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1. Aspects of excessive antibiotic consumption and environmental influences correlated with the occurrence of resistance to antimicrobial agents

Author:
Bungau, Simona; Tit, Delia Mirela; Behl, Tapan; Aleya, Lotfi; Zaha, Dana Carmen
Source:
Current opinion in environmental science & health 2021 v.19 pp. 100224
ISSN:
2468-5844
Subject:
antibiotic resistance; antibiotics,   etc   ; environmental science; soil;     Show all 4 Subjects
Abstract:
... This article explores the correlation between specific aspects of antibiotic usage, their resistance development, and environmental factors. The indiscriminate use of antibiotics led to environment contamination, selection and spreading of antibiotic-resistant organisms, and alteration of the microbial ecosystems balance. Sociobehavioural environmental factors and changes in the natural environmen ...
DOI:
10.1016/j.coesh.2020.10.012

2. Strategies for Discovering New Antibiotics from Bacteria in the Post-Genomic Era

Author:
Zhu, Jia-Wei; Zhang, Si-Jia; Wang, Wen-Guang; Jiang, Hui
Source:
Current microbiology 2020 v.77 no.11 pp. 3213-3223
ISSN:
0343-8651
Subject:
antibiotic resistance; antibiotics,   etc   ; metagenomics;     Show all 3 Subject
Abstract:
... New antibiotics are urgently required in clinical treatment and agriculture with the development of antimicrobial resistance. However, products discovered by repeating previous strategies are either not antibiotics or already known antibiotics. There is a growing demand for efficient strategies to discover new antibiotics. With the continuous improvement of gene sequencing technology and genomic d ...
DOI:
10.1007/s00284-020-02197-8

3. Application of bacteriophage-derived endolysins to combat streptococcal disease: current state and perspectives

Author:
Linden, Sara B; Alreja, Adit B; Nelson, Daniel C
Source:
Current opinion in biotechnology 2021 v.68 pp. 213-220
ISSN:
0958-1669
Subject:
antibiotic resistance; antibiotics,   etc   ; biotechnology; endolysin; humans; immunogenicity; peptidoglycans; therapeutics; toxicity;     Show all 9 Subjects
Abstract:
... The decline in new antibiotic candidates combined with an increase in antibiotic-resistance necessitates development of alternative antimicrobials. Bacteriophage-encoded endolysins (lysins) are a class of peptidoglycan hydrolases that have been proposed to fill this antimicrobial void. The past 20 years has seen a dramatic expansion of studies on endolysin discovery, structure/function, engineerin ...
DOI:
10.1016/j.copbio.2021.01.012

4. Information avoidance behavior: Does ignorance keep us uninformed about antimicrobial resistance?

Author:
Meerza, Syed Imran Ali; Brooks, Kathleen R.; Gustafson, Christopher R.; Yiannaka, Amalia
Source:
Food policy 2021 pp. 102067
ISSN:
0306-9192
Subject:
antibiotic resistance; antibiotics,   etc   ; avoidance behavior; food policy; livestock production; surveys;     Show all 6 Subjects
Abstract:
... We examine the role of subjective and objective knowledge of antimicrobial resistance (AMR) and antibiotic use in livestock production on information avoidance behavior. The study also assesses the effects of AMR information on perceptions of AMR. Survey data were collected from 1,030 individuals in the U.S. to evaluate knowledge and perceptions of AMR. Participants also made a choice to access or ...
DOI:
10.1016/j.foodpol.2021.102067

5. Impact of bacterial persisters on their host

Author:
Moldoveanu, Ana L; Rycroft, Julian A; Helaine, Sophie
Source:
Current opinion in microbiology 2021 v.59 pp. 65-71
ISSN:
1369-5274
Subject:
antibiotic resistance; antibiotics,   etc   ; bacteria; biosynthesis; evolution; immune response; pathogen survival;     Show all 7 Subjects
Abstract:
... The rise of antibiotic failure poses a severe threat to global health. There is growing concern that this failure is not solely driven by stable antibiotic resistance but also by a subpopulation of transiently non-growing, antibiotic tolerant bacteria. These ‘persisters’ have been proposed to seed relapsing infections, an important clinical outcome of treatment failure — although definitive eviden ...
DOI:
10.1016/j.mib.2020.07.006

6. Elimination of macrophage-entrapped antibiotic-resistant bacteria by a targeted metal–organic framework-based nanoplatform

Author:
Liu, Xuemeng; Deng, Qingqing; Zhang, Lu; Sang, Yanjuan; Dong, Kai; Ren, Jinsong; Qu, Xiaogang
Source:
Chemical communications 2021 v.57 no.23 pp. 2903-2906
ISSN:
1364-548X
Subject:
antibiotic resistance,   etc   ; irradiation; photosensitizing agents;     Show all 3 Subjects
Abstract:
... A novel metal–organic framework-based platform was designed and constructed for photosensitizer delivery for the elimination of intracellular antibiotic-resistant bacteria. With the merit of targeting and internalizing ability, the system could kill the stealthy bacteria efficiently under light irradiation. ...
DOI:
10.1039/d0cc08340b

7. Rapid synthesis of multifunctional β-cyclodextrin nanospheres as alkali-responsive nanocarriers and selective antibiotic adsorbents

Author:
Li, Qiuju; Wang, Dandan; Fang, Xian; Zong, Boyang; Liu, Ying; Li, Zhuo; Mao, Shun; Ostrikov, Kostya Ken
Source:
Chemical communications 2021 v.57 no.9 pp. 1161-1164
ISSN:
1364-548X
Subject:
antibiotics,   etc   ; adsorbents; nanocarriers; nanospheres; temperature;     Show all 5 Subjects
Abstract:
... Novel hypercross-linked β-cyclodextrin nanospheres are rapidly synthesized with 4-amino-6-hydroxy-2-mercaptopyrimidine as a cross-linker within 5 min at a low temperature of 60 °C in the open water phase, thereby radically simplifying and accelerating the conventional time-consuming and environmentally harsh synthesis of cyclodextrin-containing polymers. The nanospheres demonstrate excellent and c ...
DOI:
10.1039/d0cc06768g

8. Accounting for variation in and overuse of antibiotics among humans

Author:
Blaser, Martin J.; Melby, Melissa K.; Lock, Margaret; Nichter, Mark
Source:
BioEssays 2021 v.43 no.2 pp. e2000163
ISSN:
0265-9247
Subject:
antibiotics,   etc   ; Internet; caregivers; medicine; therapeutics;     Show all 5 Subjects
Abstract:
... Worldwide, antibiotic use is increasing, but many infections against which antibiotics are applied are not even caused by bacteria. Over‐the‐counter and internet sales preclude physician oversight. Regional differences, between and within countries highlight many potential factors influencing antibiotic use. Taking a systems perspective that considers pharmaceutical commodity chains, we examine an ...
DOI:
10.1002/bies.202000163

9. Antibiotics florfenicol and flumequine in the water column and sediments of Puyuhuapi Fjord, Chilean Patagonia

Author:
Jara, Bibiana; Tucca, Felipe; Srain, Benjamín M.; Méjanelle, Laurence; Aranda, Mario; Fernández, Camila; Pantoja-Gutiérrez, Silvio
Source:
Chemosphere 2021 v.275 pp. 130029
ISSN:
0045-6535
Subject:
antibiotic resistance; antibiotic resistance genes; antibiotics,   etc   ; florfenicol; flumequine; human health; models; risk; salmon; Argentina; Chile;     Show all 11 Subjects
Abstract:
... Chile is a major global producer of farmed salmon in the fjords of Patagonia, and therefore a major consumer of antibiotics. We tested whether the antibiotics florfenicol and flumequine persisted in the large Puyuhuapi Fjord after the six months following mandatory concerted treatment by all salmon farms present in the fjord. Antibiotics were detected in 26% of analyzed samples, but only within th ...
DOI:
10.1016/j.chemosphere.2021.130029

10. Overview of bioinformatic methods for analysis of antibiotic resistome from genome and metagenome data

Author:
Lee, Kihyun; Kim, Dae-Wi; Cha, Chang-Jun
Source:
The journal of microbiology 2021 v.59 no.3 pp. 270-280
ISSN:
1225-8873
Subject:
antibiotic resistance; antibiotic resistance genes; antibiotics,   etc   ; bioinformatics; computer software; metagenomics; microbiology;     Show all 7 Subjects
Abstract:
... Whole genome and metagenome sequencing are powerful approaches that enable comprehensive cataloging and profiling of antibiotic resistance genes at scales ranging from a single clinical isolate to ecosystems. Recent studies deal with genomic and metagenomic data sets at larger scales; therefore, designing computational workflows that provide high efficiency and accuracy is becoming more important. ...
DOI:
10.1007/s12275-021-0652-4

11. Copper stimulates the incidence of antibiotic resistance, metal resistance and potential pathogens in the gut of black soldier fly larvae

Author:
Wu, Nan; Liang, Jiaqi; Wang, Xiaobo; Xie, Shiyu; Xu, Xiaoyan
Source:
Journal of environmental sciences (China) 2021 v.107 pp. 150-159
ISSN:
1001-0742
Subject:
antibiotic resistance; antibiotic resistance genes; antibiotics,   etc   ; ; Enterococcus; Escherichia; Hermetia illucens; Salmonella; copper; digestive system; intestinal microorganisms; metal tolerance; China;     Show all 13 Subjects
Abstract:
... The black soldier fly larvae (BSFL) have been successfully applied to treat various organic wastes. However, the impacts of heavy metals on antibiotic resistance in the BSFL guts are poorly understood. Here, we investigated the effect of copper (exposure concentrations of 0, 100 and 800 mg/kg) on the antibiotic and metal resistance profiles in BSFL guts. A total of 83 antibiotic resistance genes ( ...
DOI:
10.1016/j.jes.2021.02.008

12. Prevalence of antibiotic resistance genes and bacterial pathogens along the soil–mangrove root continuum

Author:
Wang, Cheng; Hu, Ruiwen; Strong, P.J.; Zhuang, Wei; Huang, Weiming; Luo, Zhiwen; Yan, Qingyun; He, Zhili; Shu, Longfei
Source:
Journal of hazardous materials 2021 v.408 pp. 124985
ISSN:
0304-3894
Subject:
antibiotic resistance; antibiotic resistance genes; antibiotics,   etc   ; Escherichia coli; Klebsiella pneumoniae; Vibrio vulnificus; fungi; metagenomics; multiple drug resistance; rhizosphere; soil;     Show all 11 Subjects
Abstract:
... Plants roots are colonised by soil bacteria that are known to be the reservoir of antibiotic resistance genes (ARGs). ARGs can transfer between these microorganisms and pathogens, but to what extent these ARGs and pathogens disseminate from soil into plant is poorly understood. Here, we examined a high-resolution resistome profile along the soil–root continuum of mangrove saplings using amplicon a ...
DOI:
10.1016/j.jhazmat.2020.124985

13. Large-scale biogeographical patterns of antibiotic resistome in the forest soils across China

Author:
Song, Mengke; Song, Dandan; Jiang, Longfei; Zhang, Dayi; Sun, Yingtao; Chen, Guoen; Xu, Huijuan; Mei, Weiping; Li, Yongtao; Luo, Chunling; Zhang, Gan
Source:
Journal of hazardous materials 2021 v.403 pp. 123990
ISSN:
0304-3894
Subject:
antibiotic resistance; antibiotic resistance genes; antibiotics,   etc   ; aminoglycosides; detection limit; forests; geographical distribution; horizontal gene transfer; humans; China;     Show all 10 Subjects
Abstract:
... Soil is a reservoir of environmental resistomes. Information about their distribution, profiles, and driving forces in undisturbed environments is essential for understanding and managing modern antibiotic resistance genes (ARGs) in human disturbed environments. However, knowledge about the resistomes in pristine soils is limited, particularly at national scale. Here, we conducted a national-scale ...
DOI:
10.1016/j.jhazmat.2020.123990

14. Interference of ISEcp1-blaCTX-M-1 with the shufflon rearrangement in IncI1 plasmids

Author:
Stosic, Milan S.; Sunde, Marianne; Mo, Solveig Sølverød; Telke, Amar Anandrao; Rudi, Knut
Source:
Plasmid 2021 v.116 pp. 102578
ISSN:
0147-619X
Subject:
antibiotic resistance,   etc   ; Enterobacteriaceae; cephalosporins; fimbriae; genes; plasmids;     Show all 6 Subjects
Abstract:
... IncI1 plasmids are known disseminators of the extended-spectrum cephalosporin resistance (ESC) gene blaCTX₋M₋₁, among species of the Enterobacteriaceae family. In several IncI1 plasmids, this gene was found incorporated into the transposition unit, ISEcp1-blaCTX₋M₋₁-orf477, interrupting a shufflon region, a hallmark of IncI1 conjugative plasmids. The shufflon diversifies pilV gene that encodes the ...
DOI:
10.1016/j.plasmid.2021.102578

15. Lipoproteins in Gram-negative bacteria: new insights into their biogenesis, subcellular targeting and functional roles

Author:
El Rayes, Jessica; Rodríguez-Alonso, Raquel; Collet, Jean-François
Source:
Current opinion in microbiology 2021 v.61 pp. 25-34
ISSN:
1369-5274
Subject:
antibiotics,   etc   ; Escherichia coli; biogenesis; lipoproteins; moieties;     Show all 5 Subjects
Abstract:
... Bacterial lipoproteins are globular proteins anchored to a membrane by a lipid moiety. By discovering new functions carried out by lipoproteins, recent research has highlighted the crucial roles played by these proteins in the cell envelope of Gram-negative bacteria. Here, after discussing the wide range of activities carried out by lipoproteins in the model bacterium Escherichia coli, we review n ...
DOI:
10.1016/j.mib.2021.02.003

16. Water-Soluble Heliomycin Derivatives to Target i-Motif DNA

Author:
Tikhomirov, Alexander S.; Abdelhamid, Mahmoud A. S.; Nadysev, Georgy Y.; Zatonsky, George V.; Bykov, Eugene E.; Chueh, Pin Ju; Waller, Zoë A. E.; Shchekotikhin, Andrey E.
Source:
Journal of natural products 2021 v.84 no.5 pp. 1617-1625
ISSN:
1520-6025
Subject:
antibiotics,   etc   ; DNA; drug therapy; ligands; water solubility;     Show all 5 Subjects
Abstract:
... Heliomycin (also known as resistomycin) is an antibiotic with a broad spectrum of biological activities. However, low aqueous solubility and poor knowledge of its chemical properties have limited the development of this natural product. Here, we present an original scheme for the introduction of aminoalkylamine residues at positions 3, 5, and 7 of heliomycin and, using this, have prepared a series ...
DOI:
10.1021/acs.jnatprod.1c00162

17. A molecular assay for rapidly distinguishing the AviPro SALMONELLA VAC T vaccine strain from wild-type field isolates

Author:
Ceyssens, Pieter-Jan; Van den Bossche, An; Phan, Lac Kim; Van Hoorde, Koenraad; Mattheus, Wesley
Source:
Journal of microbiological methods 2021 v.184 pp. 106190
ISSN:
0167-7012
Subject:
antibiotic resistance,   etc   ; Salmonella; phenotype; vaccines; virulence;     Show all 5 Subjects
Abstract:
... Rapid differentiation of the AviPro Salmonella VAC T strain from wild-type Salmonella ser. Typhimurium isolates is essential for the monitoring of veterinary isolates and targeted control actions. The distinction between the two strain types is routinely made by phenotypic antimicrobial resistance testing, but this sometime leads to ambiguous results with major economic implications. In this study ...
DOI:
10.1016/j.mimet.2021.106190

18. Pharmacokinetics and bioavailability of solid dispersion formulation of tilmicosin in pigs

Author:
Zhang, Nan; Ba, Juan; Wang, Shaojie; Xu, Zhigao; Wu, Fuda; Li, Zhili; Deng, Hua; Yang, Hong
Source:
Journal of veterinary pharmacology and therapeutics 2021 v.44 no.3 pp. 359-366
ISSN:
0140-7783
Subject:
antibiotics,   etc   ; bioavailability; macrolides; oral administration; pharmacokinetics; solubility;     Show all 6 Subjects
Abstract:
... Tilmicosin (TMS) is a semisynthetic macrolide antibiotic restricted to veterinary use but is only partially soluble in aqueous solutions, which limits its administration in treatments. We developed a strategy to enhance the supersaturated solubility of TMS using amorphous solid dispersion (SD). The dissolution profile shown that the dissolution rate of TMS‐SD was obviously faster than TMS. The pha ...
DOI:
10.1111/jvp.12929

19. Phage engineering and the evolutionary arms race

Author:
Peng, Huan; Chen, Irene A
Source:
Current opinion in biotechnology 2021 v.68 pp. 23-29
ISSN:
0958-1669
Subject:
antibiotic resistance,   etc   ; bacteriophages; biotechnology; phage therapy;     Show all 4 Subjects
Abstract:
... Phages are versatile agents for delivering a variety of cargo, including nanomaterials, nucleic acids, and small molecules. A potentially important application is treatment of antibiotic-resistant infections. All of these applications require molecular engineering of the phages, including chemical modification and genetic engineering. Phages are remarkably amenable to such engineering. We review s ...
DOI:
10.1016/j.copbio.2020.09.009

20. Regulation of biochar mediated catalytic degradation of quinolone antibiotics: Important role of environmentally persistent free radicals

Author:
Zhang, Yanzhuo; Xu, Mengqi; Liu, Xiaoke; Wang, Meng; Zhao, Jing; Li, Shaoya; Yin, Muchen
Source:
Bioresource technology 2021 v.326 pp. 124780
ISSN:
0960-8524
Subject:
antibiotics,   etc   ; biochar; pollution; quinolones; remediation; technology; temperature;     Show all 7 Subjects
Abstract:
... Antibiotic pollution threatens aquatic ecosystems and water supplies, so analysis of ecofriendly remediation approaches like biochars with catalytic degradation abilities is a top priority. In this work, quinolone antibiotics were degraded by activating oxidants to generate transient radicals using the environmentally persistent free radicals (EPFRs) carried by biochar. The physical and chemical c ...
DOI:
10.1016/j.biortech.2021.124780