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1. Biomimetic antimicrobial material strategies for combating antibiotic resistant bacteria

Author:
Chee, Eunice; Brown, Ashley C.
Source:
Biomaterials science 2020 v.8 no.4 pp. 1089-1100
ISSN:
2047-4849
Subject:
antibiotic resistance; antibiotics,   etc   ; bacteria; biomimetics; drugs; medicine;     Show all 6 Subjects
Abstract:
... Antibiotic drugs have revolutionized the field of medicine for almost 90 years. However, continued use has led to the rise of antibiotic resistant bacteria, motivating the need for alternative treatments. Several strategies to combat this phenomenon have been investigated, with biomimetic strategies gaining significant appeal due to inherent compatibility with physiologically relevant environments ...
DOI:
10.1039/c9bm01393h

2. Bacterial Aggregation Leads to Collective Elimination

Author:
Kim, Kyeri; You, Lingchong
Source:
Trends in microbiology 2020 v.28 no.4 pp. 243-244
ISSN:
0966-842X
Subject:
antibiotics,   etc   ; Danio rerio; bacteria;     Show all 3 Subjects
Abstract:
... Faster growing bacteria tend to be killed faster by antibiotics. In a complex environment exposed to antibiotics, however, the fate of a bacterial population depends on diverse factors. In a new study, Schlomann et al. describes how sublethal antibiotics can trigger the purging of bacteria by the zebrafish. ...
DOI:
10.1016/j.tim.2019.12.001

3. Current and near-future technologies for antibiotic susceptibility testing and resistant bacteria detection

Author:
Dietvorst, Jiri; Vilaplana, Lluïsa; Uria, Naroa; Marco, Maria-Pilar; Muñoz-Berbel, Xavier
Source:
Trends in analytical chemistry 2020 v.127 pp. 115891
ISSN:
0165-9936
Subject:
antibiotic resistance; antibiotics,   etc   ; bacteria; infectious diseases; markets; microbial detection; screening;     Show all 7 Subjects
Abstract:
... The emergence and spread of bacterial resistances to antibiotics is now leading to the antibiotic crisis. This is driven by the antibiotic misuse and disabuse, rendered possible due to the absence of fast and accurate technologies for antibiotic screening and resistant bacteria identification in infectious diseases. Technologies that provide sensitive, quick and easy read-outs, conveying informati ...
DOI:
10.1016/j.trac.2020.115891

4. The role of stereochemistry of antibiotic agents in the development of antibiotic resistance in the environment

Author:
Elder, Felicity C.T.; Feil, Edward J.; Snape, JasoN.; Gaze, William H.; Kasprzyk-Hordern, BarbarA.
Source:
Environment international 2020 v.139 pp. 105681
ISSN:
0160-4120
Subject:
antibiotic resistance; antibiotics,   etc   ; chloramphenicol; enantiomerism; environmental assessment; risk assessment; stereochemistry;     Show all 7 Subjects
Abstract:
... Antibiotic resistance (ABR) is now recognised as a serious global health and economic threat that is most efficiently managed via a ‘one health’ approach incorporating environmental risk assessment. Although the environmental dimension of ABR has been largely overlooked, recent studies have underlined the importance of non-clinical settings in the emergence and spread of resistant strains. Despite ...
DOI:
10.1016/j.envint.2020.105681

5. Occurrence of antibiotic residues in Apulian honey: potential risk of environmental pollution by antibiotics

Author:
Savarino, Alessandra Emilia; Terio, Valentina; Barrasso, Roberta; Ceci, Edmondo; Panseri, Sara; Chiesa, Luca Maria; Bonerba, Elisabetta
Source:
Italian journal of food safety 2020 v.9 no.1 pp. 8678
ISSN:
2239-7132
Subject:
antibiotic residues; antibiotics,   etc   ; beehives; foods; honey; nests; pollution; risk;     Show all 8 Subjects
Abstract:
... The presence of antibiotic residues in honey is widely documented and is attributed almost exclusively to improper beekeeping practices, due to the frequent use of drugs for the treatment of beehive diseases. Therefore, the aim of our research was to evaluate the presence of antibiotics in honeycomb using the Anti-Microbial Array II (AM II) and IV (AM IV) method and to assess the relationship betw ...
DOI:
10.4081/ijfs.2020.8678
PubMed:
32300572
PubMed Central:
PMC7154605

6. Antimicrobial Resistance as a Problem for the Quality of Boar Semen

Author:
Stojanov, Igor; Milovanović, Aleksandar; Barna, Tomislav; Prodanov Radulović, Jasna; Apić, Jelena; Stojanović, Dragica; Maksimović, Nevena
Source:
Acta veterinaria 2020 v.70 no.1 pp. 136-146
ISSN:
1820-7448
Subject:
antibiotic resistance; antibiotics,   etc   ; bacteria; boars; monitoring; mucosa; prepuce; semen; spermatozoa;     Show all 9 Subjects
Abstract:
... The aim of the study was to determine whether the bacteria from the environment and from the mucous membrane of the boar prepuce have antimicrobial resistance and whether the result obtained is similar/same to the bacteria that can be found in native boar semen. The study addresses the problem of the presence of primarily resistant bacterial strains in the boar sperm, which, due to their reduced s ...
DOI:
10.2478/acve-2020-0010

7. The impact of dietary fiber and probiotics in infectious diseases

Author:
Yang, Huan; Sun, Yiran; Cai, Rui; Chen, Ying; Gu, Bing
Source:
Microbial pathogenesis 2020 v.140 pp. 103931
ISSN:
0882-4010
Subject:
antibiotic resistance; antibiotics,   etc   ; dietary fiber; infectious diseases; intestinal microorganisms; probiotics;     Show all 6 Subjects
Abstract:
... Although antibiotics are commonly used to treat infectious diseases, emergence of antibiotic resistant strains highlights the necessity for developing novel alternative approaches. Meanwhile, clinically, antibiotics can destroy the gut microbes balance, which is not conducive to the recovery of infectious disorders. As a result, recent studies have begun to explore potential prevention and treatme ...
DOI:
10.1016/j.micpath.2019.103931

8. Alleviated Antibiotic-Resistant Genes in the Rhizosphere of Agricultural Soils with Low Antibiotic Concentration

Author:
Song, Mengke; Peng, Ke; Jiang, Longfei; Zhang, Dayi; Song, Dandan; Chen, Guoen; Xu, Huijuan; Li, Yongtao; Luo, Chunling
Source:
Journal of agricultural and food chemistry 2020 v.68 no.8 pp. 2457-2466
ISSN:
1520-5118
Subject:
antibiotic resistance genes; antibiotics,   etc   ; agricultural soils; crops; manure amendments; rhizosphere;     Show all 6 Subjects
Abstract:
... The influence of the rhizosphere on the abundance and diversity of antibiotic resistance genes (ARGs) has been recognized but there is a lack of consensus because of broad ranges of plant species and antibiotic concentrations across different habitats and the elusive underlying mechanisms. Here, we profiled antibiotic concentrations and resistomes in the rhizosphere and bulk soils by cultivating 1 ...
DOI:
10.1021/acs.jafc.9b06634

9. Ion Mobility Mass Spectrometry as an Efficient Tool for Identification of Streptorubin B in Streptomyces coelicolor M145

Author:
Marshall, Andrew P.; Johnson, Andrew R.; Vega, Marvin M.; Thomson, Regan J.; Carlson, Erin E.
Source:
Journal of natural products 2020 v.83 no.1 pp. 159-163
ISSN:
1520-6025
Subject:
antibiotics,   etc   ; Streptomyces coelicolor; mass spectrometry;     Show all 3 Subjects
Abstract:
... Ion mobility spectrometry was utilized to corroborate the identity of streptorubin B (2) as the natural product produced by Streptomyces coelicolor. Natural product 2 was initially assigned as butylcycloheptylprodigiosin (3), and only relatively recently was this assignment clarified. We present additional evidence of this assignment by comparing collisional cross sections (Ω) of synthetic standar ...
DOI:
10.1021/acs.jnatprod.9b00828
PubMed:
31904955
PubMed Central:
PMC7045693

10. Biodegradation of antibiotics: The new resistance determinants – part II

Author:
Reis, Ana C.; Kolvenbach, Boris A.; Nunes, Olga C.; Corvini, Philippe F.X.
Source:
New biotechnology 2020 v.54 pp. 13-27
ISSN:
1871-6784
Subject:
antibiotic residues; antibiotic resistance; antibiotics,   etc   ; beta-lactams; biodegradation; ionophores; macrolides; microbial communities; quinolones;     Show all 9 Subjects
Abstract:
... Antibiotic residues are widespread in the environment and their presence is known to contribute to the propagation of antibiotic resistance. Nevertheless, knowledge on processes involved in their degradation is scattered. This second part of a two part review aims at compiling knowledge on the (bio-) degradation of antibiotics, focusing on β-lactams, macrolides, quinolones and ionophores, as well ...
DOI:
10.1016/j.nbt.2019.08.003

11. Acidic conditions enhance the removal of sulfonamide antibiotics and antibiotic resistance determinants in swine manure

Author:
Lin, Hui; Sun, Wanchun; Yu, Qiaogang; Ma, Junwei
Source:
Environmental pollution 2020 v.263 pp. 114439
ISSN:
0269-7491
Subject:
antibiotic resistance; antibiotic resistance genes; antibiotics,   etc   ; Firmicutes; Proteobacteria; acidification; animal manure management; bacteria; bacterial communities; gene transfer; pH; pig manure;     Show all 12 Subjects
Abstract:
... Manure pH may vary depending on its inherent composition or additive contents. However, the effect of pH on the fate of antibiotics and antibiotic resistance determinants in manure remains unclear. This work demonstrated that pH adjustment promoted the removal of different sulfonamide antibiotics (SAs) within swine manure under incubation conditions, which increased from 26–60.8% to 75.0–86.0% by ...
DOI:
10.1016/j.envpol.2020.114439

12. Simultaneous removal and high tolerance of norfloxacin with electricity generation in microbial fuel cell and its antibiotic resistance genes quantification

Author:
Ondon, Brim Stevy; Li, Shengnan; Zhou, Qixing; Li, Fengxiang
Source:
Bioresource technology 2020 v.304 pp. 122984
ISSN:
0960-8524
Subject:
antibiotic resistance; antibiotic resistance genes; antibiotics,   etc   ; chemical oxygen demand; electrical charges; electricity generation; microbial fuel cells; norfloxacin; wastewater treatment;     Show all 9 Subjects
Abstract:
... Norfloxacin (NFLX) is a synthetic antibiotic widely used in the treatment of infectious diseases. In this work, the performance of microbial fuel cells (MFCs) toward NFLX degradation, electricity production and the antibiotics resistances genes (ARGs) generation was investigated. NFLX degradation efficiency and COD removal reached 65.5% and 94.5% respectively. The increase in NFLX concentration (1 ...
DOI:
10.1016/j.biortech.2020.122984

13. Water environments: metal-tolerant and antibiotic-resistant bacteria

Author:
Squadrone, Stefania
Source:
Environmental monitoring and assessment 2020 v.192 no.4 pp. 238
ISSN:
0167-6369
Subject:
antibiotic resistance; antibiotic resistance genes; antibiotics,   etc   ; animal pathogens; bacteria; disease resistance; environmental health; freshwater; human health; metal tolerance; metals; risk;     Show all 12 Subjects
Abstract:
... The potential threat of both metals and antibiotics to the environment and human health has raised significant concerns in the last decade. Metal-resistant and antibiotic-resistant bacteria are found in most environments, including water, and the risk posed to humans and animals due to the spread of antibiotic-resistant bacteria and antibiotic-resistant genes in the environment is increasing. Bact ...
DOI:
10.1007/s10661-020-8191-8

14. Does reduced usage of antibiotics in livestock production mitigate the spread of antibiotic resistance in soil, earthworm guts, and the phyllosphere?

Author:
Zhou, Shu-yi-dan; Zhu, Dong; Giles, Madeline; Daniell, Tim; Neilson, Roy; Yang, Xiao-ru
Source:
Environment international 2020 v.136 pp. 105359
ISSN:
0160-4120
Subject:
antibiotic resistance; antibiotic resistance genes; antibiotics,   etc   ; agricultural industry; animal husbandry; earthworms; livestock; livestock production; phyllosphere; pig manure; soil;     Show all 11 Subjects
Abstract:
... The overuse of antibiotics in animal husbandry is widespread and believed to significantly contribute to the selection of antibiotic resistance genes (ARGs) in animals. Thus, there is a global drive to reduce antibiotic use in the agricultural sector. However, it has not been established whether a reduction in the use of antibiotics in livestock production would be effective in reducing the spread ...
DOI:
10.1016/j.envint.2019.105359

15. LR-HSQMBC versus LR-selHSQMBC: Enhancing the Observation of Tiny Long-Range Heteronuclear NMR Correlations

Author:
Motiram-Corral, Kumar; Nolis, Pau; Saurí, Josep; Parella, Teodor
Source:
Journal of natural products 2020 v.83 no.4 pp. 1275-1282
ISSN:
1520-6025
Subject:
antibiotics,   etc   ; antiparasitic agents; nuclear magnetic resonance spectroscopy;     Show all 3 Subjects
Abstract:
... The detection of ultra-long-range (⁴JCH and higher) heteronuclear connectivities can complement the conventional use of HMBC/HSQMBC data in structure elucidation NMR studies of proton-deficient natural products, where two-bond and three-bond correlations are usually observed. The performance of the selHSQMBC experiment with respect to its broadband HSQMBC counterpart is evaluated. Despite its freq ...
DOI:
10.1021/acs.jnatprod.0c00058

16. On the catalytic mechanism of bacteriophage endolysins: Opportunities for engineering

Author:
Love, Michael J.; Abeysekera, Gayan S.; Muscroft-Taylor, Andrew C.; Billington, Craig; Dobson, Renwick C.J.
Source:
Biochimica et biophysica acta 2020 v.1868 no.1 pp. 140302
ISSN:
1570-9639
Subject:
antibiotics,   etc   ; bacteria; bacteriophages; catalytic activity; endolysin; engineering;     Show all 6 Subjects
Abstract:
... Bacteriophage endolysins have the potential to be a long-term antibacterial replacement for antibiotics. The exogenous application of endolysins on some bacteria results in rapid cell lysis. The prospects for endolysins are furthered by the ability to engineer them; novel endolysins can be developed with optimised stability, specificity, and lytic function. But the success of endolysin engineering ...
DOI:
10.1016/j.bbapap.2019.140302

17. Unearthing Hidden Chemical Potential from Discarded Actinobacterial Libraries

Author:
Timmermans, Marshall L.; Ross, Avena C.
Source:
Trends in biotechnology 2020 v.38 no.1 pp. 7-9
ISSN:
0167-7799
Subject:
antibiotics,   etc   ; bacteria; biosynthesis; gene editing; mutants;     Show all 5 Subjects
Abstract:
... The redundancy of natural product biosynthesis in microbes poses a practical challenge for discovering new antimicrobial compounds from bacteria. The recent application of clustered regularly interspaced short palindromic repeats (CRISPR) technology by Culp et al. to inactivate the production of abundant antibiotics generates a metabolic clean slate for the detection and/or isolation of new and le ...
DOI:
10.1016/j.tibtech.2019.11.003

18. An automatic representation of peptides for effective antimicrobial activity classification

Author:
Beltran, Jesus A.; Del Rio, Gabriel; Brizuela, Carlos A.
Source:
Computational and Structural Biotechnology Journal 2020 v.18 pp. 455-463
ISSN:
2001-0370
Subject:
antibiotics,   etc   ; algorithms; antimicrobial peptides; antimicrobial properties; chromosomes;     Show all 5 Subjects
Abstract:
... Antimicrobial peptides (AMPs) are a promising alternative to small-molecules-based antibiotics. These peptides are part of most living organisms’ innate defense system. In order to computationally identify new AMPs within the peptides these organisms produce, an automatic AMP/non-AMP classifier is required. In order to have an efficient classifier, a set of robust features that can capture what di ...
DOI:
10.1016/j.csbj.2020.02.002
PubMed:
32180904
PubMed Central:
PMC7063200

19. Problems of conventional disinfection and new sterilization methods for antibiotic resistance control

Author:
Zhang, Guosheng; Li, Weiying; Chen, Sheng; Zhou, Wei; Chen, Jiping
Source:
Chemosphere 2020 v.254 pp. 126831
ISSN:
0045-6535
Subject:
antibiotic resistance; antibiotic resistance genes,   etc   ; bacteria; chlorine; disinfection; ozone; water treatment;     Show all 7 Subjects
Abstract:
... The problem of bacterial antibiotic resistance has attracted considerable research attention, and the effects of water treatment on antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) are being increasingly investigated. As an indispensable part of the water treatment process, disinfection plays an important role in controlling antibiotic resistance. At present, there were m ...
DOI:
10.1016/j.chemosphere.2020.126831

20. Struvite-supported biochar composite effectively lowers Cu bio-availability and the abundance of antibiotic-resistance genes in soil

Author:
Li, Yuan; Wang, Xuejiang; Wang, Yuan; Wang, Fei; Xia, Siqing; Zhao, Jianfu
Source:
The Science of the total environment 2020 v.724 pp. 138294
ISSN:
0048-9697
Subject:
antibiotic resistance; antibiotic resistance genes,   etc   ; Actinobacteria; Firmicutes; bacterial communities; bioavailability; biochar; copper; pollution; soil;     Show all 10 Subjects
Abstract:
... The accumulation of heavy metals and the accelerated dissemination of antibiotic-resistance genes (ARGs) in soil receiving long-term manure application are causing worldwide concern. In this study, struvite-supported biochar composite (MAP/BC) obtained by N and P recovery from pig slurry with Mg(OH)₂-modified biochar (Mg(OH)₂/BC) was used as a novel amendment for the remediation of Cu- and ARG-con ...
DOI:
10.1016/j.scitotenv.2020.138294