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apoptosis, etc ; DNA; Western blotting; autophagy; flame retardants; flow cytometry; humans; neurons; neurotoxicity; phosphates; phosphorylation; protective effect; rats; China; Show all 14 Subjects
Abstract:
... Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) is a commonly used organophosphate-based flame retardant and can bio-accumulate in human tissues and organs. As its structure is similar to that of neurotoxic organophosphate pesticides, the neurotoxicity of TDCIPP has raised widespread concerns. TDCIPP can increase neuronal apoptosis and induce autophagy. However, its regulatory mechanism remains un ...
... Although damaged cells can be repaired, cells that are considered unlikely to be repaired are eliminated through apoptosis, a type of predicted cell death found in multicellular organisms. Apoptosis is a structured cell death involving alterations to the cell morphology and internal biochemical changes. This process involves the expansion and cracking of cells, changes in cell membranes, nuclear f ...
... By comparing the structures of Bax and Bak megapores, Cosentino et al. (2022) reveal new insights suggesting the two pro-apoptotic proteins co-assemble into structures that release DNA from mitochondria and thereby trigger inflammation. ...
apoptosis, etc ; databases; genes; metastasis; pancreatic neoplasms; Show all 5 Subjects
Abstract:
... The previous study has established that brusatol exhibits growth inhibitory and pro-apoptotic effects. However, whether brusatol can suppress the invasion and migration of pancreatic cancer cells remains unclear. Information in The Cancer Genome Atlas database indicates that NRF2 expression is tightly associated with the status of lymphatic metastasis and overall survival. Gene set enrichment anal ...
apoptosis, etc ; cancer therapy; death; homeostasis; humans; Show all 5 Subjects
Abstract:
... X-linked inhibitor of apoptosis protein (XIAP) finely tunes the balance between survival and death to control homeostasis. XIAP is found aberrantly expressed in cancer, which has been shown to promote resistance to therapy-induced apoptosis and confer poor outcome. Despite its predominant cytoplasmic localization in human tissues, growing evidence implicates the expression of XIAP in other subcell ...
apoptosis, etc ; cancer therapy; carcinoma; cytotoxicity; fluorescence; Show all 5 Subjects
Abstract:
... A β-galactosidase activatable fluorescent turn-on theranostic Gal-CGem exhibits gemcitabine release specifically in β-galactosidase overexpressing hepatic carcinoma cells. The cytotoxicity of Gal-CGem in cancer cells is achieved through the apoptotic cell death pathway. Overall, Gal-CGem is a new frontline prodrug in cancer therapy that has provided antineoplastic information through fluorescence ...
apoptosis, etc ; bioinformatics; death; metastasis; neoplasms; sequence homology; Show all 6 Subjects
Abstract:
... Metastasis is the main cause of death in 90% of patients with tumors, and epithelial-mesenchymal transition (EMT) plays a key role in this process. Family with sequence similarity 96 member A (FAM96A) is an evolutionarily conserved protein related to cytosolic iron assembly. However, no research has been conducted on its role in tumor metastasis. Bioinformatics analysis with Kaplan–Meier analysis ...
apoptosis, etc ; atrophy; disease progression; immunotherapy; thymocytes; virology; Show all 6 Subjects
Abstract:
... Type-I interferon (IFN-I) signals exert a critical role in disease progression during viral infections. However, the immunomodulatory mechanisms by which IFN-I dictates disease outcomes remain to be fully defined. Here we report that IFN-I signals mediate thymic atrophy in viral infections, with more severe and prolonged loss of thymic output and unique kinetics and subtypes of IFN-α/β expression ...
apoptosis, etc ; pathogenesis; psoriasis; quality control; sequence analysis; Show all 5 Subjects
Abstract:
... Psoriasis is a systemic chronic inflammatory skin disorder that was prone to recurrence. The RNA binding protein GNL3 has an important function in maintaining the proliferative ability of stem cells, and its overexpression leads to apoptosis. GNL3 is expressed in the epidermis, however, its regulatory mechanism in psoriasis vulgaris is still poorly understood. To identify the role of GNL3 in the p ...
apoptosis, etc ; amyloid; cytotoxicity; insulin; phosphatidylserines; plasma membrane; Show all 6 Subjects
Abstract:
... Phosphatidylserine (PS) in the plasma membrane plays an important role in cell signaling and apoptosis. Cell degeneration is also linked to numerous amyloid diseases, pathologies that are associated with aggregation of misfolded proteins. In this work, we examine the effect of both saturated PS (DMPS) and unsaturated PS (DOPS and POPS) on the aggregation properties of insulin, as well as the struc ...
apoptosis, etc ; microRNA; myeloid leukemia; oncogenes; research; viability; Show all 6 Subjects
Abstract:
... MicroRNA (miRNA)-222-3p is overexpressed in numerous tumors, where it acts as an oncogene. Although miRNA-222 is highly expressed in acute myeloid leukemia (AML), its functions and the mechanisms underlying these functions have not yet been fully elucidated. This study aimed to investigate the regulatory roles of miRNA-222-3p in AML and the molecular mechanisms underlying these roles. In this stud ...
K. I. Kirsanov; L. P. Sycheva; E. A. Lesovaya; E. M. Zhidkova; O. A. Vlasova; A. V. Osipova; E. S. Lylova; D. D. Grigorieva; E. M. Kulakova; L. G. Solenova; G. A. Belitsky; I. N. Mikhaylova; M. G. Yakubovskaya
apoptosis, etc ; drug therapy; exposure duration; health services; mutagens; Show all 5 Subjects
Abstract:
... Healthcare professionals of chemotherapy departments are in a regular contact with anticancer drugs that have genotoxic properties. The analysis of the cytogenetic status of healthcare professionals (54 individuals) was for the first time carried out using a new promising noninvasive method, buccal micronucleus cytome assay with the calculation of integral indices. The effect was estimated with di ...
apoptosis, etc ; antioxidant activity; chondrocytes; research; selenium; selenocysteine; selenoproteins; Show all 7 Subjects
Abstract:
... Kashin-Beck disease (KBD) is a chronic, degenerative osteoarthropathy related to selenium (Se) deficiency. Se participates in the synthesis of selenoprotein in the form of selenocysteine. In total, 25 selenoproteins, encoded by 25 genes, are currently found in humans; however, the effects of selenoprotein genes on chondrocyte apoptosis, particularly in apoptosis-related genes, remain poorly elucid ...
apoptosis, etc ; cancer therapy; exhibitions; natural killer cells; neoplasm cells; Show all 5 Subjects
Abstract:
... Natural killer (NK)-based therapies against cancer are emerging, but the understanding of NK cell functions needs to be completed to optimize these treatments. In this issue, Pan et al. (2022) show that pro-apoptotic molecules, such as BH3-mimetics, synergize with NK cells to induce mitochondria-driven apoptosis in tumor cells, thereby enhancing the efficacy of NK cell therapies. ...
apoptosis, etc ; aluminum; digestive tract; intestinal microorganisms; intestinal mucosa; permeability; Show all 6 Subjects
Abstract:
... Aluminum is the most abundant metal element in the Earth's crust, which exists naturally in the form of aluminum compounds. Aluminum is mainly absorbed through the gastrointestinal tract, which varies with different aluminum compounds. During this process, aluminum could induce the disruption of intestinal mucosa barrier. However, its underlying mechanism has not been elucidated yet. Previous stud ...
apoptosis, etc ; amyloid; cytokines; dimerization; mitochondria; neurotoxicity; prions; secretion; therapeutics; Show all 9 Subjects
Abstract:
... Current therapeutic strategies for Alzheimer’s disease (AD) mainly focus on amyloid β oligomer (AβO) formation or clearance. However, most of them have failed to yield good clinical results. There is an urgent need to explore an alternative therapeutic target for AD treatments. Recent studies have indicated that the cellular prion protein (PrPC) is one of the cell-surface receptors of AβO that med ...
apoptosis, etc ; acetylation; animal injuries; autophagy; biotechnology; exosomes; microtubules; polymerization; Show all 8 Subjects
Abstract:
... Spinal cord injury (SCI) is catastrophic to humans and society. However, there is currently no effective treatment for SCI. Autophagy is known to serve critical roles in both the physiological and pathological processes of the body, but its facilitatory and/or deleterious effects in SCI are yet to be completely elucidated. This study aimed to use primary Schwann cell-derived exosomes (SCDEs) to tr ...
apoptosis, etc ; cell proliferation; colorectal neoplasms; genes; microRNA; neoplasm progression; Show all 6 Subjects
Abstract:
... Colorectal cancer (CRC) is the third main cause of cancer‐relevant deaths worldwide, and its incidence has increased in recent decades. Previous studies have indicated that certain long noncoding RNAs (lncRNAs) have regulatory roles in tumor occurrence and progression. Often, lncRNAs are competitive endogenous RNAs that sponge microRNAs to up‐regulate mRNAs. Here, we examined the role of a novel l ...
apoptosis, etc ; autophagy; cellular microenvironment; death; homeostasis; organelles; quality control; Show all 7 Subjects
Abstract:
... The definition for autophagy holds a ‘single’ meaning as a conserved cellular process that constitutes a recycling pathway for damaged organelles and long-lived proteins to maintain nutrient homeostasis and mediate quality control within the cell. But this process of autophagy may behave ambiguously depending on the physiological stress as the stress progresses in the cellular microenvironment; th ...
apoptosis, etc ; drugs; myeloid leukemia; necroptosis; transcription factors; transcriptional activation; Show all 6 Subjects
Abstract:
... A large body of work has shown that MYB acts as a master transcription regulator in hematopoietic cells and has pinpointed MYB as a potential drug target for acute myeloid leukemia (AML). Here, we have examined the MYB-inhibitory potential of the HDAC inhibitor LAQ824, which was identified in a screen for novel MYB inhibitors. We show that nanomolar concentrations of LAQ824 and the related HDAC in ...