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1. All Ways Lead to Rome—Meiotic Stabilization Can Take Many Routes in Nascent Polyploid Plants

Author:
Adrián Gonzalo
Source:
Genes 2022 v.13 no.1 pp. -
ISSN:
2073-4425
Subject:
aneuploidy,   etc   ; allopolyploidy; coevolution; diploidy; epigenetics; fractionation; meiosis; mutation;     Show all 8 Subjects
Abstract:
... Newly formed polyploids often show extensive meiotic defects, resulting in aneuploid gametes, and thus reduced fertility. However, while many neopolyploids are meiotically unstable, polyploid lineages that survive in nature are generally stable and fertile; thus, those lineages that survive are those that are able to overcome these challenges. Several genes that promote polyploid stabilization are ...
DOI:
10.3390/genes13010147

2. Detection of Chromosomal Aneuploidies in Human Blastomeres Using FISH Increases the Success of IVF by Improving the Chances of Embryo Progress to Delivery

Author:
A. Semikhodskii; M. Ismayilova
Source:
Cytology and genetics 2022 v.56 no.3 pp. 209-217
ISSN:
0095-4527
Subject:
aneuploidy,   etc   ; autosomes; birth rate; blastomeres; fish; humans; polyploidy;     Show all 7 Subjects
Abstract:
... The efficiency of PGT-A have been studied in patients with previous IVF failure, recurrent pregnancy loss, idiopathic infertility and infertility due to other causes. More than 50% of all embryos produced in four experimental and one control groups were found to be aneuploid. Aneuploidies of autosomes 15 and 18 and of both sex chromosomes were the ones most frequently observed. Most aneuploidies w ...
DOI:
10.3103/S0095452722030124

3. Single-cell Sequencing Reveals Clearance of Blastula Chromosomal Mosaicism in In Vitro Fertilization Babies

Author:
Yuan Gao; Jinning Zhang; Zhenyu Liu; Shuyue Qi; Xinmeng Guo; Hui Wang; Yanfei Cheng; Shuang Tian; Minyue Ma; Hongmei Peng; Lu Wen; Fuchou Tang; Yuanqing Yao
Source:
Genomics, proteomics & bioinformatics 2022 pp. -
ISSN:
1672-0229
Subject:
aneuploidy,   etc   ; biopsy; chromosomes; genomics; karyotyping; multiomics; polyploidy; proteomics; sequence analysis; transcriptomics;     Show all 10 Subjects
Abstract:
... Although chromosomal mosaic embryos detected by trophectoderm (TE) biopsy offer healthy embryos available for transfer, high-resolution postnatal karyotyping and chromosome testing of the transferred embryos are insufficient. Here, we applied single-cell multi-omics sequencing for seven infants with blastula chromosomal mosaicism detected by TE biopsy. The chromosome ploidy was examined by single- ...
DOI:
10.1016/j.gpb.2022.07.004

4. WDR62 regulates mouse oocyte meiotic maturation related to p-JNK and H3K9 trimethylation

Author:
Yong-Sheng Wang; Chao Chen; Muhammad Jamil Ahmad; Fan Chen; Zhi-Ming Ding; Sheng-Ji Yang; Yang-Wu Chen; Ze-Qun Duan; Ming Liu; Ai-Xin Liang; Chang-Jiu He; Guo-Hua Hua; Li-Jun Huo
Source:
international journal of biochemistry & cell biology 2022 v.144 pp. 106169
ISSN:
1357-2725
Subject:
aneuploidy,   etc   ; biogenesis; centrioles; chromosomes; cytokinesis; meiosis; mice; mitotic spindle apparatus; oocytes;     Show all 9 Subjects
Abstract:
... WDR62 (WD40-repeat protein 62) participates in diverse biological process, especially mitotic spindle organization via regulating centriole biogenesis and the function of centriole-associated protein. However, the role of WDR62 exerts in spindle assembly and meiotic progression control in oocytes lacking typical centrosomes remains obscure. In a previous study, we reported that WDR62 is involved i ...
DOI:
10.1016/j.biocel.2022.106169

5. microRNAs in the blastocoel fluid as accessible indicators of chromosomal normality

Author:
Masoumeh Esmaeilivand; Amir Fattahi; Ali Abedelahi; Kobra Hamdi; Laya Farzadi; Sepide Goharitaban; Behrooz Niknafs
Source:
Reproductive Biology 2022 v.22 no.4 pp. 100695
ISSN:
1642-431X
Subject:
aneuploidy,   etc   ; biomarkers; blastocyst; embryo implantation; microRNA; polyploidy; quantitative polymerase chain reaction;     Show all 7 Subjects
Abstract:
... MicroRNAs (miRNAs) derived from the pre-implantation blastocoel fluid (BF) have attracted interest as accessible biomarkers indicative of embryonic health in ongoing IVF cycles. Therefore, we investigated expression levels of some aneuploidy-associated miRNAs and implantation-related mRNAs as predictive markers for embryo chromosomal normality. In this study, the BF of 25 blastocysts that had been ...
DOI:
10.1016/j.repbio.2022.100695

6. Next Generation Sequencing after Invasive Prenatal Testing in Fetuses with Congenital Malformations: Prenatal or Neonatal Investigation

Author:
Alexandra Emms; James Castleman; Stephanie Allen; Denise Williams; Esther Kinning; Mark Kilby
Source:
Genes 2022 v.13 no.9 pp. -
ISSN:
2073-4425
Subject:
aneuploidy,   etc   ; cohort studies; edema; etiology; genome; heart diseases; karyotyping; microarray technology; ultrasonics;     Show all 9 Subjects
Abstract:
... Congenital malformations diagnosed by ultrasound screening complicate 3–5% of pregnancies and many of these have an underlying genetic cause. Approximately 40% of prenatally diagnosed fetal malformations are associated with aneuploidy or copy number variants, detected by conventional karyotyping, QF-PCR and microarray techniques, however monogenic disorders are not diagnosed by these tests. Next g ...
DOI:
10.3390/genes13091517

7. The characteristics of abnormal meiosis and functional aneuploid pollen of odd-allotetraploid lily ‘Honesty’ unveiled using in situ hybridization

Author:
Kongzhong Xiao; Ziyu Zhu; Ni Zou; Lu Zhang; Yanni Sun; Shujun Zhou
Source:
Scientia horticulturae 2022 v.300 pp. 111091
ISSN:
0304-4238
Subject:
aneuploidy,   etc   ; anaphase; chromatids; chromosome pairing; hybridization; meiosis; metaphase; microsporogenesis; pollen; pollen germination; tetraploidy;     Show all 11 Subjects
Abstract:
... Odd-allotetraploid lilies, like LAAA, have abnormal meiosis, but there are few reports on the characteristics of their chromosomal behavior and functional pollen. This study analyzed an odd-allotetraploid lily, ‘Honesty’ (LAAA), for its microsporogenesis and functional aneuploid pollen grains using cytogenetic methods together with hybridization. Its microsporogenesis showed that, (1) the homo(eo) ...
DOI:
10.1016/j.scienta.2022.111091

8. Intraoperative Flow Cytometry for the Characterization of Gynecological Malignancies

Author:
Zoi Anastasiadi; Stefania Mantziou; Christos Akrivis; Minas Paschopoulos; Eufemia Balasi; Georgios D. Lianos; George A. Alexiou; Michail Mitsis; George Vartholomatos; Georgios S. Markopoulos
Source:
Biology 2022 v.11 no.9 pp. -
ISSN:
2079-7737
Subject:
aneuploidy,   etc   ; DNA; cell cycle; dissection; endometrium; flow cytometry; lymph nodes; neoplasms; prognosis; surgery;     Show all 10 Subjects
Abstract:
... Cell-cycle analysis has shown the presence of aneuploidy to be associated with poor prognosis. We developed an innovative rapid cell-cycle analysis protocol (the Ioannina protocol) that permitted the intraoperative identification of neoplastic cells in a plethora of malignancies. Herein, we aimed to investigate the potential role of cell-cycle analysis in the intraoperative characterization of gyn ...
DOI:
10.3390/biology11091339

9. The multifaceted role of micronuclei in tumour progression: A whole organism perspective.

Author:
Molly Guscott; Akash Saha; Jovanna Maharaj; Sarah E. McClelland
Source:
international journal of biochemistry & cell biology 2022 v.152 pp. 106300
ISSN:
1357-2725
Subject:
aneuploidy,   etc   ; chromatin; chromosomal instability; chromosome number; chromosome segregation; genome; metastasis; neoplasm progression; neoplasms;     Show all 9 Subjects
Abstract:
... Within most tumour types, cancerous cells exist in a state of aneuploidy, an incorrect chromosome number or structure. Additionally, tumour cells frequently exhibit chromosomal instability; the ongoing loss or gain of whole or parts of chromosomes during cell division. Chromosomal instability results in a high rate of chromosome segregation defects, and a constantly changing genomic landscape. A s ...
DOI:
10.1016/j.biocel.2022.106300

10. Production and cytology of Brassica autoallohexaploids with two and four copies of two subgenomes

Author:
Bowei Cai; Tai Wang; Fang Yue; Arrashid Harun; Bin Zhu; Wei Qian; Xianhong Ge; Zaiyun Li
Source:
Theoretical and applied genetics 2022 v.135 no.8 pp. 2641-2653
ISSN:
0040-5752
Subject:
aneuploidy,   etc   ; Brassica; allotetraploidy; chromosomes; diploidy; evolution; fish; fluorescence; genome; germplasm; interspecific hybridization; meiosis; pollen;     Show all 13 Subjects
Abstract:
... KEY MESSAGE: Different digenomic Brassica autoallohexaploids were produced from the crosses of three allotetraploids and ancestral diploids and characterized for the cytological behavior of two subgenomes with two and four copies. Interspecific hybridization and allopolyploidization present an important pathway for plant evolution and breeding. In this study, different types of digenomic autoalloh ...
DOI:
10.1007/s00122-022-04136-6

11. Kinesin KIF15 regulates tubulin acetylation and spindle assembly checkpoint in mouse oocyte meiosis

Author:
Yuan-Jing Zou; Meng-Meng Shan; Xiang Wan; Jing-Cai Liu; Kun-Huan Zhang; Jia-Qian Ju; Chun-Hua Xing; Shao-Chen Sun
Source:
Cellular and molecular life sciences 2022 v.79 no.8 pp. 422
ISSN:
1420-682X
Subject:
aneuploidy,   etc   ; acetylation; embryogenesis; kinesin; kinetochores; mass spectrometry; meiosis; mice; microtubules; mitosis; oocytes; precipitin tests; tubulin;     Show all 13 Subjects
Abstract:
... Microtubule dynamics ensure multiple cellular events during oocyte meiosis, which is critical for the fertilization and early embryo development. KIF15 (also termed Hklp2) is a member of kinesin-12 family motor proteins, which participates in Eg5-related bipolar spindle formation in mitosis. In present study, we explored the roles of KIF15 in mouse oocyte meiosis. KIF15 expressed during oocyte mat ...
DOI:
10.1007/s00018-022-04447-3

12. Meiosis in allopolyploid Arabidopsis suecica

Author:
Candida Nibau; Adrián Gonzalo; Aled Evans; William Sweet‐Jones; Dylan Phillips; Andrew Lloyd
Source:
plant journal 2022 v.111 no.4 pp. 1110-1122
ISSN:
0960-7412
Subject:
aneuploidy,   etc   ; Arabidopsis thaliana; allopolyploidy; anaphase; autotetraploidy; chromosome segregation; chromosomes; diploidy; eukaryotic cells; evolution; meiosis; metaphase;     Show all 12 Subjects
Abstract:
... Polyploidy is a major force shaping eukaryote evolution but poses challenges for meiotic chromosome segregation. As a result, first‐generation polyploids often suffer from more meiotic errors and lower fertility than established wild polyploid populations. How established polyploids adapt their meiotic behaviour to ensure genome stability and accurate chromosome segregation remains an active resea ...
DOI:
10.1111/tpj.15879

13. Micronucleus formation during early cleavage division is a potential hallmark of preimplantation embryonic loss in cattle

Author:
Tatsuma Yao; Akane Ueda; Atchalalt Khurchabilig; Daisuke Mashiko; Mikiko Tokoro; Hiroki Nagai; Tei Sho; Satoko Matoba; Kazuo Yamagata; Satoshi Sugimura
Source:
Biochemical and biophysical research communications 2022 v.617 pp. 25-32
ISSN:
0006-291X
Subject:
aneuploidy,   etc   ; assisted reproductive technologies; blastocyst; chromosome segregation; embryogenesis; embryonic mortality; histones; livestock production; progeny; research;     Show all 10 Subjects
Abstract:
... In assisted reproductive technology (ART)-derived embryos of non-rodent mammals, including humans and cattle, chromosome segregation errors are highly likely to occur during early cleavage division, resulting in aneuploidy, including mosaicism. However, the relationship between chromosomal segregation errors during early cleavage and subsequent embryonic development has not been detailed in these ...
DOI:
10.1016/j.bbrc.2022.05.075

14. Effect of aneuploidy of a non‐essential chromosome on gene expression in maize

Author:
Xiaowen Shi; Hua Yang; Chen Chen; Jie Hou; Tieming Ji; Jianlin Cheng; James A. Birchler
Source:
plant journal 2022 v.110 no.1 pp. 193-211
ISSN:
0960-7412
Subject:
aneuploidy,   etc   ; Zea mays; corn; dose response; gene dosage; gene expression; gene expression regulation; leaves; microRNA;     Show all 9 Subjects
Abstract:
... The non‐essential supernumerary maize (Zea mays) B chromosome (B) has recently been shown to contain active genes and to be capable of impacting gene expression of the A chromosomes. However, the effect of the B chromosome on gene expression is still unclear. In addition, it is unknown whether the accumulation of the B chromosome has a cumulative effect on gene expression. To examine these questio ...
DOI:
10.1111/tpj.15665

15. Octocrylene exposure impairs mouse oocyte quality by inducing spindle defects and mitochondria dysfunction

Author:
Haoya Chang; Jian Li; Chunhui Zhang; Weiping Qian
Source:
Toxicology 2022 v.479 pp. 153306
ISSN:
0300-483X
Subject:
aneuploidy,   etc   ; Oryzias latipes; apoptosis; chromosomes; extrusion; food chain; germinal vesicle; meiosis; mice; mitochondria; reproductive toxicology; sediments; soil; spermatozoa;     Show all 14 Subjects
Abstract:
... One of organic ultraviolet (UV) filters, Octocrylene (OCL), is mainly used in various cosmetic products, which is being frequently detected in soil, sediment, aquatic systems and food chain. There is evidence confirmed the reproductive toxicity of OCL in Japanese medaka. However, less was known about the effects of OCL exposure on oocyte quality. Here, we investigated the impacts of OCL on mouse o ...
DOI:
10.1016/j.tox.2022.153306

16. Replication stress impairs chromosome segregation and preimplantation development in human embryos

Author:
Katherine L. Palmerola; Selma Amrane; Alejandro De Los Angeles; Shuangyi Xu; Ning Wang; Joao de Pinho; Michael V. Zuccaro; Angelo Taglialatela; Dashiell J. Massey; Jenna Turocy; Alex Robles; Anisa Subbiah; Bob Prosser; Rogerio Lobo; Alberto Ciccia; Amnon Koren; Timour Baslan; Dieter Egli
Source:
Cell 2022 v.185 no.16 pp. 2988-3007.e20
ISSN:
0092-8674
Subject:
aneuploidy,   etc   ; DNA damage; DNA replication; chromosome breakage; chromosome segregation; chromosomes; developmental stages; humans; interphase; mitosis; transcription (genetics);     Show all 11 Subjects
Abstract:
... Human cleavage-stage embryos frequently acquire chromosomal aneuploidies during mitosis due to unknown mechanisms. Here, we show that S phase at the 1-cell stage shows replication fork stalling, low fork speed, and DNA synthesis extending into G2 phase. DNA damage foci consistent with collapsed replication forks, DSBs, and incomplete replication form in G2 in an ATR- and MRE11-dependent manner, fo ...
DOI:
10.1016/j.cell.2022.06.028

17. Toxic effects of 4-methylimidazole on the maturation and fertilization of mouse oocytes

Author:
Yajuan Lu; Hanyu Tang; Junjie Xu; Fei Sun
Source:
Food and chemical toxicology 2022 v.164 pp. 113051
ISSN:
0278-6915
Subject:
aneuploidy,   etc   ; body weight; carcinogenesis; cell death; females; humans; meiosis; mice; mitochondria; oocytes; reactive oxygen species; reproductive toxicology; toxicity;     Show all 13 Subjects
Abstract:
... Individuals of all ages, including children and teenagers, consume 4-methylimidazole (4-MI) in their food. 4-MI is a caramel-colored waste product that has previously been linked to human carcinogenesis and has shown possible signs of reproductive toxicity. This study aimed to determine whether 4-MI is harmful to oocytes during meiosis and fertilization. Female mice were intragastrically administe ...
DOI:
10.1016/j.fct.2022.113051

18. Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq

Author:
Joseph M. Replogle; Reuben A. Saunders; Angela N. Pogson; Jeffrey A. Hussmann; Alexander Lenail; Alina Guna; Lauren Mascibroda; Eric J. Wagner; Karen Adelman; Gila Lithwick-Yanai; Nika Iremadze; Florian Oberstrass; Doron Lipson; Jessica L. Bonnar; Marco Jost; Thomas M. Norman; Jonathan S. Weissman
Source:
Cell 2022 v.185 no.14 pp. 2559-2575.e28
ISSN:
0092-8674
Subject:
aneuploidy,   etc   ; RNA; biogenesis; dissection; genes; genomics; genotype-phenotype correlation; humans; mitochondria; mitochondrial genome; phenotype; ribosomes; sequence analysis; transcription (genetics);     Show all 14 Subjects
Abstract:
... A central goal of genetics is to define the relationships between genotypes and phenotypes. High-content phenotypic screens such as Perturb-seq (CRISPR-based screens with single-cell RNA-sequencing readouts) enable massively parallel functional genomic mapping but, to date, have been used at limited scales. Here, we perform genome-scale Perturb-seq targeting all expressed genes with CRISPR interfe ...
DOI:
10.1016/j.cell.2022.05.013

19. Two ploidy levels present in the invasive Campuloclinium macrocephalum (pompom weed) in South Africa – Implications for biocontrol

Author:
Lucy N. Gitonga; Glynis V. Cron; Kelsey L. Glennon; Andrew J. McConnachie; Marcus J. Byrne
Source:
Weed research 2022 v.62 no.1 pp. 59-67
ISSN:
0043-1737
Subject:
aneuploidy,   etc   ; Campuloclinium macrocephalum; biological control; coevolution; cytotypes; diploidy; flow cytometry; oviposition; phenotypic variation; research; tetraploidy; triploidy; weeds; Argentina; South Africa;     Show all 15 Subjects
Abstract:
... The highly invasive Campuloclinium macrocephalum (Asteraceae; ‘pompom weed’), native to South America, was introduced to South Africa where it has flourished and now threatens the native diversity of the grasslands it has invaded. The Argentine C. macrocephalum population is known to comprise at least three ploidy levels, and exhibit aneuploidy. Ploidy levels had not yet been assessed across South ...
DOI:
10.1111/wre.12513

20. Insights into Species Delimitation of Selected Species in the Flowering Plant Genus Medicago Section Buceras (Leguminosae)

Author:
Julia E. Steier; Terezie Mandáková; Martin F. Wojciechowski; Kelly P. Steele
Source:
Systematic botany 2022 v.47 no.2 pp. 431-440
ISSN:
0363-6445
Subject:
aneuploidy,   etc   ; Medicago sativa; Medicago truncatula; Trigonella; alfalfa; chromosome number; chromosomes; forage crops; genetic variation; genome; genomics; models; paraphyly; polyploidy;     Show all 14 Subjects
Abstract:
... The genus Medicago (Leguminosae, Papilionoideae) contains about 90 species including the important forage crop alfalfa Medicago sativa and the genomic model Medicago truncatula. Despite intensive research on the genus because of its agricultural importance, there is a relative lack of information about chromosome number and genome size in some Medicago species, especially those from Medicago secti ...
DOI:
10.1600/036364422X16512564801533