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antifungalagents, etc ; antiviral agents; databases; hypoglycemic agents; sludge; sorption; Show all 6 Subjects
Abstract:
... Sludge agronomical reuse is of major interest due to the beneficial contribution of nutrients. However, it implies the introduction of unregulated pharmaceuticals into amended-soils and creates a controversial issue about sludge management. To limit their dissemination, it is essential to identify the compounds of interest and understand their attenuation mechanisms through the sludge processes. T ...
antifungalagents, etc ; biochemistry; drug resistance; fungi; genetics; human health; public health; Show all 7 Subjects
Abstract:
... Fungi have a profound impact on human health, leading to billions of infections and millions of deaths worldwide each year. Exacerbating the public health burden is the continued emergence of drug-resistant fungal pathogens coupled with a dearth of treatment options to combat serious infections. Despite this health threat, scientific advances in chemistry, genetics, and biochemistry methodologies ...
antifungalagents, etc ; abiotic stress; agrobiodiversity; antifungal properties; corn; endophytes; germination; lipidomics; proteomics; Show all 9 Subjects
Abstract:
... Plant pathogens are responsible for important damages to valuable crops causing important economic losses. Agrobiodiversity protection is crucial for the valorization of local varieties that could possess higher resistance to biotic and abiotic stress. At the beginning of germination, seeds are susceptible to pathogens attacks, thus they can release endogenous antimicrobial compounds of different ...
Lana Rubia B. Rosseto; Eloiza Cristina Martelli; Jessica Cassia da Silva; Bruna Larissa Nascimento; Daniele S. B. Junges; Mateus F. Delabeneta; Ana Paula Paris; Marcos Ereno Auler; Rafael Andrade Menolli; Rita C. G. Simão; Claudete R. Paula; Rinaldo F. Gandra
antifungalagents, etc ; Candida albicans; Wickerhamomyces anomalus; hemolysis; humans; industry; models; probiotics; secretion; yeasts; Show all 10 Subjects
Abstract:
... Mycocins are substances that have the potential to affect other sensitive yeasts or microorganisms. Wickerhamomyces anomalus is a yeast that produces mycocins that have great biotechnological potential, being highly competitive in many habitats, as it is adaptable to a wide range of environmental conditions. Thus, they are targets for studies in different areas, including the environment, industry ...
antifungalagents, etc ; Brassica; Medicago; Verticillium dahliae; conidia; fungi; mycelium; oats; pathogens; saponins; vascular wilt; Show all 11 Subjects
Abstract:
... Control methods alternative to synthetic pesticides are among the priorities for both organic and conventional farming systems. Plants are potential sources of compounds with antimicrobial properties. In this study, the antifungal potentialities of saponins derived from Medicago species and oat grains and of brassica sprouts have been explored for the control of Verticillium dahliae, a widely dist ...
antifungalagents, etc ; disease prevention; fluorosis; hepatotoxicity; morbidity; pathophysiology; pharmacogenomics; risk reduction; therapeutics; triazoles; yeasts; Show all 11 Subjects
Abstract:
... Azoles are among the most effective and widely used class of antifungals for prophylaxis as well as empirical and directed therapy against yeast and mould infections. Their use appears to be increasing worldwide. All triazoles cause hepatotoxicity, drug–drug interactions, and QTc prolongation (except isavuconazole); however, there are growing concerns following increasing reports of off-target end ...
antifungalagents, etc ; Candida albicans; biofilm; drug resistance; fungi; immune evasion; immune system; pathogens; therapeutics; Show all 9 Subjects
Abstract:
... Candida albicans, a fungal pathogen, can form biofilms on medical devices and host tissue, resulting in serious life-threatening infections. Because those fungal biofilms are inherently resistant to traditional antifungal therapies and the host immune system, biofilm-associated infections pose a huge clinical challenge. In this review, we summarize the most important insights into C. albicans biof ...
antifungalagents, etc ; Ricinus communis; Scopulariopsis; alkaloids; antifungal properties; keratinophilic fungi; methanol; pyridones; rapid methods; Show all 9 Subjects
Abstract:
... The present study introduces an effective and rapid method for isolation of antifungal compound ricinine from Ricinus communis (L.). In this respect, the tender leaves of R. communis were extracted using methanol and tested for antifungal activity against a panel of dermatophytes and plant pathogenic fungi. Primarily, the total extract exhibited broad-spectrum antifungal activity with the zones of ...
antifungalagents, etc ; Candida parapsilosis; animal pathogens; carbon; computer simulation; metabolism; metabolites; models; nitrogen; pathogenesis; therapeutics; Show all 11 Subjects
Abstract:
... Candida parapsilosis is an emerging human pathogen whose incidence is rising worldwide, while an increasing number of clinical isolates display resistance to first-line antifungals, demanding alternative therapeutics. Genome-Scale Metabolic Models (GSMMs) have emerged as a powerful in silico tool for understanding pathogenesis due to their systems view of metabolism, but also to their drug target ...
antifungalagents, etc ; Aspergillus fumigatus; amino acid substitution; aspergillosis; azoles; genes; heart transplant; kidneys; mycology; patients; Show all 10 Subjects
Abstract:
... We present a case of a 55-year-old man with a heart transplant who acquired Invasive Aspergillosis by Aspergillus fumigatus with the focus in the kidney. During about two years of antifungal treatment, most of the time with voriconazole, it was possible to obtain nine isolates of A. fumigatus, with the same genotypic characteristics, but with an increase in MIC for several azoles. The two last iso ...
antifungalagents, etc ; azoles; biodiversity; biological assessment; drug design; drug resistance; eukaryotic cells; fungi; structure-activity relationships; Show all 9 Subjects
Abstract:
... Fungal infections have greatly contributed to infectious-related deaths in the past century. This issue has become worse with the advent of immunity-impairing conditions such as HIV. The eukaryote nature of fungal pathogens makes them harder to eradicate than bacterial infections. Given the importance of the problem, considerable efforts have been made to the synthesis and biological assessment of ...
... Autophagy, a widespread degradation system in eukaryotes, plays an important role in maintaining the homeostasis of the cellular environment and the recycling of substances. Optical probes for the tracking of autophagy can be used as an effective tool not only to visualize the autophagy process but also to study autophagy-targeted drugs. Various molecule probes for autophagy of cancer cells emerge ...
... Food waste is a cheap and abundant organic resource that can be used as a substrate for the production of the broad-spectrum antifungal compound iturin A. To increase the efficiency of food waste biotransformation, different artificial consortia incorporating the iturin A producer Bacillus amyloliquefaciens HM618 together with engineered Bacillus subtilis WB800N producing lipase or amylase were co ...
antifungalagents, etc ; COVID-19 infection; One Health initiative; anthelmintics; antibiotic resistance; azoles; coccidiostats; drug development; public health; Show all 9 Subjects
Abstract:
... Antimicrobials including antibiotics, antiparasitic, and antifungals, are subjected to resistance. In this context, Public Health Organizations called for a One Health approach because antimicrobials used to treat different infectious diseases in animals and plants may be the same than those used in humans. Whereas mechanisms of resistance transmission from animals or environment to humans should ...
antifungalagents, etc ; Zea mays; agronomy; corn; drought; seed germination; seed size; seedling growth; seedlings; seeds; temperature; water supply; Show all 12 Subjects
Abstract:
... Germination and seedling development are essential stages in a plant’s life cycle, greatly influenced by temperature and moisture conditions. The aim of this study was to determine maize (Zea mays L.) seeds’ germination and seedling development under various abiotic stresses. Eight different temperature levels, 5, 10, 15, 20, 25, 30, 35, and 40 °C, were used. Drought and waterlogging stresses were ...
antifungalagents, etc ; Candida albicans; carbon; fungi; glucose; immune response; multiple drug resistance; mycology; pathogens; stress response; therapeutics; virulence; Show all 12 Subjects
Abstract:
... Commensal fungus-Candida albicans turn pathogenic during the compromised immunity of the host, causing infections ranging from superficial mucosal to dreadful systemic ones. C. albicans has evolved various adaptive measures which collectively contribute towards its enhanced virulence. Among fitness attributes, metabolic flexibility and vigorous stress response are essential for its pathogenicity a ...
Gabriel Davi Marena; Matheus Aparecido dos Santos Ramos; Gabriela Corrêa Carvalho; José Alberto Paris Junior; Flávia Aparecida Resende; Ione Corrêa; Gabriela Yuki Bressanim Ono; Victor Hugo Sousa Araujo; Bruna Almeida Furquim de Camargo; Tais Maria Bauab; Marlus Chorilli
antifungalagents, etc ; antifungal properties; biocompatibility; cross infection; flavonoids; fungi; mutagens; nanomedicine; phytotherapy; public health; quinones; research; terpenoids; toxicity; Show all 14 Subjects
Abstract:
... Fungal infections are one of the main public health problems, especially in immunocompromised patients, nosocomial environments, patients with chronic diseases, and transplant recipients. These diseases are increasingly frequent and lethal because the microorganism has a high capacity to acquire resistance to available therapy. The main resistance factors are the emergence of new strains and the u ...
antifungalagents, etc ; Antarctic plants; Botrytis cinerea; Colobanthus quitensis; anthocyanins; antifungal properties; conidia; fruits; median effective concentration; mycelium; oxidative stress; Show all 11 Subjects
Abstract:
... Botrytis cinerea, a responsible for grey rot that mainly affects fruit and represent a problem in fruit-exporting countries. Synthetic antifungals are used for its control. However, it has developed a specific resistance towards them. Therefore, a search for new natural alternatives that are friendly to the environment has increased in the last decade. In this work, the activity of in vitro-cultur ...
... Most current protocols for the diagnosis of fungal infections are based on culture-dependent methods that allow the evaluation of fungal morphology and the identification of the etiologic agent of mycosis. Most current protocols for the diagnosis of fungal infections are based on culture-dependent methods that enable the examination of the fungi for further identification of the etiological agent ...
antifungalagents, etc ; Candida; biomarkers; candidiasis; cell viability; diagnostic techniques; disease control; drug resistance; epidemiology; pathogenesis; patient care; public health; Show all 12 Subjects
Abstract:
... Invasive candidiasis (IC) is a systemic life-threatening infection of immunocompromised humans, but remains a relatively neglected disease among public health authorities. Ongoing assessments of disease epidemiology are needed to identify and map trends of importance that may necessitate improvements in disease management and patient care. Well-established incidence increases, largely due to expan ...