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1. UPLC-Q-TOF/MS-based metabolomics reveals modulatory effects of Mesona chinensis Benth polysaccharide in liver injury mice induced by cyclophosphamide

Author:
Yuzhen Hong; Mingyue Shen; Qiang Yu; Yi Chen; Jianhua Xie
Source:
Food science and human wellness 2023 v.12 no.2 pp. 584-595
ISSN:
2213-4530
Subject:
arachidonic acid,   etc   ; Platostoma palustre; biosynthesis; body weight; cyclophosphamide; discriminant analysis; feces; food science; humans; liver; metabolites; metabolomics; models; phenylalanine; polysaccharides; principal component analysis; sphingolipids; taurine; tryptophan; tyrosine;     Show all 20 Subjects
Abstract:
... The main purpose of this study was to investigate the improvement effect of Mesona chinensis Benth polysaccharide (MP) on cyclophosphamide (CTX) induced liver injury in mice. To explore metabolic profile of liver tissue and feces among normal group, CTX-induced group and MP management group based on metabolomics method by using UPLC-Q-TOF/MS. The results showed that MP could alleviate liver injury ...
DOI:
10.1016/j.fshw.2022.07.061

2. Analysis of the pharmacodynamic difference between Xiaojin Pills taken with Chinese Baijiu and water based on serum pharmacochemistry and pharmacokinetics

Author:
Jiao Song; Wei Liao; Xuan Deng; Dingkun Zhang; Junzhi Lin; Runchun Xu; Li Han
Source:
Journal of ethnopharmacology 2023 v.300 pp. 115723
ISSN:
0378-8741
Subject:
arachidonic acid,   etc   ; Oriental traditional medicine; absorption; aconitine; analgesia; bioactive properties; blood serum; blood stasis; hyperplasia; liquid chromatography; mass spectrometry; metastasis; multivariate analysis; oleanolic acid; pain; pharmacodynamics; pharmacokinetics; prototypes; ursolic acid;     Show all 19 Subjects
Abstract:
... Xiaojin Pills (XJPs), which has the function of dissipating knots and dispersing swelling, removing blood stasis, and relieving pain, is a classic prescription for the treatment of mammary glands hyperplasia. It is also the first choice of Chinese patent medicine for the clinical treatment of mammary glands hyperplasia in contemporary traditional Chinese medicine clinics. Previous studies have sho ...
DOI:
10.1016/j.jep.2022.115723

3. Effects of different fatty acid ligands on the host-guest interaction of astaxanthin-bovine serum albumin: Thermodynamical analysis, binding site identification, and in vivo antioxidant evaluation

Author:
Donghui Li; Yunjun Liu; Yixiang Liu; Shengnan Wang; Zixin Guo; Jie Li; Yanbo Wang
Source:
Food hydrocolloids 2023 v.134 pp. 108112
ISSN:
0268-005X
Subject:
arachidonic acid,   etc   ; antioxidant activity; antioxidants; astaxanthin; bovine serum albumin; docosahexaenoic acid; dodecanoic acid; hydrocolloids; hydrogen; hydrophilicity; ligands; linoleic acid; oleic acid; palmitic acid; protein synthesis; stearic acid; thermodynamics; van der Waals forces;     Show all 18 Subjects
Abstract:
... The multi-ligand binding properties of proteins make the introduction of small-molecule ligands an effective approach through which to improve the biological functions of protein-based carriers. In this study, the effect of fatty acids (FAs) as functional ligands on the self-assembly of astaxanthin (ASTA) and bovine serum albumin (BSA) and the in vivo antioxidant properties of their ternary ligand ...
DOI:
10.1016/j.foodhyd.2022.108112

4. Pathologic, transcriptomic and microbiomic insight into the pathogenesis of intestinal parasitic tapeworm in cultured Chinese soft-shelled turtle (Pelodiscus sinensis)

Author:
Xianwen Zhou; Yu Tian; Li Liu; Lingrui Ge; Hui Zhang; Yixin Liang; Xiaoqing Wang; Yazhou Hu
Source:
Aquaculture 2023 v.562 pp. 738788
ISSN:
0044-8486
Subject:
arachidonic acid,   etc   ; Citrobacter; Edwardsiella; Eucestoda; Pelodiscus sinensis; alanine transaminase; alkaline phosphatase; alpha-linolenic acid; aquaculture; aspartate transaminase; blood serum; creatinine; cytochrome P-450; epithelium; fish; gene expression regulation; glucose; histopathology; intestinal microorganisms; intestines; linoleic acid; lipid metabolism; liver; low density lipoprotein; mechanical damage; metabolic diseases; nutrition; pathogenesis; prediction; protein content; species identification; superoxide dismutase; tapeworms; transcriptomics; xenobiotics; China;     Show all 36 Subjects
Abstract:
... Tapeworms are infamous and highly successful invasive parasites in aquatic animals, especially in fish. However, tapeworm-caused diseases in soft-shelled turtles are rarely discovered. In this study, a case of cultured Chinese soft-shelled turtle (Pelodiscus sinensis) infected with tapeworm in Changde city of China was reported, and the taxonomic identification of the tapeworm and the effects of t ...
DOI:
10.1016/j.aquaculture.2022.738788

5. Feasibility and reliability of measures of bioactive lipids in human plasma and nasal mucosa

Author:
Anna-Sara Claeson; Richard H. Lindberg; Sandra Gouveia-Figueira; Malin L. Nording
Source:
Journal of chromatography 2022 v.1206 pp. 123357
ISSN:
1570-0232
Subject:
arachidonic acid,   etc   ; biomarkers; cannabinoids; chromatography; humans; nasal mucosa; oxylipins; saliva;     Show all 8 Subjects
Abstract:
... Analysis of bioactive lipids is increasingly useful in clinical studies, and there is a need for non-invasive and easy-to-use sampling methods that meet the demands of reliability. Samples that can be taken by a non-professional and that can be taken repeatedly so as to provide more detailed information about the inflammatory process are often desired. In this study, the feasibility of non-invasiv ...
DOI:
10.1016/j.jchromb.2022.123357

6. Active microbial metabolites study on antitussive and expectorant effects and metabolic mechanisms of platycosides fraction of Platycodonis Radix

Author:
Chi Zhang; Xinhong Wang; Yuanhan Zhong; Li Zhou; Jian Liang; Jinxiang Zeng; Lifen Zhou; En Yuan; Jixiao Zhu; Chong-Zhi Wang; Chun-Su Yuan
Source:
Journal of chromatography 2022 v.1195 pp. 123171
ISSN:
1570-0232
Subject:
arachidonic acid,   etc   ; biotransformation; chromatography; glycerophospholipids; intestinal microorganisms; linoleic acid; metabolites; metabolomics;     Show all 8 Subjects
Abstract:
... A new method involving gut microbiota biotransformation, spectrum-effect relationship analysis and metabolomics analysis was developed to study the antitussive and expectorant microbial metabolites of platycosides fraction (MPFs) of Platycodonis Radix. Furthermore, their possible metabolic mechanisms were studied for the first time. The findings showed that the antitussive and expectorant effects ...
DOI:
10.1016/j.jchromb.2022.123171

7. Destruction of polyunsaturated alkyl/acyl and alkenyl/acyl glycerophosphocholine of plasma lipoproteins during incubation with group V and X secretory phospholipase A2s

Author:
Arnis Kuksis; Waldemar Pruzanski
Source:
Lipids 2022 v.57 no.2 pp. 91-104
ISSN:
0024-4201
Subject:
arachidonic acid,   etc   ; autoxidation; biochemical pathways; digestion; eicosanoids; epoxides; glycerophospholipids; hydrolysis; lipoproteins; metabolism; phospholipases;     Show all 11 Subjects
Abstract:
... Plasma lipoproteins are carriers of various glycerophospholipids including diacyl, alkenyl/acyl, and alkyl/acyl glycerophosphocholines (GPCs), which become distributed among cells and tissues during metabolism. For metabolic function, these phospholipids require hydrolysis by phospholipases, but the responsible enzymes have not been identified. We had previously shown that after complete digestion ...
DOI:
10.1002/lipd.12333

8. Comprehensive pseudotargeted metabolomics analysis based on two‐phase liquid extraction‐UHPLC‐MS/MS for the investigation of depressive rats

Author:
Minhan Huang; Ting Zhou
Source:
Journal of separation science 2022 v.45 no.15 pp. 2977-2986
ISSN:
1615-9306
Subject:
arachidonic acid,   etc   ; glycerophospholipids; liquid chromatography; metabolites; metabolomics; pentoses; separation; sphingolipids; tandem mass spectrometry;     Show all 9 Subjects
Abstract:
... Pseudotargeted analysis combines the advantages of untargeted and targeted metabolomics methods. This study proposed a comprehensive pseudotargeted metabolomics method based on two‐phase liquid extraction using ultra‐high‐performance liquid chromatography‐tandem mass spectrometry. Two‐phase liquid extraction, composed of both aqueous and organic phases, extracted a wide range of metabolites from p ...
DOI:
10.1002/jssc.202200255

9. Relevance of ω-6 GLA Added to ω-3 PUFAs Supplements for ADHD: A Narrative Review

Author:
Jelle D’Helft; Riccardo Caccialanza; Emma Derbyshire; Michael Maes
Source:
Nutrients 2022 v.14 no.16 pp. -
ISSN:
2072-6643
Subject:
arachidonic acid,   etc   ; adjuvants; anti-inflammatory agents; antioxidants; blood serum; etiology; gamma-linolenic acid;     Show all 7 Subjects
Abstract:
... The use of polyunsaturated fatty acids in Attention-Deficit/Hyperactivity Disorder (ADHD) and developmental disorders has been gaining interest with preparations containing different dosages and combinations. Gamma-linolenic acid (GLA) is an ω-6 fatty acid of emerging interest with potential roles as an adjuvant anti-inflammatory agent that could be used with ω-3 PUFAs in the treatment of ADHD and ...
DOI:
10.3390/nu14163273

10. Whole blood platelet impedance aggregometry with the ROTEM platelet device: comparison of 2 anticoagulants and storage times for the establishment of canine reference intervals

Author:
Lara M. Heimgartner; Martina Stirn; Annette P. N. Kutter; Nadja E. Sigrist; Rahel Jud Schefer
Source:
Journal of veterinary diagnostic investigation 2022 v.34 no.1 pp. 15-22
ISSN:
1943-4936
Subject:
arachidonic acid,   etc   ; blood platelets; dogs; platelet activation; point-of-care systems; statistical analysis;     Show all 6 Subjects
Abstract:
... The ROTEM platelet device, a point-of-care whole blood platelet impedance aggregometer, is an add-on to the rotational thromboelastometry ROTEM delta device. The latter has been validated in dogs. We examined whether canine whole blood is suited for analysis with the ROTEM platelet device using adenosine-5′-diphosphate (ADP) and arachidonic acid (ARA) as agonists for platelet activation, and if th ...
DOI:
10.1177/10406387211051329

11. LC-MS-based metabolomics reveals metabolic changes in short- and long-term administration of Compound Danshen Dripping Pills against acute myocardial infarction in rats

Author:
Lu Zhang; Ling-Ling Wang; Hao Zeng; Bin Li; Hua Yang; Guang-Ji Wang; Ping Li
Source:
Phytomedicine 2022 v.104 pp. 154269
ISSN:
0944-7113
Subject:
arachidonic acid,   etc   ; coronary vessels; drugs; echocardiography; glycerophospholipids; heart; metabolomics; models; myocardial infarction; oral administration; taurine;     Show all 11 Subjects
Abstract:
... Mild and systematically improving multiple metabolic disorders was a focused view for Compound Danshen Dripping Pills playing synergistic effects through multiple components and multiple targets. The difference in overall therapeutic effects and endogenous metabolic regulation between short- and long-term administration was still unclear. This study aimed to explore the difference in endogenous me ...
DOI:
10.1016/j.phymed.2022.154269

12. Effects of an ω3 fatty acid-biased diet on luteolysis, parturition, and uterine prostanoid synthesis in pregnant mice

Author:
Miho Hashimoto; Nagisa Makino; Tomoaki Inazumi; Rina Yoshida; Toshiko Sugimoto; Soken Tsuchiya; Yukihiko Sugimoto
Source:
Biochemical and biophysical research communications 2022 v.589 pp. 139-146
ISSN:
0006-291X
Subject:
arachidonic acid,   etc   ; diet; eicosapentaenoic acid; females; linseed oil; luteolysis; parturition; prostaglandins; reproductive performance; research; soybean oil;     Show all 11 Subjects
Abstract:
... The ω3 polyunsaturated fatty acids (PUFAs) are known to have beneficial effects on health and diseases, and hence their intake is encouraged. However, it remains unknown as to how ω3 PUFAs affect female reproduction processes, in which ω6 PUFA-derived prostaglandin (PG) E₂ and PGF₂α play crucial roles. We therefore compared female reproductive performance between ω3 PUFA-biased linseed oil diet-fe ...
DOI:
10.1016/j.bbrc.2021.12.029

13. Bioprospecting lipid-producing microorganisms: From metagenomic-assisted isolation techniques to industrial application and innovations

Author:
Carlos Ricardo Soccol; Brigitte Sthepani Orozco Colonia; Gilberto Vinícius de Melo Pereira; Luis Daniel Goyzueta Mamani; Susan Grace Karp; Vanete Thomaz Soccol; Rafaela de Oliveira Penha; Carlos José Dalmas Neto; Júlio César de Carvalho
Source:
Bioresource technology 2022 v.346 pp. 126455
ISSN:
0960-8524
Subject:
arachidonic acid,   etc   ; Mortierella alpina; Rhodosporidium toruloides; animals; biodiesel; bioinformatics; commercialization; docosahexaenoic acid; industrial applications; metagenomics; vegetables;     Show all 11 Subjects
Abstract:
... Traditionally, lipid-producing microorganisms have been obtained via conventional bioprospecting based on isolation and screening techniques, demanding time and effort. Thus, high-throughput sequencing combined with conventional microbiological approaches has emerged as an advanced and rapid strategy for recovering novel oleaginous microorganisms from target environments. This review highlights re ...
DOI:
10.1016/j.biortech.2021.126455

14. Effect of time in culture on fatty acid composition of copepods Tisbe sp. and Apocyclops sp.

Author:
Ruth M. Alejos Cabrera; Wilmer A. Gaspar Reyes; Leenin Flores Ramos; Gheraldine A. Ynga Huamán; Anthony Ruiz Soto; Alexander F. Niño Velásquez
Source:
Journal of the World Aquaculture Society 2022 v.53 no.2 pp. 475-484
ISSN:
0893-8849
Subject:
arachidonic acid,   etc   ; Isochrysis galbana; Tisbe; aeration; aquaculture; docosahexaenoic acid; eicosapentaenoic acid; fatty acid composition; fish; salinity;     Show all 10 Subjects
Abstract:
... The purpose of this study was to evaluate the effect of time in culture on fatty acid composition of copepods Tisbe sp. and Apocyclops sp. For experiments, Tisbe and Apocyclops copepodites were separated and placed in 4‐L containers at 5 ind/mL. The fatty acids were evaluated at three different periods (hours) of culture (treatments): T1 = 6 hr, T2 = 12 hr, and T3 = 168 hr. Culture conditions were ...
DOI:
10.1111/jwas.12827

15. Metabolic and molecular evidence for long-chain PUFA biosynthesis capacity in the grass carp Ctenopharyngodon idella

Author:
Manuel Marrero; Óscar Monroig; Juan Carlos Navarro; Alberto Ribes-Navarro; José Antonio Pérez; Ana Galindo; Covadonga Rodríguez
Source:
Comparative biochemistry and physiology 2022 v.270 pp. 111232
ISSN:
1095-6433
Subject:
arachidonic acid,   etc   ; Ctenopharyngodon idella; biosynthesis; diet; docosahexaenoic acid; eicosapentaenoic acid; farmed fish; hepatocytes; linoleic acid; radiolabeling;     Show all 10 Subjects
Abstract:
... There is a growing interest to understand the capacity of farmed fish species to biosynthesise the physiologically important long-chain (≥C₂₀) n-3 and n-6 polyunsaturated fatty acids (LC-PUFAs), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and arachidonic acid (ARA), from their C₁₈ PUFA precursors available in the diet. In fish, the LC-PUFA biosynthesis pathways involve sequential desat ...
DOI:
10.1016/j.cbpa.2022.111232

16. Effects of Germination and Popping on the Anti-Nutritional Compounds and the Digestibility of Amaranthus hypochondriacus Seeds

Author:
Carmen Valadez-Vega; Olivia Lugo-Magaña; Claudia Figueroa-Hernández; Mirandeli Bautista; Gabriel Betanzos-Cabrera; Aurea Bernardino-Nicanor; Rosa María González-Amaro; Rodrigo Alonso-Villegas; José A. Morales-González; Leopoldo González-Cruz
Source:
Foods 2022 v.11 no.14 pp. -
ISSN:
2304-8158
Subject:
arachidonic acid,   etc   ; Amaranthus hypochondriacus; digestibility; digestible protein; fatty acid composition; germination; lectins; proximate composition; saponins; trypsin; Mexico;     Show all 11 Subjects
Abstract:
... Amaranth seeds, although a valuable food in Mexico, contain anti-nutritional compounds that can affect food quality. As a part of this work, the proximate composition, fatty acid profile, protein digestibility, and the effect of germination and popping of Amaranthus hypochondriacus seeds was analyzed with the aim of eliminating anti-nutritional compounds. Untreated seeds comprised of 11.35–18.8% p ...
DOI:
10.3390/foods11142075

17. Production of 11R‐hydroxyeicosatetraenoic acid from arachidonic acid by Escherichia coli cells expressing arachidonate 11R‐lipoxygenase from Nostoc sp.

Author:
Su‐Eun Kim; Tae‐Hun Kim; Min‐Ju Kim; Deok‐Kun Oh
Source:
The journal of the American Oil Chemists' Society 2022 v.99 no.4 pp. 289-297
ISSN:
0003-021X
Subject:
arachidonic acid,   etc   ; Escherichia coli; Nostoc; catalytic activity; cysteine; docosahexaenoic acid; eicosapentaenoic acid; enzymes; oils; pH; solvents; temperature;     Show all 12 Subjects
Abstract:
... Linoleate 9R‐lipoxygenase (9R‐LOX) from Nostoc sp. SAG 25.82 was identified as arachidonate (ARA) 11R‐LOX by the determination of the product obtained from the conversion of ARA. The specific activity and catalytic efficiency (kcₐₜ/Kₘ) of the enzyme for C20 and C22 polyunsaturated fatty acids followed the order ARA > eicosapentaenoic acid > docosahexaenoic acid. The production of the lipid mediato ...
DOI:
10.1002/aocs.12572

18. The influence of a basic military training diet on whole blood fatty acid profile and the Omega-3 Index of Australian Army recruits

Author:
Gregory E. Peoples; Penelope Larsen; Heather M. Bowes; Jarrin Coombes; Jace R. Drain; Herbert Groeller; Peter L. McLennan
Source:
Applied physiology, nutrition and metabolism 2022 v.47 no.2 pp. 151-158
ISSN:
1715-5320
Subject:
arachidonic acid,   etc   ; Western diets; blood; confidence interval; docosahexaenoic acid; eicosapentaenoic acid; fatty acid composition; gas chromatography; metabolism;     Show all 9 Subjects
Abstract:
... This study described the whole blood fatty acid profile and Omega-3 Index (O3I) of Australian Army recruits at the commencement and completion of basic military training (BMT). Eighty males (17–34 y, 77.4 ± 13.0 kg, 43.5 ± 4.3 mL/kg/min) and 37 females (17–45 y, 64.3 ± 8.8 kg, 39.3 ± 2.7 mL/kg/min) volunteered to participate (N = 117). Whole blood samples of each recruit were collected using a fin ...
DOI:
10.1139/apnm-2021-0459

19. Inhibition of 20‐hydroxyeicosatetraenoic acid biosynthesis by vitamin E analogs in human and bovine cytochrome P450 microsomes

Author:
Matthew J. Kuhn; Lorraine M. Sordillo
Source:
Journal of animal physiology and animal nutrition 2022 v.106 no.1 pp. 55-60
ISSN:
0931-2439
Subject:
arachidonic acid,   etc   ; animal nutrition; biosynthesis; cytochrome P-450; dairy cattle; gamma-tocopherol; humans; inflammation; microsomes; milk; risk;     Show all 11 Subjects
Abstract:
... Dairy cattle are predisposed to disease around the time of calving due to dysfunctional inflammatory responses. Oxylipids are lipid‐derived mediators that regulate all aspects of the inflammatory response, and shifts in oxylipid profiles are correlated with disease risk. For example, 20‐hydroxyeicosatetraenoic acid (HETE) is an oxylipid derived from cytochrome P450 enzymes (CYP450) found at signif ...
DOI:
10.1111/jpn.13547

20. Changes in Serum, Red Blood Cell, and Colonic Fatty Acids in a Personalized Omega-3 Fatty Acid Supplementation Trial

Author:
Yifan Shen; Ananda Sen; D. Kim Turgeon; Jianwei Ren; Gillian Graifman; Mack T. Ruffin; William L. Smith; Dean E. Brenner; Zora Djuric
Source:
Nutrition and cancer 2022 v.74 no.2 pp. 565-578
ISSN:
1532-7914
Subject:
arachidonic acid,   etc   ; blood serum; clinical trials; colon; eicosapentaenoic acid; erythrocytes; nutrition; omega-3 fatty acids; oxidation; prostaglandins;     Show all 10 Subjects
Abstract:
... This study evaluated changes in fatty acids from sera, red blood cells, and colonic biopsies from a phase Ib clinical trial of personalized ω-3 fatty acid dosing in 47 healthy volunteers. The trial aimed to reduce colonic prostaglandin E₂ (PGE₂), a pro-inflammatory product of arachidonic acid (AA) oxidation. The personalized doses ranged 2–10 grams/day (54% eicosapentaenoic acid, EPA, 24% other ω- ...
DOI:
10.1080/01635581.2021.1903950