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1. Correction: Handling and managing bleeding wounds using tissue adhesive hydrogel: a comparative assessment on two different hydrogels

Author:
T, Thiruselvi; Raja S, Thirupathi Kumara; R, Aravindhan; K, Shanuja S.; A, Gnanamani
Source:
RSC advances 2019 v.9 no.38 pp. 21946
ISSN:
2046-2069
Subject:
animal injuries,   etc   ; hemorrhage; hydrogels;     Show all 3 Subjects
Abstract:
... Correction for ‘Handling and managing bleeding wounds using tissue adhesive hydrogel: a comparative assessment on two different hydrogels’ by Thiruselvi T et al., RSC Adv., 2016, 6, 19973–19981. ...
DOI:
10.1039/c9ra90054c

2. Homicide injury severity in association with the victim-offender relationship

Author:
Tamsen, Fredrik; Sturup, Joakim; Thiblin, Ingemar
Source:
Forensic science international 2019 v.300 pp. 151-156
ISSN:
0379-0738
Subject:
animal injuries,   etc   ; crime; forensic sciences; Sweden;     Show all 4 Subjects
Abstract:
... There are previous studies that have found associations between specific injury patterns and different victim-offender relationships (VORs) in homicides. We have used quantitative injury severity scores to further investigate this issue. The amount and severity of injuries were assessed in 178 Swedish homicide victims, retrospectively included from the years 2007–2009. We analyzed whether differen ...
DOI:
10.1016/j.forsciint.2019.05.012

3. Comprehensive therapeutics targeting the corticospinal tract following spinal cord injury

Author:
Xu, An-Kai; Gong, Zhe; He, Yu-Zhe; Xia, Kai-Shun; Tao, Hui-Min
Source:
Journal of Zhejiang University 2019 v.20 no.3 pp. 205-218
ISSN:
1673-1581
Subject:
animal injuries,   etc   ; electrical treatment; patients; spinal cord; therapeutics;     Show all 5 Subjects
Abstract:
... Spinal cord injury (SCI), which is much in the public eye, is still a refractory disease compromising the well-being of both patients and society. In spite of there being many methods dealing with the lesion, there is still a deficiency in comprehensive strategies covering all facets of this damage. Further, we should also mention the structure called the corticospinal tract (CST) which plays a cr ...
DOI:
10.1631/jzus.B1800280

4. A quite rare case of bruising abrasion-like as gun entry wound

Author:
Chérrez Bermejo, Carlos; Teijeira Álvarez, Rafael
Source:
Forensic science international 2018 v.288 pp. e1
ISSN:
0379-0738
Subject:
animal injuries,   etc   ; forensic sciences; humans; suicide;     Show all 4 Subjects
Abstract:
... An interesting case of a suicide by a home made gun is described. A review of the literature is added. The entry wound is exceptional. The case shows that the forensic assessment of a home made gun case may be very difficult and implies to evaluate all the circumstances related to it. Specific forensic signs of home made gun injuries are suggested. ...
DOI:
10.1016/j.forsciint.2018.05.013

5. Different functional bio-scaffolds share similar neurological mechanism to promote locomotor recovery of canines with complete spinal cord injury

Author:
Liu, Dingyang; Li, Xing; Xiao, Zhifeng; Yin, Wen; Zhao, Yannan; Tan, Jun; Chen, Bing; Jiang, Xingjun; Dai, Jianwu
Source:
Biomaterials 2019 v.214 pp. 119230
ISSN:
0142-9612
Subject:
animal injuries,   etc   ; axons; bone marrow; dogs; hindlimbs; humans; models; paclitaxel; resection; rodents; spinal cord;     Show all 11 Subjects
Abstract:
... Many studies have shown that rodents exhibit a certain degree of spontaneous motor function recovery even if they suffer from spinal cord complete transection injury. However, the characteristics of spontaneous locomotor recovery and its associated neurobiological mechanisms are unclear. In this study, we observed that spontaneous locomotor function recovery of hind limbs could also be detected in ...
DOI:
10.1016/j.biomaterials.2019.119230

6. Spinal cord injury: pathophysiology, treatment strategies, associated challenges, and future implications

Author:
Venkatesh, Katari; Ghosh, Shounak K.; Mullick, Madhubanti; Manivasagam, Geetha; Sen, Dwaipayan
Source:
Cell and tissue research 2019 v.377 no.2 pp. 125-151
ISSN:
0302-766X
Subject:
animal injuries,   etc   ; morbidity; neurons; pathophysiology; patients; quality of life; spinal cord; stem cells; therapeutics;     Show all 9 Subjects
Abstract:
... Axonal regeneration and formation of tripartite (axo-glial) junctions at damaged sites is a prerequisite for early repair of injured spinal cord. Transplantation of stem cells at such sites of damage which can generate both neuronal and glial population has gained impact in terms of recuperation upon infliction with spinal cord injury. In spite of the fact that a copious number of pre-clinical stu ...
DOI:
10.1007/s00441-019-03039-1

7. Intraspinal administration of interleukin-7 promotes neuronal apoptosis and limits functional recovery through JAK/STAT5 pathway following spinal cord injury

Author:
Yuan, Xiaochen; Wu, Qingbin; Wang, Peng; Jing, Yingli; Yao, Haijiang; Tang, Yinshan; Han, Ruiqin; He, Weili; Li, Zhigang; Zhang, Honggang; Xiu, Ruijuan
Source:
Biochemical and biophysical research communications 2019 v.514 no.3 pp. 1023-1029
ISSN:
0006-291X
Subject:
animal injuries,   etc   ; apoptosis; inflammation; interleukin-7; macrophages; neuroglia; neurons; spinal cord; therapeutics;     Show all 9 Subjects
Abstract:
... It has been previously reported that the blockade of interleukin-7 receptor (IL-7R) promotes functional recovery following spinal cord injury (SCI), however, the direct function and molecular mechanism of IL-7 involved in this pathogenic process are unclear. Here, we report that, contrary to IL-7R blockade, the intraspinal administration of IL-7 limits functional recovery following SCI. In additio ...
DOI:
10.1016/j.bbrc.2019.04.159

8. Scaffold-facilitated locomotor improvement post complete spinal cord injury: Motor axon regeneration versus endogenous neuronal relay formation

Author:
Li, Xing; Liu, Dingyang; Xiao, Zhifeng; Zhao, Yannan; Han, Sufang; Chen, Bing; Dai, Jianwu
Source:
Biomaterials 2019 v.197 pp. 20-31
ISSN:
0142-9612
Subject:
animal injuries,   etc   ; animal models; animals; axons; mortality; patients; quality of life; spinal cord; therapeutics;     Show all 9 Subjects
Abstract:
... Complete transected spinal cord injury (SCI) severely influences the quality of life and mortality rates of animals and patients. In the past decade, many simple and combinatorial therapeutic treatments have been tested in improving locomotor function in animals with this extraordinarily challenging SCI. The potential mechanism for promotion of locomotor function relies either on direct motor axon ...
DOI:
10.1016/j.biomaterials.2019.01.012

9. Microsurgical technique for concurrent cervical corpectomy and ventral phrenic nerve access in the rat

Author:
Ghali, Michael G.Z.
Source:
MethodsX 2019 v.6 pp. 239-245
ISSN:
2215-0161
Subject:
animal injuries,   etc   ; adults; interneurons; laminectomy; larynx; neck; nerve tissue; rats; spinal cord;     Show all 9 Subjects
Abstract:
... The phrenic nerve is useful to record as a motor output in studies investigating neural control of respiration. It may be accessed via dorsal or ventral microsurgical approaches. Since such studies frequently involve concurrent access to the spinal cord, the two approaches may be alternatively used, each with its own set of advantages and disadvantages. The dorsal approach permits easier exposure ...
DOI:
10.1016/j.mex.2018.08.007

10. Geospatial Assessment of the Post-Earthquake Hazard of the 2017 Pohang Earthquake Considering Seismic Site Effects

Author:
Kim, Han-Saem; Sun, Chang-Guk; Cho, Hyung-Ik
Source:
ISPRS international journal of geo-information 2018 v.7 no.9
ISSN:
2220-9964
Subject:
animal injuries,   etc   ; earthquakes; geophysics; infrastructure; liquefaction; sediments; surveys;     Show all 7 Subjects
Abstract:
... The 2017 Pohang earthquake (moment magnitude scale: 5.4) was South Korea’s second strongest earthquake in decades, and caused the maximum amount of damage in terms of infrastructure and human injuries. As the epicenters were located in regions with Quaternary sediments, which involve distributions of thick fill and alluvial geo-layers, the induced damages were more severe owing to seismic am ...
DOI:
10.3390/ijgi7090375

11. Energy and Nutrient Issues in Athletes with Spinal Cord Injury: Are They at Risk for Low Energy Availability?

Author:
Figel, Katherine; Pritchett, Kelly; Pritchett, Robert; Broad, Elizabeth
Source:
Nutrients 2018 v.10 no.8
ISSN:
2072-6643
Subject:
animal injuries,   etc   ; athletes; energy; nutrient intake; spinal cord;     Show all 5 Subjects
Abstract:
... Low energy availability (LEA) and nutrient intake have been well studied in able-bodied athletes, but there is a lack of research examining these issues amongst athletes with spinal cord injury (SCI). To date, there have been no studies that have examined energy availability (EA) amongst this population. Furthermore, athletes with SCI may experience unique challenges around nutrition that may incr ...
DOI:
10.3390/nu10081078

12. Engineering new neurons: in vivo reprogramming in mammalian brain and spinal cord

Author:
Wang, Lei-Lei; Zhang, Chun-Li
Source:
Cell and tissue research 2018 v.371 no.1 pp. 201-212
ISSN:
0302-766X
Subject:
animal injuries,   etc   ; adults; brain; engineering; mammals; neuroglia; neurons; spinal cord;     Show all 8 Subjects
Abstract:
... Neurons are postmitotic. Once lost because of injury or degeneration, they do not regenerate in most regions of the mammalian central nervous system. Recent advancements nevertheless clearly reveal that new neurons can be reprogrammed from non-neuronal cells, especially glial cells, in the adult mammalian brain and spinal cord. Here, we give a brief overview concerning cell fate reprogramming in v ...
DOI:
10.1007/s00441-017-2729-2

13. A novel lab-on-chip platform enabling axotomy and neuromodulation in a multi-nodal network

Author:
van de Wijdeven, Rosanne; Ramstad, Ola Huse; Valderhaug, Vibeke Devold; Köllensperger, Peter; Sandvig, Axel; Sandvig, Ioanna; Halaas, Øyvind
Source:
Biosensors & bioelectronics 2019 v.140 pp. 111329
ISSN:
0956-5663
Subject:
animal injuries,   etc   ; axons; biosensors; electrophysiology; microelectrodes; models; monitoring; neurodegenerative diseases; neurophysiology; organ-on-a-chip; pathophysiology; spinal cord;     Show all 12 Subjects
Abstract:
... Lab-on-chip platforms, such as microfluidic chips and micro-electrode arrays (MEAs) are powerful tools that allow us to manipulate and study neurons in vitro. Microfluidic chips provide a controlled extracellular environment that structures neural networks and facilitates isolation and manipulation at a sub-cellular level. Furthermore, MEAs enable measurement of extracellular electrophysiological ...
DOI:
10.1016/j.bios.2019.111329

14. Overground gait training promotes functional recovery and cortical neuroplasticity in an incomplete spinal cord injury model

Author:
Ilha, Jocemar; Meireles, Anamaria; de Freitas, Gabriel Ribeiro; do Espírito Santo, Caroline C.; Machado-Pereira, Nicolas A.M.M.; Swarowsky, Alessandra; Santos, Adair Roberto Soares
Source:
Life sciences 2019 v.232 pp. 116627
ISSN:
0024-3205
Subject:
animal injuries,   etc   ; adults; animal models; cerebellum; cortex; experimental design; gait; hindlimbs; laboratory animals; motor cortex; neuroplasticity; rats; spinal cord; surgery;     Show all 14 Subjects
Abstract:
... Evidence suggests that task-specific gait training improves locomotor impairments in people with incomplete spinal cord injury (SCI); however, plastic changes in brain areas remain poorly understood. The aim of this study was to examine the possible effects of a task-specific overground gait training on locomotor recovery and neuroplasticity markers in the cortex, cerebellum, and lumbar spinal cor ...
DOI:
10.1016/j.lfs.2019.116627

15. Case report of sudden death after a gunshot wound to the C2 vertebral bone without direct spinal cord injury: Histopathological analysis of spinal-medullary junction

Author:
Demontis, Roberto; d’Aloja, Ernesto; Manieli, Cristina; Carai, Antonio; Boi, Marianna; Serra, Maria Pina; Quartu, Marina
Source:
Forensic science international 2019 v.301 pp. e49
ISSN:
0379-0738
Subject:
animal injuries,   etc   ; blood pressure; case studies; computed tomography; death; histopathology; immunohistochemistry; medulla oblongata; myelin sheath; necropsy; neuropathology; spinal cord; staining;     Show all 13 Subjects
Abstract:
... Gunshot wounds (GSW) are one of the most common causes of penetrating spinal injury, however few data are available regarding GSW causing an indirect fatal nervous tissue injury, such as that induced by the concussive force secondary to the bullet penetration. This report describes a rare case of a death following a GSW spine injury at the level of C2 vertebral body, without direct contact with th ...
DOI:
10.1016/j.forsciint.2019.06.010

16. Therapeutic hypothermia attenuates paraplegia and neuronal damage in the lumbar spinal cord in a rat model of asphyxial cardiac arrest

Author:
Lee, Jae-Chul; Tae, Hyun-Jin; Cho, Jeong Hwi; Kim, In-Shik; Lee, Tae-Kyeong; Park, Cheol Woo; Park, Young Eun; Ahn, Ji Hyeon; Park, Joon Ha; Yan, Bing Chun; Lee, Hyang-Ah; Hong, Seongkweon; Won, Moo-Ho
Source:
Journal of thermal biology 2019 v.83 pp. 1-7
ISSN:
0306-4565
Subject:
animal injuries,   etc   ; animal models; cardiac arrest; cardiopulmonary resuscitation; death; hindlimbs; hypothermia; ischemia; motor neurons; rats; spinal cord;     Show all 11 Subjects
Abstract:
... Spinal cord ischemia can result from cardiac arrest. It is an important cause of severe spinal cord injury that can lead to serious spinal cord disorders such as paraplegia. Hypothermia is widely acknowledged as an effective neuroprotective intervention following cardiac arrest injury. However, studies on effects of hypothermia on spinal cord injury following asphyxial cardiac arrest and cardiopul ...
DOI:
10.1016/j.jtherbio.2019.04.018

17. Local delivery of FTY720 and NSCs on electrospun PLGA scaffolds improves functional recovery after spinal cord injury

Author:
Kong, Weijian; Qi, Zhiping; Xia, Peng; Chang, Yuxin; Li, Hongru; Qu, Yunpeng; Pan, Su; Yang, Xiaoyu
Source:
RSC advances 2019 v.9 no.31 pp. 17801-17811
ISSN:
2046-2069
Subject:
animal injuries,   etc   ; adverse effects; animal models; biocompatible materials; cytotoxicity; fluorescent antibody technique; nerve tissue; neural stem cells; spinal cord; staining;     Show all 10 Subjects
Abstract:
... Spinal cord injury (SCI) is a common issue in the clinic that causes severe motor and sensory dysfunction below the lesion level. FTY720, also known as fingolimod, has recently been reported to exert a positive effect on the recovery from a spinal cord injury. Through local delivery to the lesion site, FTY720 effectively integrates with biomaterials, and the systemic adverse effects are alleviated ...
DOI:
10.1039/c9ra01717h

18. Evaluating accessibility of intravenously administered nanoparticles at the lesion site in rat and pig contusion models of spinal cord injury

Author:
Gao, Yue; Vijayaraghavalu, Sivakumar; Stees, Melinda; Kwon, Brian K.; Labhasetwar, Vinod
Source:
Journal of controlled release 2019 v.302 pp. 160-168
ISSN:
0168-3659
Subject:
animal injuries,   etc   ; biodegradability; dose response; drug delivery systems; dyes; hemodynamics; intravenous injection; models; nanoparticles; rats; spinal cord; swine;     Show all 12 Subjects
Abstract:
... In spinal cord injury (SCI), timely therapeutic intervention is critical to inhibit the post-injury rapidly progressing degeneration of spinal cord. Towards that objective, we determined the accessibility of intravenously administered biodegradable nanoparticles (NPs) as a drug delivery system to the lesion site in rat and pig contusion models of SCI. Poly (d,l-lactide co-glycolide, PLGA)-based NP ...
DOI:
10.1016/j.jconrel.2019.03.026

19. Alpha-synuclein induces microglial migration via PKM2-dependent glycolysis

Author:
Qiao, Hongfei; He, Xijing; Zhang, Qiaojun; Yuan, Haifeng; Wang, Dong; Li, Libo; Hui, Yanping; Wu, Zhonghen; Li, Wenjuan; Zhang, Ni
Source:
International journal of biological macromolecules 2019 v.129 pp. 601-607
ISSN:
0141-8130
Subject:
animal injuries,   etc   ; Western blotting; biogenesis; glucose; glycolysis; lactic acid; mitochondria; neuroglia; oxidative phosphorylation; phenotype; precipitin tests; pyruvate kinase; spinal cord;     Show all 13 Subjects
Abstract:
... After spinal cord injury, microglial cells are activated and converted to an M1 phenotype. Emerging evidence supports the hypothesis that glucose reprogramming accompanies microglial activation. What contributes to the activation of microglia and glucose reprogramming, however, remains unclear. In the current study, we investigated the role and underlying mechanism of a-synuclein in regulating the ...
DOI:
10.1016/j.ijbiomac.2019.02.029

20. Would personal cooling vest be effective for use during exercise by people with thoracic spinal cord injury?

Author:
Mneimneh, Farah; Ghaddar, Nesreen; Ghali, Kamel; Moussalem, Charbel; Omeis, Ibrahim
Source:
Journal of thermal biology 2019 v.82 pp. 123-141
ISSN:
0306-4565
Subject:
animal injuries,   etc   ; abdomen; body temperature; chest; exercise; heat; heat stress; ice; latent heat; melting point; models; phase transition; spinal cord;     Show all 13 Subjects
Abstract:
... People with thoracic spinal cord injury (SCI), named people with paraplegia (PA), are vulnerable to thermal heat stress during exercise due to disruption in their thermal physiology. Using personal cooling vests with phase change material (PCM) or ice presents a possible solution for PA to suppress the increase in core temperature and body heat storage. With the limited published experimental stud ...
DOI:
10.1016/j.jtherbio.2019.04.004