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1. Assessment of the occurrence of 455 pharmaceutical compounds in sludge according to their physical and chemical properties: A review

Author:
Anastasia Sellier; Somar Khaska; Corinne Le Gal La Salle
Source:
Journal of hazardous materials 2022 v.426 pp. 128104
ISSN:
0304-3894
Subject:
antifungal agents,   etc   ; antiviral agents; databases; hypoglycemic agents; sludge; sorption;     Show all 6 Subjects
Abstract:
... Sludge agronomical reuse is of major interest due to the beneficial contribution of nutrients. However, it implies the introduction of unregulated pharmaceuticals into amended-soils and creates a controversial issue about sludge management. To limit their dissemination, it is essential to identify the compounds of interest and understand their attenuation mechanisms through the sludge processes. T ...
DOI:
10.1016/j.jhazmat.2021.128104

2. Antifungal discovery

Author:
Nicole Robbins; Leah E Cowen
Source:
Current opinion in microbiology 2022 v.69 pp. 102198
ISSN:
1369-5274
Subject:
antifungal agents,   etc   ; biochemistry; drug resistance; fungi; genetics; human health; public health;     Show all 7 Subjects
Abstract:
... Fungi have a profound impact on human health, leading to billions of infections and millions of deaths worldwide each year. Exacerbating the public health burden is the continued emergence of drug-resistant fungal pathogens coupled with a dearth of treatment options to combat serious infections. Despite this health threat, scientific advances in chemistry, genetics, and biochemistry methodologies ...
DOI:
10.1016/j.mib.2022.102198

3. Antifungal Activity and Biochemical Profiling of Exudates from Germinating Maize Nostrano di Storo Local Variety

Author:
Stefano Rosa; Stefano De Benedetti; Stefania Mazzini; Gigliola Borgonovo; Elisa Bona; Maria Cavaletto; Paola Antonia Corsetto; Martina Ghidoli; Salvatore Roberto Pilu; Alessio Scarafoni
Source:
Plants 2022 v.11 no.18 pp. -
ISSN:
2223-7747
Subject:
antifungal agents,   etc   ; abiotic stress; agrobiodiversity; antifungal properties; corn; endophytes; germination; lipidomics; proteomics;     Show all 9 Subjects
Abstract:
... Plant pathogens are responsible for important damages to valuable crops causing important economic losses. Agrobiodiversity protection is crucial for the valorization of local varieties that could possess higher resistance to biotic and abiotic stress. At the beginning of germination, seeds are susceptible to pathogens attacks, thus they can release endogenous antimicrobial compounds of different ...
DOI:
10.3390/plants11182435

4. Susceptibility of Candida albicans Strains Isolated from Vaginal Secretion in Front of the Mycocins of Wickerhamomyces anomalus

Author:
Lana Rubia B. Rosseto; Eloiza Cristina Martelli; Jessica Cassia da Silva; Bruna Larissa Nascimento; Daniele S. B. Junges; Mateus F. Delabeneta; Ana Paula Paris; Marcos Ereno Auler; Rafael Andrade Menolli; Rita C. G. Simão; Claudete R. Paula; Rinaldo F. Gandra
Source:
Probiotics and antimicrobial proteins 2022 v.14 no.3 pp. 595-601
ISSN:
1867-1306
Subject:
antifungal agents,   etc   ; Candida albicans; Wickerhamomyces anomalus; hemolysis; humans; industry; models; probiotics; secretion; yeasts;     Show all 10 Subjects
Abstract:
... Mycocins are substances that have the potential to affect other sensitive yeasts or microorganisms. Wickerhamomyces anomalus is a yeast that produces mycocins that have great biotechnological potential, being highly competitive in many habitats, as it is adaptable to a wide range of environmental conditions. Thus, they are targets for studies in different areas, including the environment, industry ...
DOI:
10.1007/s12602-022-09940-6

5. In Search of Antifungals from the Plant World: The Potential of Saponins and Brassica Species against Verticillium dahliae Kleb.

Author:
Caterina Morcia; Isabella Piazza; Roberta Ghizzoni; Stefano Delbono; Barbara Felici; Simona Baima; Federico Scossa; Elisa Biazzi; Aldo Tava; Valeria Terzi; Franca Finocchiaro
Source:
Horticulturae 2022 v.8 no.8 pp. -
ISSN:
2311-7524
Subject:
antifungal agents,   etc   ; Brassica; Medicago; Verticillium dahliae; conidia; fungi; mycelium; oats; pathogens; saponins; vascular wilt;     Show all 11 Subjects
Abstract:
... Control methods alternative to synthetic pesticides are among the priorities for both organic and conventional farming systems. Plants are potential sources of compounds with antimicrobial properties. In this study, the antifungal potentialities of saponins derived from Medicago species and oat grains and of brassica sprouts have been explored for the control of Verticillium dahliae, a widely dist ...
DOI:
10.3390/horticulturae8080729

6. Reducing the off-target endocrinologic adverse effects of azole antifungals—can it be done?

Author:
Matthew I. Balcerek; Adam G. Stewart; Paul Chapman; Syndia Lazarus
Source:
International journal of antimicrobial agents 2022 v.59 no.5 pp. 106587
ISSN:
0924-8579
Subject:
antifungal agents,   etc   ; disease prevention; fluorosis; hepatotoxicity; morbidity; pathophysiology; pharmacogenomics; risk reduction; therapeutics; triazoles; yeasts;     Show all 11 Subjects
Abstract:
... Azoles are among the most effective and widely used class of antifungals for prophylaxis as well as empirical and directed therapy against yeast and mould infections. Their use appears to be increasing worldwide. All triazoles cause hepatotoxicity, drug–drug interactions, and QTc prolongation (except isavuconazole); however, there are growing concerns following increasing reports of off-target end ...
DOI:
10.1016/j.ijantimicag.2022.106587

7. C. albicans biofilms: antifungal resistance, immune evasion, and emerging therapeutic strategies

Author:
FangMei Fan; Yi Liu; YiQing Liu; RuiXue Lv; Wei Sun; WenJing Ding; YanXing Cai; WeiWei Li; Xing Liu; Wei Qu
Source:
International journal of antimicrobial agents 2022 pp. 106673
ISSN:
0924-8579
Subject:
antifungal agents,   etc   ; Candida albicans; biofilm; drug resistance; fungi; immune evasion; immune system; pathogens; therapeutics;     Show all 9 Subjects
Abstract:
... Candida albicans, a fungal pathogen, can form biofilms on medical devices and host tissue, resulting in serious life-threatening infections. Because those fungal biofilms are inherently resistant to traditional antifungal therapies and the host immune system, biofilm-associated infections pose a huge clinical challenge. In this review, we summarize the most important insights into C. albicans biof ...
DOI:
10.1016/j.ijantimicag.2022.106673

8. Rapid Isolation of Ricinine, a Pyridone Alkaloid from Ricinus communis (L.) with Antifungal Properties

Author:
P. Saravana Kumar; Yu Li; Meijun He; P. Yuvaraj; K. Balakrishna; S. Ignacimuthu
Source:
Journal of Biologically Active Products from Nature 2022 v.12 no.1 pp. 33-41
ISSN:
2231-1874
Subject:
antifungal agents,   etc   ; Ricinus communis; Scopulariopsis; alkaloids; antifungal properties; keratinophilic fungi; methanol; pyridones; rapid methods;     Show all 9 Subjects
Abstract:
... The present study introduces an effective and rapid method for isolation of antifungal compound ricinine from Ricinus communis (L.). In this respect, the tender leaves of R. communis were extracted using methanol and tested for antifungal activity against a panel of dermatophytes and plant pathogenic fungi. Primarily, the total extract exhibited broad-spectrum antifungal activity with the zones of ...
DOI:
10.1080/22311866.2021.2021985

9. A Genome-Scale Metabolic Model for the Human Pathogen Candida Parapsilosis and Early Identification of Putative Novel Antifungal Drug Targets

Author:
Romeu Viana; Diogo Couceiro; Tiago Carreiro; Oscar Dias; Isabel Rocha; Miguel Cacho Teixeira
Source:
Genes 2022 v.13 no.2 pp. -
ISSN:
2073-4425
Subject:
antifungal agents,   etc   ; Candida parapsilosis; animal pathogens; carbon; computer simulation; metabolism; metabolites; models; nitrogen; pathogenesis; therapeutics;     Show all 11 Subjects
Abstract:
... Candida parapsilosis is an emerging human pathogen whose incidence is rising worldwide, while an increasing number of clinical isolates display resistance to first-line antifungals, demanding alternative therapeutics. Genome-Scale Metabolic Models (GSMMs) have emerged as a powerful in silico tool for understanding pathogenesis due to their systems view of metabolism, but also to their drug target ...
DOI:
10.3390/genes13020303

10. Selection of Aspergillus fumigatus isolates carrying the G448S substitution in CYP51A gene after long-term treatment with voriconazole in an immunocompromised patient

Author:
Laís Pontes; Caio Augusto Gualtieri Beraquet; Teppei Arai; Akira Watanabe; Maria Luiza Moretti; Angelica Zaninelli Schreiber
Source:
Medical mycology case reports 2022 v.36 pp. 5-9
ISSN:
2211-7539
Subject:
antifungal agents,   etc   ; Aspergillus fumigatus; amino acid substitution; aspergillosis; azoles; genes; heart transplant; kidneys; mycology; patients;     Show all 10 Subjects
Abstract:
... We present a case of a 55-year-old man with a heart transplant who acquired Invasive Aspergillosis by Aspergillus fumigatus with the focus in the kidney. During about two years of antifungal treatment, most of the time with voriconazole, it was possible to obtain nine isolates of A. fumigatus, with the same genotypic characteristics, but with an increase in MIC for several azoles. The two last iso ...
DOI:
10.1016/j.mmcr.2022.02.002

11. Current Status and Structure Activity Relationship of Privileged Azoles as Antifungal Agents (2016–2020)

Author:
A. Ahmadi; E. Mohammadnejadi; P. Karami; N. Razzaghi-Asl
Source:
International journal of antimicrobial agents 2022 v.59 no.3 pp. 106518
ISSN:
0924-8579
Subject:
antifungal agents,   etc   ; azoles; biodiversity; biological assessment; drug design; drug resistance; eukaryotic cells; fungi; structure-activity relationships;     Show all 9 Subjects
Abstract:
... Fungal infections have greatly contributed to infectious-related deaths in the past century. This issue has become worse with the advent of immunity-impairing conditions such as HIV. The eukaryote nature of fungal pathogens makes them harder to eradicate than bacterial infections. Given the importance of the problem, considerable efforts have been made to the synthesis and biological assessment of ...
DOI:
10.1016/j.ijantimicag.2022.106518

12. Role of Azole Drugs in Promoting Fungal Cell Autophagy Revealed by an NIR Fluorescence-Based Theranostic Probe

Author:
Wanzhen Yang; Yanhui Zhang; Hao Teng; Na Liu; Chunquan Sheng; Yuan Guo
Source:
Analytical chemistry 2022 v.94 no.19 pp. 7092-7099
ISSN:
1520-6882
Subject:
antifungal agents,   etc   ; analytical chemistry; antifungal properties; apoptosis; autophagy; cell membranes; eukaryotic cells; fluorescent dyes; fungi; homeostasis; pH;     Show all 11 Subjects
Abstract:
... Autophagy, a widespread degradation system in eukaryotes, plays an important role in maintaining the homeostasis of the cellular environment and the recycling of substances. Optical probes for the tracking of autophagy can be used as an effective tool not only to visualize the autophagy process but also to study autophagy-targeted drugs. Various molecule probes for autophagy of cancer cells emerge ...
DOI:
10.1021/acs.analchem.2c00859

13. Artificial consortia of Bacillus amyloliquefaciens HM618 and Bacillus subtilis for utilizing food waste to synthetize iturin A

Author:
Chang-Hao Miao; Xiao-Feng Wang; Bin Qiao; Qiu-Man Xu; Chun-Yang Cao; Jing-Sheng Cheng
Source:
Environmental science and pollution research 2022 v.29 no.48 pp. 72628-72638
ISSN:
0944-1344
Subject:
antifungal agents,   etc   ; Bacillus amyloliquefaciens; Bacillus subtilis; amylases; biotransformation; carboxylic ester hydrolases; coculture; food waste; iturin; pollution; research;     Show all 11 Subjects
Abstract:
... Food waste is a cheap and abundant organic resource that can be used as a substrate for the production of the broad-spectrum antifungal compound iturin A. To increase the efficiency of food waste biotransformation, different artificial consortia incorporating the iturin A producer Bacillus amyloliquefaciens HM618 together with engineered Bacillus subtilis WB800N producing lipase or amylase were co ...
DOI:
10.1007/s11356-022-21029-9

14. Drug resistant parasites and fungi from a one-health perspective: A global concern that needs transdisciplinary stewardship programs

Author:
Stephane Picot; Frederic Beugnet; Gilles Leboucher; Anne-Lise Bienvenu
Source:
One health 2022 v.14 pp. 100368
ISSN:
2352-7714
Subject:
antifungal agents,   etc   ; COVID-19 infection; One Health initiative; anthelmintics; antibiotic resistance; azoles; coccidiostats; drug development; public health;     Show all 9 Subjects
Abstract:
... Antimicrobials including antibiotics, antiparasitic, and antifungals, are subjected to resistance. In this context, Public Health Organizations called for a One Health approach because antimicrobials used to treat different infectious diseases in animals and plants may be the same than those used in humans. Whereas mechanisms of resistance transmission from animals or environment to humans should ...
DOI:
10.1016/j.onehlt.2021.100368

15. Impact of Temperature and Water on Seed Germination and Seedling Growth of Maize (Zea mays L.)

Author:
Hussein Khaeim; Zoltán Kende; Márton Jolánkai; Gergő Péter Kovács; Csaba Gyuricza; Ákos Tarnawa
Source:
Agronomy 2022 v.12 no.2 pp. -
ISSN:
2073-4395
Subject:
antifungal agents,   etc   ; Zea mays; agronomy; corn; drought; seed germination; seed size; seedling growth; seedlings; seeds; temperature; water supply;     Show all 12 Subjects
Abstract:
... Germination and seedling development are essential stages in a plant’s life cycle, greatly influenced by temperature and moisture conditions. The aim of this study was to determine maize (Zea mays L.) seeds’ germination and seedling development under various abiotic stresses. Eight different temperature levels, 5, 10, 15, 20, 25, 30, 35, and 40 °C, were used. Drought and waterlogging stresses were ...
DOI:
10.3390/agronomy12020397

16. Metabolic flexibility and extensive adaptability governing multiple drug resistance and enhanced virulence in Candida albicans

Author:
Sajad Ahmad Padder; Asiya Ramzan; Inayatullah Tahir; Reiaz ul Rehman; Abdul Haseeb Shah
Source:
Critical reviews in microbiology 2022 v.48 no.1 pp. 1-20
ISSN:
1549-7828
Subject:
antifungal agents,   etc   ; Candida albicans; carbon; fungi; glucose; immune response; multiple drug resistance; mycology; pathogens; stress response; therapeutics; virulence;     Show all 12 Subjects
Abstract:
... Commensal fungus-Candida albicans turn pathogenic during the compromised immunity of the host, causing infections ranging from superficial mucosal to dreadful systemic ones. C. albicans has evolved various adaptive measures which collectively contribute towards its enhanced virulence. Among fitness attributes, metabolic flexibility and vigorous stress response are essential for its pathogenicity a ...
DOI:
10.1080/1040841X.2021.1935447

17. Natural product‐based nanomedicine applied to fungal infection treatment: A review of the last 4 years

Author:
Gabriel Davi Marena; Matheus Aparecido dos Santos Ramos; Gabriela Corrêa Carvalho; José Alberto Paris Junior; Flávia Aparecida Resende; Ione Corrêa; Gabriela Yuki Bressanim Ono; Victor Hugo Sousa Araujo; Bruna Almeida Furquim de Camargo; Tais Maria Bauab; Marlus Chorilli
Source:
Phytotherapy research 2022 v.36 no.7 pp. 2710-2745
ISSN:
0951-418X
Subject:
antifungal agents,   etc   ; antifungal properties; biocompatibility; cross infection; flavonoids; fungi; mutagens; nanomedicine; phytotherapy; public health; quinones; research; terpenoids; toxicity;     Show all 14 Subjects
Abstract:
... Fungal infections are one of the main public health problems, especially in immunocompromised patients, nosocomial environments, patients with chronic diseases, and transplant recipients. These diseases are increasingly frequent and lethal because the microorganism has a high capacity to acquire resistance to available therapy. The main resistance factors are the emergence of new strains and the u ...
DOI:
10.1002/ptr.7460

18. Antifungal activity of extracts from the Antarctic plant Colobanthus quitensis Kunth. (Bartl) cultured in vitro against Botrytis cinerea Pers

Author:
Rodrigo A. Contreras; Marisol Pizarro; Nicolás Peña-Heyboer; Leonora Mendoza; Camila Sandoval; Rodrigo Muñoz-González; Gustavo E. Zúñiga
Source:
Archiv für Phytopathologie und Pflanzenschutz 2022 v.55 no.5 pp. 615-635
ISSN:
1477-2906
Subject:
antifungal agents,   etc   ; Antarctic plants; Botrytis cinerea; Colobanthus quitensis; anthocyanins; antifungal properties; conidia; fruits; median effective concentration; mycelium; oxidative stress;     Show all 11 Subjects
Abstract:
... Botrytis cinerea, a responsible for grey rot that mainly affects fruit and represent a problem in fruit-exporting countries. Synthetic antifungals are used for its control. However, it has developed a specific resistance towards them. Therefore, a search for new natural alternatives that are friendly to the environment has increased in the last decade. In this work, the activity of in vitro-cultur ...
DOI:
10.1080/03235408.2022.2035965

19. Mixed Fungal Biofilms: From Mycobiota to Devices, a New Challenge on Clinical Practice

Author:
Polyana de Souza Costa; Andressa Prado; Natalia Pecin Bagon; Melyssa Negri; Terezinha Inez Estivalet Svidzinski
Source:
Microorganisms 2022 v.10 no.9 pp. -
ISSN:
2076-2607
Subject:
antifungal agents,   etc   ; biofilm; etiological agents; fungal morphology; fungi; homeostasis; humans; immune system; morbidity; mortality; mycobiota; mycoses; pathogenesis; phenotype; virulence;     Show all 15 Subjects
Abstract:
... Most current protocols for the diagnosis of fungal infections are based on culture-dependent methods that allow the evaluation of fungal morphology and the identification of the etiologic agent of mycosis. Most current protocols for the diagnosis of fungal infections are based on culture-dependent methods that enable the examination of the fungi for further identification of the etiological agent ...
DOI:
10.3390/microorganisms10091721

20. Continuing Shifts in Epidemiology and Antifungal Susceptibility Highlight the Need for Improved Disease Management of Invasive Candidiasis

Author:
Ben Y. Parslow; Christopher R. Thornton
Source:
Microorganisms 2022 v.10 no.6 pp. -
ISSN:
2076-2607
Subject:
antifungal agents,   etc   ; Candida; biomarkers; candidiasis; cell viability; diagnostic techniques; disease control; drug resistance; epidemiology; pathogenesis; patient care; public health;     Show all 12 Subjects
Abstract:
... Invasive candidiasis (IC) is a systemic life-threatening infection of immunocompromised humans, but remains a relatively neglected disease among public health authorities. Ongoing assessments of disease epidemiology are needed to identify and map trends of importance that may necessitate improvements in disease management and patient care. Well-established incidence increases, largely due to expan ...
DOI:
10.3390/microorganisms10061208