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1. Catalytic Regioselective γ-Methylenation of α,β-Unsaturated Aldehydes Using Formaldehyde via Vinylogous Aldol Condensation

Author:
Kutwal, Mahesh S.; Dev, Sachin; Appayee, Chandrakumar
Source:
Organic letters 2019 v.21 no.8 pp. 2509-2513
ISSN:
1523-7052
Subject:
antifungal agents,   etc   ; chemical structure; condensation reactions; formaldehyde; regioselectivity;     Show all 5 Subjects
Abstract:
... The first vinylogous aldol condensation of α,β-unsaturated aldehydes using aqueous formaldehyde is developed under mild reaction conditions to form the γ-methylenated products with excellent regioselectivity. Using this methodology, a short synthesis of α-triticene, an antifungal compound, is achieved in two steps. The practicality of this methodology is demonstrated by the gram-scale synthesis. F ...
DOI:
10.1021/acs.orglett.8b04110

2. Opciones terapéuticas actuales en las micosis invasoras y papel terapéutico potencial del isavuconazol

Author:
Garcia-Vidal, Carolina
Source:
Revista iberoamericana de micología 2018 v.35 no.4 pp. 192-197
ISSN:
1130-1406
Subject:
antifungal agents,   etc   ; aspergillosis; candidiasis; fungi; therapeutics;     Show all 5 Subjects
Abstract:
... The treatment of invasive fungal infections has deeply evolved in recent years with the inclusion of new antifungals to the therapeutic treatment arsenal. A new azole, isavuconazole, has been recently approved. This review focuses on the role of isavuconazole for treating the most important invasive fungal infections: invasive candidiasis, aspergillosis, mucormicosis, infections caused by other fi ...
DOI:
10.1016/j.riam.2018.07.003

3. Integrated Pathways of Candida albicans Revealing Potential Targets and Key Factors Accountable for Pathogenicity

Author:
Mishra, Sonali; Aier, Imlimaong; Varadwaj, Pritish; Misra, Krishna
Source:
Proceedings of the National Academy of Sciences, India, Section B: biological sciences 2019 v.89 no.2 pp. 575-584
ISSN:
0369-8211
Subject:
antifungal agents,   etc   ; Candida albicans; death; drug resistance; ecosystems; gastrointestinal system; humans; hyphae; patients; virulence; yeasts;     Show all 11 Subjects
Abstract:
... Candida albicans is one of the most opportunistic commensal fungus of human biome found normally in gastrointestinal cavity of healthy humans. Its dimorphic character provides the easy switching of yeast to filamentous form. However, in immunocompromised patients, blood-stream infections often cause death, despite the use of anti-fungal therapies. Its dimorphic and highly adaptive properties make ...
DOI:
10.1007/s40011-018-0964-2

4. Impairing fluoride export of Aspergillus fumigatus mitigates its voriconazole resistance

Author:
Binder, Jasmin; Held, Jürgen; Krappmann, Sven
Source:
International journal of antimicrobial agents 2019 v.53 no.5 pp. 689-693
ISSN:
0924-8579
Subject:
antifungal agents,   etc   ; Aspergillus fumigatus; antibiotic resistance; fluorides; fluorine; fungi; gene expression; genes; humans; physiological transport; toxicity;     Show all 11 Subjects
Abstract:
... Fungi have evolved specific export activities to balance intracellular levels of the toxic ion fluoride, while the first-line antimycotic voriconazole contains fluorine. This study aimed to explore whether impaired fluoride export might result in altered susceptibilities of the human pathogenic mould Aspergillus fumigatus towards this antifungal compound. Functional characterization of the putativ ...
DOI:
10.1016/j.ijantimicag.2019.02.003

5. The fungal cell wall as a target for the development of new antifungal therapies

Author:
Cortés, Juan Carlos G.; Curto, M.-Ángeles; Carvalho, Vanessa S.D.; Pérez, Pilar; Ribas, Juan Carlos
Source:
Biotechnology advances 2019
ISSN:
0734-9750
Subject:
antifungal agents,   etc   ; beta-glucans; biosynthesis; biotechnology; cell walls; echinocandins; fungi; mammals; mycoses; therapeutics; turgor;     Show all 11 Subjects
Abstract:
... In the past three decades invasive mycoses have globally emerged as a persistent source of healthcare-associated infections. The cell wall surrounding the fungal cell opposes the turgor pressure that otherwise could produce cell lysis. Thus, the cell wall is essential for maintaining fungal cell shape and integrity. Given that this structure is absent in host mammalian cells, it stands as an impor ...
DOI:
10.1016/j.biotechadv.2019.02.008

6. Cationic surfactants as antifungal agents

Author:
Fait, M. Elisa; Bakas, Laura; Garrote, Graciela L.; Morcelle, Susana R.; Saparrat, Mario C. N.
Source:
Applied microbiology and biotechnology 2019 v.103 no.1 pp. 97-112
ISSN:
0175-7598
Subject:
antifungal agents,   etc   ; animal diseases; antifungal properties; cationic surfactants; chemical compounds; humans; mechanism of action;     Show all 7 Subjects
Abstract:
... Fungi—in being responsible for causing diseases in animals and humans as well as environmental contaminations in health and storage facilities—represent a serious concern to health security. Surfactants are a group of chemical compounds used in a broad spectrum of applications. The recently considered potential employment of cationic surfactants as antifungal or fungistatic agents has become a pro ...
DOI:
10.1007/s00253-018-9467-6

7. Optimization of composite dough for the enrichment of bread crust with antifungal active compounds

Author:
Debonne, Els; Baert, Hanne; Eeckhout, Mia; Devlieghere, Frank; Van Bockstaele, Filip
Source:
Lebensmittel-Wissenschaft + [i.e. und] Technologie 2019 v.99 pp. 417-422
ISSN:
0023-6438
Subject:
antifungal agents,   etc   ; active ingredients; air; calcium propionate; hardness; modified atmosphere packaging; shelf life; sourdough;     Show all 8 Subjects
Abstract:
... The production of composite or double-layer (DL) bread was optimized to reduce the amount of the chemical preservative calcium propionate. It was validated using sourdough (SD) in the crust (0–80 g/100 g crust dough). Par-baked (PB) and fully baked (FB) breads were evaluated based on their shelf-life extending, bread technological and sensorial properties. The shelf-life of PB bread was increased ...
DOI:
10.1016/j.lwt.2018.10.020

8. The molecular structure of an epoxide hydrolase from Trichoderma reesei in complex with urea or amide-based inhibitors

Author:
de Oliveira, Gabriel S.; Adriani, Patricia P.; Ribeiro, João Augusto; Morisseau, Christophe; Hammock, Bruce D.; Dias, Marcio Vinicius B.; Chambergo, Felipe S.
Source:
International journal of biological macromolecules 2019 v.129 pp. 653-658
ISSN:
0141-8130
Subject:
antifungal agents,   etc   ; Trichoderma reesei; active sites; anti-inflammatory activity; cardiovascular diseases; epoxide hydrolase; epoxides; fungi; humans; infectious diseases; metabolism; urea;     Show all 12 Subjects
Abstract:
... Epoxide hydrolases (EHs) are enzymes involved in the metabolism of endogenous and exogenous epoxides, and the development of EH inhibitors has important applications in the medicine. In humans, EH inhibitors are being tested in the treatment of cardiovascular diseases and show potent anti-inflammatory effects. EH inhibitors are also considerate promising molecules against infectious diseases. EHs ...
DOI:
10.1016/j.ijbiomac.2019.02.070

9. Electrospun essential oil-polycaprolactone nanofibers as antibiofilm surfaces against clinical Candida tropicalis isolates

Author:
Sahal, Gulcan; Nasseri, Behzad; Ebrahimi, Aliakbar; Bilkay, Isil Seyis
Source:
Biotechnology letters 2019 v.41 no.4-5 pp. 511-522
ISSN:
0141-5492
Subject:
antifungal agents,   etc   ; Candida tropicalis; antifungal properties; biocompatible materials; biodegradability; biofilm; cloves; hydrophobicity; minimum inhibitory concentration; nanofibers; oils; thyme; thyme oil;     Show all 13 Subjects
Abstract:
... OBJECTIVE: As an approach to prevent biofilm infections caused by Candida tropicalis on various surfaces, determination of effect of biodegradable polycaprolactone nanofibers (PCLNFs) with different concentrations of two different essential oils were tested in this study. RESULTS: Both of the tested essential oils exhibited antifungal effect (minimal inhibitory concentration; 0.25–0.49 µL/mL, mini ...
DOI:
10.1007/s10529-019-02660-y

10. Wortmannin and Wortmannine Analogues from an Undescribed Niesslia sp.

Author:
Dischler, Nicole M.; Xu, Lijian; Li, Yan; Nichols, Connie B.; Alspaugh, J. Andrew; Bills, Gerald F.; Gloer, James B.
Source:
Journal of natural products 2019 v.82 no.3 pp. 532-538
ISSN:
1520-6025
Subject:
antifungal agents,   etc   ; Candida albicans; Cryptococcus neoformans; Niesslia; Schizosaccharomyces pombe; fermentation; fungi; horse manure; metabolites; mutants; nuclear magnetic resonance spectroscopy; Texas;     Show all 12 Subjects
Abstract:
... In the course of our studies of coprophilous fungi as sources of antifungal agents, a strain of an undescribed species in the genus Niesslia (TTI-0426) was isolated from horse dung collected in Texas. An extract from fermentation cultures of this strain afforded two new antifungal wortmannin derivatives, wortmannins C and D (1 and 2), as well as four additional new related compounds, wortmannines ...
DOI:
10.1021/acs.jnatprod.8b00923

11. Inhibition of recombinant enzyme 3-hydroxy-3-methylglutaryl-CoA reductase from Candida glabrata by α-asarone-based synthetic compounds as antifungal agents

Author:
Andrade-Pavón, Dulce; Ortiz-Álvarez, Jossue; Sánchez-Sandoval, Eugenia; Tamariz, Joaquín; Hernández-Rodríguez, César; Ibarra, J. Antonio; Villa-Tanaca, Lourdes
Source:
Journal of biotechnology 2019 v.292 pp. 64-67
ISSN:
0168-1656
Subject:
antifungal agents,   etc   ; Candida glabrata; antifungal properties; azoles; cholesterol; coenzyme A; enzymes; ergosterol; inhibitory concentration 50; models; new drugs; viability;     Show all 12 Subjects
Abstract:
... Due to increasing resistance of Candida species to antifungal drugs, especially azoles, new drugs are needed. The proposed compounds 3 and 4 are analogous to α-asarone (2), a naturally occurring potent inhibitor of HMGR with hypolipidemic and antifungal activity. We used the recombinant enzyme 3-hydroxy-3-methylglutaryl coenzyme A reductase of Candida glabrata (CgHMGR) as a model to test the effec ...
DOI:
10.1016/j.jbiotec.2019.01.008

12. Global epidemiology of emerging Candida auris

Author:
Rhodes, Johanna; Fisher, Matthew C
Source:
Current opinion in microbiology 2019 v.52 pp. 84-89
ISSN:
1369-5274
Subject:
antifungal agents,   etc   ; Candida; control methods; cross infection; disease control; emerging diseases; epidemiology; genomics; health services; humans; hygiene; new species; pathogens; public health; yeasts;     Show all 15 Subjects
Abstract:
... The discovery in 2009 of a new species of yeast, Candida auris, heralded the arrival of a novel emerging human infectious disease. This review highlights the unique characteristics of C. auris that have lled to it being of public health concern worldwide, namely public health concern, namely its global emergence, its ability to cause nosocomial outbreaks in healthcare settings, its innate and emer ...
DOI:
10.1016/j.mib.2019.05.008

13. Improvement of taste and shelf life of yeasted low-salt bread containing functional sourdoughs using Lactobacillus amylovorus DSM 19280 and Weisella cibaria MG1

Author:
Belz, Markus C.E.; Axel, Claudia; Arendt, Elke K.; Lynch, Kieran M.; Brosnan, Brid; Sheehan, Elizabeth M.; Coffey, Aidan; Zannini, Emanuele
Source:
International journal of food microbiology 2019 v.302 pp. 69-79
ISSN:
0168-1605
Subject:
antifungal agents,   etc   ; Lactobacillus amylovorus; bakery industry; breadmaking quality; exopolysaccharides; loaves; metabolites; organic acids and salts; rheological properties; sensory evaluation; shelf life; sodium chloride; sourdough; sugars; taste;     Show all 15 Subjects
Abstract:
... The challenge remains for the baking industry to reduce salt levels in yeasted bread as directed by governments, retailers and consumers around the world. The two main problems associated with the reduction of salt are a lack of salty taste and the reduction in shelf-life. Both of these issues are addressed in the presented work. A range of breads containing different levels of salt (0.0%, 0.3% an ...
DOI:
10.1016/j.ijfoodmicro.2018.07.015

14. A clean and green approach for odd chain fatty acids production in Rhodococcus sp. YHY01 by medium engineering

Author:
Bhatia, Shashi Kant; Gurav, Ranjit; Choi, Tae-Rim; Han, Yeong Hoon; Park, Ye-Lim; Jung, Hye-Rim; Yang, Soo-Yeon; Song, Hun-Suk; Yang, Yung-Hun
Source:
Bioresource technology 2019 v.286 pp. 121383
ISSN:
0960-8524
Subject:
antifungal agents,   etc   ; acetates; ammonium chloride; anti-allergic agents; biodiesel; butyrates; carbon; engineering; fatty acid composition; fructose; glucose; glycerol; lactic acid; odd chain fatty acids; propionic acid;     Show all 15 Subjects
Abstract:
... Odd chain fatty acids serve as anti-allergic, anti-inflammatory, and antifungal agents, and are useful for the production of biodiesel. Rhodococcus sp. YHY01 utilizes a wide range of carbon sources and accumulate lipids i.e. fructose (37% w/w dcw) glucose (56% w/w dcw), glycerol (50% w/w dcw), acetate (42% w/w dcw), butyrate (65% w/w dcw), lactate (56% w/w dcw), and propionate (62% w/w dcw). In th ...
DOI:
10.1016/j.biortech.2019.121383

15. Effect of chitosan coatings on physical stability, antifungal and mycotoxin inhibitory activities of lecithin stabilized cinnamon oil-in-water emulsions

Author:
Wu, Dianhui; Lu, Jian; Zhong, Shaobin; Schwarz, Paul; Chen, Bingcan; Rao, Jiajia
Source:
Lebensmittel-Wissenschaft + [i.e. und] Technologie 2019 v.106 pp. 98-104
ISSN:
0023-6438
Subject:
antifungal agents,   etc   ; Fusarium graminearum; antifungal properties; chitosan; cinnamon; cinnamon oil; coatings; droplets; emulsions; lecithins; mycelium; mycotoxins; oils; pH; physical properties; spore germination; synergism;     Show all 17 Subjects
Abstract:
... The influence of chitosan coatings on the physical properties, antifungal efficacy and mycotoxin inhibitory activity of lecithin stabilized cinnamon oil-in-water emulsions was investigated. Emulsions with the oil phase consisting of 5 wt% cinnamon oil and 5 wt% medium chain triglyceride were highly unstable when stabilized with 2 wt% soy lecithin. Physical stability of emulsion was improved consid ...
DOI:
10.1016/j.lwt.2019.02.029

16. Genotypic and phenotypic characterization of Candida albicans Lebanese hospital isolates resistant and sensitive to caspofungin

Author:
Toutounji, Maggie; Tokajian, Sima; Khalaf, Roy A.
Source:
Fungal genetics and biology 2019 v.127 pp. 12-22
ISSN:
1087-1845
Subject:
antifungal agents,   etc   ; Candida albicans; amino acids; animal models; animal pathogens; biofilm; caspofungin; cell walls; chitin; death; drugs; enzymes; fungi; glucans; hospitals; humans; mutation; phenotype; virulence; Lebanon;     Show all 20 Subjects
Abstract:
... The fungus Candida albicans is both a commensal and an opportunistic human pathogen, present as part of the normal human microflora causing serious mucosal, and systemic life threatening infections. The antifungal drug caspofungin of the echinocandin family is the latest generation of antifungal drugs to be developed. It functions by inhibiting glucan synthase thus weakening the fungal cell wall l ...
DOI:
10.1016/j.fgb.2019.02.008

17. Solution structure and novel insights into phylogeny and mode of action of the Neosartorya (Aspergillus) fischeri antifungal protein (NFAP)

Author:
Hajdu, Dorottya; Huber, Anna; Czajlik, András; Tóth, Liliána; Kele, Zoltán; Kocsubé, Sándor; Fizil, Ádám; Marx, Florentine; Galgóczy, László; Batta, Gyula
Source:
International journal of biological macromolecules 2019 v.129 pp. 511-522
ISSN:
0141-8130
Subject:
antifungal agents,   etc   ; Aspergillus fischeri; Neosartorya; Neurospora crassa; Penicillium oxalicum; antifungal proteins; cell death; drug resistance; fungi; genes; genome mining; mechanism of action; models; phylogeny; prediction; solvents;     Show all 16 Subjects
Abstract:
... Small, cysteine-rich and cationic antifungal proteins from natural sources are promising candidates for the development of novel treatment strategies to prevent and combat infections caused by drug-resistant fungi. However, limited information about their structure and antifungal mechanism hampers their future applications. In the present study, we determined the solution structure, dynamics and a ...
DOI:
10.1016/j.ijbiomac.2019.02.016

18. The scent of symbiosis: gut bacteria may affect social interactions in leaf-cutting ants

Author:
Teseo, Serafino; van Zweden, Jelle S.; Pontieri, Luigi; Kooij, Pepijn W.; Sørensen, Søren J.; Wenseleers, Tom; Poulsen, Michael; Boomsma, Jacobus J.; Sapountzis, Panagiotis
Source:
Animal behaviour 2019 v.150 pp. 239-254
ISSN:
0003-3472
Subject:
antifungal agents,   etc   ; Acromyrmex echinatior; aggression; animals; antibiotics; bacterial communities; chemical analysis; diet; droplets; evolution; hosts; intestinal microorganisms; leaf-cutting ants; microsymbionts; nestmate recognition; odors; physiology; social behavior; symbiosis;     Show all 19 Subjects
Abstract:
... Animal gut microbiota affect host physiology and behaviour. In social insects, where colony level integrity is preserved via a nestmate discrimination system based on cuticular hydrocarbon mixtures, microorganismal effects may therefore influence social dynamics. Although nestmate recognition has undergone a thorough exploration during the last four decades, few studies have investigated the putat ...
DOI:
10.1016/j.anbehav.2018.12.017

19. Differential response to synthetic and natural antifungals by Alternaria tenuissima in wheat simulating media: Growth, mycotoxin production and expression of a gene related to cell wall integrity

Author:
da Cruz Cabral, Lucía; Delgado, Josué; Patriarca, Andrea; Rodríguez, Alicia
Source:
International journal of food microbiology 2019 v.292 pp. 48-55
ISSN:
0168-1605
Subject:
antifungal agents,   etc   ; Alternaria tenuissima; antifungal properties; biosynthesis; cell walls; crops; financial economics; foods; fungi; fungicides; genes; metabolites; mycotoxins; ripening; tenuazonic acid; toxicity; water activity; wheat;     Show all 18 Subjects
Abstract:
... Alternaria spp. are major contaminants of wheat crops, causing both economic losses for producers and health risk for consumers due to the accumulation of toxic metabolites. The application of synthetic fungicides in the field may trigger mycotoxin accumulation, since fungistatic levels of those compounds might cause fungal responses to stress. Hence, new alternatives are needed for its control. T ...
DOI:
10.1016/j.ijfoodmicro.2018.12.005

20. Comparisons of the restoring and reinforcement effects of carboxymethyl chitosan-silk fibroin (Bombyx Mori/Antheraea Yamamai/Tussah) on aged historic silk

Author:
Hao, Xinying; Wang, Xin; Yang, Weimei; Ran, Jiabing; Ni, Fangfang; Tong, Tong; Dai, Wei; Zheng, Lingyue; Shen, Xinyu; Tong, Hua
Source:
International journal of biological macromolecules 2019 v.124 pp. 71-79
ISSN:
0141-8130
Subject:
antifungal agents,   etc   ; Antheraea yamamai; Aspergillus flavus; Aspergillus niger; Bombyx mori; Paecilomyces variotii; antibacterial properties; crystal structure; crystallization; fibroins; hydrogen bonding; mechanical properties; polymers; silk; thermal stability;     Show all 15 Subjects
Abstract:
... This work presents the results of the reinforcement effects of regenerated silk fibroin solutions (SF) of Bombyx-Mori, Antheraea-Yamamai and Tussah on aged historic silk. Furthermore, Carboxymethyl-chitosan (CMC) was utilized as reinforcement and antibacterial filler to further improving the mechanical properties and antibacterial effects. To clarify the rationale behind this process, comprehensiv ...
DOI:
10.1016/j.ijbiomac.2018.11.203