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1. Complex central nervous system malformations in a Dutch Warmblood foal

Author:
Elizabeth Williams Louie; Ron Streeter; Melinda Story; Peter V. Scrivani; Myra Barrett; Kathleen R. Mullen
Source:
Journal of veterinary internal medicine 2022 v.36 no.3 pp. 1173-1178
ISSN:
0891-6640
Subject:
ataxia (disorder),   etc   ; Dutch Warmblood; abnormal development; athletic performance; cerebellum; colts; euthanasia; foals; magnetism; prognosis; veterinary medicine;     Show all 11 Subjects
Abstract:
... A neonatal Dutch Warmblood colt was evaluated for inability to stand, incoordination and intention tremor. Despite partial improvement in clinical signs during the first 4 days of hospitalization, neurological deficits remained. Magnetic resonance imaging identified a unilateral infratentorial arachnoid cyst‐like lesion with ipsilateral compression and displacement of the cerebellar hemisphere, ab ...
DOI:
10.1111/jvim.16407

2. Quantification and spatially explicit driving forces of the incoordination between ecosystem service supply and social demand at a regional scale

Author:
Menghao Yang; Xining Zhao; Pute Wu; Pan Hu; Xiaodong Gao
Source:
Ecological indicators 2022 v.137 pp. 108764
ISSN:
1470-160X
Subject:
ataxia (disorder),   etc   ; decision making; ecosystem management; ecosystem services; ecosystems; issues and policy; models; society; vegetation cover; China;     Show all 10 Subjects
Abstract:
... Accurate spatio-temporalquantifying of ecosystem services (ESs) supply and social demand and their coordination dynamics, and determining which factors affect such coordination and the spatial distribution patterns of these effects, is essential to guide targeted ecosystem management decisions. Unfortunately, quantitative data demonstrating the explicit spatial relationships between the biophysica ...
DOI:
10.1016/j.ecolind.2022.108764

3. Intoxication of llamas by Astragalus punae in Argentina

Author:
Marin Raul E.; Gardner Dale R.; Armien Anibal G.; Fortunato Renne H.; Uzal Francisco A.
Source:
Journal of veterinary diagnostic investigation 2022 v.6 no. pp. 1-5
ISSN:
1040-6387
Subject:
ataxia (disorder),   etc   ; Astragalus; body condition; cattle; disease course; hindlimbs; histology; indolizidines; leaves; lysosomes; plant analysis; poisoning; sheep; swainsonine; toxicity; Andes region; Argentina; Australia; China;     Show all 19 Subjects
Abstract:
... Several plants that contain indolizidine alkaloids, including swainsonine, are toxic to livestock, causing dysfunctional lysosomes and storage disease. Swainsonine induces a neurovisceral disease, known as locoism, in sheep, goats, and cattle, which occurs in several parts of the world, including, but not limited to, the western United States, China, and parts of Australia. In South America, locoi ...
Handle:
10113/7795831
DOI:
10.1177/10406387221094272

4. Crosstalk between Different DNA Repair Pathways Contributes to Neurodegenerative Diseases

Author:
Swapnil Gupta; Panpan You; Tanima SenGupta; Hilde Nilsen; Kulbhushan Sharma
Source:
Biology 2021 v.10 no.2 pp. -
ISSN:
2079-7737
Subject:
ataxia (disorder),   etc   ; DNA damage; DNA repair; amyotrophic lateral sclerosis; genomics; humans; mice;     Show all 7 Subjects
Abstract:
... Genomic integrity is maintained by DNA repair and the DNA damage response (DDR). Defects in certain DNA repair genes give rise to many rare progressive neurodegenerative diseases (NDDs), such as ocular motor ataxia, Huntington disease (HD), and spinocerebellar ataxias (SCA). Dysregulation or dysfunction of DDR is also proposed to contribute to more common NDDs, such as Parkinson’s disease (PD), Al ...
DOI:
10.3390/biology10020163

5. Normal aging induces PD-1-enriched exhausted microglia and A1-like reactive astrocytes in the hypothalamus

Author:
Yukari Suda; Toshihisa Nakashima; Hiroaki Matsumoto; Daisuke Sato; Satoshi Nagano; Haruka Mikata; Sara Yoshida; Kenichi Tanaka; Yusuke Hamada; Naoko Kuzumaki; Minoru Narita
Source:
Biochemical and biophysical research communications 2021 v.541 pp. 22-29
ISSN:
0006-291X
Subject:
ataxia (disorder),   etc   ; anxiety; astrocytes; gene expression; hypothalamus; muscles; prefrontal cortex; programmed cell death; research; transcription (genetics);     Show all 10 Subjects
Abstract:
... Hypothalamic aging is considered to be critical for systemic aging, and the accumulation of “exhausted glial cells” in the hypothalamus may contribute to brain dysfunction. In this study, we used normal aging mice and investigated aging-specific transcriptional identities of microglia and astrocytes in the hypothalamus. We confirmed that normal aging promoted anxiety, induced impairment of motor c ...
DOI:
10.1016/j.bbrc.2020.12.086

6. An analysis of coupling coordination relationship between regional economy and transportation: empirical evidence from China

Author:
Qiang Du; Xinqi Wang; Yi Li; Patrick X. W. Zou; Xiao Han; Meng Meng
Source:
Environmental science and pollution research 2022 v.29 no.23 pp. 34360-34378
ISSN:
0944-1344
Subject:
ataxia (disorder),   etc   ; entropy; models; pollution; research; sustainable development;     Show all 6 Subjects
Abstract:
... The increasing discrepancy between a regional economy and transportation imposes higher requirements for their coordinated development. This paper utilized the coupling coordination degree (CCD) model and entropy method (EM) to quantitatively study the coupling coordination state between regional economy and transportation and its spatial distribution of 30 provinces in China from 2004 to 2017. Th ...
DOI:
10.1007/s11356-022-18598-0

7. Massive Parallel Sequencing and the Problem of Overlapping Phenotypes in Hereditary Spastic Paraplegias and Spinocerebellar Ataxias

Author:
E. P. Nuzhnyi; N. Yu. Abramycheva; D. G. Safonov; E. Yu. Fedotova; S. N. Illarioshkin
Source:
Russian journal of genetics 2022 v.58 no.4 pp. 456-461
ISSN:
1022-7954
Subject:
ataxia (disorder),   etc   ; cerebellum; genes; heterozygosity; nonsense mutation; patients; phenotype;     Show all 7 Subjects
Abstract:
... Hereditary spastic paraplegia (HSP) and spinocerebellar ataxia (SCA) are heterogeneous groups of neurodegenerative disorders with the main clinical manifestations including progressive pyramidal syndrome and cerebellar ataxia. The differential diagnosis of these diseases is difficult owing to the significant genetic and phenotypic polymorphism. The use of massive parallel sequencing (MPS) technolo ...
DOI:
10.1134/S1022795422040111

8. Pathogenic mechanisms underlying spinocerebellar ataxia type 1

Author:
Leon Tejwani; Janghoo Lim
Source:
Cellular and molecular life sciences 2020 v.77 no.20 pp. 4015-4029
ISSN:
1420-682X
Subject:
ataxia (disorder),   etc   ; atrophy; cerebellum; gait; ion channels; pathogenesis; transcription (genetics);     Show all 7 Subjects
Abstract:
... The family of hereditary cerebellar ataxias is a large group of disorders with heterogenous clinical manifestations and genetic etiologies. Among these, over 30 autosomal dominantly inherited subtypes have been identified, collectively referred to as the spinocerebellar ataxias (SCAs). Generally, the SCAs are characterized by a progressive gait impairment with classical cerebellar features, and in ...
DOI:
10.1007/s00018-020-03520-z

9. Profiling of mitochondrial genomes in SCA3/MJD patients from mainland China

Author:
Hongyu Yuan; Huihua Yang; Linliu Peng; Yun Peng; Zhao Chen; Linlin Wan; Chunrong Wang; Yuting Shi; Victor Wei Zhang; Beisha Tang; Rong Qiu; Hong Jiang
Source:
Gene 2020 v.738 pp. 144487
ISSN:
0378-1119
Subject:
ataxia (disorder),   etc   ; cerebellum; genes; mitochondria; mitochondrial DNA; mitochondrial genome; pathogenesis; China;     Show all 8 Subjects
Abstract:
... Spinocerebellar ataxia type 3, also known as Machado-Joseph disease (SCA3/MJD), is the most common type of autosomal dominant cerebellar ataxias. Few studies focused on the changes of the whole mitochondrial genomes of SCA3/MJD patients and its relationship with the pathogenesis of SCA3/MJD. We adapted one-step long-range PCR to amplify the entire mitochondrial DNA (mtDNA) followed by next-generat ...
DOI:
10.1016/j.gene.2020.144487

10. Spatial-temporal pattern of land use conflict in China and its multilevel driving mechanisms

Author:
Song Jiang; Jijun Meng; Likai Zhu; Haoran Cheng
Source:
Science of the total environment 2021 v.801 pp. 149697
ISSN:
0048-9697
Subject:
ataxia (disorder),   etc   ; agricultural land; altitude; desertification; environmental assessment; grasslands; humans; land use change; landscape ecology; models; population density; population growth; regression analysis; risk; socioeconomics; urbanization; China;     Show all 17 Subjects
Abstract:
... Land use conflict describes the incoordination of land use structure when meeting the diverse human demands under the deterioration of natural environment, which is a sensitive indicator of human-environmental interaction. The increased demand for different land use types due to rapid population growth and urbanization in China places tremendous pressure on limited land resources, which raises gre ...
DOI:
10.1016/j.scitotenv.2021.149697

11. ATR Protects the Genome against R Loops through a MUS81-Triggered Feedback Loop

Author:
Dominick A. Matos; Jia-Min Zhang; Jian Ouyang; Hai Dang Nguyen; Marie-Michelle Genois; Lee Zou
Source:
Molecular cell 2020 v.77 no.3 pp. 514-527.e4
ISSN:
1097-2765
Subject:
ataxia (disorder),   etc   ; cell cycle checkpoints; enzymes; genetic instability; genome; genomics; transcription (genetics);     Show all 7 Subjects
Abstract:
... R loops arising during transcription induce genomic instability, but how cells respond to the R loop-associated genomic stress is still poorly understood. Here, we show that cells harboring high levels of R loops rely on the ATR kinase for survival. In response to aberrant R loop accumulation, the ataxia telangiectasia and Rad3-related (ATR)-Chk1 pathway is activated by R loop-induced reversed rep ...
DOI:
10.1016/j.molcel.2019.10.010
PubMed:
31708417
PubMed Central:
PMC7007873

12. Use of intralipid emulsion therapy to treat suspected oleander toxicosis in a domestic goose (Anser anser domesticus)

Author:
Emanuele Lubian; Raffaella Capitelli; Serena Nappi; Rosita Semenza Esposito; Riccardo Paolo Russo; Giorgia Lodi; Giuliano Ravasio; Edoardo Bardi
Source:
Journal of exotic pet medicine 2021 v.39 pp. 78-80
ISSN:
1557-5063
Subject:
ataxia (disorder),   etc   ; Anser anser; Nerium oleander; activated carbon; anorexia; antibiotics; emulsions; gastrointestinal system; geese; ingestion; intravenous injection; lipids; medicine; patients; poisoning; toxicity; troponin I; veterinary clinics; waterfowl;     Show all 19 Subjects
Abstract:
... Ingestion of toxic substances is a common event in companion animals and livestock, especially in waterfowl. Oleander (Nerium oleander) toxicosis is rarely reported in avian species, with symptoms including cardiac, neurological and gastrointestinal manifestations. A 6-month-old domestic goose (Anser anser domesticus) was presented for depression, anorexia, permanent sternal recumbency, weakness a ...
DOI:
10.1053/j.jepm.2021.08.018

13. Medico-legal encounters of 2015 Nepal earthquake – Path traversed and the road ahead

Author:
Rijen Shrestha; Kewal Krishan; Tanuj Kanchan
Source:
Forensic science international 2020 v.313 pp. 110339
ISSN:
0379-0738
Subject:
ataxia (disorder),   etc   ; blood; earthquakes; forensic sciences; law enforcement; politics; stakeholders; visual perception; Nepal;     Show all 9 Subjects
Abstract:
... The Gorkha Earthquake hit the region on 25th of April 2015, at 12:58, with the epicentre approximately 80 km N-NW of Kathmandu, recording 7.8 Mw on the Richter Scale. The disaster left almost 9000 individuals dead. The search and recovery as well as the subsequent Disaster Victim Identification (DVI) operations left much to be desired. The entire DVI operations consisted of examination of 365 bodi ...
DOI:
10.1016/j.forsciint.2020.110339

14. Genetic Distribution of Five Spinocerebellar Ataxia Microsatellite Loci in Mexican Native American Populations and Its Impact on Contemporary Mestizo Populations

Author:
Rocío Gómez; Yessica S. Tapia-Guerrero; Bulmaro Cisneros; Lorena Orozco; César Cerecedo-Zapata; Elvia Mendoza-Caamal; Gerardo Leyva-Gómez; Norberto Leyva-García; Luis Velázquez-Pérez; Jonathan J. Magaña
Source:
Genes 2022 v.13 no.1 pp. -
ISSN:
2073-4425
Subject:
ataxia (disorder),   etc   ; alleles; ancestry; ethnic differences; exons; genetic similarity; microsatellite repeats; multicultural diversity;     Show all 8 Subjects
Abstract:
... Spinocerebellar ataxias (SCAs) conform a heterogeneous group of neurodegenerative disorders with autosomal dominant inheritance. Five of the most frequent SCAs are caused by a CAG repeat expansion in the exons of specific genes. The SCAs incidence and the distribution of polymorphic CAG alleles vary among populations and ethnicities. Thus, characterization of the genetic architecture of ethnically ...
DOI:
10.3390/genes13010157

15. Hepatic encephalopathy in swine experimentally poisoned with Senna occidentalis seeds: Effects on astrocytes

Author:
Gabriela Soledad Chileski; Enrique Nicolás García; Javier Walter Lértora; Norma Mussart; David Roque Hernández; Luciana Andrea Cholich
Source:
Toxicon 2021 v.201 pp. 86-91
ISSN:
0041-0101
Subject:
ataxia (disorder),   etc   ; Senna occidentalis; alkaline phosphatase; ammonia; animal models; anorexia; aspartate transaminase; astrocytes; bilirubin; blood serum; cerebral cortex; creatine kinase; encephalopathy; head; myocardium; necrosis; pancreas; reproduction; shrinkage; swine;     Show all 20 Subjects
Abstract:
... Senna occidentalis may be accidently ingested by humans and animals. In this study, the percentages of S. occidentalis seeds necessary for experimental reproduction of hepatic encephalopathy were determined in a pig model and the biochemical and microscopic pathology is described in detail, with emphasis on the astrocytes. The experimental groups (G1, G2 and G3) were fed rations containing 5%, 7.5 ...
DOI:
10.1016/j.toxicon.2021.08.018

16. Lumbosacral injection of lidocaine, detomidine and lidocaine–detomidine in goats: anti-nociceptive effects and changes on haematobiochemical parameters

Author:
Mohammed Zayed; Elhussein Mahmoud; Atef Khalil; Mohammed Salah; Mohamed Moustafa; Mohamed Youssef; Ahmed Hassaneen
Source:
Journal of applied animal research 2020 v.48 no.1 pp. 57-62
ISSN:
0974-1844
Subject:
ataxia (disorder),   etc   ; analgesia; analgesics; animal research; blood; cross-over studies; detomidine; lidocaine; nociception; sedation;     Show all 10 Subjects
Abstract:
... This study was carried out to compare the analgesic effects and haematobiochemical changes produced by the administration of lidocaine, detomidine and lidocaine–detomidine combination in the epidural space of goats. All goats were assigned to all of the three different epidural treatments using a balanced crossover design with two-weeks washout period. Nociception was investigated by pinprick; tim ...
DOI:
10.1080/09712119.2020.1725520

17. Antioxidant Therapies and Oxidative Stress in Friedreich’s Ataxia: The Right Path or Just a Diversion?

Author:
Laura R. Rodríguez; Tamara Lapeña; Pablo Calap-Quintana; María Dolores Moltó; Pilar Gonzalez-Cabo; Juan Antonio Navarro Langa
Source:
Antioxidants 2020 v.9 no.8 pp. -
ISSN:
2076-3921
Subject:
ataxia (disorder),   etc   ; antioxidant activity; antioxidants; clinical trials; drugs; free radicals; models; motivation; oxidative stress; patients;     Show all 10 Subjects
Abstract:
... Friedreich’s ataxia is the commonest autosomal recessive ataxia among population of European descent. Despite the huge advances performed in the last decades, a cure still remains elusive. One of the most studied hallmarks of the disease is the increased production of oxidative stress markers in patients and models. This feature has been the motivation to develop treatments that aim to counteract ...
DOI:
10.3390/antiox9080664

18. Decoupling Analysis between Rural Population Change and Rural Construction Land Changes in China

Author:
Xueru Zhang; Jie Wang; Wei Song; Fengfei Wang; Xing Gao; Lei Liu; Kun Dong; Dazhi Yang
Source:
Land 2022 v.11 no.2 pp. -
ISSN:
2073-445X
Subject:
ataxia (disorder),   etc   ; land; models; population dynamics; rural population; surveys; temporal variation; urban population; urbanization; wastes; China;     Show all 11 Subjects
Abstract:
... Developing countries account for about 86.5% of the world’s population and are experiencing rapid urbanization. Globally, the increase in the urban population is generally accompanied by the expansion of the latter and construction lands, as well as the reduction in the rural population and rural construction lands. However, with the rapid development of urbanization in China, the rural population ...
DOI:
10.3390/land11020231

19. A multi-aspect coordination HDRED site selection framework under multi-type heterogeneous environments

Author:
Chengwei Zhao; Xuanhua Xu; Ruihuan Liu; Jishan He
Source:
Renewable energy 2021 v.171 pp. 833-848
ISSN:
0960-1481
Subject:
ataxia (disorder),   etc   ; models; renewable energy sources; China;     Show all 4 Subjects
Abstract:
... Site selection is a critical link in hot dry rock exploration and development (HDRED). However, some problems such as incoordination of the qualitative and quantitative criteria, inaccurate information descriptions, information loss or distortion, incomplete consideration of the coordinating influence of the subjective-objective aspects, and criteria’s complex interactions exist in the extant site ...
DOI:
10.1016/j.renene.2021.02.154

20. Coordinated development between green finance and environmental performance in China: The spatial-temporal difference and driving factors

Author:
Hongying Zhang; Chengxuan Geng; Jiahui Wei
Source:
Journal of cleaner production 2022 v.346 pp. 131150
ISSN:
0959-6526
Subject:
ataxia (disorder),   etc   ; autocorrelation; data collection; environmental performance; finance; issues and policy; models; population density; sustainable development; China;     Show all 10 Subjects
Abstract:
... The coordination relationship and the balance of development between green finance and environmental performance are crucial to guaranteeing sustainable development under circumstances of economic transition. The current paper demonstrates the construction of index systems pertaining to green finance and environmental performance. Based on a panel dataset of 30 Chinese provinces from 2008 to 2019, ...
DOI:
10.1016/j.jclepro.2022.131150