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1. 1-Deoxysphingolipids

Author:
Lone, M.A.; Santos, T.; Alecu, I.; Silva, L.C.; Hornemann, T.
Source:
Biochimica et biophysica acta 2019 v.1864 no.4 pp. 512-521
ISSN:
1388-1981
Subject:
biochemical pathways,   etc   ; eukaryotic cells; sphingolipids;     Show all 3 Subjects
Abstract:
... Sphingolipids (SLs) are fundamental components of eukaryotic cells. 1-Deoxysphingolipids differ structurally from canonical SLs as they lack the essential C1-OH group. Consequently, 1-deoxysphingolipids cannot be converted to complex sphingolipids and are not degraded over the canonical catabolic pathways. Pathologically elevated 1-deoxySLs are involved in several disease conditions. Within this r ...
DOI:
10.1016/j.bbalip.2018.12.013

2. Advances in heterologous biosynthesis of plant and fungal natural products by modular co-culture engineering

Author:
Chen, Tingting; Zhou, Yiyao; Lu, Yinghua; Zhang, Haoran
Source:
Biotechnology letters 2019 v.41 no.1 pp. 27-34
ISSN:
0141-5492
Subject:
biochemical pathways,   etc   ; biosynthesis; coculture; engineering; fungi;     Show all 5 Subjects
Abstract:
... Heterologous biosynthesis has been long pursued as a viable approach for high efficiency production of natural products with various industrial values. Conventional methods for heterologous biosynthesis use the mono-culture of an engineered microbe for accommodating the whole target biosynthetic pathway to produce the desired product. The emergence of modular co-culture engineering, which divides ...
DOI:
10.1007/s10529-018-2619-z

3. Harnessing Underground Metabolism for Pathway Development

Author:
Rosenberg, Jonathan; Commichau, Fabian M.
Source:
Trends in biotechnology 2019 v.37 no.1 pp. 29-37
ISSN:
0167-7799
Subject:
biochemical pathways,   etc   ; genetically modified organisms; metabolism; synthesis;     Show all 4 Subjects
Abstract:
... Fermentative production of valuable substances is an economically competitive and ecologically sustainable alternative to chemical synthesis, but it is often hampered by detrimental interactions between the heterologous pathway and the host metabolic network. These interactions are diverse and often not understood. However, the growing knowledge about convergently evolved pathways offers an expans ...
DOI:
10.1016/j.tibtech.2018.08.001

4. Visualizing sphingolipid biosynthesis in cells

Author:
Parashuraman, Seetharaman; D’Angelo, Giovanni
Source:
Chemistry and physics of lipids 2019 v.218 pp. 103-111
ISSN:
0009-3084
Subject:
biochemical pathways,   etc   ; biosynthesis; enzymes; metabolites; sphingolipids;     Show all 5 Subjects
Abstract:
... Biosynthetic pathways play a fundamental role in the building and operation of the cell by synthesizing the constituents by which the cell is constructed, and by producing signalling intermediates that play a key role in cell regulation. While a lot is known about the metabolite profile of the cells and about the biochemical pathways through which these metabolites are produced, the cellular local ...
DOI:
10.1016/j.chemphyslip.2018.11.003

5. Sceletorines A and B, two minor novel dimeric alkaloids of Mesembryanthemum tortuosum (synonym Sceletium tortuosum)

Author:
Yin, Hongquan; Ali, Zulfiqar; Ding, Yuanqing; Wang, Yan-Hong; Cunningham, Michael. J.; Ibrahim, Mohamed A.; Chittiboyina, Amar G.; Wang, Wei; Viljoen, Alvaro M.; Khan, Ikhlas A.
Source:
Phytochemistry letters 2019 v.31 pp. 78-84
ISSN:
1874-3900
Subject:
biochemical pathways,   etc   ; Sceletium tortuosum; aerial parts; alkaloids; spectroscopy;     Show all 5 Subjects
Abstract:
... Sceletorines A and B, two unique alkaloids, were isolated for the first time from the aerial parts of Mesembryanthemum tortuosum. Their structures were determined by the extensive spectroscopic methods and their absolute configuration was established with ECD calculations. Plausible biosynthetic pathways for 1 and 2 are proposed and a relationship to the previously assumed artifact, channaine is a ...
DOI:
10.1016/j.phytol.2019.03.013

6. Metagenomic analysis of the inhibitory effect of chromium on microbial communities and removal efficiency in A2O sludge

Author:
Sun, Fu-Lin; Fan, Lei-Lei; Wang, You-Shao; Huang, Li-Yan
Source:
Journal of hazardous materials 2019 v.368 pp. 523-529
ISSN:
0304-3894
Subject:
biochemical pathways,   etc   ; chromium; denitrification; genes; metagenomics; microbial communities; microorganisms; sludge;     Show all 8 Subjects
Abstract:
... This is the first study exploring the effects of persistent Cr(VI) treatment on microbial communities and function as well as the process efficiency of an A2O system. The inhibitory effect was clearly higher at a high Cr(VI) concentration than a low Cr(VI) concentration, and different Cr(VI) concentrations had distinct effects on the microbial communities as well as on the performance efficiency o ...
DOI:
10.1016/j.jhazmat.2019.01.076

7. Lignin structure and its engineering

Author:
Ralph, John; Lapierre, Catherine; Boerjan, Wout
Source:
Current opinion in biotechnology 2019 v.56 pp. 240-249
ISSN:
0958-1669
Subject:
biochemical pathways,   etc   ; cell walls; engineering; genes; lignin; phenolic compounds; polysaccharides;     Show all 7 Subjects
Abstract:
... Studies on lignin structure and its engineering are inextricably and bidirectionally linked. Perturbations of genes on the lignin biosynthetic pathway may result in striking compositional and structural changes that in turn suggest novel approaches for altering lignin and even ‘designing’ the polymer to enhance its value or with a view toward its simpler removal from the cell wall polysaccharides. ...
DOI:
10.1016/j.copbio.2019.02.019

8. Regulatory non-coding sRNAs in bacterial metabolic pathway engineering

Author:
Leistra, Abigail N.; Curtis, Nicholas C.; Contreras, Lydia M.
Source:
Metabolic engineering 2019 v.52 pp. 190-214
ISSN:
1096-7176
Subject:
biochemical pathways,   etc   ; bacteria; metabolism; non-coding RNA; phenotype;     Show all 5 Subjects
Abstract:
... Non-coding RNAs (ncRNAs) are versatile and powerful controllers of gene expression that have been increasingly linked to cellular metabolism and phenotype. In bacteria, identified and characterized ncRNAs range from trans-acting, multi-target small non-coding RNAs to dynamic, cis-encoded regulatory untranslated regions and riboswitches. These native regulators have inspired the design and construc ...
DOI:
10.1016/j.ymben.2018.11.013

9. Affective and metabolic responses to self-selected intensity cycle exercise in young men

Author:
Haile, Luke; Goss, Fredric L.; Andreacci, Joseph L.; Nagle, Elizabeth F.; Robertson, Robert J.
Source:
Physiology & behavior 2019
ISSN:
0031-9384
Subject:
biochemical pathways,   etc   ; cardiorespiratory fitness; exercise; men; oxygen consumption; sports medicine;     Show all 6 Subjects
Abstract:
... Self-selected intensity exercise has resulted in greater affective responses (AR) compared to prescribed exercise of similar intensity and many individuals self-select intensity at a moderate level identified by metabolic analysis. As such, self-selected intensity may be an effective alternative for exercise prescription designed to promote adherence and result in health and fitness benefits. Self ...
DOI:
10.1016/j.physbeh.2019.02.012

10. Iridoid glucosides in the genus Sutera (Scrophulariaceae) as chemotaxonomic markers in tribe Limoselleae

Author:
Gousiadou, Chryssoula; Kokubun, Tetsuo; Albach, Dirk C.; Gotfredsen, Charlotte H.; Jensen, Søren Rosendal
Source:
Phytochemistry 2019 v.158 pp. 149-155
ISSN:
0031-9422
Subject:
biochemical pathways,   etc   ; Microdon; Scrophulariaceae; aucubin; chemotaxonomy; glucosides; verbascoside;     Show all 7 Subjects
Abstract:
... From two species of Sutera (S. foetida and S. cordata) (Scrophulariaceae tribe Limoselleae) were isolated three known secoiridoid glucosides (12–14) as well as four iridoid congeners (8–11), all biosynthetically derived from iridodial glucoside (and/or deoxyloganic acid). In addition, two previously unknown compounds were found, namely a terpenoid glucoside lactone (suterolide, 21) and the phenyle ...
DOI:
10.1016/j.phytochem.2018.10.021

11. Respiration of the sea urchin Mesocentrotus nudus in response to large temperature fluctuations

Author:
Sin, Eunchong; Min, Won Gi; Kim, Yun-Bae; Kim, Tae Won
Source:
Marine environmental research 2019 v.144 pp. 178-185
ISSN:
0141-1136
Subject:
biochemical pathways,   etc   ; Mesocentrotus; animals; habitats; oxygen consumption; temperature; South Korea;     Show all 7 Subjects
Abstract:
... Some subtidal habitats may experience extremely large diel temperature fluctuations. To explore the potential of subtidal animals to regulate their metabolic processes, we investigated how the oxygen consumption rate (MO2) of the sea urchin Mesocentrotus nudus changes in response to extreme temperature fluctuations by mimicking temperature variations recorded at Dokdo Island, Republic of Korea. We ...
DOI:
10.1016/j.marenvres.2019.01.003

12. Hexachlorobenzene Catabolism Involves a Nucleophilic Aromatic Substitution and Flavin-N5-Oxide Formation

Author:
Adak, Sanjoy; Begley, Tadhg P.
Source:
Biochemistry 2019 v.58 no.9 pp. 1181-1183
ISSN:
1520-4995
Subject:
biochemical pathways,   etc   ; Lewis bases; catalytic activity; hexachlorobenzene; metabolism;     Show all 5 Subjects
Abstract:
... HcbA1 is a unique flavoenzyme that catalyzes the first step in the bacterial hexachlorobenzene catabolic pathway. Here we report in vitro reconstitution of the HcbA1-catalyzed reaction. Detailed mechanistic studies provide evidence for nucleophilic aromatic substitution and flavin-N5-oxide formation. ...
DOI:
10.1021/acs.biochem.9b00012

13. Chemistry of the fumiquinazolines and structurally related alkaloids

Author:
Resende, Diana I. S. P.; Boonpothong, Papichaya; Sousa, Emília; Kijjoa, Anake; Pinto, Madalena M. M.
Source:
Natural product reports 2019 v.36 no.1 pp. 7-34
ISSN:
1460-4752
Subject:
biochemical pathways,   etc   ; alkaloids; amino acids; bioactive properties; chemistry; secondary metabolites;     Show all 6 Subjects
Abstract:
... Covering: this review covers the literature from 1992 to 2018 To date, approximately 80 naturally-occurring secondary metabolites which are structurally-related to fumiquinazolines have been isolated, mainly from marine sources. These alkaloids can be classified into twelve different groups and exhibit different structure motifs depending on the amino acids from which they are derived. This review ...
DOI:
10.1039/c8np00043c

14. A sensitive and selective terahertz sensor for the fingerprint detection of lactose

Author:
Han, Baojuan; Han, Zhanghua; Qin, Jianyuan; Wang, Yongmei; Zhao, Zongshan
Source:
Talanta 2019 v.192 pp. 1-5
ISSN:
0039-9140
Subject:
biochemical pathways,   etc   ; electric field; fructose; honors and awards; lactose; transmittance;     Show all 6 Subjects
Abstract:
... Special recognition to molecules is essential for many biochemical processes, thus highly sensitive sensing methods for molecule recognition are strongly demanded. Recently, metamaterials present a unique platform for sensing applications owing to their exotic properties. In the current work, a metamaterial sensor for enhanced fingerprint detection of lactose based on resonant coupling of plasmoni ...
DOI:
10.1016/j.talanta.2018.09.029

15. Efficient glycosylation with glycosyl ortho-allylbenzoates as donors

Author:
Liang, Haijing; Ma, Lixia; Li, Changwei; Peng, Qiang; Wang, Zhaoyan; Zhang, Zhan-xin; Yu, Lan; Liu, Huanxiang; An, Fengli; Xue, Weihua
Source:
Tetrahedron letters 2019 v.60 no.1 pp. 84-87
ISSN:
0040-4039
Subject:
biochemical pathways,   etc   ; chemical structure; glycosides; glycosylation; models; organic compounds;     Show all 6 Subjects
Abstract:
... Glycosylation reactions are significant as they provide access to model compounds that are useful for elucidating biochemical pathways. Herein, we describe the development of glycosyl ortho-alkynylbenzoates as novel, bench-top stable, and readily available glycosyl donors. Glycosylation is promoted by inexpensive trimethylsilyl triflate (TMSOTf) in combination with N-iodosuccinimide (NIS) under mi ...
DOI:
10.1016/j.tetlet.2018.11.061

16. The challenge and potential of photosynthesis: unique considerations for metabolic flux measurements in photosynthetic microorganisms

Author:
Sake, Cara L.; Metcalf, Alexander J.; Boyle, Nanette R.
Source:
Biotechnology letters 2019 v.41 no.1 pp. 35-45
ISSN:
0141-5492
Subject:
biochemical pathways,   etc   ; feedstocks; isotopes; metabolic flux analysis; microorganisms; models; photosynthesis;     Show all 7 Subjects
Abstract:
... Photosynthetic microorganisms have the potential for sustainable production of chemical feedstocks and products but have had limited success due to a lack of tools and deeper understanding of metabolic pathway regulation. The application of instationary metabolic flux analysis (INST-MFA) to photosynthetic microorganisms has allowed researchers to quantify fluxes and identify bottlenecks and metabo ...
DOI:
10.1007/s10529-018-2622-4

17. Systems Metabolic Engineering Strategies: Integrating Systems and Synthetic Biology with Metabolic Engineering

Author:
Choi, Kyeong Rok; Jang, Woo Dae; Yang, Dongsoo; Cho, Jae Sung; Park, Dahyeon; Lee, Sang Yup
Source:
Trends in biotechnology 2019
ISSN:
0167-7799
Subject:
biochemical pathways,   etc   ; host strains; metabolic engineering; synthetic biology;     Show all 4 Subjects
Abstract:
... Metabolic engineering allows development of microbial strains efficiently producing chemicals and materials, but it requires much time, effort, and cost to make the strains industrially competitive. Systems metabolic engineering, which integrates tools and strategies of systems biology, synthetic biology, and evolutionary engineering with traditional metabolic engineering, has recently been used t ...
DOI:
10.1016/j.tibtech.2019.01.003

18. Towards Building a Plant Cell Atlas

Author:
Rhee, Seung Y.; Birnbaum, Kenneth D.; Ehrhardt, David W.
Source:
Trends in plant science 2019
ISSN:
1360-1385
Subject:
biochemical pathways,   etc   ; carbon; cell biology; plant biology; technology;     Show all 5 Subjects
Abstract:
... Enormous societal challenges, such as feeding and providing energy for a growing population in a dramatically changing climate, necessitate technological advances in plant science. Plant cells are fundamental organizational units that mediate the production, transport, and storage of our primary food sources, and they sequester a significant proportion of the world’s carbon. New technologies allow ...
DOI:
10.1016/j.tplants.2019.01.006

19. Understanding and Engineering Distributed Biochemical Pathways in Microbial Communities

Author:
Cao, Xinyun; Hamilton, Joshua J.; Venturelli, Ophelia S.
Source:
Biochemistry 2018 v.58 no.2 pp. 94-107
ISSN:
1520-4995
Subject:
biochemical pathways,   etc   ; microbial communities; microbiome;     Show all 3 Subjects
Abstract:
... Microbiomes impact nearly every environment on Earth by modulating the molecular composition of the environment. Temporally changing environmental stimuli and spatial organization are major variables shaping the structure and function of microbiomes. The web of interactions among members of these communities and between the organisms and the environment dictates microbiome functions. Microbial int ...
DOI:
10.1021/acs.biochem.8b01006

20. Custom-made transcriptional biosensors for metabolic engineering

Author:
Koch, Mathilde; Pandi, Amir; Borkowski, Olivier; Cardoso Batista, Angelo; Faulon, Jean-Loup
Source:
Current opinion in biotechnology 2019 v.59 pp. 78-84
ISSN:
0958-1669
Subject:
biochemical pathways,   etc   ; biosensors; green chemistry; metabolic engineering; models; recombinant fusion proteins; screening; transcription (genetics); transcription factors;     Show all 9 Subjects
Abstract:
... Transcriptional biosensors allow screening, selection, or dynamic regulation of metabolic pathways, and are, therefore, an enabling technology for faster prototyping of metabolic engineering and sustainable chemistry. Recent advances have been made, allowing for routine use of heterologous transcription factors, and new strategies such as chimeric protein design allow engineers to tap into the res ...
DOI:
10.1016/j.copbio.2019.02.016