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antibiotics, etc ; adsorption; electrical conductivity; enrofloxacin; hot water treatment; hydrophilicity; new family; photocatalysis; sodium; synergism; temperature; China; Show all 12 Subjects
Abstract:
... MXenes, a new family of two-dimensional transition metal carbides or nitrides, have attracted tremendous attention for various applications due to their unique properties such as good electrical conductivity, hydrophilicity, and ion intercalability. In this work, Ti₃C₂ MXene, or MX, is converted to MX-TiO₂ composites using a simple and rapid microwave hydrothermal treatment in HCl/NaCl mixture sol ...
Francesca E. Morreale; Stefan Kleine; Julia Leodolter; Sabryna Junker; David M. Hoi; Stepan Ovchinnikov; Anastasia Okun; Juliane Kley; Robert Kurzbauer; Lukas Junk; Somraj Guha; David Podlesainski; Uli Kazmaier; Guido Boehmelt; Harald Weinstabl; Klaus Rumpel; Volker M. Schmiedel; Markus Hartl; David Haselbach; Anton Meinhart; Markus Kaiser; Tim Clausen
... Hijacking the cellular protein degradation system offers unique opportunities for drug discovery, as exemplified by proteolysis-targeting chimeras. Despite their great promise for medical chemistry, so far, it has not been possible to reprogram the bacterial degradation machinery to interfere with microbial infections. Here, we develop small-molecule degraders, so-called BacPROTACs, that bind to t ...
antibiotics, etc ; antibiotic resistance; biotechnology; Show all 3 Subjects
Abstract:
... Application of droplet-based methods enables; (i) faster detection, (ii) increased sensitivity, (iii) characterization of the level of heterogeneity in response to antibiotics by bacterial populations, and (iv) expanded screening of the effectiveness of antibiotic combinations. Hereby we discuss the key steps and parameters of droplet-based experiments to investigate antimicrobial resistance. We a ...
Aris C. Garro; Amy D. Thompson; Desiree N. Neville; Fran Balamuth; Michael N. Levas; Anupam B. Kharbanda; Jonathan E. Bennett; Duncan S. Grant; Rachael K. Aresco; Lise E. Nigrovic; Pedi Lyme Net Network
... In our prospective cohort of children undergoing evaluation for non-cutaneous Lyme disease, 02 (13.9% of those with Lyme disease) were not initially treated with an appropriate antibiotics and 356 (13.3% without Lyme disease) received potentially unnecessary antibiotics. Rapid and accurate diagnostics are needed to further improve initial antibiotic treatment decisions. ...
antibiotics, etc ; electrochemistry; hazard characterization; humans; sulfamethoxazole; Show all 5 Subjects
Abstract:
... Sulfamethoxazole (SMX) forms the high harmfulness and causing negative health impacts to well-being human and environment that found to be major drastic concern. It is subsequently important to keep in track for monitoring of SMX through convenient detecting devices which include the requirement of being minimal expense and potential for on location environmental applications. Nanomaterials based ...
antibiotics, etc ; chemical species; nanopores; permeability; solutes; Show all 5 Subjects
Abstract:
... Biological nanopores have been at the focus of numerous studies due to their role in many biological processes as well as their (prospective) technological applications. Among many other topics, recent studies on nanopores have addressed two key areas: antibiotic permeation through bacterial channels and sensing of analytes. Although the two areas are quite far apart in terms of their objectives, ...
antibiotics, etc ; Nonomuraea; biotechnology; genetic engineering; glycopeptides; Show all 5 Subjects
Abstract:
... OBJECTIVE: To improve the production of A40926, a combined strategy of constructing the engineered strain and optimizing the medium was implemented. RESULTS: The engineered strain lcu1 with the genetic features of dbv23 deletion and dbv3-dbv20 coexpression increased by 30.6% in the production of A40926, compared to the original strain. In addition, a combined medium called M9 was designed to be fu ...
antibiotics, etc ; bacterial adhesion; chemistry; human health; Show all 4 Subjects
Abstract:
... Human health damage and economic losses due to bacterial infections are very serious issues worldwide. Excessive use of antibiotics has caused an increase in bacterial resistance. Fortunately, various non-antibiotic antibacterial materials have been developed to treat bacterial infections without bacterial resistance. This review mainly introduces functional polymers with an intrinsic antibacteria ...
antibiotics, etc ; Neisseria; antibiotic resistance; antimicrobial peptides; microbiology; Show all 5 Subjects
Abstract:
... Antibiotic resistance is already widespread in the world, and it has become a great health problem. Therefore, comprehensive efforts are needed to minimize the resistance. The exploration of alternative therapies may offer a more targeted approach with less susceptibility to resistance. Even though antimicrobial peptides (AMPs) have been introduced as emerging antibiotic sources, they are not wide ...
antibiotics, etc ; adsorption; biochar; energy; norfloxacin; pH; urea; Show all 7 Subjects
Abstract:
... N-doping is an effective way to modify biochar for enhancing the adsorption capacity. The synthesis of N-doped biochar by the ball-milling method has been attractive due to its facile and eco-friendly approach with low energy consumption. However, the commonly used N-precursor NH₃·H₂O is environmentally harmful. It is needed to prepare safe and non-toxic N-doped biochar for large-scale production. ...
antibiotics, etc ; antibiotic resistance; energy; sewage; wastewater; wastewater treatment; Show all 6 Subjects
Abstract:
... There is a growing concern that the use and misuse of antibiotics can increase the detection of antibiotic resistant genes (ARGs) in wastewater. Conventional wastewater treatment plants provide a pathway for ARGs and antibiotic resistant bacteria (ARB) to be released into natural water bodies. Research has indicated that conventional primary and secondary treatment systems can reduce ARGs/ARB to v ...
antibiotics, etc ; bacteriophages; genomics; humans; immune system; phage therapy; Show all 6 Subjects
Abstract:
... Infectious diseases pose a significant threat to both human and animal populations. Intracellular bacteria are a group of pathogens that invade and survive within the interior of eukaryotic cells, which in turn protect them from antibacterial drugs and the host immune system. Limited penetration of antibacterials into host cells results in insufficient bacterial clearance and treatment failure. Ba ...
antibiotics, etc ; carbon; corrosion; photocatalysis; photocatalysts; synthesis; wastewater treatment; Show all 7 Subjects
Abstract:
... In this paper, carbon-coated Zn doped CdS core-shell photocatalyst (Zn–CdS@C) was fabricated via one-pot solvothermal method. The obtained Zn–CdS@C architectures displayed enhanced performance in photocatalytic antibiotic removal process. The Zn doped sites and carbon shell could all contribute to the prolonged lifetime of charge carriers and furthermore, result in the improved photoactivity. More ...
antibiotics, etc ; goethite; models; nalidixic acid; polymerization; quinolones; silicates; Show all 7 Subjects
Abstract:
... Although silicates are the most common anions in aquatic systems, little is known on the roles they play on the transport of emerging contaminants, such as antibiotics. Using dynamic column experiments, we revealed the controls of Si loadings on goethite (α-FeOOH) coated sands on the transport of a widely used quinolone antibiotic, here focusing on Nalidixic Acid (NA). We find that dynamic flow-th ...
antibiotics, etc ; birnessite; ionic strength; manganese; manganese monoxide; oxidation; pH; Show all 7 Subjects
Abstract:
... Although the oxidative capacity of manganese oxides has been widely investigated, potential changes of the surface reactivity in dynamic anoxic/oxic environments have been often overlooked. In this study, we showed that the reactivity of layer structured manganese oxide (birnessite) was highly sensitive to variable redox conditions within environmentally relevant ranges of pH (4.0 – 8.0), ionic st ...
antibiotics, etc ; antibiotic resistance; bioremediation; pollution; research; synthetic biology; toxicity; Show all 7 Subjects
Abstract:
... The overuse of antibiotics and their disposal without processing are leading the environment and its inhabitants towards a serious health emergency. There is abundance of diverse antibiotic resistance genes and bacteria in environment, which demands immediate attention for the effective removal of antibiotics. There are physical and chemical methods for removal, but the generation of toxic byprodu ...
Hala Chaaban; Maulin M. Patel; Kathryn Burge; Jeffrey V. Eckert; Cristina Lupu; Ravi S. Keshari; Robert Silasi; Girija Regmi; MaJoi Trammell; David Dyer; Steven J. McElroy; Florea Lupu
antibiotics, etc ; cell proliferation; enterocolitis; inflammation; intestines; mortality; necrosis; therapeutics; Show all 8 Subjects
Abstract:
... Increasing evidence suggests that prolonged antibiotic therapy in preterm infants is associated with increased mortality and morbidities, such as necrotizing enterocolitis (NEC), a devastating gastrointestinal pathology characterized by intestinal inflammation and necrosis. While a clinical correlation exists between antibiotic use and the development of NEC, the potential causality of antibiotics ...
antibiotics, etc ; Bayesian theory; algorithms; data analysis; pharmacogenomics; pharmacokinetics; pharmacometrics; Show all 7 Subjects
Abstract:
... Nonlinear Mixed effects models are hidden variables models that are widely used in many fields such as pharmacometrics. In such models, the distribution characteristics of hidden variables can be specified by including several parameters such as covariates or correlations which must be selected. Recent development of pharmacogenomics has brought averaged/high dimensional problems to the field of n ...
antibiotics, etc ; carbon; cathodes; electric potential difference; electrochemistry; lithium batteries; Show all 6 Subjects
Abstract:
... Nowadays, transition metal fluorides (MeₓFy, Me = Fe, Co, Ni, etc.) have received extensive attention for high work voltage and large theoretical capacity. In this study, we aim to develop an effective approach to enhance its conductivity and thus improve the electrochemical performance. We propose a graphene-like N, S co-doped carbon nanosheets/FeF₃·0.33H₂O (GNSCFF) composite derived from antibio ...
antibiotics, etc ; bacterial growth; drug development; models; patients; pharmacometrics; regrowth; Show all 7 Subjects
Abstract:
... Pharmacokinetic-pharmacodynamic (PKPD) models have emerged as valuable tools for the characterisation and translation of antibiotic effects, and consequently for drug development and therapy. In contrast to traditional PKPD concepts for antibiotics like MIC and PKPD indices, PKPD models enable to describe the continuous, often species- or population-dependent time course of antimicrobial effects, ...