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1. The regulatory roles of DDIT4 in TDCIPP-induced autophagy and apoptosis in PC12 cells

Author:
Li Li; Lingyi Xi; Jin Wu; Zunquan Zhao; Youliang Chen; Weili Liu; Zhihui Pan; Mingzhu Liu; Danfeng Yang; Zhaoli Chen; Yanjun Fang
Source:
Journal of environmental sciences (China) 2023 v.125 pp. 823-830
ISSN:
1001-0742
Subject:
apoptosis,   etc   ; DNA; Western blotting; autophagy; flame retardants; flow cytometry; humans; neurons; neurotoxicity; phosphates; phosphorylation; protective effect; rats; China;     Show all 14 Subjects
Abstract:
... Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) is a commonly used organophosphate-based flame retardant and can bio-accumulate in human tissues and organs. As its structure is similar to that of neurotoxic organophosphate pesticides, the neurotoxicity of TDCIPP has raised widespread concerns. TDCIPP can increase neuronal apoptosis and induce autophagy. However, its regulatory mechanism remains un ...
DOI:
10.1016/j.jes.2022.02.046

2. Pro-apoptotic and anti-apoptotic regulation mediated by deubiquitinating enzymes

Author:
Hae-Seul Choi; Kwang-Hyun Baek
Source:
Cellular and molecular life sciences 2022 v.79 no.2 pp. 117
ISSN:
1420-682X
Subject:
apoptosis,   etc   ; cancer therapy; chromatin;     Show all 3 Subjects
Abstract:
... Although damaged cells can be repaired, cells that are considered unlikely to be repaired are eliminated through apoptosis, a type of predicted cell death found in multicellular organisms. Apoptosis is a structured cell death involving alterations to the cell morphology and internal biochemical changes. This process involves the expansion and cracking of cells, changes in cell membranes, nuclear f ...
DOI:
10.1007/s00018-022-04132-5

3. The case for brakes: Why restrain the size of Bax and Bak pores in outer mitochondrial membranes?

Author:
David W. Andrews
Source:
Molecular cell 2022 v.82 no.5 pp. 882-883
ISSN:
1097-2765
Subject:
apoptosis,   etc   ; DNA; inflammation; mitochondria;     Show all 4 Subjects
Abstract:
... By comparing the structures of Bax and Bak megapores, Cosentino et al. (2022) reveal new insights suggesting the two pro-apoptotic proteins co-assemble into structures that release DNA from mitochondria and thereby trigger inflammation. ...
DOI:
10.1016/j.molcel.2022.02.022

4. Brusatol inhibits the invasion and migration of pancreatic cancer cells by suppressing the NRF2/NF-κB/STAT3 signal cascade

Author:
Yukai Xiang; Shengjie Dai; Ding Li; Xiandong Zhu; Jiadong Su; Bicheng Chen; Minmin Wu
Source:
Journal of functional foods 2022 v.92 pp. 105024
ISSN:
1756-4646
Subject:
apoptosis,   etc   ; databases; genes; metastasis; pancreatic neoplasms;     Show all 5 Subjects
Abstract:
... The previous study has established that brusatol exhibits growth inhibitory and pro-apoptotic effects. However, whether brusatol can suppress the invasion and migration of pancreatic cancer cells remains unclear. Information in The Cancer Genome Atlas database indicates that NRF2 expression is tightly associated with the status of lymphatic metastasis and overall survival. Gene set enrichment anal ...
DOI:
10.1016/j.jff.2022.105024

5. Subcellular localization of X-linked inhibitor of apoptosis protein (XIAP) in cancer: Does that matter?

Author:
BS Mendonça; CA Ferreira; RC Maia; G Nestal de Moraes
Source:
BBA advances 2022 v.2 pp. 100050
ISSN:
2667-1603
Subject:
apoptosis,   etc   ; cancer therapy; death; homeostasis; humans;     Show all 5 Subjects
Abstract:
... X-linked inhibitor of apoptosis protein (XIAP) finely tunes the balance between survival and death to control homeostasis. XIAP is found aberrantly expressed in cancer, which has been shown to promote resistance to therapy-induced apoptosis and confer poor outcome. Despite its predominant cytoplasmic localization in human tissues, growing evidence implicates the expression of XIAP in other subcell ...
DOI:
10.1016/j.bbadva.2022.100050

6. β-Galactosidase-activated theranostic for hepatic carcinoma therapy and imaging

Author:
Mrinmoy Maiti; Kai Kikuchi; K. K. Athul; Amandeep Kaur; Sankarprasad Bhuniya
Source:
Chemical communications 2022 v.58 no.44 pp. 6413-6416
ISSN:
1364-548X
Subject:
apoptosis,   etc   ; cancer therapy; carcinoma; cytotoxicity; fluorescence;     Show all 5 Subjects
Abstract:
... A β-galactosidase activatable fluorescent turn-on theranostic Gal-CGem exhibits gemcitabine release specifically in β-galactosidase overexpressing hepatic carcinoma cells. The cytotoxicity of Gal-CGem in cancer cells is achieved through the apoptotic cell death pathway. Overall, Gal-CGem is a new frontline prodrug in cancer therapy that has provided antineoplastic information through fluorescence ...
DOI:
10.1039/d2cc01825j

7. FAM96A suppresses epithelial–mesenchymal transition and tumor metastasis by inhibiting TGFβ1 signals

Author:
Ning Zhao; Minwei He; Wei Chen; Peng Jin; Lulu Cao; Jinhai Deng; Xu Cheng; Lu Wang
Source:
Life sciences 2022 v.301 pp. 120607
ISSN:
0024-3205
Subject:
apoptosis,   etc   ; bioinformatics; death; metastasis; neoplasms; sequence homology;     Show all 6 Subjects
Abstract:
... Metastasis is the main cause of death in 90% of patients with tumors, and epithelial-mesenchymal transition (EMT) plays a key role in this process. Family with sequence similarity 96 member A (FAM96A) is an evolutionarily conserved protein related to cytosolic iron assembly. However, no research has been conducted on its role in tumor metastasis. Bioinformatics analysis with Kaplan–Meier analysis ...
DOI:
10.1016/j.lfs.2022.120607

8. Induction of thymic atrophy and loss of thymic output by type-I interferons during chronic viral infection

Author:
Thomas Démoulins; Marie-Laurence Baron; Dominique Gauchat; Nadia Kettaf; Steven James Reed; Tania Charpentier; Ulrich Kalinke; Alain Lamarre; Rafi Ahmed; Rafick-Pierre Sékaly; Surojit Sarkar; Vandana Kalia
Source:
Virology 2022 v.567 pp. 77-86
ISSN:
0042-6822
Subject:
apoptosis,   etc   ; atrophy; disease progression; immunotherapy; thymocytes; virology;     Show all 6 Subjects
Abstract:
... Type-I interferon (IFN-I) signals exert a critical role in disease progression during viral infections. However, the immunomodulatory mechanisms by which IFN-I dictates disease outcomes remain to be fully defined. Here we report that IFN-I signals mediate thymic atrophy in viral infections, with more severe and prolonged loss of thymic output and unique kinetics and subtypes of IFN-α/β expression ...
DOI:
10.1016/j.virol.2021.12.007

9. RNA-seq reveal RNA binding protein GNL3 as a key mediator in the development of psoriasis vulgaris by regulating the IL23/IL17 axis

Author:
Xiaomin Yao; Zhen Zhu; Upasana Manandhar; Han Liao; Tiexi Yu; Yueying Wang; Yawen Bian; Bo Zhang; Xuanhong Zhang; Jun Xie; Jiquan Song
Source:
Life sciences 2022 v.293 pp. 119902
ISSN:
0024-3205
Subject:
apoptosis,   etc   ; pathogenesis; psoriasis; quality control; sequence analysis;     Show all 5 Subjects
Abstract:
... Psoriasis is a systemic chronic inflammatory skin disorder that was prone to recurrence. The RNA binding protein GNL3 has an important function in maintaining the proliferative ability of stem cells, and its overexpression leads to apoptosis. GNL3 is expressed in the epidermis, however, its regulatory mechanism in psoriasis vulgaris is still poorly understood. To identify the role of GNL3 in the p ...
DOI:
10.1016/j.lfs.2021.119902

10. The degree of unsaturation of fatty acids in phosphatidylserine alters the rate of insulin aggregation and the structure and toxicity of amyloid aggregates

Author:
Mikhail Matveyenka; Stanislav Rizevsky; Dmitry Kurouski
Source:
FEBS letters 2022 v.596 no.11 pp. 1424-1433
ISSN:
0014-5793
Subject:
apoptosis,   etc   ; amyloid; cytotoxicity; insulin; phosphatidylserines; plasma membrane;     Show all 6 Subjects
Abstract:
... Phosphatidylserine (PS) in the plasma membrane plays an important role in cell signaling and apoptosis. Cell degeneration is also linked to numerous amyloid diseases, pathologies that are associated with aggregation of misfolded proteins. In this work, we examine the effect of both saturated PS (DMPS) and unsaturated PS (DOPS and POPS) on the aggregation properties of insulin, as well as the struc ...
DOI:
10.1002/1873-3468.14369

11. miRNA-222-3p enhances the proliferation and suppresses the apoptosis of acute myeloid leukemia cells by targeting Axin2 and modulating the Wnt/β-catenin pathway

Author:
Zhenyan Liu; Liang Zhong; Wenran Dan; Xuan Chu; Chen Liu; Xu Luo; Zhonghui Zhang; Yang Lu; Peng Wan; Xiao Wang; Beizhong Liu
Source:
Biochemical and biophysical research communications 2022 pp. -
ISSN:
0006-291X
Subject:
apoptosis,   etc   ; microRNA; myeloid leukemia; oncogenes; research; viability;     Show all 6 Subjects
Abstract:
... MicroRNA (miRNA)-222-3p is overexpressed in numerous tumors, where it acts as an oncogene. Although miRNA-222 is highly expressed in acute myeloid leukemia (AML), its functions and the mechanisms underlying these functions have not yet been fully elucidated. This study aimed to investigate the regulatory roles of miRNA-222-3p in AML and the molecular mechanisms underlying these roles. In this stud ...
DOI:
10.1016/j.bbrc.2022.06.054

12. Buccal Micronucleus Cytome Assay for the Evaluation of Cytogenetic Status of Healthcare Professionals Contacting with Anti-Cancer Drugs

Author:
K. I. Kirsanov; L. P. Sycheva; E. A. Lesovaya; E. M. Zhidkova; O. A. Vlasova; A. V. Osipova; E. S. Lylova; D. D. Grigorieva; E. M. Kulakova; L. G. Solenova; G. A. Belitsky; I. N. Mikhaylova; M. G. Yakubovskaya
Source:
Russian journal of genetics 2022 v.58 no.5 pp. 528-537
ISSN:
1022-7954
Subject:
apoptosis,   etc   ; drug therapy; exposure duration; health services; mutagens;     Show all 5 Subjects
Abstract:
... Healthcare professionals of chemotherapy departments are in a regular contact with anticancer drugs that have genotoxic properties. The analysis of the cytogenetic status of healthcare professionals (54 individuals) was for the first time carried out using a new promising noninvasive method, buccal micronucleus cytome assay with the calculation of integral indices. The effect was estimated with di ...
DOI:
10.1134/S1022795422050052

13. Dysregulation of Transcription Profile of Selenoprotein in Patients with Kashin-Beck Disease and Its Effect on Se Deficiency–Induced Chondrocyte Apoptosis

Author:
XiaoLi Yang; ZhaoFang Li; RongQiang Zhang; Di Zhang; YongMin Xiong; Chen Wang; XueNa Yang; Qiang Li
Source:
Biological trace element research 2022 v.200 no.4 pp. 1508-1517
ISSN:
0163-4984
Subject:
apoptosis,   etc   ; antioxidant activity; chondrocytes; research; selenium; selenocysteine; selenoproteins;     Show all 7 Subjects
Abstract:
... Kashin-Beck disease (KBD) is a chronic, degenerative osteoarthropathy related to selenium (Se) deficiency. Se participates in the synthesis of selenoprotein in the form of selenocysteine. In total, 25 selenoproteins, encoded by 25 genes, are currently found in humans; however, the effects of selenoprotein genes on chondrocyte apoptosis, particularly in apoptosis-related genes, remain poorly elucid ...
DOI:
10.1007/s12011-021-02772-5

14. Advancing natural killer therapies against cancer

Author:
Emilie Narni-Mancinelli; Eric Vivier
Source:
Cell 2022 v.185 no.9 pp. 1451-1454
ISSN:
0092-8674
Subject:
apoptosis,   etc   ; cancer therapy; exhibitions; natural killer cells; neoplasm cells;     Show all 5 Subjects
Abstract:
... Natural killer (NK)-based therapies against cancer are emerging, but the understanding of NK cell functions needs to be completed to optimize these treatments. In this issue, Pan et al. (2022) show that pro-apoptotic molecules, such as BH3-mimetics, synergize with NK cells to induce mitochondria-driven apoptosis in tumor cells, thereby enhancing the efficacy of NK cell therapies. ...
DOI:
10.1016/j.cell.2022.04.006

15. Aluminum induced intestinal dysfunction via mechanical, immune, chemical and biological barriers

Author:
Wudi Hao; Chenyu Hao; Chengrong Wu; Yuqing Xu; Cuihong Jin
Source:
Chemosphere 2022 v.288 pp. 132556
ISSN:
0045-6535
Subject:
apoptosis,   etc   ; aluminum; digestive tract; intestinal microorganisms; intestinal mucosa; permeability;     Show all 6 Subjects
Abstract:
... Aluminum is the most abundant metal element in the Earth's crust, which exists naturally in the form of aluminum compounds. Aluminum is mainly absorbed through the gastrointestinal tract, which varies with different aluminum compounds. During this process, aluminum could induce the disruption of intestinal mucosa barrier. However, its underlying mechanism has not been elucidated yet. Previous stud ...
DOI:
10.1016/j.chemosphere.2021.132556

16. Aptamer-Induced-Dimerization Strategy Attenuates AβO Toxicity through Modulating the Trophic Activity of PrPC Signaling

Author:
Shuya Liu; Shiwei Li; Jirong Lin; Jingying Li; Huanghao Yang
Source:
Journal of the American Chemical Society 2022 v.144 no.21 pp. 9264-9270
ISSN:
1520-5126
Subject:
apoptosis,   etc   ; amyloid; cytokines; dimerization; mitochondria; neurotoxicity; prions; secretion; therapeutics;     Show all 9 Subjects
Abstract:
... Current therapeutic strategies for Alzheimer’s disease (AD) mainly focus on amyloid β oligomer (AβO) formation or clearance. However, most of them have failed to yield good clinical results. There is an urgent need to explore an alternative therapeutic target for AD treatments. Recent studies have indicated that the cellular prion protein (PrPC) is one of the cell-surface receptors of AβO that med ...
DOI:
10.1021/jacs.2c00287

17. Autophagy induced by Schwann cell-derived exosomes promotes recovery after spinal cord injury in rats

Author:
Dayu Pan; Shibo Zhu; Weixin Zhang; Zhijian Wei; Fuhan Yang; Zhenglong Guo; Guangzhi Ning; Shiqing Feng
Source:
Biotechnology letters 2022 v.44 no.1 pp. 129-142
ISSN:
0141-5492
Subject:
apoptosis,   etc   ; acetylation; animal injuries; autophagy; biotechnology; exosomes; microtubules; polymerization;     Show all 8 Subjects
Abstract:
... Spinal cord injury (SCI) is catastrophic to humans and society. However, there is currently no effective treatment for SCI. Autophagy is known to serve critical roles in both the physiological and pathological processes of the body, but its facilitatory and/or deleterious effects in SCI are yet to be completely elucidated. This study aimed to use primary Schwann cell-derived exosomes (SCDEs) to tr ...
DOI:
10.1007/s10529-021-03198-8

18. BBOX1‐AS1 contributes to colorectal cancer progression by sponging hsa‐miR‐361‐3p and targeting SH2B1

Author:
Jiasheng Liu; Jie Zhu; Zhe Xiao; Xufeng Wang; Jianfei Luo
Source:
FEBS Open Bio 2022 v.12 no.5 pp. 983-992
ISSN:
2211-5463
Subject:
apoptosis,   etc   ; cell proliferation; colorectal neoplasms; genes; microRNA; neoplasm progression;     Show all 6 Subjects
Abstract:
... Colorectal cancer (CRC) is the third main cause of cancer‐relevant deaths worldwide, and its incidence has increased in recent decades. Previous studies have indicated that certain long noncoding RNAs (lncRNAs) have regulatory roles in tumor occurrence and progression. Often, lncRNAs are competitive endogenous RNAs that sponge microRNAs to up‐regulate mRNAs. Here, we examined the role of a novel l ...
DOI:
10.1002/2211-5463.12802

19. Beclin1-mediated interplay between autophagy and apoptosis: New understanding

Author:
Kumari Prerna; Vikash Kumar Dubey
Source:
International journal of biological macromolecules 2022 v.204 pp. 258-273
ISSN:
0141-8130
Subject:
apoptosis,   etc   ; autophagy; cellular microenvironment; death; homeostasis; organelles; quality control;     Show all 7 Subjects
Abstract:
... The definition for autophagy holds a ‘single’ meaning as a conserved cellular process that constitutes a recycling pathway for damaged organelles and long-lived proteins to maintain nutrient homeostasis and mediate quality control within the cell. But this process of autophagy may behave ambiguously depending on the physiological stress as the stress progresses in the cellular microenvironment; th ...
DOI:
10.1016/j.ijbiomac.2022.02.005

20. Characterization of the MYB-inhibitory potential of the Pan-HDAC inhibitor LAQ824

Author:
Maria V. Yusenko; Karl-Heinz Klempnauer
Source:
BBA advances 2022 v.2 pp. 100034
ISSN:
2667-1603
Subject:
apoptosis,   etc   ; drugs; myeloid leukemia; necroptosis; transcription factors; transcriptional activation;     Show all 6 Subjects
Abstract:
... A large body of work has shown that MYB acts as a master transcription regulator in hematopoietic cells and has pinpointed MYB as a potential drug target for acute myeloid leukemia (AML). Here, we have examined the MYB-inhibitory potential of the HDAC inhibitor LAQ824, which was identified in a screen for novel MYB inhibitors. We show that nanomolar concentrations of LAQ824 and the related HDAC in ...
DOI:
10.1016/j.bbadva.2021.100034