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1. Real-time PCR, and Recombinase Polymerase Amplification combined with SYBR Green I for naked-eye detection, along with Propidium Monoazide (PMA) for the detection of viable patulin-producing fungi in apples and by-products

Author:
Foteini Roumani; Jorge Barros-Velázquez; Alejandro Garrido-Maestu; Marta Prado
Source:
Food control 2023 v.144 pp. 109347
ISSN:
0956-7135
Subject:
biochemical pathways,   etc   ; DNA; Penicillium; food safety; genes; patulin; propidium; quantitative polymerase chain reaction; recombinase polymerase amplification; toxicity;     Show all 10 Subjects
Abstract:
... Nowadays, the application of rapid molecular-based methods such as PCR/qPCR and isothermal techniques like Recombinase Polymerase Amplification (RPA), has increased in order to overcome some of the drawbacks of traditional culture-based methods due to their high sensitivity and specificity. One of the main limitations of these techniques is their inability to differentiate between live and dead mi ...
DOI:
10.1016/j.foodcont.2022.109347

2. Yeasts from fermented Brazilian fruits as biotechnological tools for increasing phenolics bioaccessibility and improving the volatile profile in derived pulps

Author:
Elvira de Lourdes Chaves Macêdo; Tatiana Colombo Pimentel; Dirceu de Sousa Melo; Angélica Cristina de Souza; Janne Santos de Morais; Marcos dos Santos Lima; Disney Ribeiro Dias; Rosane Freitas Schwan; Marciane Magnani
Source:
Food chemistry 2023 v.401 pp. 134200
ISSN:
0308-8146
Subject:
biochemical pathways,   etc   ; Hanseniaspora opuntiae; Spondias; acetic acid; bioavailability; caatinga; digestion; ecosystems; fermentation; food chemistry; fruits; phenolic compounds; pulp; soursops; volatile compounds; yeasts;     Show all 16 Subjects
Abstract:
... Caatinga Biome fruits have been scarcely explored as a source of biotechnological yeasts. This study isolated yeasts from naturally fermented Caatinga fruits and evaluated Hanseniaspora opuntiae125,Issatchenkia terricola 129, and Hanseniaspora opuntiae 148 on fermentation of soursop and umbu-cajá pulps. All strains were able to ferment the pulps (72 h), increasing (p < 0.05) acetic acid, phenolics ...
DOI:
10.1016/j.foodchem.2022.134200

3. Novel electro-assisted micro-aerobic cathode biological technology induces oxidative demethylation of N, N-dimethylformamide for efficient ammonification of refractory membrane-making wastewater

Author:
Guang Yang; Hui Xu; Yudong Luo; Shengqiang Hei; Guangqing Song; Xia Huang
Source:
Journal of hazardous materials 2023 v.442 pp. 130001
ISSN:
0304-3894
Subject:
biochemical pathways,   etc   ; acidification; aeration; ammonia; ammonification; ammonium nitrogen; biodegradation; cathodes; chemical oxygen demand; demethylation; fermentation; hydrolysis; metagenomics; microbial communities; nitrification; oxygen; toxicology; wastewater;     Show all 18 Subjects
Abstract:
... Recalcitrant and toxicological membrane-making wastewater displays negative impacts on environment, and this is difficult to treat efficiently using conventional hydrolytic acidification. In this study, a novel electro-assisted biological reactor with micro-aerobic cathode (EABR-MAC) was developed to improve the biodegradation and ammonification of N, N-dimethylformamide (DMF) in membrane-making w ...
DOI:
10.1016/j.jhazmat.2022.130001

4. Tocopherol-assisted magnetic Ag-Fe3O4-TiO2 nanocomposite for photocatalytic bacterial-inactivation with elucidation of mechanism and its hazardous level assessment with zebrafish model

Author:
Rajaiah Alexpandi; Gurusamy Abirami; Balaji Murugesan; Ravindran Durgadevi; Roshni Prithiviraj Swasthikka; Yurong Cai; Thennarasu Ragupathi; Arumugam Veera Ravi
Source:
Journal of hazardous materials 2023 v.442 pp. 130044
ISSN:
0304-3894
Subject:
biochemical pathways,   etc   ; Danio rerio; bacterial contamination; cell membranes; death; magnetism; models; nanocomposites; nanomaterials; oxidative stress; photocatalysis; photocatalysts; proteomics; seawater; solar radiation; toxicity; water treatment;     Show all 17 Subjects
Abstract:
... In recent years, many endeavours have been prompted with photocatalytic nanomaterials by the need to eradicate pathogenic microorganisms from water bodies. Herein, a tocopherol-assisted Ag-Fe₃O₄-TiO₂ nanocomposite (TAFTN) was synthesized for photocatalytic bacterial inactivation. The prepared TAFTN became active under sunlight due to its narrowed bandgap, inactivating the bacterial contaminants vi ...
DOI:
10.1016/j.jhazmat.2022.130044

5. Induction of viable but nonculturable Salmonella spp. in liquid eggs by mild heat and subsequent resuscitation

Author:
Yue Zhang; Xinyu Liao; Jinsong Feng; Donghong Liu; Shiguo Chen; Tian Ding
Source:
Food microbiology 2023 v.109 pp. 104127
ISSN:
0740-0020
Subject:
biochemical pathways,   etc   ; Salmonella Enteritidis; Salmonella Newport; digestion; egg industry; eggs; food microbiology; genes; heat; heat treatment; liquid egg white; liquid egg yolk; liquids; sigma factors;     Show all 14 Subjects
Abstract:
... Salmonella spp. is one of the leading causes of foodborne outbreaks worldwide. Salmonella spp. has been associated with a variety of food sources, particularly egg products. They can enter a viable but nonculturable (VBNC) state in response to harsh stress. VBNC cells still retain membrane integrity and metabolic activity, which may pose health risks. However, the formation mechanism and resuscita ...
DOI:
10.1016/j.fm.2022.104127

6. Structure elucidation and in vitro rat intestinal fermentation properties of a novel sulfated glucogalactan from Porphyra haitanensis

Author:
Peilin Chen; Lu Liu; Zirun Cheng; Yi Zhang; Baodong Zheng; Xiaoke Hu; Hongliang Zeng
Source:
Food science and human wellness 2023 v.12 no.2 pp. 596-606
ISSN:
2213-4530
Subject:
biochemical pathways,   etc   ; Desulfovibrio; Lactobacillus; Porphyra; algae; butyric acid; cholesterol metabolism; fermentation; food science; functional foods; humans; intestines; inulin; microorganisms; nucleotide sequences; prediction; rats; sequence analysis;     Show all 18 Subjects
Abstract:
... This study was to investigate the structure and rat fecal microbial fermentation properties of a polysaccharide fraction (PHP2) isolated from the red marine alga Porphyra haitanensis. PHP2 was characterized as a sulfated glucogalactan, with a hypothetical backbone structure of →4)Gα(1→6)G4Sβ(1→4)Glc(1→ and a side chain of Man(1→6)Glc. PHP2 had an irregular spherical chain conformation. The 16S rRN ...
DOI:
10.1016/j.fshw.2022.07.062

7. Changes in arsenic accumulation and metabolic capacity after environmental management measures in mining area

Author:
Chen Zhao; Meng Du; Jun Yang; Guanghui Guo; Lingqing Wang; Yunxian Yan; Xuewen Li; Mei Lei; Tongbin Chen
Source:
Science of the total environment 2023 v.855 pp. 158652
ISSN:
0048-9697
Subject:
biochemical pathways,   etc   ; alcohol drinking; alcohols; algorithms; arsenic; biomarkers; biomass; cigarettes; environment; fuels; males; metabolism; metabolites; methylation; occupations; public health; soil remediation; soil restoration; urine; vegetables; wood; China;     Show all 22 Subjects
Abstract:
... Due to the public health concern of arsenic, environmental management measures in mining areas had been implemented. To assess the effect of environmental management measures in the mining area comprehensively, arsenic accumulation in the urine, hair, nails, and urinary metabolites of residents in a realgar mining area in Hunan province, China were investigated in 2019, and the changes in arsenic ...
DOI:
10.1016/j.scitotenv.2022.158652

8. Coupling methanotrophic denitrification to anammox in a moving bed biofilm reactor for nitrogen removal under hypoxic conditions

Author:
Ting Xie; Xinyu Liu; Yiming Xu; Samuel Bryson; Lu Zhao; Kai Huang; Shiqi Huang; Xiaoming Li; Qi Yang; Huiyu Dong; Mari-Karoliina H. Winkler
Source:
Science of the total environment 2023 v.856 pp. 158795
ISSN:
0048-9697
Subject:
biochemical pathways,   etc   ; Archaea; Comamonadaceae; Ignavibacteriaceae; Methylobacter; Methylomonas; Methylophilaceae; Opitutaceae; Thauera; ammonium; anaerobic ammonium oxidation; biofilm; denitrification; denitrifying microorganisms; environment; fish; genes; methane; methanol; methanotrophs; nitrates; nitrites; nitrogen;     Show all 23 Subjects
Abstract:
... Simultaneous removal of ammonium and nitrate was achieved in a methane-fed moving bed biofilm reactor (MBBR). In the reactor, methanotrophic microorganisms oxidized methane under hypoxic conditions likely to methanol, hence providing an electron donor to denitrifiers to reduce nitrate to nitrite that then allowed anaerobic ammonium oxidizing bacteria (Anammox) to remove excess ammonium as N₂. The ...
DOI:
10.1016/j.scitotenv.2022.158795

9. Toxic effects of long-term dual or single exposure to oxytetracycline and arsenic on Xenopus tropicalis living in duck wastewater

Author:
Jianbin Zhao; Xinyan Li; Yanbin Xu; Yuxin Li; Li Zheng; Tiangang Luan
Source:
Journal of environmental sciences (China) 2023 v.127 pp. 431-440
ISSN:
1001-0742
Subject:
biochemical pathways,   etc   ; Xenopus tropicalis; aquaculture; arsenic; body weight; chronic exposure; collagen; ducks; ecosystems; evolution; fibrosis; growth retardation; hepatotoxicity; inflammation; intestinal microorganisms; intestines; necrosis; oxidative stress; oxytetracycline; wastewater; China;     Show all 21 Subjects
Abstract:
... Direct discharge of aquaculture wastewater may have toxic effects, due to the presence of heavy metals, antibiotics, and even resistant pathogens, but little attention has been given. Here, tanks simulating a wild ecosystem were built to study the effects of long-term exposure to duck wastewater containing oxytetracycline (OTC) and/or arsenic (As) on the growth, physiological function, and gut mic ...
DOI:
10.1016/j.jes.2022.05.049

10. Bioplastic (PHBV) addition to soil alters microbial community structure and negatively affects plant-microbial metabolic functioning in maize

Author:
Robert W. Brown; David R. Chadwick; Huadong Zang; Martine Graf; Xuejun Liu; Kai Wang; Lucy M. Greenfield; Davey L. Jones
Source:
Journal of hazardous materials 2023 v.441 pp. 129959
ISSN:
0304-3894
Subject:
biochemical pathways,   etc   ; DNA barcoding; Zea mays; agroecosystems; ammonium; biodegradability; bioplastics; community structure; corn; dose response; metabolites; microbial activity; microbial communities; microplastics; nitrates; nitrogen; plant growth; soil; soil quality;     Show all 19 Subjects
Abstract:
... Microplastic contamination poses a significant threat to agroecosystem functioning, provoking a move away from the use of conventional oil-based plastics in agriculture, to biodegradable alternatives that may be degraded over a shorter timescale. The impact of these bioplastics on plant and soil health, however, has received relatively little attention. Here, we investigated the effect of soil loa ...
DOI:
10.1016/j.jhazmat.2022.129959

11. Advances in metabolism and genetic control of astringency in persimmon (Diospyros kaki Thunb.) fruit: A review

Author:
Catherine Amorim; Lucimara Rogéria Antoniolli; Bruna Orsi; Ricardo Alfredo Kluge
Source:
Scientia horticulturae 2023 v.308 pp. 111561
ISSN:
0304-4238
Subject:
biochemical pathways,   etc   ; Diospyros kaki; acetaldehyde; anthocyanidins; anthocyanins; astringency; biosynthesis; carbon dioxide; cultivars; ethanol; ethylene; flavanols; fruiting; fruits; gallic acid; mouth; oxidoreductases; persimmons; phenylpropanoids; pollination; polymerization; proanthocyanidins; saliva; sensation; shikimic acid; vacuoles;     Show all 26 Subjects
Abstract:
... Persimmon fruits accumulate proanthocyanidins during development. Proanthocyanidins form insoluble complexes with saliva proteins, which promote a sensation of dryness in the mouth called astringency. Persimmon cultivars are classified according to pollination and the presence of astringency at harvest. The different characteristics between persimmon cultivars lead to different metabolic pathways ...
DOI:
10.1016/j.scienta.2022.111561

12. CRISPR-based metabolic engineering in non-model microorganisms

Author:
Liangyu Lu; Xiaolin Shen; Xinxiao Sun; Yajun Yan; Jia Wang; Qipeng Yuan
Source:
Current opinion in biotechnology 2022 v.75 pp. 102698
ISSN:
0958-1669
Subject:
biochemical pathways,   etc   ; biosynthesis; biotechnology; genome;     Show all 4 Subjects
Abstract:
... Non-model microorganisms possess unique and versatile metabolic characteristics, offering great opportunities as cell factories for biosynthesis of target products. However, lack of efficient genetic tools for pathway engineering represents a big challenge to unlock the full production potential of these microbes. Over the past years, CRISPR systems have been extensively developed and applied to d ...
DOI:
10.1016/j.copbio.2022.102698

13. Computational tools and resources for designing new pathways to small molecules

Author:
Anastasia Sveshnikova; Homa MohammadiPeyhani; Vassily Hatzimanikatis
Source:
Current opinion in biotechnology 2022 v.76 pp. 102722
ISSN:
0958-1669
Subject:
biochemical pathways,   etc   ; biotechnology; enzymatic reactions;     Show all 3 Subjects
Abstract:
... The metabolic engineering community relies on computational methods for pathway design to produce important small molecules in microbial hosts. Metabolic network databases are continuously curated and updated with known and novel reactions that expand the known biochemistry based on different sets of enzymatic reaction rules. To address the complexity of the metabolic networks, elaborate methods w ...
DOI:
10.1016/j.copbio.2022.102722

14. Supramolecular systems chemistry through advanced analytical techniques

Author:
Ankit Jain; Annalisa Calò; Damià Barceló; Mohit Kumar
Source:
Analytical and bioanalytical chemistry 2022 v.414 no.18 pp. 5105-5119
ISSN:
1618-2642
Subject:
biochemical pathways,   etc   ; analytical chemistry; cytoskeleton;     Show all 3 Subjects
Abstract:
... Supramolecular chemistry is the quintessential backbone of all biological processes. It encompasses a wide range from the metabolic network to the self-assembled cytoskeletal network. Combining the chemical diversity with the plethora of functional depth that biological systems possess is a daunting task for synthetic chemists to emulate. The only route for approaching such a challenge lies in und ...
DOI:
10.1007/s00216-021-03824-4

15. Ligand-dependent modulation of MR1-restricted antigen presentation

Author:
Mariolina Salio; Claudia Gonzzalez-Lopez; Natacha Veerapen; Wael Awad; Uzi Gileadi; Giorgio Napolitani; Jamie Rossjohn; Gurdyal S Besra; Vincenzo Cerundolo
Source:
Molecular immunology 2022 v.150 no. pp. -
ISSN:
0161-5890
Subject:
biochemical pathways,   etc   ; antigen presentation; computer simulation; riboflavin;     Show all 4 Subjects
Abstract:
... Mucosal-associated invariant T (MAIT) cells are innate T cells recognising intermediates of the vitamin B2 biosynthetic pathway presented by the monomorphic MR1 molecule. We have demonstrated that in addition to their cytolytic activity important in antimicrobial defence, MAIT cells have also immune-modulatory functions, enhancing DC maturation, in vitro and in vivo. Furthermore, through an in sil ...
DOI:
10.1016/j.molimm.2022.05.055

16. Total Synthesis of (±)-Spiroaxillarone A via a Reversible Sulfa-Michael Addition

Author:
Xianwen Long; Min Zhang; Xiaodong Yang; Jun Deng
Source:
Organic letters 2022 v.24 no.6 pp. 1303-1307
ISSN:
1523-7052
Subject:
biochemical pathways,   etc   ; Plasmodium falciparum; antimalarials; chemical reactions;     Show all 4 Subjects
Abstract:
... A bioinspired strategy is described for the total synthesis of spiroaxillarone A, which exhibited significant antimalarial activity against resistant Plasmodium falciparum (IC₅₀ = 2.32 μM). The key steps include an intermolecular ethanethiol Michael addition, o-quinone Michael addition, and subsequent β-ethanethiol elimination. This synthetic sequence provides a potential biosynthetic pathway of s ...
DOI:
10.1021/acs.orglett.1c04282

17. Applicable Life-History and Molecular Traits for Studying the Effects of Anhydrobiosis on Aging in Tardigrades

Author:
Amit Kumar Nagwani; Łukasz Kaczmarek; Hanna Kmita
Source:
Diversity 2022 v.14 no.8 pp. -
ISSN:
1424-2818
Subject:
biochemical pathways,   etc   ; Tardigrada; anhydrobiosis; humans; life history; models;     Show all 6 Subjects
Abstract:
... Anhydrobiosis is induced by loss of water and indicates dehydration tolerance. Survival of dehydration is possible through changes at different levels of organism organization, including a remarkable reduction in metabolic activity at the cellular level. Thus, anhydrobiosis may be regarded as an anti-aging strategy. Accordingly, two hypotheses named after popular stories, “Sleeping Beauty” and “Th ...
DOI:
10.3390/d14080664

18. Bacillimidazoles A−F, Imidazolium-Containing Compounds Isolated from a Marine Bacillus

Author:
Jia-Xuan Yan; Qihao Wu; Eric J. N. Helfrich; Marc G. Chevrette; Doug R. Braun; Heino Heyman; Gene E. Ananiev; Scott R. Rajski; Cameron R. Currie; Jon Clardy; Tim S. Bugni
Source:
Marine drugs 2022 v.20 no.1 pp. -
ISSN:
1660-3397
Subject:
biochemical pathways,   etc   ; Bacillus (bacteria); antibacterial properties; bioinformatics; glycolysis;     Show all 5 Subjects
Abstract:
... Chemical investigations of a marine sponge-associated Bacillus revealed six new imidazolium-containing compounds, bacillimidazoles A–F (1–6). Previous reports of related imidazolium-containing natural products are rare. Initially unveiled by timsTOF (trapped ion mobility spectrometry) MS data, extensive HRMS and 1D and 2D NMR analyses enabled the structural elucidation of 1–6. In addition, a plaus ...
DOI:
10.3390/md20010043

19. Biosynthesis, total synthesis, and pharmacological activities of aryltetralin-type lignan podophyllotoxin and its derivatives

Author:
Siyu Shen; Yuru Tong; Yunfeng Luo; Luqi Huang; Wei Gao
Source:
Natural product reports 2022 v.39 no.9 pp. 1856-1875
ISSN:
1460-4752
Subject:
biochemical pathways,   etc   ; Podophyllum peltatum; biosynthesis; podophyllotoxin; supply balance;     Show all 5 Subjects
Abstract:
... Podophyllotoxin (PTOX, 1), a kind of aryltetralin-type lignan, was first discovered in the plant Podophyllum peltatum and its structure was clarified by W. Borsche and J. Niemann in 1932. Due to its potent anti-cancer and anti-viral activities, it is considered one of the molecules most likely to be developed into modern drugs. With the increasing market demand and insufficient storage of natural ...
DOI:
10.1039/d2np00028h

20. High Plasticity of the Amicetin Biosynthetic Pathway in Streptomyces sp. SHP 22-7 Led to the Discovery of Streptcytosine P and Cytosaminomycins F and G and Facilitated the Production of 12F-Plicacetin

Author:
Niraj Aryal; Junhong Chen; Keshab Bhattarai; Oliver Hennrich; Ira Handayani; Markus Kramer; Jan Straetener; Tatjana Wommer; Anne Berscheid; Silke Peter; Norbert Reiling; Heike Brötz-Oesterhelt; Christian Geibel; Michael Lämmerhofer; Yvonne Mast; Harald Gross
Source:
Journal of natural products 2022 v.85 no.3 pp. 530-539
ISSN:
1520-6025
Subject:
biochemical pathways,   etc   ; Streptomyces; cytotoxicity; enantioselectivity; plasticity; pyrimidine nucleosides;     Show all 6 Subjects
Abstract:
... A chemical reinvestigation of the Indonesian strain Streptomyces sp. SHP 22-7 led to the isolation of three new pyrimidine nucleosides, along with six known analogues and zincphyrin. The structures of the new compounds (6, 7, 10) were elucidated by employing spectroscopic techniques (NMR, MS, CD, and IR) as well as enantioselective analyses of methyl branched side chain configurations. Application ...
DOI:
10.1021/acs.jnatprod.1c01051