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1. Optically Responsive, Smart Anti-Bacterial Coatings via the Photofluidization of Azobenzenes

Author:
Kehe, Gannon M.; Mori, Dylan I.; Schurr, Michael J.; Nair, Devatha P.
Source:
ACS applied materials & interfaces 2019 v.11 no.2 pp. 1760-1765
ISSN:
1944-8252
Subject:
antibiotic resistance; antibiotics,   etc   ; bacteria; biofilm; coatings; drugs;     Show all 6 Subjects
Abstract:
... Antibacterial strategies sans antibiotic drugs have recently garnered much interest as a mechanism by which to inhibit biofilm formation and growth on surfaces due to the rise of antibiotic-resistant bacteria. Based on the photofluidization of azobenzenes, we demonstrate for the first time the ability achieve up to a 4 log reduction in bacterial biofilms by opto-mechanically activating the disrupt ...
DOI:
10.1021/acsami.8b21058

2. Devil's hand conceals behind the obscure side of AgNPs: A letter to the editor

Author:
Rasouli, Hassan
Source:
International journal of biological macromolecules 2019 v.125 pp. 510-513
ISSN:
0141-8130
Subject:
antibiotics,   etc   ; models; nanosilver; researchers;     Show all 4 Subjects
Abstract:
... From that time AgNPs become one of the most accessible and important antibacterial agents in our world, thousands of papers published regarding investigating all aspects of these materials. When the time elapsed and novel methods contrived to follow the fingerprint of AgNPs in the in vivo models, some critical concerns and arguments also appeared between researchers about the safety of these compo ...
DOI:
10.1016/j.ijbiomac.2018.12.076

3. Comments on “Antibiotic pollution in surface fresh waters: Occurrence and effects”, Science of the Total Environment, 664, 793–804 (2019)

Author:
Tran, N.H.; Trinh, Q.T.; Nguyen, Q.B.
Source:
The Science of the total environment 2019
ISSN:
0048-9697
Subject:
antibiotics,   etc   ; freshwater; pollution;     Show all 3 Subjects
Abstract:
... This article found mistakes and misunderstandings regarding the collection of occurrence data of antibiotics in surface freshwater from the previous literature. These mistakes and misunderstandings were corrected to avoid the propagation of inaccurate information in the scientific literature. ...
DOI:
10.1016/j.scitotenv.2019.03.036

4. Antimicrobial Resistance Awareness and Games

Author:
Molnar, Andreea
Source:
Trends in microbiology 2019 v.27 no.1 pp. 1-3
ISSN:
0966-842X
Subject:
antibiotic resistance,   etc   ; education; games;     Show all 3 Subjects
Abstract:
... Antibiotic resistance is an increasingly global problem that requires different approaches to be undertaken. This article argues that games could be used to complement existing antibiotic-resistance awareness campaigns as they have several characteristics that could help people engage with information. ...
DOI:
10.1016/j.tim.2018.09.007

5. Use of antibiotic disks to evolve drug-resistant bacteria

Author:
Flanagan, J. Nicole; Steck, Todd R.
Source:
Antonie van Leeuwenhoek 2018 v.111 no.9 pp. 1719-1722
ISSN:
0003-6072
Subject:
antibiotic resistance; antibiotics,   etc   ; bacteria;     Show all 3 Subject
Abstract:
... The methods used to generate antibiotic-resistant bacterial strains can be labour-intensive, costly, lengthy and/or prone to plate-to-plate variation. We propose a simple, inexpensive and easily replicated method to expose bacteria to a continuous gradient of antibiotic concentration, providing an environment of positive selective pressure for evolution of antibiotic-resistant strains. ...
DOI:
10.1007/s10482-018-1055-3

6. Bacteriophages as Environmental Reservoirs of Antibiotic Resistance

Author:
Calero-Cáceres, William; Ye, Mao; Balcázar, José Luis
Source:
Trends in microbiology 2019 v.27 no.7 pp. 570-577
ISSN:
0966-842X
Subject:
antibiotic resistance; antibiotic resistance genes,   etc   ; bacteriophages; public health;     Show all 4 Subjects
Abstract:
... Although antibiotic resistance represents a significant and growing public health concern, the contribution of bacteriophages (phages) to the mobilization of antibiotic resistance genes (ARGs) in the environment has not been extensively studied. Recent studies, however, suggest that phages play an important role in the acquisition, maintenance, and spread of ARGs than previously expected. This Opi ...
DOI:
10.1016/j.tim.2019.02.008

7. ATP-Dependent Dynamic Protein Aggregation Regulates Bacterial Dormancy Depth Critical for Antibiotic Tolerance

Author:
Pu, Yingying; Li, Yingxing; Jin, Xin; Tian, Tian; Ma, Qi; Zhao, Ziyi; Lin, Ssu-yuan; Chen, Zhanghua; Li, Binghui; Yao, Guang; Leake, Mark C.; Lo, Chien-Jung; Bai, Fan
Source:
Molecular cell 2019 v.73 no.1 pp. 143-156.e4
ISSN:
1097-2765
Subject:
antibiotic resistance; antibiotics,   etc   ; adenosine triphosphate; bacteria; dormancy; regrowth; therapeutics;     Show all 7 Subjects
Abstract:
... Cell dormancy is a widespread mechanism used by bacteria to evade environmental threats, including antibiotics. Here we monitored bacterial antibiotic tolerance and regrowth at the single-cell level and found that each individual survival cell shows different “dormancy depth,” which in return regulates the lag time for cell resuscitation after removal of antibiotic. We further established that pro ...
DOI:
10.1016/j.molcel.2018.10.022

8. Editorial of the VSI “Antibiotics and heavy metals in the environment: Facing the challenge”

Author:
Núñez-Delgado, Avelino; Zhou, Yaoyu; Necibi, Chaker; Xu, Yanbin; Fernández-Calviño, David
Source:
The Science of the total environment 2019 v.678 pp. 30-32
ISSN:
0048-9697
Subject:
antibiotics,   etc   ; databases; heavy metals; pollutants;     Show all 4 Subjects
Abstract:
... The Virtual Special Issue (VSI) “Antibiotics and Heavy Metals in the Environment: Facing the Challenge” received more than 100 submissions from research teams around the world. Finally, more than 50 papers were accepted and published. These very interesting research papers allow going ahead in the knowledge of different aspects which determine the fate of antibiotics and heavy metals in the enviro ...
DOI:
10.1016/j.scitotenv.2019.04.421

9. Total Synthesis of (+)-Pleuromutilin

Author:
Farney, Elliot P.; Feng, Sean S.; Schäfers, Felix; Reisman, Sarah E.
Source:
Journal of the American Chemical Society 2018 v.140 no.4 pp. 1267-1270
ISSN:
1520-5126
Subject:
antibiotics,   etc   ; stereoselectivity;     Show all 2 Subject
Abstract:
... An 18-step synthesis of the antibiotic (+)-pleuromutilin is disclosed. The key steps of the synthesis include a highly stereoselective SmI₂-mediated cyclization to establish the eight-membered ring and a stereospecific transannular [1,5]-hydrogen atom transfer to set the C10 stereocenter. This strategy was also used to prepare (+)-12-epi-pleuromutilin. The chemistry described here will enable effo ...
DOI:
10.1021/jacs.7b13260

10. Response of antibiotic resistance to the co-existence of chloramphenicol and copper during bio-electrochemical treatment of antibiotic-containing wastewater

Author:
Ma, Xiaofang; Guo, Ning; Ren, Shaojie; Wang, Shuguang; Wang, Yunkun
Source:
Environment international 2019 v.126 pp. 127-133
ISSN:
0160-4120
Subject:
antibiotic resistance; antibiotic resistance genes; antibiotics,   etc   ; bacterial communities; chloramphenicol; community structure; copper; heavy metals; microorganisms; transporters; wastewater;     Show all 11 Subjects
Abstract:
... Concerns have been raised regarding co-selection for antibiotic resistance among microorganisms exposed to antibiotics and metals. As a promising approach for treating antibiotics and heavy metal-containing wastewater, a bio-electrochemical system (BES) can be used for antibiotic and heavy metal removal. This study determined the fate of antibiotic resistance genes (ARGs) in a BES when exposed to ...
DOI:
10.1016/j.envint.2019.02.002

11. Variability of resistance plasmids in coagulase-negative staphylococci and their importance as a reservoir of antimicrobial resistance

Author:
Fišarová, Lenka; Pantůček, Roman; Botka, Tibor; Doškař, Jiří
Source:
Research in microbiology 2019 v.170 no.2 pp. 105-111
ISSN:
0923-2508
Subject:
antibiotic resistance; antibiotic resistance genes; antibiotics,   etc   ; Staphylococcus aureus; Staphylococcus epidermidis; animal diseases; coagulase negative staphylococci; electroporation; hospitals; humans; plasmids;     Show all 11 Subjects
Abstract:
... Coagulase-negative staphylococci (CoNS) are an important cause of human and animal diseases. Treatment of these diseases is complicated by their common antimicrobial resistance, caused by overuse of antibiotics in hospital and veterinary environment. Therefore, they are assumed to serve as a reservoir of resistance genes often located on plasmids. In this study, we analyzed plasmid content in 62 s ...
DOI:
10.1016/j.resmic.2018.11.004

12. Optical and Electrochemical Sensors and Biosensors for the Detection of Quinolones

Author:
Majdinasab, Marjan; Mitsubayashi, Kohji; Marty, Jean Louis
Source:
Trends in biotechnology 2019
ISSN:
0167-7799
Subject:
antibiotic residues; antibiotic resistance; antibiotics,   etc   ; animal-based foods; biosensors; food safety; humans; infectious diseases; livestock; monitoring; quinolones; residual effects;     Show all 12 Subjects
Abstract:
... One major concern associated with food safety is related to residual effects of antibiotics that are widely used to treat animals and results in antimicrobial resistance. Among different groups of antibiotics, the use of quinolones in livestock is of major concern due to the significance of these antimicrobial drugs for the treatment of a broad range of infectious diseases in humans. Therefore, it ...
DOI:
10.1016/j.tibtech.2019.01.004

13. Degradation of metronidazole by dielectric barrier discharge in an aqueous solution

Author:
Yang, Zhipeng; Lai, Anxing; Chen, Hangyu; Yan, Youxiang; Yang, Ye; Zhang, Weiwei; Wang, Lei
Source:
Frontiers of environmental science & engineering 2019 v.13 no.3 pp. 33
ISSN:
2095-2201
Subject:
antibiotics,   etc   ; aqueous solutions; metronidazole; organic matter; pH;     Show all 5 Subjects
Abstract:
... Degradation of metronidazole (MNZ) which is a representative and stable antibiotic by dielectric barrier discharge (DBD) in an aqueous solution has been studied. Effects of initial MNZ concentration, solution pH and coexisting organics on the degradation were investigated. The results illustrated that increasing the input power and the discharge frequency can improve the removal of MNZ. At low ini ...
DOI:
10.1007/s11783-019-1117-4

14. Hybrid breath figure method: A new insight in Petri dishes for cell culture

Author:
Huang, Chuixiu; Shen, Xiantao; Liu, Xiaojie; Chen, Zhiliang; Shu, Baolian; Wan, Libin; Liu, Huajing; He, Jun
Source:
Journal of colloid and interface science 2019 v.541 pp. 114-122
ISSN:
0021-9797
Subject:
antibiotics,   etc   ; antibacterial properties; bacteria; cell culture; mammals;     Show all 5 Subjects
Abstract:
... The traditional Petri dish, which has not been changed in almost 60 years, has clear limitations when it is applied to cell cultures in a modern biological laboratory. In this work, by integrating the advantages of both the semidirect breath figure (sDBF) method and the traditional breath figure (BF) method, we proposed for the first time a novel hybrid BF method for the fabrication of honeycomb-p ...
DOI:
10.1016/j.jcis.2019.01.074

15. Amino-functionalized biomass-derived porous carbons with enhanced aqueous adsorption affinity and sensitivity of sulfonamide antibiotics

Author:
Wang, Yu; Jiao, Wen-Bin; Wang, Jun-Tao; Liu, Gui-Fang; Cao, Hai-Lei; Lü, Jian
Source:
Bioresource technology 2019 v.277 pp. 128-135
ISSN:
0960-8524
Subject:
antibiotics,   etc   ; adsorption; carbon; pH; remediation; sulfadiazine; wastewater;     Show all 7 Subjects
Abstract:
... In view of the increasing concerns in antibiotics contamination, advanced technologies for antibiotics removal have been receiving widespread research attention in the fields of environmental sciences. This work has developed a series of amino-functionalized porous carbon materials (NH2-BPCs), via a facile chemical modification method, which have been found efficient for the removal of sulfonamide ...
DOI:
10.1016/j.biortech.2019.01.033

16. Research, Innovation, and Policy: An Alliance Combating Antimicrobial Resistance

Author:
van Hengel, Arjon J.; Marin, Laura
Source:
Trends in microbiology 2019 v.27 no.4 pp. 287-289
ISSN:
0966-842X
Subject:
antibiotic resistance,   etc   ; issues and policy; public health;     Show all 3 Subjects
Abstract:
... The surge in antimicrobial resistance (AMR) has created a crisis that has become top priority for public health and global policy. Researchers, developers, innovators, funders, and policymakers need to curb AMR’s rising trend by acting synergistically, boosting investment in developing solutions. This science–policy interface is now taking shape. ...
DOI:
10.1016/j.tim.2018.12.005

17. Assessment of Efficacy of BLIS-Producing Probiotic K12 for the Prevention of Group A Streptococcus Pharyngitis: a Short Communication

Author:
Di Pierro, Francesco
Source:
Probiotics and antimicrobial proteins 2019 v.11 no.1 pp. 332-334
ISSN:
1867-1306
Subject:
antibiotics,   etc   ; Streptococcus salivarius; pharyngitis; probiotics; schools;     Show all 5 Subjects
Abstract:
... The neutral outcome of the recently reported school-based trial of probiotic K12 (The effect of the oral probiotic Streptococcus salivarius K12 on group A streptococcus pharyngitis: a pragmatic trial in schools) can be attributed at least partially to several readily identifiable confounding factors. Mainly, the execution and outcome were negatively impacted by (a) the suboptimal efficacy and freq ...
DOI:
10.1007/s12602-018-9398-7

18. Bacteriophage-host arm race: an update on the mechanism of phage resistance in bacteria and revenge of the phage with the perspective for phage therapy

Author:
Azam, Aa Haeruman; Tanji, Yasunori
Source:
Applied microbiology and biotechnology 2019 v.103 no.5 pp. 2121-2131
ISSN:
0175-7598
Subject:
antibiotics,   etc   ; bacteria; bacteriophages; phage therapy; resistance mechanisms;     Show all 5 Subjects
Abstract:
... Due to a constant attack by phage, bacteria in the environment have evolved diverse mechanisms to defend themselves. Several reviews on phage resistance mechanisms have been published elsewhere. Thanks to the advancement of molecular techniques, several new phage resistance mechanisms were recently identified. For the practical phage therapy, the emergence of phage-resistant bacteria could be an o ...
DOI:
10.1007/s00253-019-09629-x

19. Innate glycosidic activity in metallic implants for localized synthesis of antibacterial drugs

Author:
ter Meer, Marja; Dillion, Ross; Nielsen, Signe Maria; Walther, Raoul; Meyer, Rikke L.; Daamen, Willeke F.; van den Heuvel, Lambertus P.; van der Vliet, J. Adam; Lomme, Roger M. L. M.; Hoogeveen, Yvonne L.; Schultze Kool, Leo J.; Schaffer, Jeremy E.; Zelikin, Alexander N.
Source:
Chemical communications 2019 v.55 no.4 pp. 443-446
ISSN:
1364-548X
Subject:
antibiotics,   etc   ; bacterial growth; fluoroquinolones; glycosidic linkages; hydrolysis;     Show all 5 Subjects
Abstract:
... Iron-containing metallic implants are shown herein to mediate hydrolysis of glycosidic linkages. Using glucuronide prodrugs for broad-spectrum fluoroquinolone antibacterial agents, we capitalize on this behaviour and perform localized synthesis of antimicrobials which affords a significant zone of inhibition of bacterial growth around the metallic material. ...
DOI:
10.1039/c8cc08737g

20. ARGA, a pipeline for primer evaluation on antibiotic resistance genes

Author:
Wei, Ziyan; Wu, Yueni; Feng, Kai; Yang, Min; Zhang, Yu; Tu, Qichao; Wang, Jun; Deng, Ye
Source:
Environment international 2019 v.128 pp. 137-145
ISSN:
0160-4120
Subject:
antibiotic resistance genes; antibiotics,   etc   ; amino acid sequences; databases; metagenomics; molecular biology; nucleotide sequences; oligodeoxyribonucleotides; surveys;     Show all 9 Subjects
Abstract:
... Molecular biology techniques have assisted in the investigation of antibiotic resistance genes (ARGs) from various environments. However, their accuracy relies on primer quality and data interpretation, both of which require a full-coverage sequence database for ARGs. Here, based upon the abandoned Antibiotic Resistance Genes Database (ARDB), we created an updated sequence database of antibiotic r ...
DOI:
10.1016/j.envint.2019.04.030