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1. Multi-function adsorbent-photocatalyst MXene-TiO2 composites for removal of enrofloxacin antibiotic from water

Author:
Siwanat Sukidpaneenid; Chamorn Chawengkijwanich; Chonlada Pokhum; Toshihiro Isobe; Pakorn Opaprakasit; Paiboon Sreearunothai
Source:
Journal of environmental sciences (China) 2023 v.124 pp. 414-428
ISSN:
1001-0742
Subject:
antibiotics,   etc   ; adsorption; electrical conductivity; enrofloxacin; hot water treatment; hydrophilicity; new family; photocatalysis; sodium; synergism; temperature; China;     Show all 12 Subjects
Abstract:
... MXenes, a new family of two-dimensional transition metal carbides or nitrides, have attracted tremendous attention for various applications due to their unique properties such as good electrical conductivity, hydrophilicity, and ion intercalability. In this work, Ti₃C₂ MXene, or MX, is converted to MX-TiO₂ composites using a simple and rapid microwave hydrothermal treatment in HCl/NaCl mixture sol ...
DOI:
10.1016/j.jes.2021.09.042

2. BacPROTACs mediate targeted protein degradation in bacteria

Author:
Francesca E. Morreale; Stefan Kleine; Julia Leodolter; Sabryna Junker; David M. Hoi; Stepan Ovchinnikov; Anastasia Okun; Juliane Kley; Robert Kurzbauer; Lukas Junk; Somraj Guha; David Podlesainski; Uli Kazmaier; Guido Boehmelt; Harald Weinstabl; Klaus Rumpel; Volker M. Schmiedel; Markus Hartl; David Haselbach; Anton Meinhart; Markus Kaiser; Tim Clausen
Source:
Cell 2022 v.185 no.13 pp. 2338-2353.e18
ISSN:
0092-8674
Subject:
antibiotics,   etc   ; protein degradation; proteinases;     Show all 3 Subjects
Abstract:
... Hijacking the cellular protein degradation system offers unique opportunities for drug discovery, as exemplified by proteolysis-targeting chimeras. Despite their great promise for medical chemistry, so far, it has not been possible to reprogram the bacterial degradation machinery to interfere with microbial infections. Here, we develop small-molecule degraders, so-called BacPROTACs, that bind to t ...
DOI:
10.1016/j.cell.2022.05.009

3. Droplet-based methods for tackling antimicrobial resistance

Author:
Artur Ruszczak; Simona Bartkova; Marta Zapotoczna; Ott Scheler; Piotr Garstecki
Source:
Current opinion in biotechnology 2022 pp. 102755
ISSN:
0958-1669
Subject:
antibiotics,   etc   ; antibiotic resistance; biotechnology;     Show all 3 Subjects
Abstract:
... Application of droplet-based methods enables; (i) faster detection, (ii) increased sensitivity, (iii) characterization of the level of heterogeneity in response to antibiotics by bacterial populations, and (iv) expanded screening of the effectiveness of antibiotic combinations. Hereby we discuss the key steps and parameters of droplet-based experiments to investigate antimicrobial resistance. We a ...
DOI:
10.1016/j.copbio.2022.102755

4. Empiric antibiotics for children with suspected Lyme disease

Author:
Aris C. Garro; Amy D. Thompson; Desiree N. Neville; Fran Balamuth; Michael N. Levas; Anupam B. Kharbanda; Jonathan E. Bennett; Duncan S. Grant; Rachael K. Aresco; Lise E. Nigrovic; Pedi Lyme Net Network
Source:
Ticks and tick-borne diseases 2022 pp. 101989
ISSN:
1877-959X
Subject:
antibiotics,   etc   ; Lyme disease; diagnostic techniques;     Show all 3 Subjects
Abstract:
... In our prospective cohort of children undergoing evaluation for non-cutaneous Lyme disease, 02 (13.9% of those with Lyme disease) were not initially treated with an appropriate antibiotics and 356 (13.3% without Lyme disease) received potentially unnecessary antibiotics. Rapid and accurate diagnostics are needed to further improve initial antibiotic treatment decisions. ...
DOI:
10.1016/j.ttbdis.2022.101989

5. A recent advancement on nanomaterials for electrochemical sensing of sulfamethaoxole and its futuristic approach

Author:
G. Padmalaya; K. Krishna Kumar; P. Senthil Kumar; B.S. Sreeja; Sanchali Bose
Source:
Chemosphere 2022 v.290 pp. 133115
ISSN:
0045-6535
Subject:
antibiotics,   etc   ; electrochemistry; hazard characterization; humans; sulfamethoxazole;     Show all 5 Subjects
Abstract:
... Sulfamethoxazole (SMX) forms the high harmfulness and causing negative health impacts to well-being human and environment that found to be major drastic concern. It is subsequently important to keep in track for monitoring of SMX through convenient detecting devices which include the requirement of being minimal expense and potential for on location environmental applications. Nanomaterials based ...
DOI:
10.1016/j.chemosphere.2021.133115

6. Atomistic Simulation of Molecules Interacting with Biological Nanopores: From Current Understanding to Future Directions

Author:
Abhishek Acharya; Jigneshkumar Dahyabhai Prajapati; Ulrich Kleinekathöfer
Source:
Journal of physical chemistry 2022 v.126 no.22 pp. 3995-4008
ISSN:
1520-5207
Subject:
antibiotics,   etc   ; chemical species; nanopores; permeability; solutes;     Show all 5 Subjects
Abstract:
... Biological nanopores have been at the focus of numerous studies due to their role in many biological processes as well as their (prospective) technological applications. Among many other topics, recent studies on nanopores have addressed two key areas: antibiotic permeation through bacterial channels and sensing of analytes. Although the two areas are quite far apart in terms of their objectives, ...
DOI:
10.1021/acs.jpcb.2c01173

7. Production enhancement of the glycopeptide antibiotic A40926 by an engineered Nonomuraea gerenzanensis strain

Author:
Bingyu Yan; Wen Gao; Li Tian; Shuai Wang; Huijun Dong
Source:
Biotechnology letters 2022 v.44 no.2 pp. 259-269
ISSN:
0141-5492
Subject:
antibiotics,   etc   ; Nonomuraea; biotechnology; genetic engineering; glycopeptides;     Show all 5 Subjects
Abstract:
... OBJECTIVE: To improve the production of A40926, a combined strategy of constructing the engineered strain and optimizing the medium was implemented. RESULTS: The engineered strain lcu1 with the genetic features of dbv23 deletion and dbv3-dbv20 coexpression increased by 30.6% in the production of A40926, compared to the original strain. In addition, a combined medium called M9 was designed to be fu ...
DOI:
10.1007/s10529-021-03210-1

8. Versatile polymer-based strategies for antibacterial drug delivery systems and antibacterial coatings

Author:
Kexin You; Bin Gao; Meiyu Wang; Xiaoyu Wang; Kingsley Chidiebere Okoro; Amirbek Rakhimbekzoda; Yakai Feng
Source:
Journal of materials chemistry B 2022 v.10 no.7 pp. 1005-1018
ISSN:
2050-7518
Subject:
antibiotics,   etc   ; bacterial adhesion; chemistry; human health;     Show all 4 Subjects
Abstract:
... Human health damage and economic losses due to bacterial infections are very serious issues worldwide. Excessive use of antibiotics has caused an increase in bacterial resistance. Fortunately, various non-antibiotic antibacterial materials have been developed to treat bacterial infections without bacterial resistance. This review mainly introduces functional polymers with an intrinsic antibacteria ...
DOI:
10.1039/d1tb02417e

9. Antimicrobial Peptides as a Promising Therapeutic Strategy for Neisseria Infections

Author:
Parvin Askari; Masoud Yousefi; Mohsen Foadoddini; Alireza Neshani; Mahdi Aganj; Nasim Lotfi; Aref Movaqar; Kiarash Ghazvini; Mohammad Hasan Namaei
Source:
Current microbiology 2022 v.79 no.4 pp. 102
ISSN:
0343-8651
Subject:
antibiotics,   etc   ; Neisseria; antibiotic resistance; antimicrobial peptides; microbiology;     Show all 5 Subjects
Abstract:
... Antibiotic resistance is already widespread in the world, and it has become a great health problem. Therefore, comprehensive efforts are needed to minimize the resistance. The exploration of alternative therapies may offer a more targeted approach with less susceptibility to resistance. Even though antimicrobial peptides (AMPs) have been introduced as emerging antibiotic sources, they are not wide ...
DOI:
10.1007/s00284-022-02767-y

10. Norfloxacin adsorption and subsequent degradation on ball-milling tailored N-doped biochar

Author:
Jingqi Wu; Tongshuai Wang; Yuyan Liu; Wei Tang; Shuyu Geng; Jiawei Chen
Source:
Chemosphere 2022 v.303 pp. 135264
ISSN:
0045-6535
Subject:
antibiotics,   etc   ; adsorption; biochar; energy; norfloxacin; pH; urea;     Show all 7 Subjects
Abstract:
... N-doping is an effective way to modify biochar for enhancing the adsorption capacity. The synthesis of N-doped biochar by the ball-milling method has been attractive due to its facile and eco-friendly approach with low energy consumption. However, the commonly used N-precursor NH₃·H₂O is environmentally harmful. It is needed to prepare safe and non-toxic N-doped biochar for large-scale production. ...
DOI:
10.1016/j.chemosphere.2022.135264

11. Antibiotics and antibiotic resistant bacteria/genes in urban wastewater: A comparison of their fate in conventional treatment systems and constructed wetlands

Author:
Moushumi Hazra; Himanshu Joshi; John B. Williams; Joy E.M. Watts
Source:
Chemosphere 2022 v.303 pp. 135148
ISSN:
0045-6535
Subject:
antibiotics,   etc   ; antibiotic resistance; energy; sewage; wastewater; wastewater treatment;     Show all 6 Subjects
Abstract:
... There is a growing concern that the use and misuse of antibiotics can increase the detection of antibiotic resistant genes (ARGs) in wastewater. Conventional wastewater treatment plants provide a pathway for ARGs and antibiotic resistant bacteria (ARB) to be released into natural water bodies. Research has indicated that conventional primary and secondary treatment systems can reduce ARGs/ARB to v ...
DOI:
10.1016/j.chemosphere.2022.135148

12. Applications of bacteriophages against intracellular bacteria

Author:
Paulina Śliwka; Marta Ochocka; Aneta Skaradzińska
Source:
Critical reviews in microbiology 2022 v.48 no.2 pp. 222-239
ISSN:
1549-7828
Subject:
antibiotics,   etc   ; bacteriophages; genomics; humans; immune system; phage therapy;     Show all 6 Subjects
Abstract:
... Infectious diseases pose a significant threat to both human and animal populations. Intracellular bacteria are a group of pathogens that invade and survive within the interior of eukaryotic cells, which in turn protect them from antibacterial drugs and the host immune system. Limited penetration of antibacterials into host cells results in insufficient bacterial clearance and treatment failure. Ba ...
DOI:
10.1080/1040841X.2021.1960481

13. One-pot synthesis of Zn–CdS@C nanoarchitecture with improved photocatalytic performance toward antibiotic degradation

Author:
Tianyu Liu; Baojia Wang; Ting Wang; Chenjie Li; Wei Wang; Min Wang; Jintao Zhang
Source:
Chemosphere 2022 v.300 pp. 134621
ISSN:
0045-6535
Subject:
antibiotics,   etc   ; carbon; corrosion; photocatalysis; photocatalysts; synthesis; wastewater treatment;     Show all 7 Subjects
Abstract:
... In this paper, carbon-coated Zn doped CdS core-shell photocatalyst (Zn–CdS@C) was fabricated via one-pot solvothermal method. The obtained Zn–CdS@C architectures displayed enhanced performance in photocatalytic antibiotic removal process. The Zn doped sites and carbon shell could all contribute to the prolonged lifetime of charge carriers and furthermore, result in the improved photoactivity. More ...
DOI:
10.1016/j.chemosphere.2022.134621

14. Silicate surface coverage controls quinolone transport in saturated porous media

Author:
Lian Zhou; Wei Cheng; Rémi Marsac; Jean-François Boily; Khalil Hanna
Source:
Journal of colloid and interface science 2022 v.607 pp. 347-356
ISSN:
0021-9797
Subject:
antibiotics,   etc   ; goethite; models; nalidixic acid; polymerization; quinolones; silicates;     Show all 7 Subjects
Abstract:
... Although silicates are the most common anions in aquatic systems, little is known on the roles they play on the transport of emerging contaminants, such as antibiotics. Using dynamic column experiments, we revealed the controls of Si loadings on goethite (α-FeOOH) coated sands on the transport of a widely used quinolone antibiotic, here focusing on Nalidixic Acid (NA). We find that dynamic flow-th ...
DOI:
10.1016/j.jcis.2021.08.142

15. Alteration of birnessite reactivity in dynamic anoxic/oxic environments

Author:
Qinzhi Li; Dieter Schild; Mathieu Pasturel; Johannes Lützenkirchen; Khalil Hanna
Source:
Journal of hazardous materials 2022 v.433 pp. 128739
ISSN:
0304-3894
Subject:
antibiotics,   etc   ; birnessite; ionic strength; manganese; manganese monoxide; oxidation; pH;     Show all 7 Subjects
Abstract:
... Although the oxidative capacity of manganese oxides has been widely investigated, potential changes of the surface reactivity in dynamic anoxic/oxic environments have been often overlooked. In this study, we showed that the reactivity of layer structured manganese oxide (birnessite) was highly sensitive to variable redox conditions within environmentally relevant ranges of pH (4.0 – 8.0), ionic st ...
DOI:
10.1016/j.jhazmat.2022.128739

16. Antibiotic residues in environment: antimicrobial resistance development, ecological risks, and bioremediation

Author:
Mansi Apreja; Aarjoo Sharma; Sanjeev Balda; Kirti Kataria; Neena Capalash; Prince Sharma
Source:
Environmental science and pollution research 2022 v.29 no.3 pp. 3355-3371
ISSN:
0944-1344
Subject:
antibiotics,   etc   ; antibiotic resistance; bioremediation; pollution; research; synthetic biology; toxicity;     Show all 7 Subjects
Abstract:
... The overuse of antibiotics and their disposal without processing are leading the environment and its inhabitants towards a serious health emergency. There is abundance of diverse antibiotic resistance genes and bacteria in environment, which demands immediate attention for the effective removal of antibiotics. There are physical and chemical methods for removal, but the generation of toxic byprodu ...
DOI:
10.1007/s11356-021-17374-w

17. Early Antibiotic Exposure Alters Intestinal Development and Increases Susceptibility to Necrotizing Enterocolitis: A Mechanistic Study

Author:
Hala Chaaban; Maulin M. Patel; Kathryn Burge; Jeffrey V. Eckert; Cristina Lupu; Ravi S. Keshari; Robert Silasi; Girija Regmi; MaJoi Trammell; David Dyer; Steven J. McElroy; Florea Lupu
Source:
Microorganisms 2022 v.10 no.3 pp. -
ISSN:
2076-2607
Subject:
antibiotics,   etc   ; cell proliferation; enterocolitis; inflammation; intestines; mortality; necrosis; therapeutics;     Show all 8 Subjects
Abstract:
... Increasing evidence suggests that prolonged antibiotic therapy in preterm infants is associated with increased mortality and morbidities, such as necrotizing enterocolitis (NEC), a devastating gastrointestinal pathology characterized by intestinal inflammation and necrosis. While a clinical correlation exists between antibiotic use and the development of NEC, the potential causality of antibiotics ...
DOI:
10.3390/microorganisms10030519

18. Fast selection of nonlinear mixed effect models using penalized likelihood

Author:
Edouard Ollier
Source:
Computational statistics & data analysis 2022 v.167 pp. 107373
ISSN:
0167-9473
Subject:
antibiotics,   etc   ; Bayesian theory; algorithms; data analysis; pharmacogenomics; pharmacokinetics; pharmacometrics;     Show all 7 Subjects
Abstract:
... Nonlinear Mixed effects models are hidden variables models that are widely used in many fields such as pharmacometrics. In such models, the distribution characteristics of hidden variables can be specified by including several parameters such as covariates or correlations which must be selected. Recent development of pharmacogenomics has brought averaged/high dimensional problems to the field of n ...
DOI:
10.1016/j.csda.2021.107373

19. In situ synthesis of graphene-like N, S co-doped carbon nanosheets/FeF3·0.33H2O composite as cathode material for Li-ion battery

Author:
Jing Ding; Xiangyang Zhou; Chucheng Luo; Herong Xu; Juan Yang; Jingjing Tang
Source:
Journal of materials science 2022 v.57 no.2 pp. 1261-1270
ISSN:
0022-2461
Subject:
antibiotics,   etc   ; carbon; cathodes; electric potential difference; electrochemistry; lithium batteries;     Show all 6 Subjects
Abstract:
... Nowadays, transition metal fluorides (MeₓFy, Me = Fe, Co, Ni, etc.) have received extensive attention for high work voltage and large theoretical capacity. In this study, we aim to develop an effective approach to enhance its conductivity and thus improve the electrochemical performance. We propose a graphene-like N, S co-doped carbon nanosheets/FeF₃·0.33H₂O (GNSCFF) composite derived from antibio ...
DOI:
10.1007/s10853-021-06625-3

20. Pharmacokinetic-pharmacodynamic models for time courses of antibiotic effects: VSI: Antimicrobial Pharmacometrics

Author:
Iris K. Minichmayr; Vincent Aranzana-Climent; Lena E. Friberg
Source:
International journal of antimicrobial agents 2022 pp. 106616
ISSN:
0924-8579
Subject:
antibiotics,   etc   ; bacterial growth; drug development; models; patients; pharmacometrics; regrowth;     Show all 7 Subjects
Abstract:
... Pharmacokinetic-pharmacodynamic (PKPD) models have emerged as valuable tools for the characterisation and translation of antibiotic effects, and consequently for drug development and therapy. In contrast to traditional PKPD concepts for antibiotics like MIC and PKPD indices, PKPD models enable to describe the continuous, often species- or population-dependent time course of antimicrobial effects, ...
DOI:
10.1016/j.ijantimicag.2022.106616