed equally to this work., Ming; Luo, Guoshun; Wang, Yuankai; Krische, Michael J.
Source:
Chemical communications 2019 v.55 no.7 pp. 981-984
ISSN:
1364-548X
Subject:
alcohols,   etc   ; aldehydes; allylation; enantioselectivity; hydrogen; iridium; terpenoids;     Show all 7 Subjects
Abstract:
... Highly enantioselective iridium catalyzed carbonyl (2-vinyl)allylation or “isoprenylation” is achieved via hydrogen auto-transfer or 2-propanol-mediated reductive coupling from primary alcohol or aldehyde reactants, respectively. Using this method, asymmetric total syntheses of the terpenoid natural products (+)-ipsenol and (+)-ipsdienol were achieved. ...
DOI:
10.1039/c8cc09706b

15. Optical resolution via catalytic generation of chiral auxiliary

Author:
Kiyama, Hiroki; Inokuma, Tsubasa; Kuroda, Yusuke; Yamaoka, Yousuke; Takasu, Kiyosei; Yamada, Ken-ichi
Source:
Tetrahedron letters 2019 v.60 no.2 pp. 175-177
ISSN:
0040-4039
Subject:
alcohols,   etc   ; enantiomers; gel chromatography; hydrolysis; imines;     Show all 5 Subjects
Abstract:
... A new catalytic method for separating enantiomers of racemic compounds is proposed. Catalytic asymmetric addition of racemic trans-2-substituted cyclohexanols to imines provided diastereomeric mixtures of aminals, and the subsequent separation of the enantiomers by silica-gel column chromatography and the hydrolysis of the aminals produced the alcohols in an optically active form. ...
DOI:
10.1016/j.tetlet.2018.12.006

16. Biomaterials of PVA and PVP in medical and pharmaceutical applications: Perspectives and challenges

Author:
Teodorescu, Mirela; Bercea, Maria; Morariu, Simona
Source:
Biotechnology advances 2019 v.37 no.1 pp. 109-131
ISSN:
0734-9750
Subject:
polyvinyl alcohol,   etc   ; biocompatible materials; mixing; synergism;     Show all 4 Subjects
Abstract:
... Poly(vinyl alcohol) (PVA) has attracted considerable research interest and is recognized among the largest volume of synthetic polymers that have been produced worldwide for almost one century. This is due to its exceptional properties which dictated its extensive use in a wide variety of applications, especially in medical and pharmaceutical fields. However, studies revealed that PVA-based biomat ...
DOI:
10.1016/j.biotechadv.2018.11.008

17. The first chemoenzymatic total synthesis of the phytotoxic nonenolide putaminoxin and its (5S,6E,9S)-diastereomer

Author:
Dickmann, David; Diekmann, Martin; Holec, Claudia; Pietruszka, Jörg
Source:
Tetrahedron 2019 v.75 no.6 pp. 689-696
ISSN:
0040-4020
Subject:
alcohol dehydrogenase; alcohols,   etc   ; chemical reactions; chemical structure; enzymatic treatment; nuclear magnetic resonance spectroscopy; phytotoxicity; spectral analysis;     Show all 8 Subjects
Abstract:
... The limitations of an alcohol dehydrogenase regarding the oxidative kinetic resolution of homoallylic alcohol containing alkyl chains were investigated, leading to a valuable building block for the total synthesis of phytotoxic nonenolide putaminoxin. The enzymatic approach towards the enantioenriched homoallylic alcohol was compared to classical, nonenzymatic approaches using asymmetric reagent c ...
DOI:
10.1016/j.tet.2018.12.027

18. Low-temperature catalytic hydrogenation of bio-based furfural and relevant aldehydes using cesium carbonate and hydrosiloxane

Author:
Long, Jingxuan; Zhao, Wenfeng; Xu, Yufei; Wu, Weibo; Fang, Chengjiang; Li, Hu; Yang, Song
Source:
RSC advances 2019 v.9 no.6 pp. 3063-3071
ISSN:
2046-2069
Subject:
alcohols; furfuryl alcohol,   etc   ; activation energy; carbonates; catalysts; cesium; furfural; hydrides; hydrogen; hydrogenation; silane;     Show all 11 Subjects
Abstract:
... Selective hydrogenation of unsaturated compounds is mainly carried out by using high-pressure hydrogen in the presence of a precious or transition metal catalyst. Here, we describe a benign approach to efficiently catalyze the hydrogenation of furfural (FUR) to furfuryl alcohol (FFA) over commercially available cesium carbonate using nontoxic and cheap polymethylhydrosiloxane (PMHS) as hydrogen so ...
DOI:
10.1039/c8ra08616h

19. Kinetic profiles of the stereoselective reduction of acetophenone and its derivatives promoted by Galactomyces candidus GZ1. A mechanistic interpretation

Author:
Decarlini, María F.; Bordón, Daniela L.; Vázquez, Ana M.; Demmel, Gabriela I.; Rossi, Laura I.; Aimar, Mario L.
Source:
Biocatalysis and agricultural biotechnology 2019 v.17 pp. 7-14
ISSN:
1878-8181
Subject:
alcohol dehydrogenase; alcohol oxidase,   etc   ; Galactomyces; acetophenones; anaerobic conditions; biocatalysts; oxygen; stereoselectivity;     Show all 8 Subjects
Abstract:
... A mechanistic interpretation of the kinetic profiles obtained for the stereoselective reduction of acetophenone promoted by Galactomyces candidus GZ1 under aerobic and anaerobic conditions was made. Based on experimental and bibliographical data, a mechanism which may involve the participation of two alcohol dehydrogenases with opposite stereoselectivities and alcohol oxidase is discussed. Due to ...
DOI:
10.1016/j.bcab.2018.10.010

20. Expression of engineered carbonyl reductase from Ogataea minuta in Rhodococcus opacus and its application to whole-cell bioconversion in anhydrous solvents

Author:
Honda, Kohsuke; Ono, Tomohiro; Okano, Kenji; Miyake, Ryoma; Dekishima, Yasumasa; Kawabata, Hiroshi
Source:
Journal of bioscience and bioengineering 2019 v.127 no.2 pp. 145-149
ISSN:
1389-1723
Subject:
alcohol dehydrogenase; benzyl alcohol; isopropyl alcohol,   etc   ; Ogataea; Rhodococcus opacus; Thermoanaerobacter ethanolicus; biocatalysts; biotransformation; directed evolution; drugs; ketones; lipophilicity; manufacturing; mutants; solvents; yeasts;     Show all 16 Subjects
Abstract:
... The carbonyl reductase from the methylotrophic yeast Ogataea minuta can catalyze the regio- and enantio-selective reduction of prochiral ketones to chiral alcohols, and is available for industrial manufacturing of statin drugs. We previously conducted a directed evolution experiment of the enzyme, and obtained a mutant (OCR_V166A) with improved tolerance to organic solvents. This expanded the appl ...
DOI:
10.1016/j.jbiosc.2018.07.011