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1. Mepanipyrim induces cardiotoxicity of zebrafish (Danio rerio) larvae via promoting AhR-regulated COX expression pathway

Author:
Chao Shen; Jing He; Kongyang Zhu; Naying Zheng; Yue Yu; Chengyong He; Chunyan Yang; Zhenghong Zuo
Source:
Journal of environmental sciences (China) 2023 v.125 pp. 650-661
ISSN:
1001-0742
Subject:
antagonists,   etc   ; Danio rerio; agonists; bioassays; calcium; cardiomyocytes; cardiotoxicity; electron transport chain; gene expression; heart rate; human health; mepanipyrim; mitochondria; toxicity; viticulture; China;     Show all 16 Subjects
Abstract:
... The wide use of pesticides has seriously threatened human health and the survival of beneficial organisms. The fungicide mepanipyrim is widely used in viticulture practices. Studies of mepanipyrim-induced toxicity in organisms are still scarce, especially studies on cardiotoxicity. In this study, we aimed to investigate mepanipyrim-induced cardiotoxicity in zebrafish (Danio rerio) larvae. We found ...
DOI:
10.1016/j.jes.2022.01.012

2. Glutamatergic receptor and neuroplasticity in depression: Implications for ketamine and rapastinel as the rapid-acting antidepressants

Author:
Ya-Ting Wang; Ning-Ning Zhang; Ling-Jie Liu; Hong Jiang; Die Hu; Zhen-Zhen Wang; Nai-Hong Chen; Yi Zhang
Source:
Biochemical and biophysical research communications 2022 v.594 pp. 46-56
ISSN:
0006-291X
Subject:
antagonists,   etc   ; antidepressants; ketamine; neuroplasticity; research;     Show all 5 Subjects
Abstract:
... To explore the convergent downstream pathways of ketamine and rapastinel and drive further development of identification for following generational rapid-acting antidepressants in the synaptic process. Ketamine is an NMDAR antagonist and is proven effective in depression for the rapid and sustained antidepressant response, while rapastinel is an NMDAR positive allosteric modulator, producing antid ...
DOI:
10.1016/j.bbrc.2022.01.024

3. The influence of prorenin/(pro)renin receptor on progesterone secretion by the bovine corpus luteum

Author:
Andressa Minussi Pereira Dau; Paulo Roberto da Rosa; Joabel dos Santos; Juliana Ferst; Mariana de Macedo; Monique Rovani; Fabio Comim; Alfredo Quites Antoniazzi; Bernardo Gasperin; Rogério Ferreira; Paulo Bayard Gonçalves
Source:
Animal reproduction science 2022 v.241 pp. 106985
ISSN:
0378-4320
Subject:
antagonists,   etc   ; luteolysis; phosphorylation; progesterone; renin; secretion;     Show all 6 Subjects
Abstract:
... The aim of this study was to evaluate the role of prorenin/(pro)renin receptor activation on luteal progesterone (P4) secretion. Our hypothesis was that the nonproteolytic activation of (pro)renin receptor [P(RR)] is part of the regulatory mechanism responsible for corpus luteum (CL) function. In the first three experiments, prorenin was found to stimulate the production of P4, which is not inhibi ...
DOI:
10.1016/j.anireprosci.2022.106985

4. ERα, but not ERβ and GPER, Mediates Estradiol-Induced Secretion of TSH in Mouse Pituitary

Author:
Yu Xiao; Dong Chen
Source:
Applied biochemistry and biotechnology 2022 v.194 no.6 pp. 2492-2502
ISSN:
0273-2289
Subject:
antagonists,   etc   ; agonists; biotechnology; estradiol; estrogen receptors; females; mice; secretion;     Show all 8 Subjects
Abstract:
... Although estradiol (E2) plays a critical role in the promotion of pituitary development and in the regulation of various pituitary hormones, its effects on the thyroid-stimulating hormone (TSH) remain unaddressed. The actions of E2 are mediated by two classical nuclear estrogen receptors α (ERα) and β (ERβ) and the G protein-coupled estrogen receptor (GPER). However, the types of estrogen receptor ...
DOI:
10.1007/s12010-022-03823-w

5. Angiotensin Type-1 Receptor Inhibition Reduces NLRP3 Inflammasome Upregulation Induced by Aging and Neurodegeneration in the Substantia Nigra of Male Rodents and Primary Mesencephalic Cultures

Author:
Aloia Quijano; Carmen Diaz-Ruiz; Andrea Lopez-Lopez; Begoña Villar-Cheda; Ana Muñoz; Ana I. Rodriguez-Perez; Jose L. Labandeira-Garcia
Source:
Antioxidants 2022 v.11 no.2 pp. -
ISSN:
2076-3921
Subject:
antagonists,   etc   ; brain; dopamine; inflammasomes; interleukin-18; males; renin-angiotensin system;     Show all 7 Subjects
Abstract:
... The tissue renin–angiotensin system (RAS) has been shown to be involved in prooxidative and proinflammatory changes observed in aging and aging-related diseases such as dopaminergic degeneration in Parkinson’s disease (PD). We studied the activation of the NLRP3 inflammasome in the substantia nigra with aging and early stages of dopaminergic degeneration in PD models and, particularly, if the brai ...
DOI:
10.3390/antiox11020329

6. Environmental cadmium impairs blood-testis barrier via activating HRI-responsive mitochondrial stress in mice

Author:
Guo-Xiang Zhou; Wei-Bo Liu; Li-Min Dai; Hua-Long Zhu; Yong-Wei Xiong; Dai-Xin Li; De-Xiang Xu; Hua Wang
Source:
Science of the total environment 2022 v.810 pp. 152247
ISSN:
0048-9697
Subject:
antagonists,   etc   ; cadmium; environment; males; melatonin; mice; mitochondria; occludins; stress response;     Show all 9 Subjects
Abstract:
... Cadmium (Cd) is a well-known testicular toxicant. Blood-testis barrier (BTB), a vital part of testes, which has been reported to be damaged upon Cd exposure. However, the detailed mechanism about Cd-mediated disruption of BTB remains unclear. This study aims to investigate the role of Heme-Regulated Inhibitor (HRI)-responsive mitochondrial stress in Cd-mediated disruption of BTB. Male mice are int ...
DOI:
10.1016/j.scitotenv.2021.152247

7. MMP-responsive transformation nanomaterials with IAP antagonist to boost immune checkpoint therapy

Author:
Ting Wang; Zheng He; Cong-Shan Yuan; Zhen-Wei Deng; Fang Li; Xi-Guang Chen; Ya Liu
Source:
Journal of controlled release 2022 v.343 pp. 765-776
ISSN:
0168-3659
Subject:
antagonists,   etc   ; T-lymphocytes; growth retardation; metalloproteinases; models; pancreatic neoplasms; resection;     Show all 7 Subjects
Abstract:
... The clinical effect of immune checkpoint therapy is limited by the poor blocking efficiency of immune checkpoints and the insufficient infiltration of tumor-specific T cells. Here, we constructed enzyme-responsive PVA–peptide conjugates (PPCs) to achieve re-assembly with enhanced accumulation in the tumor region, enable enhanced PD-L1 occupancy and improve the blocking efficiency. The self-assembl ...
DOI:
10.1016/j.jconrel.2022.02.018

8. Testicular effects of a postnatal GnRH antagonist in domestic cats

Author:
Mariela Grisolia-Romero; Marcela Faya; Cynthia Marchetti; Hanna Körber; Sandra Goericke-Pesch; Cristina Gobello
Source:
Acta veterinaria Hungarica 2022 v.70 no.1 pp. 44-50
ISSN:
1588-2705
Subject:
antagonists,   etc   ; body weight; epithelium; histology; males; placebos; puberty; testes; testosterone;     Show all 9 Subjects
Abstract:
... The aim of this study was to describe the histological effects of two high postnatal doses of the potent third-generation GnRH antagonist, acyline in the domestic cat testicle. Secondly, the physical, endocrine, and steroidogenic findings of this pharmaceutical protocol are also reported. Twelve postnatal littermate male kittens were administered acyline in a dose of 2.2 mg/100 g SC weekly for 2 w ...
DOI:
10.1556/004.2021.00052

9. Brain site-specific regulation of hedonic intake by orexin and DYN peptides: role of the PVN and obesity

Author:
Mattar P.; Uribe-Cerda S.; Pezoa C.; Guarnieri T.; Kotz C. M.; Teske J. A.; Morselli E.; Perez-Leighton C.
Source:
Nutritional Neuroscience pp. -
ISSN:
1028-415X
Subject:
antagonists,   etc   ; cafeteria foods; energy intake; neurophysiology; obesity; paraventricular hypothalamic nucleus; peptides;     Show all 7 Subjects
Abstract:
... The orexin peptides promote hedonic intake and other reward behaviors through different brain sites. The opioid dynorphin peptides are co-released with orexin peptides but block their effects on reward in the ventral tegmental area (VTA). We previously showed that in the paraventricular hypothalamic nucleus (PVN), dynorphin and not orexin peptides enhance hedonic intake, suggesting they have brain ...
Handle:
10113/7680325
DOI:
10.1080/1028415x.2020.1840049
CHORUS:
10.1080/1028415x.2020.1840049

10. Competitive blocking of LRP4–sclerostin binding interface strongly promotes bone anabolic functions

Author:
Svetlana Katchkovsky; Biplab Chatterjee; Chen-Viki Abramovitch-Dahan; Niv Papo; Noam Levaot
Source:
Cellular and molecular life sciences 2022 v.79 no.2 pp. 113
ISSN:
1420-682X
Subject:
antagonists,   etc   ; bone formation; immunoglobulins; ligands; low density lipoprotein; mutants; osteoblasts; yeasts;     Show all 8 Subjects
Abstract:
... Induction of bone formation by Wnt ligands is inhibited when sclerostin (Scl), an osteocyte-produced antagonist, binds to its receptors, the low-density lipoprotein receptor-related proteins 5 or 6 (LRP5/6). Recently, it was shown that enhanced inhibition is achieved by Scl binding to the co-receptor LRP4. However, it is not clear if the binding of Scl to LRP4 facilitates Scl binding to LRP5/6 or ...
DOI:
10.1007/s00018-022-04127-2

11. Dectin-1b activation by arabinoxylans induces trained immunity in human monocyte-derived macrophages

Author:
Bart G.J. Moerings; Jeroen van Bergenhenegouwen; Matthew Furber; Suzanne Abbring; Henk A. Schols; Renger F. Witkamp; Coen Govers; Jurriaan J. Mes
Source:
International journal of biological macromolecules 2022 v.209 pp. 942-950
ISSN:
0141-8130
Subject:
antagonists,   etc   ; antibodies; arabinoxylan; humans; innate immunity; macrophages; particle size; rice; solubility;     Show all 9 Subjects
Abstract:
... Arabinoxylans of various structures and sources have shown to possess the ability to induce a range of immune responses in different cell types in vitro and in vivo. Although the underlying mechanisms remain to be fully established, several studies point towards the involvement of activation of pattern recognition receptors (PRRs). Activation of specific PRRs (i.e., Dectin-1 and CR3) has also been ...
DOI:
10.1016/j.ijbiomac.2022.04.071

12. Endocrine disruptors on and in fruits and vegetables: Estimation of the potential exposure of the French population

Author:
Alexandre Lee; Souad Bensaada; Valérie Lamothe; Melissa Lacoste; Catherine Bennetau-Pelissero
Source:
Food chemistry 2022 v.373 pp. 131513
ISSN:
0308-8146
Subject:
antagonists,   etc   ; agonists; daidzein; food chemistry; genistein; plant estrogens; plant protection; France;     Show all 8 Subjects
Abstract:
... Fruits and vegetables are considered to be healthy compared to fats, carbohydrates, and meats. However, their production involves plant protection products (PPPs) or they can contain phytoestrogens which may exhibit endocrine effects. Thus, the exposure to the main PPPs and to phytoestrogens known as endocrine disruptors (EDs) is estimated. PPPs include fungicides, growth substances, herbicides, a ...
DOI:
10.1016/j.foodchem.2021.131513

13. IL- 1R1 blockade attenuates liver injury through inhibiting the recruitment of myeloid-derived suppressor cells in sepsis

Author:
Minjie Luo; Hao Wang; Ke Liu; Meidong Liu; Sipin Tan; Yaxi Zhu; Huali Zhang
Source:
Biochemical and biophysical research communications 2022 pp. -
ISSN:
0006-291X
Subject:
antagonists,   etc   ; bone marrow; humans; liver; macrophages; phenotype; prognosis; protective effect; research;     Show all 9 Subjects
Abstract:
... Myeloid-derived suppressor cells (MDSCs) mobilize and migrate from bone marrow to peripheral tissues or immune organs, which is associated with poor prognosis in sepsis. Intervention of MDSCs might be a potential target for the effective treatment of sepsis. In the present study, we demonstrated that IL-1R1 blockade with either recombinant human IL-1R antagonist Anakinra or IL-1R1 deficiency had a ...
DOI:
10.1016/j.bbrc.2022.06.038

14. Antillatoxin-Stimulated Neurite Outgrowth Involves the Brain-Derived Neurotrophic Factor (BDNF) - Tropomyosin Related Kinase B (TrkB) Signaling Pathway

Author:
Suneet Mehrotra; Marsha L. Pierce; Zhengyu Cao; Sairam V. Jabba; William H. Gerwick; Thomas F. Murray
Source:
Journal of natural products 2022 v.85 no.3 pp. 562-571
ISSN:
1520-6025
Subject:
antagonists,   etc   ; Moorea producens; calcium; lipopeptides; neurites; neuroplasticity; sodium channels; tetrodotoxin; transfection; tropomyosins;     Show all 10 Subjects
Abstract:
... Voltage-gated sodium channel (VGSC) activators promote neurite outgrowth by augmenting intracellular Na⁺ concentration ([Na⁺]ᵢ) and upregulating N-methyl-d-aspartate receptor (NMDAR) function. NMDAR activation stimulates calcium (Ca²⁺) influx and increases brain-derived neurotrophic factor (BDNF) release and activation of tropomyosin receptor kinase B (TrkB) signaling. The BDNF-TrkB pathway has be ...
DOI:
10.1021/acs.jnatprod.1c01001

15. Critical review on negative emerging contaminant removal efficiency of wastewater treatment systems: Concept, consistency and consequences

Author:
Manish Kumar; Jayalaxmi Ngasepam; Kiran Dhangar; Jurgen Mahlknecht; Suvendu Manna
Source:
Bioresource technology 2022 v.352 pp. 127054
ISSN:
0960-8524
Subject:
beta-adrenergic antagonists,   etc   ; blood pressure; byproducts; carbadox; humans; pollutants; toxicity; wastewater treatment;     Show all 8 Subjects
Abstract:
... Emerging contaminants (ECs) are not completely removed by wastewater treatment owing to their capabilities of making complexes, toxic derivatives, byproduct formation, and dynamic partitioning. Negative contaminant removal i.e., higher concentrations (up to 5731%) of these ECs in the effluent with respect to the influent sampled on the same occasions, is globally prevalent in almost all types of t ...
DOI:
10.1016/j.biortech.2022.127054

16. Evaluation of site-selective drug effects on GABA receptors using nanovesicle-carbon nanotube hybrid devices

Author:
Inkyoung Park; Inwoo Yang; Youngtak Cho; Yoonji Choi; Junghyun Shin; Shashank Shekhar; Seung Hwan Lee; Seunghun Hong
Source:
Biosensors & bioelectronics 2022 v.200 pp. 113903
ISSN:
0956-5663
Subject:
antagonists,   etc   ; agonists; biosensors; carbon nanotubes; dose response; drugs; neurotransmitters; synaptic transmission; transistors;     Show all 9 Subjects
Abstract:
... Site-selective drug effects on the ion-channel activities of γ-aminobutyric acid type A (GABAA) receptors are evaluated by using a nanovesicle-carbon nanotube hybrid device. Here, nanovesicles containing GABAA receptors are immobilized on the channel region of a carbon nanotube field-effect transistor. The receptor responses of this hybrid device to GABA are detected with a high sensitivity down t ...
DOI:
10.1016/j.bios.2021.113903

17. Fluorescent opioid receptor ligands as tools to study opioid receptor function

Author:
Despina Giakomidi; Mark F. Bird; Remo Guerrini; Girolamo Calo; David G. Lambert
Source:
Journal of pharmacological and toxicological methods 2022 v.113 pp. 107132
ISSN:
1056-8719
Subject:
antagonists,   etc   ; agonists; antibodies; chemistry; fluorescence; fluorescent dyes; immunohistochemistry; ligands; peptide receptors; toxicology;     Show all 10 Subjects
Abstract:
... Opioid receptors are divided into the three classical types: MOP(μ:mu), DOP(δ:delta) and KOP(κ:kappa) that are naloxone-sensitive and an additional naloxone-insensitive nociceptin/orphanin FQ(N/OFQ) peptide receptor(NOP). Studies to determine opioid receptor location and turnover variably rely on; (i) measuring receptor mRNA, (ii) genetically tagging receptors, (iii) labelling receptors with radio ...
DOI:
10.1016/j.vascn.2021.107132

18. Stimulation of brain corticotropin-releasing factor receptor type1 facilitates the rat micturition via brain glutamatergic receptors

Author:
Yurika Hata; Takahiro Shimizu; Suo Zou; Masaki Yamamoto; Yohei Shimizu; Hideaki Ono; Takaaki Aratake; Shogo Shimizu; Youichirou Higashi; Nobutaka Shimizu; Takashi Karashima; Motoaki Saito
Source:
Biochemical and biophysical research communications 2022 v.607 pp. 54-59
ISSN:
0006-291X
Subject:
antagonists,   etc   ; anesthesia; bladder; brain; corticotropin-releasing hormone; males; neuropeptides; rats; research; urethane;     Show all 10 Subjects
Abstract:
... Corticotropin-releasing factor (CRF), a representative stress-related neuropeptide, in the central nervous system reportedly both facilitates and suppresses the micturition, therefore, roles of central CRF in regulation of the micturition are still controversial. In this study, we investigated (1) effects of intracerebroventricularly (icv)-administered CRF on the micturition, and (2) brain CRF rec ...
DOI:
10.1016/j.bbrc.2022.03.124

19. Brain-derived neurotrophic factor for high-throughput evaluation of selective Sigma-1 receptor ligands

Author:
Dhwanil A. Dalwadi; Stephanie Kim; John Schetz; Derek A. Schreihofer; Seongcheol Kim
Source:
Journal of pharmacological and toxicological methods 2022 v.113 pp. 107129
ISSN:
1056-8719
Subject:
antagonists,   etc   ; agonists; brain; calcium; drugs; endoplasmic reticulum; ligands; medicinal properties; neurites; therapeutics; toxicology;     Show all 11 Subjects
Abstract:
... The Sigma-1 receptor (S1R) is an endoplasmic reticulum (ER) chaperone protein that has been implicated in attenuating inflammatory stress-mediated brain injuries. Selective S1R agonists represent a new class of therapeutic agent for treating neuropsychiatric and neurodegenerative disorders, however, to date, no S1R ligand has been approved for therapeutic purposes. We used three potential methods ...
DOI:
10.1016/j.vascn.2021.107129

20. EphrinB2/ephB2 activation facilitates colonic synaptic potentiation and plasticity contributing to long-term visceral hypersensitivity in irritable bowel syndrome

Author:
Lei Zhang; Ruiyun Wang; Yuhua Chen; Pengcheng Yang; Tao Bai; Jun Song; Xiaohua Hou
Source:
Life sciences 2022 v.295 pp. 120419
ISSN:
0024-3205
Subject:
antagonists,   etc   ; Trichinella spiralis; calcium; hypersensitivity; irritable bowel syndrome; neuroplasticity; pain; phosphorylation; plasticity; therapeutics;     Show all 10 Subjects
Abstract:
... Sustained visceral hypersensitivity is a hallmark of irritable bowel syndrome (IBS) could be partially explained by enteric neural remodeling. Particularly, synaptic plasticity in the enteric nervous system, a form of enteric “memory”, has been speculated as a participant in the pain maintenance in IBS. This study aimed to elucidate the role of ephrinB2/ephB2 in enteric synaptic plasticity and vis ...
DOI:
10.1016/j.lfs.2022.120419