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1. The Coming Decade of Cell Death Research: Five Riddles

Author:
Green, Douglas R.
Source:
Cell 2019 v.177 no.5 pp. 1094-1107
ISSN:
0092-8674
Subject:
apoptosis,   etc   ; mammals; necroptosis;     Show all 3 Subjects
Abstract:
... Active cell death, in its many forms, is a fundamental biological process. Studies over the past several decades have explored the functions and consequences of cellular demise and elucidated several of the key cell death pathways. Here, I pose five questions, or riddles, that might provide a guide to the next decade of cell death research. Focusing mainly on four types of active cell death (apopt ...
DOI:
10.1016/j.cell.2019.04.024

2. Controlling proteolysis of Clp peptidase: a possible target for combating mitochondrial diseases

Author:
da Silva, Ronivaldo Rodrigues
Source:
The international journal of biochemistry & cell biology 2019 v.110 pp. 140-142
ISSN:
1357-2725
Subject:
apoptosis,   etc   ; mammals; mitochondria; peptidases; proteolysis;     Show all 5 Subjects
Abstract:
... Some mechanisms of cellular stress, aging, and apoptosis are related to proteolysis. With respect to ClpP, little is known about the mechanical manner in which the substrate is hydrolyzed in and released from the degradation chamber. Furthermore, what would be the real influence of ClpP in mammalian UPRmt? ...
DOI:
10.1016/j.biocel.2019.03.007

3. In search of nutritional anti-aging targets: TOR inhibitors, SASP modulators, and BCL-2 family suppressors

Author:
Sharma, Rohit; Padwad, Yogendra
Source:
Nutrition 2019 v.65 pp. 33-38
ISSN:
0899-9007
Subject:
apoptosis,   etc   ; functional foods; nutritional intervention; phenotype; rapamycin;     Show all 5 Subjects
Abstract:
... In pursuit of developing anti-aging or age-delaying strategies, nutritional interventions have long been considered promising candidates. However, emerging advances in the understanding of the causes and effects of senescence per se have enhanced the prospects of a more focused approach in the exploration of therapies aimed at the modulation of aging. The aim of this study was to review recent dev ...
DOI:
10.1016/j.nut.2019.01.020

4. MiR-375 induces ROS and apoptosis in ST cells by targeting the HIGD1A gene

Author:
Guo, Jia; Yang, Chun; Zhang, Shaoxuan; Liang, Mengdi; Qi, Jiajia; Wang, Zhenbo; Peng, Yinghua; Sun, Boxing
Source:
Gene 2019 v.685 pp. 136-142
ISSN:
0378-1119
Subject:
apoptosis,   etc   ; Sertoli cells; anaerobic conditions; genes; swine;     Show all 5 Subjects
Abstract:
... HIGD1A can reduce ROS and apoptosis in cells under low-glucose or hypoxic conditions, and HIGD1A is one of the target genes for miR-375, according to our previous studies. However, it is not known whether miR-375 can indirectly regulate ROS and apoptosis in porcine Sertoli cells. To answer this question, HIGD1A and miR-375 were overexpressed in porcine Sertoli cells, and ROS and apoptosis were ass ...
DOI:
10.1016/j.gene.2018.10.086

5. The triptolide‐induced apoptosis of osteoclast precursor by degradation of cIAP2 and treatment of rheumatoid arthritis of TNF‐transgenic mice

Author:
Wang, Shengli; Liu, Zhigang; Wang, Jingchun; Wang, Yifei; Liu, Jianhua; Ji, Xinying; Wang, Xinchun
Source:
Phytotherapy research 2019 v.33 no.2 pp. 342-349
ISSN:
0951-418X
Subject:
apoptosis,   etc   ; mice; osteoclasts; rheumatoid arthritis; splenocytes;     Show all 5 Subjects
Abstract:
... This study aims to discuss the effect of triptolide (TPL) on rheumatoid arthritis (RA) and the mechanism related to osteoclast precursor (OCP) and osteoclast (OC). TNF‐transgenic RA mice were treated with different doses of TPL by gavage. After the administration was finished, the curative effects were evaluated and compared, and the OCP apoptosis rates, the OC number, and the OC differentiation a ...
DOI:
10.1002/ptr.6224

6. Binding of SRSF4 to a novel enhancer modulates splicing of exon 6 of Fas pre-mRNA

Author:
Jang, Ha Na; Liu, Yongchao; Choi, Namjeong; Oh, Jagyeong; Ha, Jiyeon; Zheng, Xuexiu; Shen, Haihong
Source:
Biochemical and biophysical research communications 2018 v.506 no.3 pp. 703-708
ISSN:
0006-291X
Subject:
apoptosis,   etc   ; alternative splicing; exons;     Show all 3 Subjects
Abstract:
... Alternative splicing of exon 6 in Fas pre-mRNA generates a membrane bound pro-apoptotic isoform or soluble anti-apoptotic isoform. SRSF4 is a member of Arginine-Serine rich (SR) protein family. Here we demonstrate that increased SRSF4 expression stimulates exon 6 inclusion, and that reduced SRSF4 expression promotes exon 6 exclusion. We also show that weaker but not stronger 5’ splice-site strengt ...
DOI:
10.1016/j.bbrc.2018.10.123

7. Phosphorylation alters Bim‐mediated Mcl‐1 stabilization and priming

Author:
Conage‐Pough, Jason E.; Boise, Lawrence H.
Source:
TheFEBS journal 2018 v.285 no.14 pp. 2626-2640
ISSN:
1742-464X
Subject:
apoptosis,   etc   ; mutation; phosphorylation; proteins;     Show all 4 Subjects
Abstract:
... Mcl‐1 is a highly labile protein, subject to extensive post‐translational regulation. This distinguishes Mcl‐1 from other antiapoptotic proteins and necessitates further study to better understand how interactions with proapoptotic Bcl‐2 proteins affect its regulation. One such protein, Bim, is known to stabilize Mcl‐1, and Bim phosphorylation has been associated with increased Mcl‐1 binding. Cons ...
DOI:
10.1111/febs.14505

8. Correction to: Cypripedin, a phenanthrenequinone from Dendrobium densiflorum, sensitizes non-small cell lung cancer H460 cells to cisplatin-mediated apoptosis

Author:
Wattanathamsan, Onsurang; Treesuwan, Surassawadee; Sritularak, Boonchoo; Pongrakhananon, Varisa
Source:
Natural medicines 2018 v.72 no.3 pp. 816
ISSN:
1340-3443
Subject:
apoptosis,   etc   ; Dendrobium; lung neoplasms;     Show all 3 Subjects
Abstract:
... In original publication of the article, unfortunately one of the author names was published incorrectly as “Boonchu Sritularuk”. The correct name is “Boonchoo Sritularak”. ...
DOI:
10.1007/s11418-018-1200-3

9. Combined apoptotic effects of peptide and miRNA in a peptide/miRNA nanocomplex

Author:
Kim, Hyungjin; Kitamatsu, Mizuki; Ohtsuki, Takashi
Source:
Journal of bioscience and bioengineering 2019 v.128 no.1 pp. 110-116
ISSN:
1389-1723
Subject:
apoptosis,   etc   ; bioactive properties; cytoplasm; microRNA; photoirradiation; small interfering RNA;     Show all 6 Subjects
Abstract:
... The present study investigated combined biological effects of peptide and miRNA in a peptide/miRNA nanocomplex. We utilized TatBim peptide as a cell-penetrating peptide-based RNA carrier with apoptotic activity. miRNA with apoptotic activity (miR-34a) was used for complex formation to investigate the additional effects of the combination with TatBim peptide. TatBim peptide and the miRNA formed nan ...
DOI:
10.1016/j.jbiosc.2019.01.003

10. Optimizing PLG nanoparticle-peptide delivery platforms for transplantation tolerance using an allogeneic skin transplant model

Author:
Shah, Sahil; Daneshmandi, Saeed; Hughes, Kevin R.; Yu, Shuangjin; Bedoya, Angela M.; Shea, Lonnie D.; Luo, Xunrong
Source:
Biomaterials 2019 v.210 pp. 70-82
ISSN:
0142-9612
Subject:
apoptosis,   etc   ; allografting; antigens; engineering; immunomodulation; models; nanoparticles; peptides; phagocytes; splenocytes;     Show all 10 Subjects
Abstract:
... A robust regimen for inducing allogeneic transplantation tolerance involves pre-emptive recipient treatment with donor splenocytes (SP) rendered apoptotic by 1-ethyl-3-(3′-dimethylaminopropyl)-carbodiimide(ECDI) treatment. However, such a regimen is limited by availability of donor cells, cost of cell procurement, and regulatory hurdles associated with cell-based therapies. Nanoparticles (NP) deli ...
DOI:
10.1016/j.biomaterials.2019.04.030

11. Fat regulates expression of four-jointed reporters in vivo through a 20 bp element independently of the Hippo pathway

Author:
Arbouzova, Natalia I.; Fulford, Alexander D.; Zhang, Hongtao; McNeill, Helen
Source:
Developmental biology 2019 v.450 no.1 pp. 23-33
ISSN:
0012-1606
Subject:
apoptosis,   etc   ; cadherins; cell polarity; enhancer elements; eyes; transcription factors;     Show all 6 Subjects
Abstract:
... Development of an organism requires accurate coordination between the growth of a tissue and orientation of cells within the tissue. The large cadherin Fat has been shown to play a role in both of these processes. Fat is involved in the establishment of planar cell polarity and regulates growth through the Hippo pathway, a developmental cascade that controls proliferation and apoptosis. Both Fat a ...
DOI:
10.1016/j.ydbio.2019.03.004

12. Dose and frequency in cancer therapy. Theoretical non-autonomous model of p53 network

Author:
Silva, E.; Martin, R. R.; Pomuceno, J. P.; Mansilla, R.; Betancourt-Mar, J. A.; Cocho, G.; Nieto-Villar, J. M.
Source:
Biological rhythm research 2019 v.50 no.3 pp. 483-489
ISSN:
1744-4179
Subject:
apoptosis,   etc   ; DNA; models; neoplasms; therapeutics; time series analysis;     Show all 6 Subjects
Abstract:
... A non-autonomous model for the regulation of apoptosis by p53 is proposed as a model for cancer chronotherapy. A perturbation is introduced that simulates damage caused to DNA in a periodic regime. To characterize the resulting system dynamics, the techniques used were stroboscopic analysis, Poincare section and power spectrum. The complexity of the time series was determined using the LZ index. P ...
DOI:
10.1080/09291016.2018.1465697

13. Mitochondrial targeting of TR3 is involved in TPA induced apoptosis in breast cancer cells

Author:
Zhong, Caineng; Mai, Yuchang; Gao, Hengyuan; Zhou, Wenbin; Zhou, Dongxian
Source:
Gene 2019 v.693 pp. 61-68
ISSN:
0378-1119
Subject:
apoptosis,   etc   ; antineoplastic activity; breast neoplasms; carcinogenesis; mitochondria; neoplasm cells;     Show all 6 Subjects
Abstract:
... TPA is considered to be a tumor promoting molecule that induces the expression of COX-2 protein. However, it is contradictory to find that TPA can induce tumor cell apoptosis and exert antitumor activity. Therefore, the role of TPA in tumorigenesis and development has not yet been elucidated. Here we show that TPA can promote the apoptosis of breast cancer cells and increase the ratio of Bax/Bcl-2 ...
DOI:
10.1016/j.gene.2018.12.072

14. Full anti-apoptotic function of Bcl-XL complexed with Beclin-1 verified by live-cell FRET assays

Author:
Wen, Junlin; Mai, Zihao; Zhao, Mengxin; Wang, Xiaoping; Chen, Tongsheng
Source:
Biochemical and biophysical research communications 2019 v.511 no.3 pp. 700-704
ISSN:
0006-291X
Subject:
apoptosis,   etc   ; autophagy; binding sites; energy transfer; fluorescence; staurosporine; stoichiometry;     Show all 7 Subjects
Abstract:
... Binding of Bcl-XL to Beclin-1 reduces Beclin-1’s capacity to induce autophagy. This report aims to explore whether this interaction affects Bcl-XL’s anti-apoptotic function. Using fluorescence resonance energy transfer (FRET) two-hybrid assay to quantify the stoichiometry of Bcl-XL-Beclin-1 complex in living cells coexpressing Bcl-XL-CFP and Beclin-1-YFP, we showed that Bcl-XL bond to Beclin-1 to ...
DOI:
10.1016/j.bbrc.2019.02.107

15. Ran1 is essential for parental macronuclear import of apoptosis‐inducing factor and programmed nuclear death in Tetrahymena thermophila

Author:
Liang, Haixia; Xu, Jing; Wang, Wei
Source:
TheFEBS journal 2019 v.286 no.5 pp. 913-929
ISSN:
1742-464X
Subject:
apoptosis,   etc   ; DNA fragmentation; Tetrahymena thermophila; chromatin; death; mitochondria; mutants;     Show all 7 Subjects
Abstract:
... During programmed nuclear death (PND), apoptosis‐inducing factor (AIF) translocates from mitochondria to the parental macronucleus (MAC) in Tetrahymena thermophila. In the degenerating parental MAC, AIF induces chromatin condensation and large‐scale DNA fragmentation in a caspase‐independent manner. However, the regulation of AIF nuclear translocation and molecular mechanism of PND are less clear. ...
DOI:
10.1111/febs.14761

16. Changing the Apoptosis Pathway through Evolutionary Protein Design

Author:
Shultis, David; Mitra, Pralay; Huang, Xiaoqiang; Johnson, Jarrett; Khattak, Naureen Aslam; Gray, Felicia; Piper, Clint; Czajka, Jeff; Hansen, Logan; Wan, Bingbing; Chinnaswamy, Krishnapriya; Liu, Liu; Wang, Mi; Pan, Jingxi; Stuckey, Jeanne; Cierpicki, Tomasz; Borchers, Christoph H.; Wang, Shaomeng; Lei, Ming; Zhang, Yang
Source:
Journal of molecular biology 2019 v.431 no.4 pp. 825-841
ISSN:
0022-2836
Subject:
apoptosis,   etc   ; calorimetry; caspase-9; luminescence; mutation; peptides; proteins; proteolysis;     Show all 8 Subjects
Abstract:
... One obstacle in de novo protein design is the vast sequence space that needs to be searched through to obtain functional proteins. We developed a new method using structural profiles created from evolutionarily related proteins to constrain the simulation search process, with functions specified by atomic-level ligand–protein binding interactions. The approach was applied to redesigning the BIR3 d ...
DOI:
10.1016/j.jmb.2018.12.016

17. IL- 17A modulates osteoclast precursors' apoptosis through autophagy-TRAF3 signaling during osteoclastogenesis

Author:
Xue, Yan; Liang, Zhengeng; Fu, Xiaomin; Wang, Tao; Xie, Qi; Ke, Dianshan
Source:
Biochemical and biophysical research communications 2019 v.508 no.4 pp. 1088-1092
ISSN:
0006-291X
Subject:
apoptosis,   etc   ; autophagy; interleukin-17; orthodontics; osteoclasts; signal transduction;     Show all 6 Subjects
Abstract:
... Osteoclasts play an important role in bone remodeling. The inflammatory cytokine IL-17A could modulate the RANKL-induced osteoclastogenesis by regulating the autophagic activity. It is well accepted that protective autophagy has an anti-apoptotic effect. It is necessary to elucidate whether IL-17A can influence the apoptosis of osteoclast precursors (OCPs) through autophagy responses during osteoc ...
DOI:
10.1016/j.bbrc.2018.12.029

18. Preparation and Membrane Distribution of Fluorescent Derivatives of Ceramide

Author:
Matsufuji, Takaaki; Kinoshita, Masanao; Matsumori, Nobuaki
Source:
Langmuir 2019 v.35 no.6 pp. 2392-2398
ISSN:
1520-5827
Subject:
apoptosis,   etc   ; cell membranes; cell proliferation; ceramides; fluorescent dyes; hydrophilicity; sphingomyelins;     Show all 7 Subjects
Abstract:
... Ceramide is a bioactive lipid with significant roles in several biological processes including cell proliferation, apoptosis, and raft formation. Although fluorescent derivatives of ceramide are required to probe the behavior of ceramide in cells and cell membranes, commercial fluorescent ceramide derivatives do not reproduce the membrane behavior of native ceramide because of the introduction of ...
DOI:
10.1021/acs.langmuir.8b03176

19. An accessible and high-throughput strategy of continuously monitoring apoptosis by fluorescent detection of caspase activation

Author:
Hanson, Kelly M.; Finkelstein, Jacob N.
Source:
Analytical biochemistry 2019 v.564-565 pp. 96-101
ISSN:
0003-2697
Subject:
apoptosis,   etc   ; automation; caspases; cost effectiveness; dose response; fluorescence; monitoring; staining;     Show all 8 Subjects
Abstract:
... We present a real-time, high-throughput, and cost-effective method of detecting apoptosis in vitro using a previously developed reagent that detects caspase activation by fluorescence. Current methods of assessing apoptosis fail to account for the dimension of time, and thus are limited in data yielded per sample. This reagent allows real-time detection of apoptosis, but until now has been restric ...
DOI:
10.1016/j.ab.2018.10.022

20. Survival of an epidemic MDR strain of Mycobacterium tuberculosis and its non-prosperous variant within activated macrophages

Author:
Yokobori, Noemí; Monteserin, Johana; Rearte, Bárbara; Paul, Roxana; Símboli, Norberto; López, Beatriz; Ritacco, Viviana; Sasiain, María del Carmen
Source:
Infection, genetics, and evolution 2019 v.73 pp. 248-254
ISSN:
1567-1348
Subject:
apoptosis,   etc   ; Mycobacterium tuberculosis; genotype; humans; interferon-gamma; macrophage activation; macrophages; multiple drug resistance; pathogens;     Show all 9 Subjects
Abstract:
... The fitness of a pathogen results from the interaction of multiple factors favoring either epidemiological success or failure. Herein, we studied the performance of the M strain, a highly successful multidrug resistant Mycobacterium tuberculosis genotype, and its non-prosperous variant, the 410 strain, in activated human monocyte-derived macrophages. Both strains showed comparable ability to induc ...
DOI:
10.1016/j.meegid.2019.05.005