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1. Effects of maternal exposure to a bacterial antigen and altered post-hatching rearing conditions on avian offspring behaviour

Author:
Martyka, Rafał; Śliwińska, Ewa B.; Tryjanowski, Piotr
Source:
Behavioral ecology and sociobiology 2021 v.75 no.3 pp. 59
ISSN:
0340-5443
Subject:
bacterial antigens,   etc   ; Parus major; aggression; body weight; ecology; fledglings; food availability; immunization; maternal exposure; progeny; sociobiology;     Show all 11 Subjects
Abstract:
... The early-life environment plays a crucial role in shaping morphological, physiological, and behavioural traits, with potential long-term consequences for fitness. Indeed, a set of factors experienced by offspring during prenatal and early post-natal development has been recognised to affect behavioural trait expression in later life. Several studies have shown that in birds, nutritional and socia ...
DOI:
10.1007/s00265-021-02995-5

2. Study on immunogenicity and antigenicity of a novel brucella multiepitope recombined protein

Author:
Yin, Dehui; Bai, Qiongqiong; Li, Li; Xu, Kun; Zhang, Jinpeng
Source:
Biochemical and biophysical research communications 2021 v.540 pp. 37-41
ISSN:
0006-291X
Subject:
bacterial antigens,   etc   ; B-lymphocytes; T-lymphocytes; blood serum; brucellosis; epitopes; financial economics; flow cytometry; goats; immune response; immunogenicity; mice; prediction; recombinant proteins; research; serodiagnosis; splenocytes; vaccine development;     Show all 18 Subjects
Abstract:
... Currently, brucellosis is a reemerged zoonotic infectious disease with an increased incidence in recent years. A simple, rapid and sensitive method for diagnosing brucellosis can help to reduce medical burden and economic loss. Previously, a multiple epitope recombinant protein was constructed based on linear B-cell epitope prediction tools. In this study, the recombinant protein was used as an an ...
DOI:
10.1016/j.bbrc.2020.12.098

3. Establishment and evaluation of an indirect ELISA for detection of antibodies to goat Klebsiella pneumonia

Author:
Chen, Ruichang; Shang, Hongqi; Niu, Xiangyun; Huang, Jin; Miao, Yongqiang; Sha, Zhou; Qin, Liting; Huang, He; Peng, Duo; Zhu, Ruiliang
Source:
BMC veterinary research 2021 v.17 no.1 pp. 107
ISSN:
1746-6148
Subject:
bacterial antigens,   etc   ; Enterobacter; Gram-negative bacteria; Klebsiella pneumoniae; agglutination; blood serum; carbonates; cross reaction; death; detection limit; goats; humans; industry; livestock production; phosphates; pneumonia; polyclonal antibodies; septicemia; veterinary medicine;     Show all 19 Subjects
Abstract:
... BACKGROUND: Klebsiella pneumonia, a Gram-negative bacterium belonging to the genus Enterobacter, causes many human and livestock diseases. Notably, infected goats may develop pneumonia, septicemia, which can lead to occasional death, resulting in great economic losses in goat-farming industry. However, there are little systematic methods for detection of goat Klebsiella pneumoniae in livestock pro ...
DOI:
10.1186/s12917-021-02820-1

4. The contribution of the immune response to enhanced colibacillosis upon preceding viral respiratory infection in broiler chicken in a dual infection model

Author:
Weerts, Erik A.W.S.; Matthijs, Mieke G.R.; Bonhof, Josette; van Haarlem, Daphne A.; Dwars, R. Marius; Gröne, Andrea; Verheije, M. Hélène; Jansen, Christine A.
Source:
Veterinary immunology and immunopathology 2021 v.238 pp. 110276
ISSN:
0165-2427
Subject:
bacterial antigens,   etc   ; Avian metapneumovirus; Avian orthoavulavirus 1; Escherichia coli; Infectious bronchitis virus; air; body weight; broiler chickens; euthanasia; gene expression; immune response; immunohistochemistry; immunopathology; interleukin-10; interleukin-17; interleukin-6; lungs; macrophages; models; monocytes; pneumonia; tracheitis;     Show all 22 Subjects
Abstract:
... Colibacillosis in chickens caused by avian pathogenic Escherichia coli (APEC) is known to be aggravated by preceding infections with infectious bronchitis virus (IBV), Newcastle disease virus (NDV) and avian metapneumovirus (aMPV). The mechanism behind these virus-induced predispositions for secondary bacterial infections is poorly understood. Here we set out to investigate the immunopathogenesis ...
DOI:
10.1016/j.vetimm.2021.110276

5. A novel antigen immunochromatography fluorometric strip for rapid detection and application of pathogenic bacterial high-quality antibody

Author:
Fang, Shuiqin; Liu, Cheng; Wan, Shaoye; Tian, Yachen; Li, Dezhi; Wu, Meijiao; Wu, Youxue; Liu, Qing
Source:
Journal of immunological methods 2021 v.494 pp. 113014
ISSN:
0022-1759
Subject:
bacterial antigens,   etc   ; Acidovorax avenae subsp. citrulli; Escherichia coli O157; Vibrio parahaemolyticus; antibodies; antibody affinity; antibody detection; ascites; enzyme-linked immunosorbent assay; fluorometry; goats; hybridomas; immunoaffinity chromatography; rapid methods; surveys;     Show all 15 Subjects
Abstract:
... Unlike traditional immunoassay strips, a novel antigen immunechromatography fluorometric strip (AICFS) using inactivated bacterial antigen instead of an antibody as a test line and goat anti-mouse IgG-FITC as a tracer was developed. The applicability survey of AICFS indicated that E. coli O157:H7 (D3) and Acidovorax citrulli (6F) hybridoma cell cultures could be detected, but Vibrio parahemolyticu ...
DOI:
10.1016/j.jim.2021.113014

6. The Pathogenesis of Tuberculosis–The Koch Phenomenon Reinstated

Author:
Hunter, Robert L.
Source:
Pathogens 2020 v.9 no.10
ISSN:
2076-0817
Subject:
bacterial antigens,   etc   ; T-lymphocytes; adults; animal models; granuloma; humans; hypersensitivity; macrophages; pathogenesis; pathogens; pneumonia; research; tuberculosis; vaccines;     Show all 14 Subjects
Abstract:
... Research on the pathogenesis of tuberculosis (TB) has been hamstrung for half a century by the paradigm that granulomas are the hallmark of active disease. Human TB, in fact, produces two types of granulomas, neither of which is involved in the development of adult type or post-primary TB. This disease begins as the early lesion; a prolonged subclinical stockpiling of secreted mycobacterial antige ...
DOI:
10.3390/pathogens9100813

7. Recombinant Lactococcus Lactis Displaying Omp31 Antigen of Brucella melitensis Can Induce an Immunogenic Response in BALB/c Mice

Author:
Shirdast, Hoda; Ebrahimzadeh, Fatemeh; Taromchi, Amir Hossein; Mortazavi, Yousef; Esmaeilzadeh, Abdolreza; Sekhavati, Mohammad Hadi; Nedaei, Keivan; Mirabzadeh, Esmat
Source:
Probiotics and antimicrobial proteins 2021 v.13 no.1 pp. 80-89
ISSN:
1867-1306
Subject:
bacterial antigens,   etc   ; Brucella melitensis; Lactococcus lactis; antibody formation; bacterial vaccines; brucellosis; cell-mediated immunity; genetic vectors; humoral immunity; immunogenicity; immunoglobulin A; immunoglobulin G; immunoglobulin M; interferon-gamma; interleukin-10; interleukin-4; intraperitoneal injection; live vaccines; mice; mucosal immunity; oral administration; outer membrane proteins; recombinant antigens; signal peptide; vaccination; vector vaccines;     Show all 26 Subjects
Abstract:
... Since Brucella infection mostly occurs through the mucosal surfaces, immune response induced by vaccine that is delivered by a way of mucosal route can be drastically enhanced to control the brucellosis. Omp31is the major outer membrane protein of Brucella, and is considered as a protective antigen against Brucella infection. Accordingly, Lactococcus lactis has been used as an antigen-delivering v ...
DOI:
10.1007/s12602-020-09684-1

8. Characterization of a novel live attenuated Edwardsiella piscicida vaccine based on the overexpressed type III secretion system and systematic deletion of the associated effectors

Author:
Yin, Kaiyu; Ma, Jiabao; Jin, Peng; Sun, Xiang; Liu, Xiaohong; Wang, Qiyao
Source:
Fish & shellfish immunology 2020 v.106 pp. 536-545
ISSN:
1050-4648
Subject:
bacterial antigens,   etc   ; Edwardsiella piscicida; aquaculture; bacteria; blood serum; immunogenicity; intraperitoneal injection; kidneys; live vaccines; shellfish; sigma factors; spleen; turbot; vaccination; virulence;     Show all 15 Subjects
Abstract:
... Edwardsiella piscicida causes edwardsiellosis in a variety of fish species and leads to tremendous economic losses in the global aquaculture industries. Thus, effective and safe prevention and control of this bacterium are urgently needed to combat the related infections. Live attenuated vaccines (LAVs) effectively prevent infectious diseases. However, most of the existing E. piscicida LAVs are ba ...
DOI:
10.1016/j.fsi.2020.07.021

9. Pathological and Immunohistochemical Analyses of Naturally Occurring Equine Glanders Using an Anti-BpaB Antibody

Author:
Erdemsurakh, Ochbayar; Purevdorj, Baatarjargal; Ochirbat, Khurtsbaatar; Adilbish, Altanchimeg; Vanaabaatar, Batbaatar; Aoshima, Keisuke; Kobayashi, Atsushi; Kimura, Takashi
Source:
Veterinary pathology 2020 v.57 no.6 pp. 807-811
ISSN:
1544-2217
Subject:
bacterial antigens,   etc   ; Burkholderia mallei; Gram-negative bacteria; abdomen; agglutination; animal pathology; complement; cytoplasm; epithelium; glanders; hindlimbs; histopathology; horses; immunohistochemistry; macrophages; monoclonal antibodies; neutrophils; nose; Mongolia;     Show all 19 Subjects
Abstract:
... Glanders is caused by the gram-negative bacterium Burkholderia mallei. In this study, we investigated the histopathology and immunohistochemical localization of B. mallei in natural cases of equine glanders. Four horses showing clinical signs of nasal discharge and multiple cutaneous nodules or papulae in the hindlimbs and abdomen were reported in Mongolia. They tested positive for B. mallei infec ...
DOI:
10.1177/0300985820953422

10. Fusion of Dendritic Cells Activating Rv2299c Protein Enhances the Protective Immunity of Ag85B-ESAT6 Vaccine Candidate against Tuberculosis

Author:
Back, Yong Woo; Bae, Hyun Shik; Choi, Han-Gyu; Binh, Dang Thi; Son, Yeo-Jin; Choi, Seunga; Kim, Hwa-Jung
Source:
Pathogens 2020 v.9 no.11
ISSN:
2076-0817
Subject:
bacterial antigens,   etc   ; Mycobacterium tuberculosis; T-lymphocytes; antibacterial properties; dendritic cells; immunity; infection; interleukin-2; lungs; lymph nodes; pathogens; spleen; tuberculosis; vaccines;     Show all 14 Subjects
Abstract:
... In Mycobacterium tuberculosis infection, naïve T cells that encounter mycobacterial antigens through dendritic cells (DCs) induce various CD4⁺ T-cell responses; therefore, appropriate DC activation is the key for protective immunity against tuberculosis. We previously found that Rv2299c-matured DCs induce Th1 differentiation with bactericidal activity. In this study, to prove that Rv2299c could en ...
DOI:
10.3390/pathogens9110865

11. The effect of foal or adult horse plasma on equine monocyte-derived dendritic cell phenotype and function

Author:
Lopez, Brina S.; Hurley, David J.; Giancola, Shyla; Giguère, Steeve; Hart, Kelsey A.
Source:
Veterinary immunology and immunopathology 2020 v.228 pp. 110099
ISSN:
0165-2427
Subject:
bacterial antigens,   etc   ; Staphylococcus aureus; adaptive immunity; adults; cell structures; dendritic cells; flow cytometry; foals; immunoassays; immunopathology; interleukin-10; interleukin-17; interleukin-4; morbidity; mortality; phagocytosis; phenotype;     Show all 17 Subjects
Abstract:
... Immunological and endocrine immaturity in foals increases foal morbidity and mortality from bacterial sepsis. Dendritic cells (DC) are critical in activating the adaptive immune response, but foal DC are phenotypically and functionally different than those of adult horses. Age-related variations in availability of some soluble plasma factors, such as hormones, might govern some age-related differe ...
DOI:
10.1016/j.vetimm.2020.110099

12. Bacterial outer membrane vesicles as a platform for biomedical applications: An update

Author:
Li, Min; Zhou, Han; Yang, Chen; Wu, Yi; Zhou, Xuechang; Liu, Hang; Wang, Yucai
Source:
Journal of controlled release 2020 v.323 pp. 253-268
ISSN:
0168-3659
Subject:
bacterial antigens,   etc   ; Gram-negative bacteria; adhesins; adjuvants; bacterial outer membranes; bacterial vaccines; drug carriers; immunotherapy; lipid bilayers; neoplasms; pathogen-associated molecular patterns;     Show all 11 Subjects
Abstract:
... Outer membrane vesicles (OMVs) are produced by Gram-negative bacteria both in vitro and in vivo. OMVs are nano-sized spherical vehicles formed by lipid bilayer membranes and contain multiple parent bacteria-derived components. Based on the presence of bacterial antigens, pathogen-associated molecular patterns (PAMPs), adhesins, various proteins and the vesicle structure, OMVs have been developed f ...
DOI:
10.1016/j.jconrel.2020.04.031

13. Autotransporter-Mediated Display of Complement Receptor Ligands by Gram-Negative Bacteria Increases Antibody Responses and Limits Disease Severity

Author:
Holland-Tummillo, Kristen M; Shoudy, Lauren E; Steiner, Donald; Kumar, Sudeep; Rosa, Sarah J; Namjoshi, Prachi; Singh, Anju; Sellati, Timothy J; Gosselin, Edmund J; Hazlett, Karsten RO
Source:
Pathogens 2020 v.9 no.5
ISSN:
2076-0817
Subject:
bacterial antigens,   etc   ; Escherichia coli; Francisella tularensis; Gram-negative bacteria; Klebsiella pneumoniae; adjuvants; antibody formation; complement; disease severity; ligands; macrophages; mice; models; pathogens; phosphorylation; proteins; vaccines; weight loss;     Show all 18 Subjects
Abstract:
... The targeting of immunogens/vaccines to specific immune cells is a promising approach for amplifying immune responses in the absence of exogenous adjuvants. However, the targeting approaches reported thus far require novel, labor-intensive reagents for each vaccine and have primarily been shown as proof-of-concept with isolated proteins and/or inactivated bacteria. We have engineered a plasmid-bas ...
DOI:
10.3390/pathogens9050375

14. Rapid production in maize seedlings of the Ag85B antigen of Mycobacterium avium subsp. paratuberculosis using an Agrobacterium-mediated transient expression system

Author:
Rojas, Mario; Monreal-Escalante, Elizabeth; Gomez-Anduro, Gracia; Rosales-Mendoza, Sergio; Ascencio, Felipe; Hernandez-Gonzalez, Julio; Angulo, Carlos
Source:
Plant cell, tissue, and organ culture 2020 v.141 no.1 pp. 31-40
ISSN:
0167-6857
Subject:
bacterial antigens,   etc   ; Mycobacterium avium subsp. paratuberculosis; Zea mays; antibodies; corn; edible vaccines; humoral immunity; immunoglobulin A; immunoglobulin G; intestines; livestock; mice; paratuberculosis; seedlings; transgenes; transgenic plants;     Show all 16 Subjects
Abstract:
... Transient expression systems for plants have several advantages for the development of innovative plant-made vaccines. This technology has the potential to render veterinary vaccines against relevant diseases, such as paratuberculosis, a chronic intestinal infectious disease affecting livestock. This study showed that Agrobacterium-mediated transient transformation of maize seedlings allows the pr ...
DOI:
10.1007/s11240-019-01764-7

15. Field evaluation of a novel oral reservoir-targeted vaccine against Borrelia burgdorferi utilizing an inactivated whole-cell bacterial antigen expression vehicle

Author:
Stafford, Kirby C., III; Williams, Scott C.; van Oosterwijk, Jolieke G.; Linske, Megan A.; Zatechka, Steve; Richer, Luciana M.; Molaei, Goudarz; Przybyszewski, Chris; Wikel, Stephen K.
Source:
Experimental & applied acarology 2020 v.80 no.2 pp. 257-268
ISSN:
0168-8162
Subject:
bacterial antigens,   etc   ; Borrelia burgdorferi; Ixodes scapularis; Peromyscus leucopus; acarology; enzootic diseases; field experimentation; larvae; markets; parasitism; pathogens; residential areas; vaccination; vaccines; Connecticut; Midwestern United States;     Show all 16 Subjects
Abstract:
... Blacklegged ticks (Ixodes scapularis) are the principal vector for Borrelia burgdorferi, among other infectious agents, in the northeastern, mid-Atlantic, and upper midwestern USA. White-footed mice (Peromyscus leucopus) are the primary and most competent reservoir host of B. burgdorferi in the Northeast. Live reservoir-targeted vaccines (RTVs) to limit enzootic transmission of B. burgdorferi were ...
DOI:
10.1007/s10493-019-00458-1

16. iTRAQ-based proteomic analysis of Mycoplasma bovis NM-28 strain from two generations for vaccine screening

Author:
Wang, Yanfang; Zhou, Yaping; Zhang, Jianhua; Wang, Xiaohui; Lv, Tianxing; Shi, Xiaona; Huang, Haibi; Bai, Fan; Wu, Qian; Hao, Yongqing
Source:
Vaccine 2020 v.38 no.3 pp. 549-561
ISSN:
0264-410X
Subject:
bacterial antigens,   etc   ; Mycoplasma bovis; Western blotting; bacteria; cows; growth curves; inactivated vaccines; membrane proteins; nutrition; production costs; proteomics; quantitative polymerase chain reaction; screening; vaccine development;     Show all 14 Subjects
Abstract:
... Mycoplasma bovis is an important pathogenic bacterium affecting cows and cattle. Clinically, an inactivated vaccine of M. bovis is mainly used to prevent infection by this bacterium. The changes that occur in the antigen when M. bovis is continuously passaged in vitro remain unknown. Therefore, we performed an in vitro serial passage of the M. bovis NM-28 strain, which was isolated and identified ...
DOI:
10.1016/j.vaccine.2019.10.061

17. Morphology of Naturally-Occurring Tuberculosis in Cattle Caused by Mycobacterium caprae

Author:
Ozturk-Gurgen, H.; Rieseberg, B.; Leipig-Rudolph, M.; Straubinger, R.K.; Hermanns, W.
Source:
Journal of comparative pathology 2020 v.174 pp. 120-139
ISSN:
0021-9975
Subject:
bacterial antigens,   etc   ; Mycobacterium; aerosols; bacteria; bovine tuberculosis; cattle; histopathology; immunohistochemistry; inflammation; liver; lungs; lymph nodes; respiratory tract diseases; small intestine; staining; tissues; Germany;     Show all 17 Subjects
Abstract:
... This study describes the pathomorphological alterations of bovine tuberculosis through gross and histopathological examinations, assessment of the distribution of lesions and the demonstration of mycobacteria. Samples from lungs, liver, small intestine, their regional lymph nodes and retropharyngeal lymph nodes were collected from 84 cattle with tuberculosis from the Allgäu, Germany. Organs were e ...
DOI:
10.1016/j.jcpa.2019.11.010

18. Comparative Characteristics of the Diagnostic Potential of Mycobacterial Synthetic Antigens for the Seroriagnosis of Lepra and Tuberculosis

Author:
Korolyova-Ushakova, A. G.; Baranova, E. V.; Ignatov, S. G.; Soloviev, P. V.; Kondakov, N. N.; Mel’nikova, T. M.; Abronina, P. I.; Podval’nyi, N. M.; Kononov, L. O.; Biketov, S. F.
Source:
Applied biochemistry and microbiology 2019 v.55 no.6 pp. 696-703
ISSN:
0003-6838
Subject:
bacterial antigens,   etc   ; Mycobacterium tuberculosis; blood serum; bovine serum albumin; epitopes; glycolipids; serodiagnosis; sugars; tuberculosis;     Show all 9 Subjects
Abstract:
... Seven artificial mycobacterial antigens have been synthesized via the conjugation of synthetic carbohydrate epitopes of M. leprae phenolic glycolipid (PGL-1) and M. tuberculosis lipoarabinomannan (LAM) with bovine serum albumin (BSA). Each antigen has a different number of carbohydrate epitopes with a different structure and input sequence of the sugar residues. According to the serum reactivity, ...
DOI:
10.1134/S0003683819060097

19. Risk-based bioengineering strategies for reliable bacterial vaccine production

Author:
Kamminga, Tjerko; Slagman, Simen-Jan; Martins dos Santos, Vitor A.P.; Bijlsma, Jetta J.E.; Schaap, Peter J.
Source:
Trends in biotechnology 2019
ISSN:
0167-7799
Subject:
bacterial antigens,   etc   ; bacterial vaccines; biochemical pathways; bioengineering; models; process design; screening;     Show all 7 Subjects
Abstract:
... Design of a reliable process for bacterial antigen production requires understanding of and control over critical process parameters. Current methods for process design use extensive screening experiments for determining ranges of critical process parameters yet fail to give clear insights into how they influence antigen potency. To address this gap, we propose to apply constraint-based genome-sca ...
DOI:
10.1016/j.tibtech.2019.03.005

20. Development of antibody anti-FimC-Salmonella typhi as a detection kit model of typhoid diseases by antigen capture approach

Author:
Nurjayadi, Muktiningsih; Kurnia Dewi, Fera; Kartika, Irma Ratna; Hasan, Umar; Setianingsih, Ida; asiah, Nur; Wiguna, Delia Ayu; Marcella, Anis; Puspasari, Fernita; Sulfianti, Asri; Agustini, Kurnia; Wardoyo, Wibowo Mangun; El-Enshasy, Hesham Ali
Source:
Biocatalysis and agricultural biotechnology 2019 v.19 pp. 101157
ISSN:
1878-8181
Subject:
bacterial antigens,   etc   ; antibodies; bacteria; blood; blood sampling; death; developing countries; drugs; immunoblotting; models; prototypes; recombinant proteins; typhoid fever;     Show all 13 Subjects
Abstract:
... Typhoid fever is a world health problem, with 200,000 recorded death annually in developing countries. The discovery of new drug discovery and detection methods for typhoid is still continuing. In previous research, the 31 kilo Dalton (kDa) recombinant protein Fim-C-S typhi was successfully expressed. It was also reported that the recombinant protein Fim-C-S. typhi could induce the occurrence of a ...
DOI:
10.1016/j.bcab.2019.101157