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1. First description of Lachnoanaerobaculum orale as a possible cause of human bacteremia

Author:
Yoko Ida; Takahiro Okuyama; Koji Araki; Kumiko Sekiguchi; Takashi Watanabe; Hiroaki Ohnishi
Source:
Anaerobe 2022 v.73 pp. 102506
ISSN:
1075-9964
Subject:
beta-lactams,   etc   ; bacteremia; blood; blood flow; case studies; clindamycin; desorption; drug therapy; fever; fluoroquinolones; human diseases; humans; lymphocytic leukemia; metronidazole; patients;     Show all 15 Subjects
Abstract:
... Lachnoanaerobaculum spp. is an obligate anaerobic, gram-positive, spore-forming, rod-shaped bacillus. Here, we report the first known case of bacteremia due to L. orale, which was detected in a patient with acute lymphoblastic leukemia. A 69-year-old man developed neutropenic fever with severe stomatitis during chemotherapy for leukemia. The bacteria strain isolated from blood culture was successf ...
DOI:
10.1016/j.anaerobe.2021.102506

2. Prioritisation tool for targeting the monitoring of veterinary pharmaceuticals in soils at a national level: The case of Spain

Author:
Antonio Rodríguez; Irene Iglesias; Ana de la Torre
Source:
European journal of soil science 2022 v.73 no.4 pp. e13268
ISSN:
1351-0754
Subject:
beta-lactams,   etc   ; European Union; animal production; antibiotics; biodiversity; cost effectiveness; cropland; ecosystems; livestock; models; pastures; pies; pollution; prioritization; prototypes; soil; veterinary drugs; Spain;     Show all 18 Subjects
Abstract:
... Antibiotics used in animal production are a major source of environmental contamination since most of them are excreted in manure. However, studies on the impact of antimicrobial effects have focused on humans and livestock, neglecting the environment. The European Union (EU) adopted a strategy to prioritise environmental monitoring and develop tools to make it cost‐effective. Our aim was to build ...
DOI:
10.1111/ejss.13268

3. Application of pharmacokinetic/pharmacodynamic concepts to the development of treatment regimens for sporadic canine urinary tract infections: Challenges and paths forward

Author:
Marilyn N. Martinez; Ron A. Miller; Tomás Martín‐Jiménez; Michele J. Sharkey
Source:
Journal of veterinary pharmacology and therapeutics 2022 v.45 no.5 pp. 415-425
ISSN:
0140-7783
Subject:
beta-lactams,   etc   ; anti-infective agents; antimicrobial properties; bladder; blood; dogs; drug development; drug resistance; fluoroquinolones; inoculum; muscles; pathogens; pharmacodynamics; pharmacokinetics; therapeutics; tissues; urine;     Show all 17 Subjects
Abstract:
... Antimicrobial efficacy can be predicted based on infection site exposure to the antimicrobial agent relative to the in vitro susceptibility of the pathogen to that agent. When infections occur in soft tissues (e.g., muscle, blood, and ligaments), exposure at the infection site is generally assumed to reflect an equilibrium between the unbound concentrations in plasma and that in the interstitial f ...
DOI:
10.1111/jvp.13088

4. Urban monitoring of antimicrobial resistance during a COVID-19 surge through wastewater surveillance

Author:
Anthony Harrington; Van Vo; Katerina Papp; Richard L. Tillett; Ching-Lan Chang; Hayley Baker; Shirley Shen; Amei Amei; Cassius Lockett; Daniel Gerrity; Edwin C. Oh
Source:
Science of the total environment 2022 v.853 pp. 158577
ISSN:
0048-9697
Subject:
beta-lactams,   etc   ; Actinobacteria; Bacteroidetes; COVID-19 infection; Firmicutes; Proteobacteria; antibiotic resistance; beta-lactamase; colistin; environment; epidemiology; fluoroquinolones; fungi; mixed infection; monitoring; multiple drug resistance; pathogens; sewage; wastewater; wastewater treatment; Nevada;     Show all 21 Subjects
Abstract:
... During the early phase of the COVID-19 pandemic, infected patients presented with symptoms similar to bacterial pneumonias and were treated with antibiotics before confirmation of a bacterial or fungal co-infection. We reasoned that wastewater surveillance could reveal potential relationships between reduced antimicrobial stewardship, specifically misprescribing antibiotics to treat viral infectio ...
DOI:
10.1016/j.scitotenv.2022.158577

5. Quality of care indicators in the MAnageMent of BlOOdstream infections caused by Enterobacteriaceae (MAMBOO-E study): state of the art and research agenda

Author:
Maddalena Giannella; Pietro Malosso; Luigia Scudeller; Linda Bussini; Chiara Rebuffi; Milo Gatti; Michele Bartoletti; Stefano Ianniruberto; Livia Pancaldi; Renato Pascale; Sara Tedeschi; Pierluigi Viale; Mical Paul
Source:
International journal of antimicrobial agents 2021 v.57 no.4 pp. 106320
ISSN:
0924-8579
Subject:
beta-lactams,   etc   ; Enterobacteriaceae; blood; blood flow; infectious diseases; mortality; observational studies;     Show all 7 Subjects
Abstract:
... The impact on outcome of five interventions was reviewed in order to investigate the state of the art for management of Enterobacteriaceae bloodstream infection (E-BSI).We searched for randomised controlled trials (RCTs) and observational studies published from January 2008 to March 2019 in PubMed, EMBASE and Cochrane Library. Populations consisted of patients with E-BSI. Interventions were as fol ...
DOI:
10.1016/j.ijantimicag.2021.106320

6. Occurrence of Antimicrobial Resistance Genes in the Oral Cavity of Cats with Chronic Gingivostomatitis

Author:
Wayne Tsang; Annika Linde; Janina A. Krumbeck; Guangxi Wu; Young J. Kim; Gerald H. Lushington; Tonatiuh Melgarejo
Source:
Animals 2021 v.11 no.12 pp. -
ISSN:
2076-2615
Subject:
beta-lactams,   etc   ; Malassezia; aminoglycosides; antibiotic resistance; cats; databases; dysbiosis; fungi; macrolides; medicine; mouth;     Show all 11 Subjects
Abstract:
... Feline chronic gingivostomatitis (FCGS) is a severe immune-mediated inflammatory disease with concurrent oral dysbiosis (bacterial and fungal). Broad-spectrum antibiotics are used empirically in FCGS. Still, neither the occurrence of antimicrobial-resistant (AMR) bacteria nor potential patterns of co-occurrence between AMR genes and fungi have been documented in FCGS. This study explored the diffe ...
DOI:
10.3390/ani11123589

7. Beta-lactam monotherapy or combination therapy for bloodstream infections or pneumonia due to Pseudomonas aeruginosa: a meta-analysis

Author:
Lorenzo Onorato; Margherita Macera; Federica Calò; Paolo Cirillo; Giovanni Di Caprio; Nicola Coppola
Source:
International journal of antimicrobial agents 2022 v.59 no.3 pp. 106512
ISSN:
0924-8579
Subject:
beta-lactams,   etc   ; Pseudomonas aeruginosa; blood flow; confidence interval; meta-analysis; mortality; pneumonia; relative risk; therapeutics;     Show all 9 Subjects
Abstract:
... To compare the clinical and microbiological outcomes of patients treated with beta-lactam monotherapy or combination therapy for Pseudomonas aeruginosa infections. MEDLINE, Google Scholar and the Cochrane Library. Experimental and observational studies published as full papers up to December 2020 that compared the efficacy of beta-lactams used as monotherapy or in combination with other active age ...
DOI:
10.1016/j.ijantimicag.2021.106512

8. Associations between human bacterial pathogens and ARGs are magnified in leachates as landfill ages

Author:
Dong Wu; Liuhong Wang; Yinglong Su; Jan Dolfing; Bing Xie
Source:
Chemosphere 2021 v.264 pp. 128446
ISSN:
0045-6535
Subject:
beta-lactams,   etc   ; Actinobacteria; Firmicutes; Proteobacteria; aminoglycosides; antibiotic resistance; bacterial communities; humans; landfills; macrolides; nitrogen metabolism; wastes;     Show all 12 Subjects
Abstract:
... Landfills constitute the largest treatment and disposal reservoirs of anthropogenic waste on earth and they are continuously releasing antibiotic resistance genes (ARGs) to the environment for decades via leachates. Little is known about the association between ARGs and human bacterial pathogens as a function of time. Here, we quantified 10 subtypes of ARGs, integrons, and human bacterial pathogen ...
DOI:
10.1016/j.chemosphere.2020.128446

9. Molecular dissemination of emerging antibiotic, biocide, and metal co-resistomes in the Himalayan hot springs

Author:
Nitish Sharma; Reena Kumari; Monika Thakur; Amit K. Rai; Sudhir P. Singh
Source:
Journal of environmental management 2022 v.307 pp. 114569
ISSN:
0301-4797
Subject:
beta-lactams,   etc   ; Thiobacillus; Vogesella; antibiotic resistance; antibiotic resistance genes; arsenic; biocides; coevolution; copper; energy; environmental impact; environmental management; fluoroquinolones; fosfomycin; hot springs; humans; hydrogen peroxide; iron; mercury; metabolism; metagenomics; metal tolerance; multiple drug resistance; streptomycin; tetracycline; triclosan; trimethoprim; vancomycin; Himalayan region; India;     Show all 30 Subjects
Abstract:
... Growing resistance among microbial communities against antimicrobial compounds, especially antibiotics, is a significant threat to living beings. With increasing antibiotic resistance in human pathogens, it is necessary to examine the habitats having community interests. In the present study, a metagenomic approach has been employed to understand the causes, dissemination, and effects of antibioti ...
DOI:
10.1016/j.jenvman.2022.114569

10. The Effects of Indole on Intracellular Polyamine Content and Antibiotic Susceptibility of Escherichia coli

Author:
L. Y. Nesterova; A. V. Akhova; A. G. Tkachenko
Source:
Moscow University biological sciences bulletin 2021 v.76 no.4 pp. 196-201
ISSN:
0096-3925
Subject:
beta-lactams,   etc   ; Escherichia coli; aminoglycosides; antibiotic resistance; cadaverine; culture media; eukaryotic cells; fluoroquinolones; indoles; putrescine; spermidine; spermine;     Show all 12 Subjects
Abstract:
... Small regulatory molecules, such as indole and polyamines, are involved in the regulation of a variety of processes in bacteria, including protective response to antibiotics. It is known that small regulatory molecules can affect each other. However, there is still no data on the mutual effects of indole and polyamines. It is reported here that micromolar concentrations of indole in the culture me ...
DOI:
10.3103/S009639252104009X

11. Disentangling the Effects of Physicochemical, Genetic, and Microbial Properties on Phase-Driven Resistome Dynamics during Multiple Manure Composting Processes

Author:
Cheng Wang; Weijing Zhu; P. J. Strong; Fengxiang Zhu; Xingguo Han; Chunlai Hong; Weiping Wang; Yanlai Yao
Source:
Environmental science & technology 2021 v.55 no.21 pp. 14732-14745
ISSN:
1520-5851
Subject:
beta-lactams,   etc   ; antibiotic resistance; antibiotic resistance genes; antibiotics; cattle; chickens; insect larvae; microorganisms; phylogeny; pig manure; technology; variance;     Show all 12 Subjects
Abstract:
... Composting alters manure-derived antibiotic resistance genes (ARGs) to a certain extent, which is largely dependent upon the composting phase, manure type, microbial phylogeny, and physicochemical properties. However, little is known about how these determinants influence the fate and dynamics of ARGs as well as the mechanisms underlying the ecological process of ARGs during composting. Here, we i ...
DOI:
10.1021/acs.est.1c03933

12. On-farm soil resistome is modified after treating dairy calves with the antibiotic florfenicol

Author:
Jinxin Liu; Feng Yu; Douglas R. Call; David A. Mills; Anyun Zhang; Zhe Zhao
Source:
Science of the total environment 2021 v.750 pp. 141694
ISSN:
0048-9697
Subject:
beta-lactams,   etc   ; aminoglycosides; antibiotic resistance; antibiotic resistance genes; environment; florfenicol; intestinal microorganisms; quantitative polymerase chain reaction; soil; soil microorganisms;     Show all 10 Subjects
Abstract:
... We determined the immediate impact of exposure to antibiotic-treated animals on housing soil microbiome and resistome. Fecal (n = 36) and soil (n = 108) samples from dairy calves (n = 6) treated with and without florfenicol over 30 days were collected. There were temporary changes in the gut microbiome of antibiotic-treated calves as measured by Shannon diversity (16S rRNA gene sequencing; P = 0.0 ...
DOI:
10.1016/j.scitotenv.2020.141694

13. Direct and practical Gilman-Speeter synthesis of 3,4-trisubstituted β-lactams via the Thorpe-Ingold effect

Author:
Maria Panagiotou; Vasileios Demos; Plato Α. Magriotis
Source:
Tetrahedron letters 2020 v.61 no.40 pp. 152375
ISSN:
0040-4039
Subject:
beta-lactams,   etc   ; chemical reactions; chemical structure; diastereoselectivity; imines;     Show all 5 Subjects
Abstract:
... A highly efficient Gilman-Speeter synthesis of 3,4-trisubstituted β-lactams possessing a 4-aryl substituent is described, employing a direct, uncatalyzed Mannich reaction between TMS imines and TMS ketene acetals. The process avoids cryogenic conditions, making it more amenable to process-scale use than related methods for β-lactam synthesis. A Gilman-Speeter diastereoselective version using a sul ...
DOI:
10.1016/j.tetlet.2020.152375

14. First report of cross resistance to silver and antibiotics in Klebsiella pneumoniae isolated from patients and polluted water in Tunisia

Author:
Samar Ben Miloud; Md Muntasir Ali; Ilhem Boutiba; Rob Van Houdt; Chedly Chouchani
Source:
Water and environment journal 2021 v.35 no.2 pp. 730-739
ISSN:
1747-6585
Subject:
beta-lactams,   etc   ; Klebsiella pneumoniae; cross infection; cross resistance; environment; genes; hospitals; pathogens; phenotype; plasmids; silver; silver nitrate; water; water pollution; Tunisia;     Show all 15 Subjects
Abstract:
... Klebsiella pneumoniae, ubiquitously found in a variety of environmental sources, is an important pathogen in burn wounds and nosocomial infections. Burn wounds have been commonly treated with silver compounds, which are also used in a multitude of (non)medical products. As the latter increased silver discharge into different environments, we evaluated and compared silver resistance in K. pneumonia ...
DOI:
10.1111/wej.12665

15. Nanopore sequencing analysis of integron gene cassettes in sewages and soils

Author:
Xin-Li An; Olusegun K. Abass; Cai-Xia Zhao; Mei-Rong Xu; Ting Pan; Qiang Pu; Hu Liao; Hu Li; Yong-Guan Zhu; Jian-Qiang Su
Source:
Science of the total environment 2022 v.817 pp. 152766
ISSN:
0048-9697
Subject:
beta-lactams,   etc   ; aminoglycosides; anthropogenic activities; antibiotic resistance; antibiotic resistance genes; antibiotics; bioreactors; environment; integrases; manure spreading; nanopores; sewage; sewage treatment; soil;     Show all 14 Subjects
Abstract:
... Integrons are genetic elements that can facilitate rapid spread of antibiotic resistance by insertion and removal of genes. However, knowledge about the diversity and distribution of gene cassettes embedded in class 1 integron is still limited. In this study, we sequenced integron gene cassettes using nanopore sequencing and quantified antibiotic resistance genes (ARGs) and integrase genes in the ...
DOI:
10.1016/j.scitotenv.2021.152766

16. Outpatient antibiotic use attributable to viral acute lower respiratory tract infections during the cold season in France, 2010-2017

Author:
Felix Cheysson; Christian Brun-Buisson; Lulla Opatowski; Lenaig Le Fouler; Céline Caserio-Schönemann; Isabelle Pontais; Didier Guillemot; Laurence Watier
Source:
International journal of antimicrobial agents 2021 v.57 no.6 pp. 106339
ISSN:
0924-8579
Subject:
beta-lactams,   etc   ; antibiotics; bronchiolitis; cold; cold season; confidence interval; databases; elderly; health insurance; macrolides; pneumonia; respiratory system; time series analysis; France;     Show all 14 Subjects
Abstract:
... Antibiotic stewardship requires clear insight into antibiotic overuse and the syndromes that lead to prescription.The aim of this study was to estimate the proportion of antibiotic prescriptions attributable to acute lower respiratory tract infections (LRTIs) during the cold season.Using individual data from the French National Health Insurance (NHI) database, weekly time series were constructed o ...
DOI:
10.1016/j.ijantimicag.2021.106339

17. The microbiome of a polluted urban lake harbors pathogens with diverse antimicrobial resistance and virulence genes

Author:
Jorge Quillaguamán; Daniel Guzmán; Melina Campero; Claudia Hoepfner; Laura Relos; Daniela Mendieta; Shawn M. Higdon; Daniel Eid; Carla E. Fernández
Source:
Environmental pollution 2021 v.273 pp. 116488
ISSN:
0269-7491
Subject:
beta-lactams,   etc   ; Pseudomonas aeruginosa; antibiotic resistance; cross infection; fluoroquinolones; genes; human population; industrial wastewater; lakes; macrolides; metagenomics; microbiome; pollution; risk; sediments; virulence; Bolivia;     Show all 17 Subjects
Abstract:
... Bacterial resistance to antibiotics is one of the greatest threats to the modern human population. Paradoxically, urban settlements are often culpable in generating such resistance by influencing the adaptation of bacterial communities via pollution of natural ecosystems. Urban lakes are well-known examples of this problem, as they often receive discharges of both domestic and industrial wastewate ...
DOI:
10.1016/j.envpol.2021.116488

18. Concise Synthesis and Antimicrobial Evaluation of the Guanidinium Alkaloid Batzelladine D: Development of a Stereodivergent Strategy

Author:
You-Chen Lin; Aubert Ribaucourt; Yasamin Moazami; Joshua G. Pierce
Source:
Journal of the American Chemical Society 2020 v.142 no.21 pp. 9850-9857
ISSN:
1520-5126
Subject:
beta-lactams,   etc   ; alkaloids; antimicrobial properties; guanidinium; stereochemistry; stereoisomers; stereoselective synthesis;     Show all 7 Subjects
Abstract:
... Herein, we describe a stereodivergent route to (±)-batzelladine D (2), (+)-batzelladine D (2), (−)-batzelladine D (2), and a series of stereochemical analogues and explore their antimicrobial activity for the first time. The concise synthetic approach enables access to the natural products in a sequence of 8–12 steps from readily available building blocks. Highlights of the synthetic strategy incl ...
DOI:
10.1021/jacs.0c04091

19. Analysis of 56,348 Genomes Identifies the Relationship between Antibiotic and Metal Resistance and the Spread of Multidrug-Resistant Non-Typhoidal Salmonella

Author:
Gavin J. Fenske; Joy Scaria
Source:
Microorganisms 2021 v.9 no.7 pp. -
ISSN:
2076-2607
Subject:
beta-lactams,   etc   ; antibiotic resistance; arsenic; computer simulation; data collection; food pathogens; genomics; mercury; metal tolerance; multiple drug resistance; operon; plasmids; public health; replicon; serotypes; silver;     Show all 16 Subjects
Abstract:
... Salmonella enterica is common foodborne pathogen that generates both enteric and systemic infections in hosts. Antibiotic resistance is common is certain serovars of the pathogen and of great concern to public health. Recent reports have documented the co-occurrence of metal resistance with antibiotic resistance in one serovar of S. enterica. Therefore, we sought to identify possible co-occurrence ...
DOI:
10.3390/microorganisms9071468

20. Risk of sharing resistant bacteria and/or resistance elements between dogs and their owners

Author:
Zahra Naziri; Meisam Poormaleknia; Azar Ghaedi Oliyaei
Source:
BMC veterinary research 2022 v.18 no.1 pp. 203
ISSN:
1746-6148
Subject:
beta-lactams,   etc   ; Escherichia coli; antibiotic resistance; beta-lactamase; beta-lactamase bacteria; chloramphenicol; feces; humans; medicine; pet ownership; phenotype; polymerase chain reaction; risk; tetracycline; veterinary medicine;     Show all 15 Subjects
Abstract:
... BACKGROUND: The indiscriminate use and the similarity of prescribed antibiotics especially beta-lactams in human and small animal medicine, along with the close communication between pets and humans, increases the risk of the transfer of antibiotic-resistant bacteria and/or resistance elements especially integrons, between them. Therefore, we aimed to compare the frequencies of extended spectrum b ...
DOI:
10.1186/s12917-022-03298-1