PubAg

Main content area

You searched for: Subject "antimalarials" Remove constraint Subject: "antimalarials"
Start Over

Search

1,298  Search Results

« Previous | 1 - 20 of 1,298 |
Number of results to display per page

Search Results

1. Malaria Parasite Clearance: What Are We Really Measuring?

Author:
Khoury, David S.; Zaloumis, Sophie G.; Grigg, Matthew J.; Haque, Ashraful; Davenport, Miles P.
Source:
Trends in parasitology 2020 v.36 no.5 pp. 413-426
ISSN:
1471-4922
Subject:
antimalarials,   etc   ; clinical trials; drug development; malaria; parasites;     Show all 5 Subjects
Abstract:
... Antimalarial drugs are vital for treating malaria and controlling transmission. Measuring drug efficacy in the field requires large clinical trials and thus we have identified proxy measures of drug efficacy such as the parasite clearance curve. This is often assumed to measure the rate of drug activity against parasites and is used to predict optimal treatment regimens required to completely clea ...
DOI:
10.1016/j.pt.2020.02.005

2. Epoxy-Tethered Diels–Alder Reaction toward the Tricyclic Core of Kalihinols

Author:
Krishna Chaitanya, Nandikolla; Dinda, Shrabani; Mainkar, Prathama S.; Chandrasekhar, Srivari
Source:
Organic letters 2020 v.22 no.9 pp. 3557-3560
ISSN:
1523-7052
Subject:
antimalarials,   etc   ; chemical structure; cycloaddition reactions; nerol;     Show all 4 Subjects
Abstract:
... A chiral-template-driven intramolecular Diels–Alder reaction has been used to build the tricyclic core of kalihinols, a group of antimalarial marine natural products. The key starting materials are commercially available nerol and sulcatone. ...
DOI:
10.1021/acs.orglett.0c00998

3. Potential anti-influenza effective plants used in Turkish folk medicine: A review

Author:
Sargin, Seyid Ahmet
Source:
Journal of ethnopharmacology 2021 v.265 pp. 113319
ISSN:
0378-8741
Subject:
antimalarials,   etc   ; COVID-19 infection; Centaurea; Eucalyptus; Melissa officinalis; Mentha piperita; Olea europaea; Origanum vulgare; Rosa canina; Sambucus nigra; Severe acute respiratory syndrome-related coronavirus; active ingredients; avian influenza; chlorogenic acid; databases; flora; inventories; mechanism of action; pandemic; quercetin; screening; swine influenza; traditional medicine; Middle East; Turkey (country);     Show all 25 Subjects
Abstract:
... Due to the outbreaks such as SARS, bird flu and swine flu, which we frequently encounter in our century, we need fast solutions with no side effects today more than ever. Due to having vast ethnomedical experience and the richest flora (34% endemic) of Europe and the Middle East, Turkey has a high potential for research on this topic. Plants that locals have been using for centuries for the preven ...
DOI:
10.1016/j.jep.2020.113319

4. Ethnopharmacological survey of herbal remedies used for treating malaria in Yemen

Author:
Al-Adhroey, Abdulelah H.; Al-Abhar, Yahya M.; Noman, Nahlah M.; Al-Mekhlafi, Hesham M.
Source:
Journal of herbal medicine 2020 v.21 pp. 100332
ISSN:
2210-8033
Subject:
antimalarials,   etc   ; databases; herbal medicines; malaria; phytochemicals; questionnaires; surveys; traditional medicine; Yemen;     Show all 9 Subjects
Abstract:
... This is the first ethnopharmacological survey among traditional healers in Yemen that has been conducted to investigate the herbal remedies used in the treatment of malaria. Sixteen traditional healers from three governorates in Yemen participated in this survey in which a pre-tested questionnaire was used to collect information on the herbal remedies used for the treatment of malaria. Overall, 18 ...
DOI:
10.1016/j.hermed.2020.100332

5. Advancements in the synthesis of fused tetracyclic quinoline derivatives

Author:
Mekheimer, Ramadan A.; Al-Sheikh, Mariam A.; Medrasi, Hanadi Y.; Sadek, Kamal U.
Source:
RSC advances 2020 v.10 no.34 pp. 19867-19935
ISSN:
2046-2069
Subject:
antimalarials,   etc   ; anti-inflammatory activity; catalysts; cycloaddition reactions; ionic liquids; microwave treatment; photocatalysis; quinoline; ultraviolet radiation;     Show all 9 Subjects
Abstract:
... Fused tetracyclic systems containing a quinoline nucleus represent an important class of heterocyclic bioactive natural products and pharmaceuticals because of their significant and wide-spectrum biological properties. Several of these compounds have been obtained with diverse pharmacological and biological activities, such as antiplasmodial, antifungal, antibacterial, potent antiparasitic, antipr ...
DOI:
10.1039/d0ra02786c

6. Iron-catalysed alkylation of 2-methyl and 4-methyl azaarenes with alcohols via C–H bond activation

Author:
Kabadwal, Lalit Mohan; Bera, Sourajit; Banerjee, Debasis
Source:
Chemical communications 2020 v.56 no.35 pp. 4777-4780
ISSN:
1364-548X
Subject:
antimalarials,   etc   ; alcohols; alkylation; carbon-hydrogen bond activation; catalytic activity; chemical bonding; deuterium; enamines; iron; pyrazines;     Show all 10 Subjects
Abstract:
... The first Fe-catalysed alkylation of 2-methyl and 4-methyl-azaarenes with a series of alkyl and hetero-aryl alcohols is reported (>39 examples and up to 95% yield). Multi-functionalisation of pyrazines and synthesis of anti-malarial drug (±) Angustureine significantly broaden the scope of this methodology. Preliminary mechanistic investigation, deuterium labeling and kinetic experiments including ...
DOI:
10.1039/d0cc01593h

7. Falcipain cysteine proteases of malaria parasites: An update

Author:
Rosenthal, Philip J.
Source:
Biochimica et biophysica acta 2020 v.1868 no.3 pp. 140362
ISSN:
1570-9639
Subject:
antimalarials,   etc   ; Plasmodium falciparum; cysteine proteinases; drug therapy; erythrocytic stage; hemoglobin; human diseases; hydrolysis; malaria; parasites;     Show all 10 Subjects
Abstract:
... The malaria parasite Plasmodium falciparum expresses four related papain-family cysteine proteases known as falcipains. These proteases play critical roles in the parasite life cycle, and as such are potential targets for new modes of antimalarial chemotherapy, as discussed in this review.This review summarizes available knowledge describing falcipain cysteine proteases of malaria parasites.Based ...
DOI:
10.1016/j.bbapap.2020.140362

8. Paecilodepsipeptide D, a cyclohexadepsipeptide from cultures of the whitefly pathogenic fungus Conoideocrella luteorostrata BCC 76664

Author:
Isaka, Masahiko; Palasarn, Somporn; Rachtawee, Pranee; Srichomthong, Kitlada; Mongkolsamrit, Suchada
Source:
Phytochemistry letters 2019 v.34 pp. 65-67
ISSN:
1874-3900
Subject:
antimalarials,   etc   ; Aleyrodidae; lipophilicity; spectral analysis; virulent strains;     Show all 5 Subjects
Abstract:
... Paecilodepsipeptide D (1), a new cyclohexadepsipeptide was isolated together with known paecilodepsipeptides A–C (2–4) from the whitefly pathogenic fungus Conoideocrella luteorostrata BCC 76664. The structure of 1 was elucidated by spectroscopic analyses and was further confirmed by the chemical correlation to paecilodepsipeptide A (2) by converting both compounds into the same di-O-prenyl derivat ...
DOI:
10.1016/j.phytol.2019.09.017

9. Investigation of antiplasmodial efficacy of lupeol and ursolic acid isolated from Ficus benjamina leaves extract

Author:
Singh, Amandeep; Mukhtar, Hayat Mohammad; Kaur, Hardeep; Kaur, Lakhvir
Source:
Natural product research 2020 v.34 no.17 pp. 2514-2517
ISSN:
1478-6427
Subject:
antimalarials,   etc   ; Ficus benjamina; Plasmodium; antiplasmodial properties; gel chromatography; inhibitory concentration 50; leaf extracts; leaves; lupeol; malaria; petroleum; ursolic acid;     Show all 12 Subjects
Abstract:
... This study emphasizes on the investigation of antiplasmodial activity of triterpenoids isolated from Ficus benjamina leaves. An unsaponified fraction of petroleum ether extract of plant leaves was subjected to silica gel column chromatography which led to the isolation of two known triterpenoids; namely ursolic acid and lupeol. These compounds were evaluated for antiplasmodial activity by schizont ...
DOI:
10.1080/14786419.2018.1540476

10. Plasmodium stage-selective antimalarials from Lophira lanceolata stem bark

Author:
Soré, Harouna; Lopatriello, Annalisa; Ebstie, Yehenew A.; Tenoh Guedoung, Alain R.; Hilou, Adama; Pereira, José A.; Kijjoa, Anake; Habluetzel, Annette; Taglialatela-Scafati, Orazio
Source:
Phytochemistry 2020 v.174 pp. 112336
ISSN:
0031-9422
Subject:
antimalarials,   etc   ; Culicidae; Lophira lanceolata; Plasmodium; bark; glycosylation; humans; malaria; mass spectrometry; medicinal plants; moieties; nuclear magnetic resonance spectroscopy; parasites; phytochemicals;     Show all 14 Subjects
Abstract:
... Targeting the transmissible stages of the Plasmodium parasite that develop in the human and mosquito host is a crucial strategy for malaria control and elimination. Medicinal plants offer a prolific source for the discovery of new antimalarial compounds. The recent identification of the gametocytocidal activity of lophirone E, obtained from the African plant Lophira lanceolata (Ochnaceae), inspire ...
DOI:
10.1016/j.phytochem.2020.112336

11. Limonoids from Cipadessa baccifera

Author:
Yu, Jin-Hai; Zhang, Hua; Zhou, Bin; Zimbres, Flavia M.; Dalal, Seema; Liu, Qun-Fang; Cassera, Maria B.; Yue, Jian-Min
Source:
Journal of natural products 2020 v.83 no.6 pp. 1751-1765
ISSN:
1520-6025
Subject:
antimalarials,   etc   ; Cipadessa baccifera; X-ray diffraction; computational methodology; inhibitory concentration 50; leaves; limonoids; nuclear magnetic resonance spectroscopy; spectral analysis;     Show all 9 Subjects
Abstract:
... Eighteen new limonoids, including eight methyl angolensates (1–8) and 10 cipadesins (9–18), were isolated from the leaves of Cipadessa baccifera. Their structures were characterized by means of spectroscopic data analyses, single-crystal X-ray diffraction, and quantum chemistry computational methods. The C-6 configurations in those compounds possessing a C-6 hydroxy group were all assigned as S re ...
DOI:
10.1021/acs.jnatprod.9b00666

12. Xanthones from a lignicolous freshwater fungus (BCC 28210)

Author:
Yoiprommarat, Seangaroon; Kongthong, Surisa; Choowong, Wilunda; Boonyuen, Nattawut; Isaka, Masahiko; Bunyapaiboonsri, Taridaporn
Source:
Natural product research 2020 v.34 no.9 pp. 1233-1237
ISSN:
1478-6427
Subject:
antimalarials,   etc   ; Bacillus cereus; Chaetosphaeriaceae; Plasmodium falciparum; antibacterial properties; freshwater; fungi; inhibitory concentration 50; metabolites; spectral analysis; xanthones;     Show all 11 Subjects
Abstract:
... Four xanthones (1‒4) and a known compound, mansonone D (5), were isolated from the lignicolous freshwater fungus BCC 28210 (family, Chaetosphaeriaceae). The structures of these compounds were elucidated by extensive spectroscopic analysis. Among the isolated metabolites, compound 2 and the known mansonone D (5) displayed antimalarial activity against Plasmodium falciparum K1 with IC₅₀ values of 7. ...
DOI:
10.1080/14786419.2018.1556655

13. Fungi from the extremes of life: an untapped treasure for bioactive compounds

Author:
Ibrar, Muhammad; Ullah, Muhammad Wajid; Manan, Sehrish; Farooq, Umer; Rafiq, Muhammad; Hasan, Fariha
Source:
Applied microbiology and biotechnology 2020 v.104 no.7 pp. 2777-2801
ISSN:
0175-7598
Subject:
antimalarials,   etc   ; Aspergillus; Penicillium; acclimation; anti-allergic agents; antifouling activities; antioxidants; bioactive compounds; cytotoxicity; ecosystems; extremophiles; fungi; metabolites; therapeutics;     Show all 14 Subjects
Abstract:
... More than 80% of the Earth surface is consisted of hostile and harsh environments, classified as extreme from an anthropogenic perspective. Microorganisms with acclimatized nature dominate these extreme ecosystems of the biosphere. Survivals in such environments initiate an inductive force leading to the production of noteworthy metabolites having peculiar biochemistry. Recent investigations on ex ...
DOI:
10.1007/s00253-020-10399-0

14. Galtonosides A–E: Antiproliferative and Antiplasmodial Cholestane Glycosides from Galtonia regalis

Author:
Du, Yongle; Martin, Brooke A.; Valenciano, Ana Lisa; Clement, Jason A.; Goetz, Michael; Cassera, Maria B.; Kingston, David G. I.
Source:
Journal of natural products 2020 v.83 no.4 pp. 1043-1050
ISSN:
1520-6025
Subject:
antimalarials,   etc   ; Ornithogalum; Plasmodium falciparum; antiplasmodial properties; drug resistance; fractionation; glycosides; inhibitory concentration 50; nuclear magnetic resonance spectroscopy;     Show all 9 Subjects
Abstract:
... An extract of Galtonia regalis from the Natural Products Discovery Institute showed moderate antiplasmodial activity, with an IC₅₀ value less than 1.25 μg/mL. The two known cholestane glycosides 1 and 2 and the five new cholestane glycosides galtonosides A–E (3–7) were isolated after bioassay-directed fractionation. The structures of the new compounds were determined by interpretation of their NMR ...
DOI:
10.1021/acs.jnatprod.9b01064
PubMed:
32227943
PubMed Central:
PMC7183436

15. Antimalarial 9-Methoxystrobilurins, Oudemansins, and Related Polyketides from Cultures of Basidiomycete Favolaschia Species

Author:
Kornsakulkarn, Jittra; Palasarn, Somporn; Choowong, Wilunda; Thongpanchang, Tienthong; Boonyuen, Nattawut; Choeyklin, Rattaket; Boonpratuang, Thitiya; Isaka, Masahiko; Thongpanchang, Chawanee
Source:
Journal of natural products 2020 v.83 no.4 pp. 905-917
ISSN:
1520-6025
Subject:
antimalarials,   etc   ; Cercopithecus aethiops; Favolaschia; cytotoxicity; fibroblasts; fungi; inhibitory concentration 50; kidneys; lung neoplasms; polyketides; structure-activity relationships;     Show all 11 Subjects
Abstract:
... Fourteen new compounds, oudemansins 1–4, oudemansinols 5–7, favolasins 8–10, favolasinin (12), polyketides 13–15, and (R,E)-2,4-dimethyl-5-phenyl-4-pentene-2,3-diol (16), together with nine known compounds were isolated from the basidiomycete fungus Favolaschia sp. BCC 18686. Two new compounds, favolasin E (11) and 9-oxostrobilurin E (17), were isolated from the closely related organism Favolaschi ...
DOI:
10.1021/acs.jnatprod.9b00647

16. Daphne giraldii Nitsche (Thymelaeaceae): Phytochemistry, pharmacology and medicinal uses

Author:
Han, Shuang; Li, Ling-zhi; Song, Shao-jiang
Source:
Phytochemistry 2020 v.171 pp. 112231
ISSN:
0031-9422
Subject:
antimalarials,   etc   ; Daphne; bark; blood; chemical composition; coumarins; cytotoxicity; flavonoids; languages; lignans; medicinal properties; rhizomes; sedatives; shrubs; therapeutics;     Show all 15 Subjects
Abstract:
... Daphne giraldii Nitsche., a member of the genus Daphne (Thymelaeaceae), is a deciduous shrub with mild toxicity. Its rhizome bark, generally called ‘Zushima’ in Chinese, has many medicinal folkloric uses and good therapeutic effects. Previous studies investigating the chemical constituents and pharmacological activities of D. giraldii have focused on several major classes of compounds, such as cou ...
DOI:
10.1016/j.phytochem.2019.112231

17. HRP2: Transforming Malaria Diagnosis, but with Caveats

Author:
Poti, Kristin E.; Sullivan, David J.; Dondorp, Arjen M.; Woodrow, Charles J.
Source:
Trends in parasitology 2020 v.36 no.2 pp. 112-126
ISSN:
1471-4922
Subject:
antimalarials,   etc   ; Plasmodium falciparum; antigens; diagnostic techniques; genes; immunoaffinity chromatography; malaria; point-of-care systems; rapid methods; Eritrea; Latin America;     Show all 11 Subjects
Abstract:
... The major growth in point-of-care malaria diagnosis over the past decade has been based on immunochromatographic malaria rapid diagnostic tests (mRDTs), which generally detect Plasmodium falciparum via its abundant histidine-rich protein 2 (HRP2). Here, we review the discovery and biology of HRP2, as well as the strengths and weaknesses of HRP2-based diagnosis compared with alternative antigens. W ...
DOI:
10.1016/j.pt.2019.12.004

18. In vivo antimalarial activity and pharmacokinetics of artelinic acid-choline derivative liposomes in rodents

Author:
Duan, Shuai; Wang, Ruili; Wang, Rongrong; Tang, Jiaqi; Xiao, Xiaoyang; Li, Ning; Guo, Wenju; Yang, Qingshan; Ren, Guolian; Zhang, Shuqiu
Source:
Parasitology 2020 v.147 no.1 pp. 58-64
ISSN:
1469-8161
Subject:
antimalarials,   etc   ; Plasmodium yoelii; biochemical pathways; choline; drug resistance; enzymes; esterification; films (materials); intravenous injection; pharmacokinetics; phosphatidylcholines; rats; synergism;     Show all 13 Subjects
Abstract:
... It is urgent to develop new antimalarial drugs with good therapeutic effects to address the emergence of drug resistance. Here, the artelinic acid-choline derivative (AD) was synthesized by dehydration reaction and esterification reaction, aimed to avoid the emergence of drug resistance by synergistic effect of artemisinins and choline derivative, which could compete with choline for rate-limiting ...
DOI:
10.1017/S0031182019001306

19. Boron trifluoride etherate promoted microwave-assisted synthesis of antimalarial acridones

Author:
Kancharla, Papireddy; Dodean, Rozalia A.; Li, Yuexin; Kelly, Jane X.
Source:
RSC advances 2019 v.9 no.72 pp. 42284-42293
ISSN:
2046-2069
Subject:
antimalarials,   etc   ; acylation; boron; microwave treatment; multiple drug resistance; parasites;     Show all 6 Subjects
Abstract:
... A microwave-assisted, rapid and efficient method using boron trifluoride etherate (BF₃.Et₂O) for the synthesis of acridones, via an intramolecular acylation of N-phenylanthranilic acid derivatives, has been developed. The reaction proceeds under solvent-free conditions, tolerates a wide range of functional groups, and provides rapid access to a range of acridones in good to excellent yields. Sever ...
DOI:
10.1039/c9ra09478d

20. Bismuth-catalyzed methylation and alkylation of quinone derivatives with tert-butyl peroxybenzoate as an oxidant

Author:
Yang, Jian; Dong, Yu; He, Shuai; Shi, Zhi-Chuan; Wang, Yu; Wang, Ji-Yu
Source:
Tetrahedron 2019 v.75 no.50 pp. 130729
ISSN:
0040-4020
Subject:
antimalarials,   etc   ; benzoquinones; catalytic activity; menadione; methylation; moieties; oxidants; reaction mechanisms;     Show all 8 Subjects
Abstract:
... A bismuth-catalyzed methylation of quinones in the presence of tert-butyl peroxybenzoate (TBPB) was developed via a radical reaction mechanism. Particularly, TBPB was used not only as an efficient oxidant, but also as a green methyl source in such transformation. Moreover, this method could also be efficiently extended to the alkylation of quinones. This reaction tolerated a series of functional g ...
DOI:
10.1016/j.tet.2019.130729