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You searched for: Subject "angiogenesis" Remove constraint Subject: "angiogenesis"
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1. Anti-angiogenic carbon nanovesicles loaded with bevacizumab for the treatment of age-related macular degeneration

Author:
Anisha Anand; Hong-Jyuan Jian; Hao-Hsin Huang; Li Er Hean; Yu-Jia Li; Jui-Yang Lai; Hung-Da Chou; Yu-Chuan Kang; Wei-Chi Wu; Chi-Chun Lai; Chih-Ching Huang; Huan-Tsung Chang
Source:
Carbon 2023 v.201 pp. 362-370
ISSN:
0008-6223
Subject:
angiogenesis,   etc   ; antibodies; bioavailability; carbon; carbonization; cell proliferation; cost effectiveness; cytotoxicity; drugs; encapsulation; epithelium; macular degeneration; patients; rabbits; therapeutics; vascular endothelial growth factors; vision;     Show all 17 Subjects
Abstract:
... Intraocular angiogenesis mediated by vascular endothelial growth factor (VEGF) and the related ocular disease, age-related macular degeneration (AMD), is the leading cause of loss of vision worldwide. Though anti-VEGF antibodies are used to control AMD, administration of high doses or frequent dosing, and poor ocular retention of the drug adversely affect the patient outcomes. Herein, we report th ...
DOI:
10.1016/j.carbon.2022.09.045

2. Pigment epithelium-derived factor and its role in microvascular-related diseases

Author:
Yuzhuo Wang; Xiucheng Liu; Xiaoyu Quan; Xichun Qin; Yeqing Zhou; Zhiwei Liu; Zhixiang Chao; Caili Jia; Hao Qin; Hao Zhang
Source:
Biochimie 2022 v.200 pp. 153-171
ISSN:
0300-9084
Subject:
angiogenesis,   etc   ; blood; therapeutics;     Show all 3 Subjects
Abstract:
... Microvascular diseases are among the most clinically important diseases, and vascular abnormalities are central in the development of such diseases. Pigment epithelium-derived factor (PEDF), a potent inhibitor of angiogenesis, exerts antiangiogenic effects without affecting the structure and function of normal blood vessels. PEDF also has neurotrophic effects, which may be a potential direction fo ...
DOI:
10.1016/j.biochi.2022.05.019

3. Analysis of MSCs' secretome and EVs cargo: Evaluation of functions and applications

Author:
Valentina Urrata; Marco Trapani; Mara Franza; Francesco Moschella; Anna Barbara Di Stefano; Francesca Toia
Source:
Life sciences 2022 v.308 pp. 120990
ISSN:
0024-3205
Subject:
angiogenesis,   etc   ; bone formation; cytokines; epigenetics;     Show all 4 Subjects
Abstract:
... Mesenchymal stem cells (MSCs) can exert different functions and can be used in several medical fields. In the last years, MSC properties have been attributed to their secreted factors such as soluble proteins, cytokines and growth factors. Moreover, a key role is played by the extracellular vesicles (EVs) which lead a heterogeneous cargo of proteins, lipids and small and long non-coding RNAs that ...
DOI:
10.1016/j.lfs.2022.120990

4. Overcoming functional challenges in autologous and engineered fat grafting trends

Author:
Gretel S. Major; Jeremy W. Simcock; Tim B.F. Woodfield; Khoon S. Lim
Source:
Trends in biotechnology 2022 v.40 no.1 pp. 77-92
ISSN:
0167-7799
Subject:
angiogenesis,   etc   ; adipose tissue; biofabrication; resorption;     Show all 4 Subjects
Abstract:
... Autologous fat grafting offers significant promise for the repair of soft tissue deformities; however, high resorption rates indicate that engineered solutions are required to improve adipose tissue (AT) survival. Advances in material development and biofabrication have laid the foundation for the generation of functional AT constructs; however, a balance needs to be struck between clinically feas ...
DOI:
10.1016/j.tibtech.2021.04.006

5. Ginseng in vascular dysfunction: A review of therapeutic potentials and molecular mechanisms

Author:
He Zhang; Cheng Hu; Jiaojiao Xue; Di Jin; Lulu Tian; Daqing Zhao; Xiangyan Li; Wenxiu Qi
Source:
Phytotherapy research 2022 v.36 no.2 pp. 857-872
ISSN:
0951-418X
Subject:
angiogenesis,   etc   ; Panax; hypertension; metabolic syndrome; phytotherapy; research;     Show all 6 Subjects
Abstract:
... Vascular dysfunction can lead to a variety of fatal diseases, including cardiovascular and cerebrovascular diseases, metabolic syndrome, and cancer. Although a large number of studies have reported the therapeutic effects of natural compounds on vascular‐related diseases, ginseng is still the focus of research. Ginseng and its active substances have bioactive effects against different diseases wit ...
DOI:
10.1002/ptr.7369

6. Cerebrovasculature pumps up progenitors

Author:
Ryann M. Fame
Source:
Cell 2022 v.185 no.20 pp. 3645-3647
ISSN:
0092-8674
Subject:
angiogenesis,   etc   ; brain stem; humans; neurogenesis; stem cells;     Show all 5 Subjects
Abstract:
... Fetal human brain stem cell niches that contain multipotent neural progenitors are progressively vascularized during development. Crouch et al. (Crouch et al., 2022) report endothelial and mural lineage trajectories that build developing prenatal vascular in second trimester fetal brain. This cerebral angiogenesis in neural progenitor zones occurs simultaneously with and can promote neurogenesis. ...
DOI:
10.1016/j.cell.2022.09.014

7. Engineering Neutrophil Immunomodulatory Hydrogels Promoted Angiogenesis

Author:
Zehua Gao; Yuanman Yu; Kai Dai; Tingting Zhang; Luli Ji; Xuanlin Wang; Jing Wang; Changsheng Liu
Source:
ACS applied materials & interfaces 2022 v.14 no.35 pp. 39746-39758
ISSN:
1944-8252
Subject:
angiogenesis,   etc   ; gelatin; hydrogels; inflammation; ischemia; neutrophils; phenotype;     Show all 7 Subjects
Abstract:
... Timely restoration of blood supply following ischemia is critical to rescue damaged tissue. However, clinical efficacy is hampered by the inflammatory response after ischemia. Whether inflammation fine tunes the angiogenesis and the function of blood vessels via the heterogeneity of neutrophils remain poorly understood. Herein, the objective of this work is to incorporate the growth factors secret ...
DOI:
10.1021/acsami.2c08600

8. Angiogenesis goes computational – The future way forward to discover new angiogenic targets?

Author:
Abhishek Subramanian; Pooya Zakeri; Mira Mousa; Halima Alnaqbi; Fatima Yousif Alshamsi; Leo Bettoni; Ernesto Damiani; Habiba Alsafar; Yvan Saeys; Peter Carmeliet
Source:
Computational and Structural Biotechnology Journal 2022 v.20 pp. 5235-5255
ISSN:
2001-0370
Subject:
angiogenesis,   etc   ; biotechnology; endothelial cells; genes; multiomics; prioritization; surveys;     Show all 7 Subjects
Abstract:
... Multi-omics technologies are being increasingly utilized in angiogenesis research. Yet, computational methods have not been widely used for angiogenic target discovery and prioritization in this field, partly because (wet-lab) vascular biologists are insufficiently familiar with computational biology tools and the opportunities they may offer. With this review, written for vascular biologists who ...
DOI:
10.1016/j.csbj.2022.09.019

9. Mechanically active small intestinal submucosa hydrogel for accelerating chronic wound healing

Author:
Xiao-Ya Chen; Yi Wang; Shi-Qing Ma; Yi-Qian Huang; Wei Jing; Peng-Fei Wei; Xue-Qiao Yu; Bo Zhao
Source:
Journal of materials chemistry B 2022 v.10 no.33 pp. 6279-6286
ISSN:
2050-7518
Subject:
angiogenesis,   etc   ; bioactive properties; biocompatibility; hydrogels; immunomodulation; intestines; rats;     Show all 7 Subjects
Abstract:
... The treatment of chronic wounds is still a challenge worldwide. Here, inspired by mechanically induced embryonic wound healing, we design a mechanically active small intestinal submucosa based hydrogel (SIS-PNIPAm). The mechanical activity, biocompatibility, and bioactivity (angiogenesis and immunoregulation) of the SIS-PNIPAm hydrogel enable the fast healing of diabetic rat full-thickness wounds. ...
DOI:
10.1039/d2tb01355j

10. Applications of bone regeneration hydrogels in the treatment of bone defects: a review

Author:
Yukun Xiong; Yuzhu Xiong
Source:
Journal of materials science 2022 v.57 no.2 pp. 887-913
ISSN:
0022-2461
Subject:
angiogenesis,   etc   ; biocompatibility; bones; hydrogels; immune response; mineralization; osteoblasts;     Show all 7 Subjects
Abstract:
... Hydrogels can be designed as scaffolds in bone tissue engineering for more efficient healing of bone defects. Bone regeneration hydrogels have attracted extensive attention because of their good biocompatibility and excellent ability in promoting bone regeneration. This review will introduce the methods of bone regeneration hydrogels in the treatment of bone defects. Namely, promoting differentiat ...
DOI:
10.1007/s10853-021-06675-7

11. AAV expressing an mTOR‐inhibiting siRNA exhibits therapeutic potential in retinal vascular disorders by preserving endothelial integrity

Author:
Seho Cha; Won‐il Seo; Ha‐Na Woo; Hee Jong Kim; Steven Hyun Seung Lee; Jin Kim; Jun‐Sub Choi; Keerang Park; Joo Yong Lee; Beom Jun Lee; Heuiran Lee
Source:
FEBS Open Bio 2022 v.12 no.1 pp. 71-81
ISSN:
2211-5463
Subject:
angiogenesis,   etc   ; Dependoparvovirus; RNA; rapamycin; therapeutics; vascular endothelial growth factors;     Show all 6 Subjects
Abstract:
... Expanding on previous demonstrations of the therapeutic effects of adeno‐associated virus (AAV) carrying small‐hairpin RNA (shRNA) in downregulating the mechanistic target of rapamycin (mTOR) in in vivo retinal vascular disorders, vascular endothelial growth factor (VEGF)‐stimulated endothelial cells were treated with AAV2‐shmTOR to examine the role of mTOR inhibition in retinal angiogenesis. AAV2 ...
DOI:
10.1002/2211-5463.13281

12. Lipid nanoparticle-encapsulated VEGFa siRNA facilitates cartilage formation by suppressing angiogenesis

Author:
Yi Chen; Wei Chen; Yiming Ren; Shuling Li; Miao Liu; Jiahua Xing; Yudi Han; Youbai Chen; Ran Tao; Lingli Guo; Xiang Sui; Quanyi Guo; Shuyun Liu; Yan Han
Source:
International journal of biological macromolecules 2022 v.221 pp. 1313-1324
ISSN:
0141-8130
Subject:
angiogenesis,   etc   ; cartilage; hydrogels; lipids; microfluidic technology; nanoparticles; nose; oxygen;     Show all 8 Subjects
Abstract:
... Cartilage is an important tissue that is widely found in joints, ears, nose and other organs. The limited capacity to regenerate makes cartilage reconstruction an urgent clinical demand. Due to the avascular nature of cartilage, we hypothesized that inhibition of vascularization contributes to cartilage formation. Here, we used VEGFa siRNA to inhibit the infiltration of the local vascular system. ...
DOI:
10.1016/j.ijbiomac.2022.09.065

13. Biogenesis, classification, and role of LncRNAs in tumor angiogenesis: A focus on tumor and its neighbouring cells, and interaction with miRNAs

Author:
Selvaraj Vimalraj; Raghunandhakumar Subramanian
Source:
Process biochemistry 2022 v.122 pp. 347-355
ISSN:
1359-5113
Subject:
angiogenesis,   etc   ; biogenesis; metastasis; microRNA; neoplasms; nucleotides; therapeutics; transcription (genetics);     Show all 8 Subjects
Abstract:
... Angiogenesis is crucial for tumor development and metastasis. Regulation of tumor-associated angiogenesis appears to be a promising strategy for limiting the growth of tumours. The tumor microenvironment encompasses several signalling molecules and pathways that modulate angiogenesis including long non-coding RNAs (lncRNAs). LncRNAs are a group of endogenous RNAs that are longer than 200 nucleotid ...
DOI:
10.1016/j.procbio.2022.09.021

14. OI inhibits development of ovarian cancer by blocking crosstalk between cancer cells and macrophages via HIF-1α pathway

Author:
Zhiyan Zhan; Zhen Wang; Yiwen Bao; Wenxue Liu; Li Hong
Source:
Biochemical and biophysical research communications 2022 v.606 pp. 142-148
ISSN:
0006-291X
Subject:
angiogenesis,   etc   ; macrophages; metastasis; ovarian neoplasms; research; survival rate; therapeutics;     Show all 7 Subjects
Abstract:
... Intraperitoneal implantation of ovarian cancer (OC) decreases the survival rate in clinical practice. However, there are still great deficiencies in the therapeutic strategies of inhibiting the metastasis of OC. Here, we showed that 4-octyl itaconate (OI, a cell-permeable itaconate derivative) treatment didn't influence the development of OC in vitro. Instead, OI treatment repressed the activation ...
DOI:
10.1016/j.bbrc.2022.03.106

15. Tumor-derived exosomal lincRNA ROR promotes angiogenesis in nasopharyngeal carcinoma

Author:
Siyu Zhang; Jing Cai; Yan Ji; Shengkai Zhou; Mengyu Miao; Rui Zhu; Keying Li; Ziyi Xue; Songqun Hu
Source:
Molecular and cellular probes 2022 pp. 101868
ISSN:
0890-8508
Subject:
angiogenesis,   etc   ; Danio rerio; blood serum; carcinoma; exosomes; models; therapeutics;     Show all 7 Subjects
Abstract:
... Long intergenic noncoding RNAs (lincRNAs) are expressed aberrantly in several malignancies, including nasopharyngeal carcinoma (NPC), where linc-ROR expression was found to be elevated. Being a hallmark of malignant tumors, angiogenesis has prompted us to investigate the impact of linc-ROR on NPC angiogenesis. This study demonstrates that linc-ROR is substantially expressed in serum exosomes from ...
DOI:
10.1016/j.mcp.2022.101868

16. Manufacturing functional hydrogels for inducing angiogenic–osteogenic coupled progressions in hard tissue repairs: prospects and challenges

Author:
Anuj Kumar; Ankur Sood; Ritu Singhmar; Yogendra Kumar Mishra; Vijay Kumar Thakur; Sung Soo Han
Source:
Biomaterials science 2022 v.10 no.19 pp. 5472-5497
ISSN:
2047-4849
Subject:
angiogenesis,   etc   ; biocompatible materials; blood; bone mineralization; bones; hydrogels; manufacturing;     Show all 7 Subjects
Abstract:
... In large bone defects, inadequate vascularization within the engineered constructs has been a major challenge in developing clinically impactful products. It is fairly determined that bone tissues and blood vessels are established concurrently throughout tissue repairs after an injury. Thus, the coupling of angiogenesis–osteogenesis is an essential course of action in bone tissue restoration. The ...
DOI:
10.1039/d2bm00894g

17. SOX4 promotes high-glucose-induced inflammation and angiogenesis of retinal endothelial cells by activating NF-κB signaling pathway

Author:
Haifeng Wei; Quan Gu
Source:
Open life sciences 2022 v.17 no.1 pp. 393-400
ISSN:
2391-5412
Subject:
angiogenesis,   etc   ; blindness; diabetic retinopathy; glucose; humans; inflammation; pancreas; viability;     Show all 8 Subjects
Abstract:
... Diabetic retinopathy (DR) is a type of main microvascular complication of diabetes mellitus (DM) and an important factor that causes blindness in adults. SOX4 is a transcription factor expressed in the pancreas and is essential for normal endocrine pancreatic development. However, the effect and the regulatory mechanism of SOX4 on DR have not been reported. In the present study, upregulation of SO ...
DOI:
10.1515/biol-2022-0045

18. The Dual Role of Mesenchymal Stromal Cells and Their Extracellular Vesicles in Carcinogenesis

Author:
Zarema Gilazieva; Aleksei Ponomarev; Albert Rizvanov; Valeriya Solovyeva
Source:
Biology 2022 v.11 no.6 pp. -
ISSN:
2079-7737
Subject:
angiogenesis,   etc   ; apoptosis; carcinogenesis; cell cycle; extracellular matrix; neoplasm progression; neoplasms;     Show all 7 Subjects
Abstract:
... Mesenchymal stem cells (MSCs) are a major component of the tumor microenvironment (TME) and play an important role in tumor progression. MSCs remodel the extracellular matrix, participate in the epithelial–mesenchymal transition, promote the spread of metastases, and inhibit antitumor immune responses in the TME; however, there are also data pertaining to the antitumor effects of MSCs. MSCs activa ...
DOI:
10.3390/biology11060813

19. Biphasic effect of sulforaphane on angiogenesis in hypoxia via modulation of both Nrf2 and mitochondrial dynamics

Author:
Yaqian Wang; Fangfang Chen; Yuan Zhang; Xiangyu Zheng; Shiyan Liu; Meijuan Tang; Ziling Wang; Pan Wang; Yongping Bao; Dan Li
Source:
Food & function 2022 v.13 no.5 pp. 2884-2898
ISSN:
2042-650X
Subject:
angiogenesis,   etc   ; Brassicaceae; glucosinolates; heme oxygenase (biliverdin-producing); hypoxia; mitochondria; sulforaphane;     Show all 7 Subjects
Abstract:
... Sulforaphane (SFN) is an isothiocyanate (ITC) derived from a glucosinolate, glucoraphinin found in cruciferous vegetables. There are few studies that focus on the role of SFN in angiogenesis under hypoxic conditions. The effect of SFN on angiogenesis and the underlying mechanisms including the roles of Nrf2 and mitochondrial dynamics were investigated using cultured human umbilical vein endothelia ...
DOI:
10.1039/d1fo04112f

20. The complex hydrogel based on diatom biosilica and hydroxybutyl chitosan for wound healing

Author:
Hussein E. Rozan; Guangsheng Wu; Zhongzheng Zhou; Qinfeng Li; Mohamed Sharaf; Xiguang Chen
Source:
Colloids and surfaces 2022 v.216 pp. 112523
ISSN:
0927-7765
Subject:
angiogenesis,   etc   ; Bacillariophyceae; Escherichia coli; biocompatibility; chitosan; collagen; cytotoxicity; doxycycline; hydrogels;     Show all 9 Subjects
Abstract:
... In this study, doxycycline (DOXY)-loaded diatom biosilica (DBs) were developed and coated with hydroxybutyl chitosan (HBC) hydrogel for wound healing. The HBC/DBs/DOXY composite hydrogel had significant inhibitory activity against S. aureus (100%) and E. coli (98%). In addition, the HBC/DBs/DOXY hydrogel showed minimum cytotoxicity on L929 cells in vitro, indicating the great biocompatibility of t ...
DOI:
10.1016/j.colsurfb.2022.112523