U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Https

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PubAg

Main content area

You searched for: Subject "antiparasitic properties" Remove constraint Subject: "antiparasitic properties"
Start Over

Search

482  Search Results

« Previous | 1 - 20 of 482 |
Number of results to display per page

Search Results

1. Quebrachitol from Putranjiva roxburghii Wall. (Putranjivaceae) a potent antimalarial: Pre-clinical efficacy and its interaction with PfLDH

Author:
Sonali Mishra; Saurabh Kumar; Ramdas; Sonam Khare; Aparna Shukla; Karuna Shanker; Anirban Pal; Feroz Khan; Mahendra P. Darokar
Source:
Parasitology international 2023 v.92 pp. 102675
ISSN:
1383-5769
Subject:
antiparasitic properties,   etc   ; Plasmodium falciparum; Putranjiva roxburghii; antimalarials; benzoic acid; body weight; branches; butanol; drug resistance; ethanol; in vitro studies; lactate dehydrogenase; parasitemia; parasitology; phytochemicals; traditional medicine;     Show all 16 Subjects
Abstract:
... Researchers are exploring natural resources in search of a new and effective anti-malarial compound to address the challenges in malarial treatment due to emerging incidences of drug-resistant strains. Following background knowledge of traditional medicine, we evaluated the in-vitro and in-vivo anti-malarial efficacy of Putranjiva P. roxburghii (Putranjivaceae) twigs ethanol extracts and fraction ...
DOI:
10.1016/j.parint.2022.102675

2. Integration of metabolomics and transcriptomics revealed the biosynthetic mechanism of anti-parasitic compounds in Salinivibrio proteolyticus strain YCSC6

Author:
Guangxun Du; Lingyun Qu; Ping Gao; Wenhao Huang; Chenghua Li; Dewen Ding
Source:
Journal of oceanology and limnology 2022 v.40 no.1 pp. 245-259
ISSN:
2096-5508
Subject:
antiparasitic properties,   etc   ; Salinivibrio; aquaculture; biochemical pathways; biosynthesis; culture media; fermentation; limnology; metabolomics; oceanography; octanoic acid; polyketides; secondary metabolites; transcriptomics;     Show all 14 Subjects
Abstract:
... The fermentation broth of Salinivibrio proteolyticus strain YCSC6 shows potent anti-parasitic activity against Uronema marinum, with activity varying in each fermentation stage. To investigate the biosynthetic mechanism of anti-parasitic compounds in strain YCSC6, a comprehensive analysis of metabolomics and transcriptomics over four different time points (12, 24, 48, and 72 h) was performed. Meta ...
DOI:
10.1007/s00343-021-0466-6

3. Brazilian green propolis reduces worm burden and hepatic granuloma formation in a Schistosoma mansoni experimental murine model

Author:
Lucas A. de L. Paula; Mário F. C. Santos; Mariana C. Pagotti; Rodrigo C. S. Veneziani; Jairo K. Bastos; Conor R. Caffrey; Sérgio R. Ambrósio; Lizandra G. Magalhães
Source:
Parasitology research 2022 v.121 no.2 pp. 775-780
ISSN:
0932-0113
Subject:
antiparasitic properties,   etc   ; Schistosoma mansoni; animal models; anthelmintics; eggs; females; granuloma; histology; ileum; liver; parasites; parasitology; propolis; research; schistosomiasis mansoni;     Show all 15 Subjects
Abstract:
... Characterized as an acute and chronic parasitic disease, schistosomiasis mansoni has as its central pathology the formation of hepatic granulomas in response to the parasite’s eggs trapped in the host’s liver. In recent years, research on propolis has grown; however, there is little anthelmintic work on this bee product. In the propolis scenario, Brazilian ones receive attention, with green and re ...
DOI:
10.1007/s00436-021-07408-0

4. Anti-malarial effect of a combination of risedronate and azithromycin against Plasmodium yoelii nigeriensis infection in Swiss mice

Author:
Solomon Tesfaye; Kaleab Asres; Sebastian Guenther; Prati Pal Singh
Source:
Parasitology international 2022 v.91 pp. 102655
ISSN:
1383-5769
Subject:
antiparasitic properties,   etc   ; Plasmodium yoelii nigeriensis; azithromycin; bioavailability; biochemical pathways; blood serum; erythrocytes; folic acid; malaria; parasitemia; parasites; parasitology; pyrimethamine; sulfadoxine; therapeutics;     Show all 15 Subjects
Abstract:
... Combination therapy is used to retard the selection of malaria parasite strains resistant to individual components of a combination of drugs. This approach has proved to be a success in the combination of sulphadoxine and pyrimethamine, which targets two different steps in the folate pathway of malaria parasites. However, after the success of this therapeutic combination, the efficacy of other com ...
DOI:
10.1016/j.parint.2022.102655

5. Effects of anti‐Leishmania compounds in the behavior of the sand fly vector Lutzomyia longipalpis

Author:
Tainá Neves Ferreira; Reginaldo Peçanha Brazil; Mary Ann McDowell; Edézio Ferreira Cunha‐Júnior; Paulo Roberto Ribeiro Costa; Chaquip Daher Netto; Eduardo Caio Torres Santos; Fernando Ariel Genta
Source:
Pest management science 2022 v.78 no.7 pp. 2792-2805
ISSN:
1526-498X
Subject:
antiparasitic properties,   etc   ; Leishmania amazonensis; Leishmania infantum; Lutzomyia longipalpis; cell culture; deet; diet; digestive system; females; ingestion; leishmaniasis; naphthoquinones; parasites; pest management; sand; sugars;     Show all 16 Subjects
Abstract:
... BACKGROUND: Leishmaniasis is an infectious parasitic disease caused by pathogens of the genus Leishmania transmitted through the bite of adult female sand flies. To reduce case numbers, it is necessary to combine different control approaches, especially those aimed at the sand fly vectors. Innovative forms of control with the use of attractive sugar baits explored the fact that adult sand flies ne ...
DOI:
10.1002/ps.6900

6. Biological activities and physicochemical characterization of alkaline lignins obtained from branches and leaves of Buchenavia viridiflora with potential pharmaceutical and biomedical applications

Author:
Denise Maria Figueiredo Araújo; Iranildo José da Cruz Filho; Tiago Santos; Daniel Tarciso Martins Pereira; Diego Santa Clara Marques; Alice da Conceição Alves de Lima; Thiago Mendonça de Aquino; George Jackson de Moraes Rocha; Maria do Carmo Alves de Lima; Fátima Nogueira
Source:
International journal of biological macromolecules 2022 v.219 pp. 224-245
ISSN:
0141-8130
Subject:
antiparasitic properties,   etc   ; Buchenavia; Plasmodium falciparum; antioxidant activity; branches; cellulose; chemical composition; cytokines; cytotoxicity; erythrocytes; hemicellulose; lignin; macrophages; molecular weight; neoplasms; splenocytes; thermal stability; trees; wood; Amazonia;     Show all 20 Subjects
Abstract:
... In this work, we investigated in vitro different biological activities of alkaline lignins extracted from the species Buchenavia viridiflora, a tree from the Amazon rainforest used as a wood product. The chemical composition results for the twig and leaves were, respectively (%): cellulose (30.88 and 24. 28), hemicellulose (21.62 and 23.03), lignin (29.93 and 25.46), extractives (13.06 and 20.52), ...
DOI:
10.1016/j.ijbiomac.2022.07.225

7. Administration of spruce bark (Picea abies) extracts in young lambs exhibits anticoccidial effects but reduces milk intake and body weight gain

Author:
Berit Marie Blomstrand; Heidi Larsen Enemark; Håvard Steinshamn; Inga Marie Aasen; Juni Rosann Engelien Johanssen; Spiridoula Athanasiadou; Stig Milan Thamsborg; Kristin Marie Sørheim
Source:
Acta veterinaria scandinavica 2022 v.64 no.1 pp. 10
ISSN:
1751-0147
Subject:
antiparasitic properties,   etc   ; Eimeria; Picea abies; animal welfare; bark; bark extracts; body weight changes; coccidiosis; coccidiostats; diarrhea; excretion; feces; feed intake; milk consumption; oocysts; oral administration; secondary metabolites;     Show all 17 Subjects
Abstract:
... BACKGROUND: Eimeria spp. are widespread apicomplexan parasites known to cause coccidiosis in livestock, resulting in reduced animal welfare and productivity, particularly in sheep. The treatment options are limited, and there is an emerging development of resistance against registered pharmaceuticals. Spruce bark is rich in plant secondary metabolites (PSM), such as condensed tannins, which are bi ...
DOI:
10.1186/s13028-022-00629-y

8. Molecular characterisation and biological activity of an antiparasitic peptide from Sciaenops ocellatus and its immune response to Cryptocaryon irritans

Author:
Yuan Jin; Yong Mao; Su-Fang Niu; Ying Pan; Wei-Hao Zheng; Jun Wang
Source:
Molecular immunology 2022 v.141 pp. 1-12
ISSN:
0161-5890
Subject:
antiparasitic properties,   etc   ; Cryptocaryon irritans; Protozoa; Sciaenops ocellatus; antimicrobial peptides; antiparasitic agents; cytokines; erythrocytes; fish; humans; hydrophobicity; immune response; isoelectric point; kidneys; mariculture; quantitative polymerase chain reaction; sequence analysis; spleen; therapeutics; tissue distribution;     Show all 20 Subjects
Abstract:
... Cryptocaryon irritans, a holotrichous ciliate parasitic protozoan, can trigger marine white spot disease and cause substantial economic losses in mariculture. However, methods of preventing and curing the disease have negatively affect fish, human, other organisms, and the natural environment. The antiparasitic activity of some antimicrobial peptides (AMPs) has garnered extensive attention of scho ...
DOI:
10.1016/j.molimm.2021.08.010

9. The pharmacokinetics and antiparasitic activity of ivermectin in Hutsul and Toric horses

Author:
Alla Vyniarska; Hubert Ziółkowski; Hanna Madej‐Śmiechowska; Jerzy J. Jaroszewski
Source:
Journal of veterinary pharmacology and therapeutics 2021 v.44 no.1 pp. 11-17
ISSN:
0140-7783
Subject:
antiparasitic properties,   etc   ; body weight; high performance liquid chromatography; horses; ivermectin; pharmacokinetics; therapeutics;     Show all 7 Subjects
Abstract:
... The aim of this study was to compare the pharmacokinetics of ivermectin and its antiparasitic activity in two horse breeds. Eight Hutsul and 14 Toric horses were administered ivermectin orally at a dose of 0.2 mg/kg body weight. Blood samples were collected for 96 hr, and faecal samples were collected one day before and on days 14 and 21 after drug administration. Ivermectin concentrations in plas ...
DOI:
10.1111/jvp.12924

10. Reactive Oxygen Species as the Brainbox in Malaria Treatment

Author:
Chinedu Ogbonnia Egwu; Jean-Michel Augereau; Karine Reybier; Françoise Benoit-Vical
Source:
Antioxidants 2021 v.10 no.12 pp. -
ISSN:
2076-3921
Subject:
antiparasitic properties,   etc   ; Plasmodium falciparum; artemisinin; indigenous species; malaria; oxidative stress; quinolines; reactive oxygen species;     Show all 8 Subjects
Abstract:
... Several measures are in place to combat the worldwide spread of malaria, especially in regions of high endemicity. In part, most common antimalarials, such as quinolines and artemisinin and its derivatives, deploy an ROS-mediated approach to kill malaria parasites. Although some antimalarials may share similar targets and mechanisms of action, varying levels of reactive oxygen species (ROS) genera ...
DOI:
10.3390/antiox10121872

11. Antiparasitic activity of two Brazilian plants: Eugenia mattosii and Marlierea eugeniopsoides

Author:
Giovana Vechi; Adrielli Tenfen; Efrain Salamanca Capusiri; Alberto Gimenez; Valdir Cechinel-Filho
Source:
Natural product research 2021 v.35 no.22 pp. 4876-4880
ISSN:
1478-6427
Subject:
antiparasitic properties,   etc   ; Eugenia; Leishmania amazonensis; Leishmania braziliensis; chloroform; cytotoxicity; fluorometry; giardiasis; leishmaniasis; public health; research;     Show all 11 Subjects
Abstract:
... Parasitoses are very common throughout the world, generating serious consequences for public health. Leishmaniosis and giardiasis are examples of fairly recurrent, but neglected diseases. Several higher plants have demonstrated promising activity against the parasites. The aim of this study was to evaluate the biological activity of extracts, fractions and isolated compounds from the leaves and st ...
DOI:
10.1080/14786419.2020.1739676

12. Maca against Echinococcosis?—A Reverse Approach from Patient to In Vitro Testing

Author:
Tanja Karpstein; Sheena Chaudhry; Solange Bresson-Hadni; Michael Hayoz; Ghalia Boubaker; Andrew Hemphill; Reto Rufener; Marc Kaethner; Isabelle Schindler; Yolanda Aebi; Antonio Sa Cunha; Carlo R. Largiadèr; Britta Lundström-Stadelmann
Source:
Pathogens 2021 v.10 no.10 pp. -
ISSN:
2076-0817
Subject:
antiparasitic properties,   etc   ; Echinococcus multilocularis; Lepidium meyenii; albendazole; benzimidazole; cytotoxicity; echinococcosis; males; metacestodes; mice; parasites; patients; plant extracts; spleen;     Show all 14 Subjects
Abstract:
... Drug-based treatment of alveolar echinococcosis (AE) with benzimidazoles is in most cases non-curative, thus has to be taken lifelong. Here, we report on a 56-year-old male AE patient who received standard benzimidazole treatment and biliary plastic stents, and additionally self-medicated himself with the Peruvian plant extract Maca (Lepidium meyenii). After 42 months, viable parasite tissue had d ...
DOI:
10.3390/pathogens10101335

13. Synergistic effect of combination chemotherapy with praziquantel and DW-3-15 for Schistosoma japonicum in vitro and in vivo

Author:
Zi-Yin Yang; Zi-Hao Liu; Ya-Nan Zhang; Chen Li; Lei Liu; Wen-Jie Pu; Shi-Qi Xie; Jing Xu; Chao-Ming Xia
Source:
Parasites & vectors 2021 v.14 no.1 pp. 550
ISSN:
1756-3305
Subject:
antiparasitic properties,   etc   ; Schistosoma japonicum; adults; drug therapy; eggs; granuloma; histopathology; patents; praziquantel; schistosomiasis; schistosomula; synergism; tropical diseases; viability;     Show all 14 Subjects
Abstract:
... BACKGROUND: Schistosomiasis is a debilitating and neglected tropical disease for which praziquantel (PZQ) remains the first-choice drug for treatment and control of the disease. In our previous studies, we found that the patented compound DW-3-15 (patent no. ZL201110142538.2) displayed significant and stabilized antiparasitic activity through a mechanism that might be distinct from PZQ. Here, we i ...
DOI:
10.1186/s13071-021-05065-x

14. Overcoming the Prokaryote/Eukaryote Barrier in Tuberculosis Treatment: A Prospect for the Repurposing and Use of Antiparasitic Drugs

Author:
José Manuel Ezquerra-Aznárez; Pedro E. Almeida da Silva; José A. Aínsa
Source:
Microorganisms 2021 v.9 no.11 pp. -
ISSN:
2076-2607
Subject:
antiparasitic properties,   etc   ; Mycobacterium tuberculosis; antibiotic resistance; antiparasitic agents; etiological agents; eukaryotic cells; industry; pandemic; prokaryotic cells; therapeutics; toxicity; tuberculosis;     Show all 12 Subjects
Abstract:
... Antimicrobial resistance, the so-called silent pandemic, is pushing industry and academia to find novel antimicrobial agents with new mechanisms of action in order to be active against susceptible and drug-resistant microorganisms. In the case of tuberculosis, the need of novel anti-tuberculosis drugs is specially challenging because of the intricate biology of its causative agent, Mycobacterium t ...
DOI:
10.3390/microorganisms9112335

15. A Comprehensive Review on Ethnobotany, Phytochemistry and Pharmacology of Rauvolfia L. (Apocynaceae)

Author:
Saranya Surendran; Ramasubbu Raju; Priya Prasannan; Anjana Surendran
Source:
Botanical review 2021 v.87 no.3 pp. 311-376
ISSN:
0006-8101
Subject:
antiparasitic properties,   etc   ; Rauvolfia; anti-inflammatory activity; antioxidants; cardioprotective effect; cytotoxicity; ethnobotany; hypertension; insecticidal properties; phytochemicals; plant tissues; sedatives; tissue culture;     Show all 13 Subjects
Abstract:
... Rauvolfia, commonly known as devil peppers belongs to the family Apocynaceae has recorded as native to tropical areas of the world with about 110 species of smaller to medium-large sized shrubs/trees. The ethnopharmacologial studies were attempted to prove the medicinal values of several species of Rauvolfia by many researchers. Although, there is poor exploration on information on the account on ...
DOI:
10.1007/s12229-021-09262-2

16. Licarin A, a neolignan isolated from Nectandra oppositifolia Nees & Mart. (Lauraceae), exhibited moderate preclinical efficacy against Schistosoma mansoni infection

Author:
Ana C. Mengarda; Marcos P. Silva; Maria E. Cirino; Thiago R. Morais; Geanne A. A. Conserva; João Henrique G. Lago; Josué de Moraes
Source:
Phytotherapy research 2021 v.35 no.9 pp. 5154-5162
ISSN:
0951-418X
Subject:
antiparasitic properties,   etc   ; Nectandra; Schistosoma mansoni; adults; animal models; drug therapy; eggs; humans; lignans; metabolites; parasites; phytotherapy; praziquantel; research; schistosomiasis; splenomegaly;     Show all 16 Subjects
Abstract:
... Schistosomiasis is a widespread human parasitic disease currently affecting over 200 million people, particularly in poor communities. Chemotherapy for schistosomiasis relies exclusively on praziquantel (PZQ). Previous studies have shown that licarin A (LIC‐A), a dihydrobenzofuran neolignan, exhibited in vitro antiparasitic activity against Schistosoma mansoni adult worms. This study aimed to inve ...
DOI:
10.1002/ptr.7184

17. Biosynthesis and extrinsic toxicity of copper oxide nanoparticles against cattle parasites: An eco-friendly approach

Author:
Chinnaperumal Kamaraj; Pachiyappan Rajiv Gandhi; Rajappan Chandra Satish Kumar; Govindasamy Balasubramani; Guilherme Malafaia
Source:
Environmental research 2022 v.214 pp. 114009
ISSN:
0013-9351
Subject:
antiparasitic properties,   etc   ; Haemaphysalis; Hippobosca; Rhipicephalus microplus; antiparasitic agents; biofabrication; biomass; biosynthesis; cows; cupric oxide; leaf extracts; nanoparticles; research; ticks; toxicity;     Show all 15 Subjects
Abstract:
... Plant extracts' ability to collect metals and decrease metal ions makes them a superior candidate for the biosynthesis of nanoparticles; hence, they are referred to as bio-nano factories since both living and dead dried biomass are employed to produce metallic nanoparticles. The antiparasitic activity of biosynthesized copper oxide nanoparticles (CuO NPs) was examined against cow tick larvae (Rhip ...
DOI:
10.1016/j.envres.2022.114009

18. Antiparasitic activity of aqueous extract of Anethum graveolens against Entamoeba histolytica: In vitro and in vivo study

Author:
Al-Shimaa M. Abas; Somia M. Elagib
Source:
Biocatalysis and agricultural biotechnology 2021 v.34 pp. 102026
ISSN:
1878-8181
Subject:
antiparasitic properties,   etc   ; Anethum graveolens; Entamoeba histolytica; agricultural biotechnology; amebiasis; biocatalysis; cholesterol; dill; hepatoprotective effect; liver; liver abscess; metronidazole; mortality; triacylglycerols; trophozoites;     Show all 15 Subjects
Abstract:
... Amebic liver abscess is one of the most dangerous extraintestinal amebiasis caused by Entamoeba histolytica. The most dangerous problem in it is that until now there are no effective drugs for it. This study evaluated the antiamoebic activity of dill extract as a promising agent for hepatoprotection against liver abscess. In vitro studies involved serial dilutions of the extract at final concentra ...
DOI:
10.1016/j.bcab.2021.102026

19. Bioactive (Poly)phenols, Volatile Compounds from Vegetables, Medicinal and Aromatic Plants

Author:
Teresa Pinto; Alfredo Aires; Fernanda Cosme; Eunice Bacelar; Maria Cristina Morais; Ivo Oliveira; Jorge Ferreira-Cardoso; Rosário Anjos; Alice Vilela; Berta Gonçalves
Source:
Foods 2021 v.10 no.1 pp. -
ISSN:
2304-8158
Subject:
antiparasitic properties,   etc   ; antioxidants; bioactive compounds; cardiovascular diseases; essential oil crops; foods; neoplasms; neurodegenerative diseases; polyphenols; prebiotics; research; researchers; vegetables; volatile compounds;     Show all 14 Subjects
Abstract:
... Polyphenols, as well as volatile compounds responsible for aromatic features, play a critical role in the quality of vegetables and medicinal, and aromatic plants (MAPs). The research conducted in recent years has shown that these plants contain biologically active compounds, mainly polyphenols, that relate to the prevention of inflammatory processes, neurodegenerative diseases, cancers, and cardi ...
DOI:
10.3390/foods10010106

20. In vitro anti-parasitic activity and mechanism of β-carboline derivatives isolated from the extracellular product of Salinivibrio proteolyticus strain YCSC6

Author:
Guang-xun Du; Chun-xiao Sun; Yan-kai Liu; Qing Dong; Ping Gao; De-hai Li; Ling-yun Qu
Source:
Aquaculture 2021 v.534 pp. 736337
ISSN:
0044-8486
Subject:
antiparasitic properties,   etc   ; DNA; Salinivibrio; aquaculture; fractionation; marine fish; median effective concentration; oxygen; parasites; plasma membrane; reactive oxygen species; structure-activity relationships;     Show all 12 Subjects
Abstract:
... Uronema marinum, a well-known pathogenic parasite found in various marine fish species, caused severe economic losses in the field of aquaculture. This study aimed to assess the anti-parasitic activity and clarify the anti-parasitic mechanism of active compounds isolated from the extracellular product of Salinivibrio proteolyticus strain YCSC6 against U. marinum in vitro. Two β-carboline derivativ ...
DOI:
10.1016/j.aquaculture.2020.736337