PubAg

Main content area

You searched for: Subject "apoptosis" Remove constraint Subject: "apoptosis"
Start Over

Search

30,566  Search Results

« Previous | 1 - 20 of 30,566 |
Number of results to display per page

Search Results

1. The role of ceramide in regulating endoplasmic reticulum function

Author:
Zelnik, Iris D.; Ventura, Ana E.; Kim, Jiyoon L.; Silva, Liana C.; Futerman, Anthony H.
Source:
Biochimica et biophysica acta 2020 v.1865 no.1 pp. 158489
ISSN:
1388-1981
Subject:
apoptosis,   etc   ; Golgi apparatus; ceramides; endoplasmic reticulum;     Show all 4 Subjects
Abstract:
... Sphingolipids (SLs) are an important class of membrane lipids containing a long chain sphingoid base backbone. SL synthesis is compartmentalized between two major cell organelles, the endoplasmic reticulum (ER) and the Golgi apparatus. The initial steps of sphingolipid synthesis take place in the ER, where the simplest SL, ceramide, is synthesized. Although ceramide is a critical membrane componen ...
DOI:
10.1016/j.bbalip.2019.06.015

2. Apoptotic cell death regulation in neurons

Author:
Hollville, Emilie; Romero, Selena E.; Deshmukh, Mohanish
Source:
TheFEBS journal 2019 v.286 no.17 pp. 3276-3298
ISSN:
1742-464X
Subject:
apoptosis,   etc   ; embryogenesis; neurons;     Show all 3 Subjects
Abstract:
... Apoptosis plays a major role in shaping the developing nervous system during embryogenesis as neuronal precursors differentiate to become post‐mitotic neurons. However, once neurons are incorporated into functional circuits and become mature, they greatly restrict their capacity to die via apoptosis, thus allowing the mature nervous system to persist in a healthy and functional state throughout li ...
DOI:
10.1111/febs.14970
PubMed:
31230407
PubMed Central:
PMC6718311

3. The Coming Decade of Cell Death Research: Five Riddles

Author:
Green, Douglas R.
Source:
Cell 2019 v.177 no.5 pp. 1094-1107
ISSN:
0092-8674
Subject:
apoptosis,   etc   ; mammals; necroptosis;     Show all 3 Subjects
Abstract:
... Active cell death, in its many forms, is a fundamental biological process. Studies over the past several decades have explored the functions and consequences of cellular demise and elucidated several of the key cell death pathways. Here, I pose five questions, or riddles, that might provide a guide to the next decade of cell death research. Focusing mainly on four types of active cell death (apopt ...
DOI:
10.1016/j.cell.2019.04.024
PubMed:
31100266
PubMed Central:
PMC6534278

4. Study on the activity and mechanism of skimmianine against human non-small cell lung cancer

Author:
Zuo, Yangsong; Pu, Juan; Chen, Guiming; Shen, Wenyi; Wang, Baoran
Source:
Natural product research 2019 v.33 no.5 pp. 759-762
ISSN:
1478-6427
Subject:
apoptosis,   etc   ; humans; lung neoplasms;     Show all 3 Subjects
Abstract:
... The present research was to investigate the effects of skimmianine (SK) in four non-small cell lung cancer (NSCLC) cells. We found that SK can significantly inhibit the growth of NSCLC cells and markedly induce apoptosis in NSCLC cells. The effects of growth inhibition and apoptosis induction were in a concentration–response relationship and caspase-dependent manner. ...
DOI:
10.1080/14786419.2017.1408096

5. Doxorubicin-polyglycerol-nanodiamond conjugates disrupt STAT3/IL-6-mediated reciprocal activation loop between glioblastoma cells and astrocytes

Author:
Chen, Zhuo; Yuan, Shen-Jun; Li, Ke; Zhang, Quan; Li, Tong-Fei; An, Hui-Chao; Xu, Hua-Zhen; Yue, Yuan; Han, Min; Xu, Yong-Hong; Komatsu, Naoki; Zhao, Li; Chen, Xiao
Source:
Journal of controlled release 2020 v.320 pp. 469-483
ISSN:
0168-3659
Subject:
apoptosis,   etc   ; astrocytes; drug therapy; glioblastoma; interleukin-6; macrophages;     Show all 6 Subjects
Abstract:
... Astrocytes are key stromal components in glioblastoma (GBM) and have complex interactions with the GBM cells (GBC) promoting the survival, progression and therapy resistance of GBM. In this study, we first demonstrated the existence of a reciprocal activation loop mediated by the STAT3/IL-6 signaling between GBC and astrocytes. This loop of reciprocity was found to be initiated by the constitutive ...
DOI:
10.1016/j.jconrel.2020.01.044

6. Yap/Taz are required for establishing the cerebellar radial glia scaffold and proper foliation

Author:
Hughes, Lucinda J.; Park, Raehee; Lee, Min Jung; Terry, Bethany K.; Lee, David J.; Kim, Hansol; Cho, Seo-Hee; Kim, Seonhee
Source:
Developmental biology 2020 v.457 no.1 pp. 150-162
ISSN:
0012-1606
Subject:
apoptosis,   etc   ; cell polarity; cerebellum; embryogenesis; morphogenesis; neuroglia; phenotype; proteins;     Show all 8 Subjects
Abstract:
... Yap/Taz are well-established downstream effectors of the Hippo pathway, known to regulate organ size by directing proliferation and apoptosis. Although the functions of Yap/Taz have been extensively studied, little is known about their role in brain development. Here, through genetic ablation, we show that Yap/Taz are required for cerebellar morphogenesis. Yap/Taz deletion in neural progenitors ca ...
DOI:
10.1016/j.ydbio.2019.10.002
PubMed:
31586559
PubMed Central:
PMC6910221

7. LncRNA UCA1 protects cardiomyocytes against hypoxia/reoxygenation induced apoptosis through inhibiting miR-143/MDM2/p53 axis

Author:
Wang, Qiang-Sheng; Zhou, Jun; Li, Xun
Source:
Genomics 2020 v.112 no.1 pp. 574-580
ISSN:
0888-7543
Subject:
apoptosis,   etc   ; cardiomyocytes; hypoxia; models; myocardial infarction; rats; signal transduction; therapeutics;     Show all 8 Subjects
Abstract:
... lncUCA1 is abundantly expressed in the heart, indicating it may be important in maintaining normal myocardial function. However, the underlying mechanism of lncUCA1 in heart disease, particularly myocardial infarction (MI), is still in its infancy.LncUCA1 and miR-143 expression were measured in hearts of MI models. Overexpression and knockdown of lncUCA1 in neonatal rat cardiomyocytes were perform ...
DOI:
10.1016/j.ygeno.2019.04.009

8. The Dark Side of Estrogen Stops Translation to Induce Apoptosis

Author:
Lamb, Heather M.; Hardwick, J. Marie
Source:
Molecular cell 2019 v.75 no.6 pp. 1087-1089
ISSN:
1097-2765
Subject:
apoptosis,   etc   ; enzymes; estrogen receptors; estrogens;     Show all 4 Subjects
Abstract:
... The role of hormones in triggering cell death has been controversial. In this issue of Molecular Cell, Li et al. (2019) have defined a molecular pathway where an unexpected estrogen receptor, phosphodiesterase 3A, allows its partner Schlafen-12 to inhibit survival pathways, ultimately leading to apoptosis. ...
DOI:
10.1016/j.molcel.2019.08.022

9. Controlling proteolysis of Clp peptidase: a possible target for combating mitochondrial diseases

Author:
da Silva, Ronivaldo Rodrigues
Source:
The international journal of biochemistry & cell biology 2019 v.110 pp. 140-142
ISSN:
1357-2725
Subject:
apoptosis,   etc   ; mammals; mitochondria; peptidases; proteolysis;     Show all 5 Subjects
Abstract:
... Some mechanisms of cellular stress, aging, and apoptosis are related to proteolysis. With respect to ClpP, little is known about the mechanical manner in which the substrate is hydrolyzed in and released from the degradation chamber. Furthermore, what would be the real influence of ClpP in mammalian UPRmt? ...
DOI:
10.1016/j.biocel.2019.03.007

10. Effect of gga-miR-155 on cell proliferation, apoptosis and invasion of Marek’s disease virus (MDV) transformed cell line MSB1 by targeting RORA

Author:
Ding, Ke; Yu, Zu-Hua; Yu, Chuan; Jia, Yan-Yan; He, Lei; Liao, Cheng-Shui; Li, Jing; Zhang, Chun-Jie; Li, Yin-Ju; Wu, Ting-Cai; Cheng, Xiang-Chao; Zhou, Zi-Yu; Yu, Zu-Ling
Source:
BMC veterinary research 2020 v.16 no.1 pp. 23
ISSN:
1746-6148
Subject:
apoptosis,   etc   ; Mardivirus; Marek disease; carcinogenesis; cell proliferation; chickens; gene expression regulation; interphase; microRNA; neoplasms; oncogenes; tissues;     Show all 12 Subjects
Abstract:
... BACKGROUND: Marek’s disease (MD) is caused by the oncogenic Marek’s disease virus (MDV), and is a highly contagious avian infection with a complex underlying pathology that involves lymphoproliferative neoplasm formation. MicroRNAs (miRNAs) act as oncogenes or tumor suppressors in most cancers. The gga-miR-155 is downregulated in the MDV-infected chicken tissues or lymphocyte lines, although its e ...
DOI:
10.1186/s12917-020-2239-4
PubMed:
31992293
PubMed Central:
PMC6988224

11. Tetramethylpyrazine reverses high-glucose induced hypoxic effects by negatively regulating HIF-1α induced BNIP3 expression to ameliorate H9c2 cardiomyoblast apoptosis

Author:
Liu, Shih-Ping; Shibu, Marthandam Asokan; Tsai, Fuu-Jen; Hsu, Yuan-Man; Tsai, Chang-Hai; Chung, Jing-Gung; Yang, Jai-Sing; Tang, Chih-Hsin; Wang, Shulin; Li, Qiaowen; Huang, Chih-Yang
Source:
Nutrition & metabolism 2020 v.17 no.1 pp. 12
ISSN:
1743-7075
Subject:
apoptosis,   etc   ; cell viability; cytotoxicity; glucose; hypoxia; hypoxia-inducible factor 1; patients; protein synthesis; pyrazines;     Show all 9 Subjects
Abstract:
... BACKGROUND: Diabetic patients are highly vulnerable to hypoxic injury, which is associated with hypoxia induced BNIP3 expression that subsequently activate apoptosis. Our previous research show that Tetramethylpyrazine (TMP), a food flavoring agent, represses the hypoxia induced BNIP3 expression attenuate myocardial apoptosis. In this study, we evaluate the effect of TMP to provide protection agai ...
DOI:
10.1186/s12986-020-0432-x
PubMed:
32021640
PubMed Central:
PMC6995207

12. Disruption of conserved polar interactions causes a sequential release of Bim mutants from the canonical binding groove of Mcl1

Author:
Marimuthu, Parthiban; Razzokov, Jamoliddin; Eshonqulov, Gofur
Source:
International journal of biological macromolecules 2020 v.158 pp. 364-374
ISSN:
0141-8130
Subject:
apoptosis,   etc   ; crystal structure; dissociation; molecular dynamics; mutants; neoplasms; peptides; point mutation; proteins;     Show all 9 Subjects
Abstract:
... Mcl1 is an important anti-apoptotic member of the Bcl2 family proteins that are upregulated in several cancer malignancies. The canonical binding groove (CBG) located at the surface of Mcl1 exhibits a critical role in binding partners selectively via the BH3-domain of pro-apoptotic Bcl2 family members that trigger the downregulation of Mcl1 function. There are several crystal structures of point-m ...
DOI:
10.1016/j.ijbiomac.2020.04.243

13. Molecular and Cellular Mechanisms for PRRSV Pathogenesis and Host Response to Infection

Author:
An, Tong-Qing; Li, Jiang-Nan; Su, Chia-Ming; Yoo, Dongwan
Source:
Virus research 2020 v.286 pp. 197980
ISSN:
0168-1702
Subject:
apoptosis,   etc   ; Porcine reproductive and respiratory syndrome virus; cytokines; financial economics; innate immunity; microRNA; pathogenesis; pork industry;     Show all 8 Subjects
Abstract:
... Porcine reproductive and respiratory syndrome virus (PRRSV) has caused tremendous amounts of economic losses to the swine industry for more than three decades, but its control is still unsatisfactory. A significant amount of information is available for host cell-virus interactions during infection, and it is evident that PRRSV has evolved to equip various strategies to disrupt the host antiviral ...
DOI:
10.1016/j.virusres.2020.197980
PubMed:
32311386
PubMed Central:
PMC7165118

14. Live attenuated Edwardsiella ictaluri vaccines enhance the protective innate immune responses of channel catfish B cells

Author:
Kordon, Adef O.; Kalindamar, Safak; Majors, Kara; Abdelhamed, Hossam; Tan, Wei; Karsi, Attila; Pinchuk, Lesya M.
Source:
Developmental and comparative immunology 2020 v.109 pp. 103711
ISSN:
0145-305X
Subject:
apoptosis,   etc   ; B-lymphocytes; Edwardsiella ictaluri; Ictalurus punctatus; blood serum; catfish; fish diseases; live vaccines; phagocytosis; septicemia;     Show all 10 Subjects
Abstract:
... Edwardsiella ictaluri causes enteric septicemia of catfish. Our group developed two E. ictaluri live attenuated vaccines (LAVs). However, their effects on the innate functions of catfish B cells are still unexplored. We evaluated phagocytosis and killing of wild-type (WT) E. ictaluri opsonized with sera from vaccinated fish and the survival of B cells exposed to E. ictaluri strains. We assessed ph ...
DOI:
10.1016/j.dci.2020.103711

15. CircCBFB-mediated miR-28-5p facilitates abdominal aortic aneurysm via LYPD3 and GRIA4

Author:
Yue, Jianing; Zhu, Ting; Yang, Jue; Si, Yi; Xu, Xin; Fang, Yuan; Fu, Weiguo
Source:
Life sciences 2020 v.253 pp. 117533
ISSN:
0024-3205
Subject:
apoptosis,   etc   ; aneurysm; bioinformatics; cell growth; circular RNA; glutamic acid; messenger RNA; microRNA; myocytes; smooth muscle;     Show all 10 Subjects
Abstract:
... Abdominal aortic aneurysm (AAA) is featured by the growth impediment and apoptosis surge of VSMCs (vascular smooth muscle cells). MicroRNAs (miRNAs) are suggested to affect cellular behaviors including cell growth and apoptosis. This study concentrated on unraveling the emerging role of miR-28-5p in abdominal aortic aneurysm.Previously, miR-28-5p was reported to be highly expressed in AAA. Functio ...
DOI:
10.1016/j.lfs.2020.117533

16. MicroRNA-342 targets Cofilin 1 to suppress the growth, migration and invasion of human breast cancer cells

Author:
Liu, Cong; Xing, Hua; Luo, Xiao; Wang, Yimin
Source:
Archives of biochemistry and biophysics 2020 v.687 pp. 108385
ISSN:
0003-9861
Subject:
apoptosis,   etc   ; bioinformatics; breast neoplasms; breasts; cell lines; human diseases; luciferase; neoplasm cells; therapeutics;     Show all 9 Subjects
Abstract:
... MicroRNA-342–3p (miR-342) has been shown to act as a tumor-suppressor in different cancer types. However, the role and therapeutic implications of miR-342 via modulation of Cofilin 1 (CFL1) has not been studied in any type of cancer. Given the importance of Cofilin signalling in breast, this study was undertaken to explore the therapeutic implications of miR-342 and its target CFL1 in breast cance ...
DOI:
10.1016/j.abb.2020.108385

17. MMPs and ADAMs/ADAMTS inhibition therapy of abdominal aortic aneurysm

Author:
Li, Yongqi; Wang, Weicheng; Li, Lei; Khalil, Raouf A.
Source:
Life sciences 2020 v.253 pp. 117659
ISSN:
0024-3205
Subject:
apoptosis,   etc   ; aneurysm; extracellular matrix; inflammation; innate immunity; metalloproteinases; mortality; myocytes; oxidative stress; smooth muscle; therapeutics;     Show all 11 Subjects
Abstract:
... Abdominal aortic aneurysm (AAA) is a chronic vascular degenerative disease featured by progressive dilation and remodeling of the vascular wall, which may lead to aortic rupture and high mortality. The occurrence and development of AAA involve multiple mechanisms, including extracellular matrix degradation, chronic inflammation, oxidative stress, apoptosis of vascular smooth muscle cells and innat ...
DOI:
10.1016/j.lfs.2020.117659

18. Dynamic monitoring and quantitative characterization of intracellular H2O2 content by using SERS based boric acid nanoprobe

Author:
Cheng, Wendai; Tang, Ping; He, Xuanmeng; Xing, Xinyue; Xing, Meishuang; Lu, Liupeng; Ju, Peng; Wang, Yi; Liu, Shengde; Lu, Xiaoxu; Zhong, Liyun
Source:
Talanta 2020 v.214 pp. 120863
ISSN:
0039-9140
Subject:
apoptosis,   etc   ; Raman spectroscopy; boric acid; cell growth; gold; hydrogen peroxide; monitoring; nanogold; nanorods; thiols;     Show all 10 Subjects
Abstract:
... Quantitative characterization of intracellular H₂O₂ content, which is still difficult by the conventional biochemical methods due to the lack of real-time and non-invasive technique of single cell measurement, is a useful solution for cell state assessment. Based on the surface enhanced Raman scattering (SERS), we construct a novel boric acid (BA) nanoprobe to perform quantitative characterization ...
DOI:
10.1016/j.talanta.2020.120863

19. Role of NGF on sperm traits: A review

Author:
Castellini, Cesare; Mattioli, Simona; Dal Bosco, Alessandro; Mancinelli, Alice Cartoni; Rende, Mario; Stabile, Anna Maria; Pistilli, Alessandra
Source:
Theriogenology 2020 v.150 pp. 210-214
ISSN:
0093-691X
Subject:
apoptosis,   etc   ; acrosome reaction; epididymis; mammals; necrosis; nerve growth factor; nervous system; receptors; seminal plasma; spermatozoa;     Show all 10 Subjects
Abstract:
... The nerve growth factor (NGF), a member of the neurotrophins family, plays an important role in the nervous system but also in the reproductive apparatus and in sperm traits. The aim of this review is to summarize the effect of NGF on sperm functions of mammals. NGF was detected in seminal plasma of many animal species and its receptors, TrkA and p75NTR, are present in both epididymal and ejaculat ...
DOI:
10.1016/j.theriogenology.2020.01.039

20. Neuro-protection of Chlorogenic acid against Al-induced apoptosis in PC12 cells via modulation of Al metabolism and Akt/GSK-3β pathway

Author:
Cheng, Dai; Wang, Guangliang; Wang, Xuerui; Tang, Jinlei; Yu, Qianqian; Zhang, Xinyu; Wang, Shuo
Source:
Journal of functional foods 2020 v.70 pp. 103984
ISSN:
1756-4646
Subject:
apoptosis,   etc   ; aluminum; aluminum chloride; chlorogenic acid; metabolism; neurotoxicity; polyphenols; protective effect; signal transduction;     Show all 9 Subjects
Abstract:
... Dietary polyphenols showed good scavenging effects on the neurotoxicity of aluminum (Al). The aim of this study was to explore the mechanism of CGA on AlCl₃ in PC12 cells. Based on the protective effect of CGA on the apoptosis of PC12 cells induced by AlCl₃, we designed a scheme of intervention with CGA before, during and after AlCl₃ treatment. The results showed that the co-treatment of CGA and A ...
DOI:
10.1016/j.jff.2020.103984