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- Author:
- Tebug, Stanly Fon; Mouiche, Mohamed Moctar Mouliom; Abia, Wilfred Angie; Teno, Gabriel; Tiambo, Christian Keambou; Moffo, Frédéric; Awah-Ndukum, Julius
- Source:
- Preventive veterinary medicine 2021 v.186 pp. 105212
- ISSN:
- 0167-5877
- Subject:
- beta-lactams, etc ; animal health; animal production; antibiotic resistance; continuing education; disease diagnosis; education programs; gender; guidelines; information sources; macrolides; questionnaires; surveys; tetracycline; veterinarians; working conditions; Sub-Saharan Africa; Show all 17 Subjects
- Abstract:
- ... The use of antimicrobial (AM) in animal production is an important contributor to antimicrobial resistance (AMR) worldwide. Animal health professionals should play a key role in ensuring judicious use of AM. However, they are subjected to influence from clinical and non-clinical factors. The present study evaluates the perceptions and concerns of animal health practitioners regarding antimicrobial ...
- DOI:
- 10.1016/j.prevetmed.2020.105212
-
https://dx.doi.org/10.1016/j.prevetmed.2020.105212
- Author:
- Panagiotou, Maria; Demos, Vasileios; Magriotis, Plato Α.
- Source:
- Tetrahedron letters 2020 v.61 no.40 pp. 152375
- ISSN:
- 0040-4039
- Subject:
- beta-lactams, etc ; chemical reactions; chemical structure; diastereoselectivity; imines; Show all 5 Subjects
- Abstract:
- ... A highly efficient Gilman-Speeter synthesis of 3,4-trisubstituted β-lactams possessing a 4-aryl substituent is described, employing a direct, uncatalyzed Mannich reaction between TMS imines and TMS ketene acetals. The process avoids cryogenic conditions, making it more amenable to process-scale use than related methods for β-lactam synthesis. A Gilman-Speeter diastereoselective version using a sul ...
- DOI:
- 10.1016/j.tetlet.2020.152375
-
https://dx.doi.org/10.1016/j.tetlet.2020.152375
- Author:
- Lin, You-Chen; Ribaucourt, Aubert; Moazami, Yasamin; Pierce, Joshua G.
- Source:
- Journal of the American Chemical Society 2020 v.142 no.21 pp. 9850-9857
- ISSN:
- 1520-5126
- Subject:
- beta-lactams, etc ; alkaloids; antimicrobial properties; guanidinium; stereochemistry; stereoisomers; stereoselective synthesis; Show all 7 Subjects
- Abstract:
- ... Herein, we describe a stereodivergent route to (±)-batzelladine D (2), (+)-batzelladine D (2), (−)-batzelladine D (2), and a series of stereochemical analogues and explore their antimicrobial activity for the first time. The concise synthetic approach enables access to the natural products in a sequence of 8–12 steps from readily available building blocks. Highlights of the synthetic strategy incl ...
- DOI:
- 10.1021/jacs.0c04091
-
http://dx.doi.org/10.1021/jacs.0c04091
- Author:
- Geng, Hui-Qing; Hou, Chen-Yang; Wang, Le-Cheng; Peng, Jin-Bao; Wu, Xiao-Feng
- Source:
- Journal of catalysis 2020 v.381 pp. 271-274
- ISSN:
- 0021-9517
- Subject:
- beta-lactams, etc ; alcohols; catalytic activity; molybdenum; nitroaromatic compounds; oxidants; palladium; Show all 7 Subjects
- Abstract:
- ... In this communication, a highly selective palladium-catalyzed carbonylative four components procedure for the transformation of allenes, alcohols and nitroarenes has been developed. The desired 2-aminomethyl substituted 3-arylacrylates were produced in good yields with Mo(CO)₆ as the solid CO source. Furthermore, nitroarenes have been used as reaction partners and oxidant in this catalytic system. ...
- DOI:
- 10.1016/j.jcat.2019.11.009
-
https://dx.doi.org/10.1016/j.jcat.2019.11.009
- Author:
- Rane, Vipul P.; Ahirrao, Vinod K.; Patil, Kiran R.; Jadhav, Rajiv A.; Yeole, Ravindra D.
- Source:
- Chromatographia 2020 v.83 no.3 pp. 423-437
- ISSN:
- 0009-5893
- Subject:
- beta-lactam antibiotics; beta-lactams, etc ; acetonitrile; ammonium; antibacterial properties; clinical trials; drugs; formates; hydrophilicity; liquid chromatography; phosphates; quality control; solvents; spectrometers; tandem mass spectrometry; thermal stress; Show all 16 Subjects
- Abstract:
- ... Zidebactam (ZID) is a novel drug in clinical development; it potentiates the antibacterial activity of β-lactam antibiotics. Two reversed phase liquid chromatographic (RP-LC) methods were developed for ZID; a mass spectrometer (MS) compatible method for identification and another UV detection method for the quantification of impurities. Four impurities and three degradation products (DPs) were ide ...
- DOI:
- 10.1007/s10337-019-03845-3
-
http://dx.doi.org/10.1007/s10337-019-03845-3
- Author:
- Heffernan, Aaron James; Sime, Fekade Bruck; Sun, Jing; Lipman, Jeffrey; Kumar, Anand; Andrews, Katherine; Ellwood, David; Grimwood, Keith; Roberts, Jason
- Source:
- International journal of antimicrobial agents 2020 v.55 no.3 pp. 105839
- ISSN:
- 0924-8579
- Subject:
- beta-lactam antibiotics; beta-lactams, etc ; aminoglycosides; cohort studies; endocarditis; meta-analysis; mortality; nephrotoxicity; neutropenia; patients; randomized clinical trials; risk; systematic review; therapeutics; Show all 14 Subjects
- Abstract:
- ... Combining aminoglycosides with β-lactam antibiotics for treating serious infections has not been associated with reduced mortality in previous meta-analyses. However, the multiple daily aminoglycoside dosing regimen principally used in most of the included studies is inconsistent with current practice.To determine if a combination of an aminoglycoside administered as a single daily dose and a β-la ...
- DOI:
- 10.1016/j.ijantimicag.2019.10.020
-
https://dx.doi.org/10.1016/j.ijantimicag.2019.10.020
- Author:
- Kavanaugh, Logan G.; Flanagan, J. Nicole; Steck, Todd R.
- Source:
- International journal of antimicrobial agents 2020 v.56 no.1 pp. 105994
- ISSN:
- 0924-8579
- Subject:
- beta-lactam antibiotics, etc ; Burkholderia multivorans; bacteria; chronic diseases; cross resistance; drugs; genes; mutation; sequence analysis; Show all 9 Subjects
- Abstract:
- ... Antibiotic collateral sensitivity (CS) occurs when a bacterium that acquires resistance to a treatment drug exhibits decreased resistance to a different drug. Here we identify reciprocal CS networks and candidate genes in Burkholderia multivorans. Burkholderia multivorans was evolved to become resistant to each of six antibiotics. The antibiogram of the evolved strain was compared with the immedia ...
- DOI:
- 10.1016/j.ijantimicag.2020.105994
-
https://dx.doi.org/10.1016/j.ijantimicag.2020.105994
- Author:
- Zhang, Yuxuan; Lu, Jian; Wu, Jun; Wang, Jianhua; Lin, Yichen
- Source:
- The Science of the total environment 2020 v.720 pp. 137712
- ISSN:
- 0048-9697
- Subject:
- beta-lactams, etc ; antibiotic resistance genes; bacteria; bacterial communities; coasts; continental shelf; principal component analysis; sediments; Show all 8 Subjects
- Abstract:
- ... Extensive and improper overuse of antibiotics resulted in the prevalence of antibiotic resistance genes (ARGs). As the typical semi-enclosed continental shelf sea, the Bohai Sea has been considered as one of the most polluted marine areas in China. However, no comprehensive investigation on the spatial distribution of ARGs in sediments from the Bohai Sea has been reported. A large-scale sampling w ...
- DOI:
- 10.1016/j.scitotenv.2020.137712
-
https://dx.doi.org/10.1016/j.scitotenv.2020.137712
- Author:
- Tam, Heng-Keat; Malviya, Viveka N.; Foong, Wuen-Ee; Herrmann, Andrea; Malloci, Giuliano; Ruggerone, Paolo; Vargiu, Attilio V.; Pos, Klaas M.
- Source:
- Journal of molecular biology 2020 v.432 no.4 pp. 861-877
- ISSN:
- 0022-2836
- Subject:
- beta-lactams, etc ; Escherichia coli; binding sites; carboxylation; hydrophobicity; molecular models; toxic substances; Show all 7 Subjects
- Abstract:
- ... AcrAB(Z)-TolC is the main drug efflux transporter complex in Escherichia coli. The extrusion of various toxic compounds depends on several drug binding sites within the trimeric AcrB transporter. Membrane-localized carboxylated substrates, such as fusidic acid and hydrophobic β-lactams, access the pump via a groove between the transmembrane helices TM1 and TM2. In this article, the transport route ...
- DOI:
- 10.1016/j.jmb.2019.12.025
- PubMed:
- 31881208
- PubMed Central:
- PMC7071731
-
https://dx.doi.org/10.1016/j.jmb.2019.12.025
- Author:
- Ahirrao, Vinod K.; Rane, Vipul P.; Patil, Kiran R.; Jadhav, Rajiv A.; Bhamare, Vijay S.; Yadav, Dharamvir S.; Yeole, Ravindra D.
- Source:
- Chromatographia 2020 v.83 no.2 pp. 219-228
- ISSN:
- 0009-5893
- Subject:
- beta-lactams, etc ; Gram-negative bacteria; aerosols; clinical trials; drugs; ion exchange chromatography; mass spectrometry; pyridines; sulfates; Show all 9 Subjects
- Abstract:
- ... Zidebactam (ZID), a novel β-lactam enhancer drug being developed to treat infections caused by Gram-negative bacteria, currently is in phase III clinical development. Two ionic impurities observed in liquid chromatography with charged aerosol detector (CAD) analysis were identified through liquid-chromatography mass spectrometry (LC–MS) as sulfate (SO₄⁻²) and monomethyl sulfate (CH₃OSO₃⁻¹, MMS). T ...
- DOI:
- 10.1007/s10337-019-03836-4
-
http://dx.doi.org/10.1007/s10337-019-03836-4
- Author:
- Reis, Ana C.; Kolvenbach, Boris A.; Nunes, Olga C.; Corvini, Philippe F.X.
- Source:
- New biotechnology 2020 v.54 pp. 13-27
- ISSN:
- 1871-6784
- Subject:
- beta-lactams, etc ; antibiotic residues; antibiotic resistance; antibiotics; biodegradation; ionophores; macrolides; microbial communities; quinolones; Show all 9 Subjects
- Abstract:
- ... Antibiotic residues are widespread in the environment and their presence is known to contribute to the propagation of antibiotic resistance. Nevertheless, knowledge on processes involved in their degradation is scattered. This second part of a two part review aims at compiling knowledge on the (bio-) degradation of antibiotics, focusing on β-lactams, macrolides, quinolones and ionophores, as well ...
- DOI:
- 10.1016/j.nbt.2019.08.003
-
https://dx.doi.org/10.1016/j.nbt.2019.08.003
- Author:
- Kyriazopoulou, Evdoxia; Sinapidis, Dimitrios; Halvatzis, Stamatios; Velissaris, Dimitrios; Alexiou, Nikolaos; Kosmas, Vasilios; Adami, Maria-Evangelia; Kyprianou, Miltiades; Kyprianou, Aikaterini; Stefos, Aggelos; Lada, Malvina; Koutoukas, Pantelis; Pavlaki, Maria; Kyriakoudi, Anna; Makina, Anna; Gogos, Charalambos; Niederman, Michael S.; Giamarellos-Bourboulis, Evangelos J.
- Source:
- International journal of antimicrobial agents 2020 v.55 no.1 pp. 105836
- ISSN:
- 0924-8579
- Subject:
- beta-lactams, etc ; azithromycin; clarithromycin; fluoroquinolones; patients; pneumonia; regression analysis; retrospective studies; survival rate; Show all 9 Subjects
- Abstract:
- ... Although analysis of retrospective studies has documented survival benefit from the addition of a macrolide to the treatment regimen for community-acquired pneumonia (CAP), no data are available to determine if there is differential efficacy between members of the macrolide family. In order to investigate this, an analysis was undertaken of data from 1174 patients with CAP who met the new Sepsis-3 ...
- DOI:
- 10.1016/j.ijantimicag.2019.10.017
-
https://dx.doi.org/10.1016/j.ijantimicag.2019.10.017
- Author:
- Ajibola, Akinranti S.; Tisler, Selina; Zwiener, Christian
- Source:
- Analytical methods 2020 v.12 no.4 pp. 576-586
- ISSN:
- 1759-9679
- Subject:
- beta-lactam antibiotics; beta-lactams, etc ; antibiotic residues; ciprofloxacin; detection limit; electrospray ionization mass spectrometry; liquid chromatography; macrolides; oxytetracycline; salts; sewage sludge; solid phase extraction; solvents; sorbents; spectrometers; sulfonamides; tandem mass spectrometry; thiamphenicol; trimethoprim; wastewater treatment; Nigeria; Show all 21 Subjects
- Abstract:
- ... A modified quick, easy, cheap, effective, rugged and safe (QuEChERS) based methodology with a dispersive solid-phase extraction (d-SPE) clean-up followed by liquid chromatography-triple quadrupole mass spectrometry analysis was developed and validated for simultaneous determination of seventeen multiclass antibiotics in sewage sludge. The target antibiotics included four sulfonamides, three fluoro ...
- DOI:
- 10.1039/c9ay02188d
-
http://dx.doi.org/10.1039/c9ay02188d
- Author:
- Caro, Y.S.; Cámara, M.S.; De Zan, M.M.
- Source:
- Talanta 2020 v.210 pp. 120619
- ISSN:
- 0039-9140
- Subject:
- beta-lactam antibiotics, etc ; calibration; detectors; drug resistance; drugs; guidelines; hospitals; liquid chromatography; monitoring; patients; pharmacokinetics; precision medicine; sepsis (infection); Show all 13 Subjects
- Abstract:
- ... Due to their broad spectrum of activity and wide therapeutic index, β-lactam antibiotics (β-LA) are commonly used to treat severe sepsis in critically ill patients in intensive care units. This group of patients experiences important physiological changes that alter their pharmacokinetics, and thus, therapeutic drug monitoring (TDM) of β-LA is increasingly used to improve personalized medicine by ...
- DOI:
- 10.1016/j.talanta.2019.120619
-
https://dx.doi.org/10.1016/j.talanta.2019.120619
- Author:
- Bilodeau, Didier A.; Margison, Kaitlyn D.; Ahmed, Noreen; Strmiskova, Miroslava; Sherratt, Allison R.; Pezacki, John Paul
- Source:
- Chemical communications 2020 v.56 no.13 pp. 1988-1991
- ISSN:
- 1364-548X
- Subject:
- beta-lactams, etc ; alkynes; biocompatible materials; catalytic activity; copper; cycloaddition reactions; lipids; membrane proteins; micelles; models; peptides; surfactants; Show all 12 Subjects
- Abstract:
- ... Kinugasa reactions hold potential for bioorthogonal chemistry in that the reagents can be biocompatible. Unlike other bioorthogonal reaction products, β-lactams are potentially reactive, which can be useful for synthesizing new biomaterials. A limiting factor for applications consists of slow reaction rates. Herein, we report an optimized aqueous copper(i)-catalyzed alkyne–nitrone cycloaddition in ...
- DOI:
- 10.1039/c9cc09473c
-
http://dx.doi.org/10.1039/c9cc09473c
- Author:
- Synofzik, Judith; Dar’in, Dmitry; Novikov, Mikhail S.; Kantin, Grigory; Bakulina, Olga; Krasavin, Mikhail
- Source:
- Journal of organic chemistry 2019 v.84 no.18 pp. 12101-12110
- ISSN:
- 1520-6904
- Subject:
- beta-lactams, etc ; catalytic activity; chemical reactions; chemical structure; diastereoselectivity; imines; Show all 6 Subjects
- Abstract:
- ... Thermally promoted reaction of α-acyl-α-diazoacetates with imines has been investigated. The transformation, earlier reported predominantly under transition metal catalyzed conditions, delivers α-alkoxycarbonyl-substituted β-lactams with outstanding diastereoselectivity. DFT calculations performed in order to evaluate energetically feasible reaction pathways revealed the intermediacy of 1,3-oxazin ...
- DOI:
- 10.1021/acs.joc.9b02030
-
http://dx.doi.org/10.1021/acs.joc.9b02030
- Author:
- Takabatake, Tetsuhiko; Yoneda, Takumi; Otsuka, Jyo; Kagawa, Natsuko; Toyota, Masahiro
- Source:
- Tetrahedron letters 2019 pp. 150942
- ISSN:
- 0040-4039
- Subject:
- beta-lactams, etc ; absorption; artificial intelligence; arylation; cholesterol; drugs; moieties; stereoselectivity; Show all 8 Subjects
- Abstract:
- ... An artificial intelligence designed SCH 47949 synthesis is achieved in a stereoselective manner. The key step contains a stereoselective one-pot construction of the trans β-lactam framework via thermal electrocyclization. N-arylation of the β-lactam ring system and a series of functional group transformations synthesized SCH 47949 in a reasonable chemical yield. ...
- DOI:
- 10.1016/j.tetlet.2019.07.033
-
https://dx.doi.org/10.1016/j.tetlet.2019.07.033
- Author:
- Jouanneau, Morgan; Vellalath, Sreekumar; Kang, Guowei; Romo, Daniel
- Source:
- Tetrahedron 2019 v.75 no.24 pp. 3348-3354
- ISSN:
- 0040-4020
- Subject:
- beta-lactams, etc ; alcohols; chemical bonding; chemical structure; derivatization; epoxides; therapeutics; Show all 7 Subjects
- Abstract:
- ... β-Lactones, β-lactams and epoxides are privileged structural motifs found in both therapeutics and natural products. Herein we report several strategies for annulation of these motifs onto natural products that are not known to covalently modify their cellular targets. These strategies can facilitate identification of previously unidentified cellular targets or identify novel cellular targets of t ...
- DOI:
- 10.1016/j.tet.2019.04.068
-
https://dx.doi.org/10.1016/j.tet.2019.04.068
- Author:
- Hosseini, Abolfazl; Schreiner, Peter R.
- Source:
- Organic letters 2019 v.21 no.10 pp. 3746-3749
- ISSN:
- 1523-7052
- Subject:
- beta-lactams, etc ; calcium carbide; chemical reactions; chemical structure; synthesis; Show all 5 Subjects
- Abstract:
- ... A new Kinugasa reaction protocol has been elaborated for the one-pot synthesis of 4-substituted β-lactams utilizing calcium carbide and nitrone derivatives. Calcium carbide is thereby activated by TBAF·3H₂O in the presence of CuCl/NMI. The ease of synthesis and use of inexpensive chemicals provides rapid access of practical quantities of β-lactams exclusively substituted at position 4. ...
- DOI:
- 10.1021/acs.orglett.9b01192
-
http://dx.doi.org/10.1021/acs.orglett.9b01192
- Author:
- Jonek, Markus; Buhl, Hannes; Leibold, Michael; Bruhn, Clemens; Siemeling, Ulrich
- Source:
- Zeitschrift für Naturforschung 2019 v.74 no.4 pp. 365-372
- ISSN:
- 1865-7117
- Subject:
- beta-lactams, etc ; X-ray diffraction; deprotonation; isomers; selenium; Show all 5 Subjects
- Abstract:
- ... The reaction of [iPr₂N=CHCl]Cl with 2-phenylbenzthiazolidine (Ph-BtzH) and subsequent anion metathesis afforded the formamidinium salt [(Ph-Btz)CH(NiPr₂)][PF₆] ([1aH][PF₆]). The reaction of [1aH][PF₆] with (Me₃Si)₂NNa in the presence of grey selenium furnished the selenourea derivative 1aSe as trapping product of the acyclic diaminocarbene 1a. In the absence of selenium, a 2H-1,4-benzothiazine der ...
- DOI:
- 10.1515/znb-2019-0017
-
https://dx.doi.org/10.1515/znb-2019-0017