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1. Effects of artificially induced complete mixing on dissolved organic matter in a stratified source water reservoir

Author:
Zhao, Lingyun; Li, Nan; Huang, Tinglin; Zhang, Haihan; Si, Fan; Li, Kai; Qi, Yunzhi; Hua, Fengyao; Huang, Cheng
Source:
Journal of environmental sciences (China) 2022 v.111 pp. 130-140
ISSN:
1001-0742
Subject:
biochemical pathways,   etc   ; biomineralization; dissolved organic carbon; dissolved oxygen; molecular weight; water quality; water reservoirs; water temperature; China;     Show all 9 Subjects
Abstract:
... Naturally complete mixing promotes the spontaneous redistribution of dissolved oxygen (DO), representing an ideal state for maintaining good water quality, and conducive to the biomineralization of organic matter. Water lifting aerators (WLAs) can extend the periods of complete mixing and increase the initial mixing temperature. To evaluate the influence of artificial-induced continuously mixing o ...
DOI:
10.1016/j.jes.2021.03.024

2. Combination of mesenchymal stromal cells and machine perfusion is a novel strategy for organ preservation in solid organ transplantation

Author:
Zhao, Lingfei; Hu, Chenxia; Han, Fei; Chen, Dajin; Ma, Yanhong; Cai, Fanghao; Chen, Jianghua
Source:
Cell and tissue research 2021 v.384 no.1 pp. 13-23
ISSN:
0302-766X
Subject:
biochemical pathways,   etc   ; organ transplantation; research;     Show all 3 Subjects
Abstract:
... Organ preservation is a prerequisite for an urgent increase in the availability of organs for solid organ transplantation (SOT). An increasing amount of expanded criteria donor (ECD) organs are used clinically. Currently, the paradigm of organ preservation is shifting from simple reduction of cellular metabolic activity to maximal simulation of an ex vivo physiological microenvironment. An ideal o ...
DOI:
10.1007/s00441-020-03406-3

3. Total synthesis of alstofonidine via its putative biosynthetic congener

Author:
Sridhara Shanmukha Rao, B.; Ramu, Chennam; Sudhakar, Gangarajula
Source:
Tetrahedron 2021 v.82 pp. 131930
ISSN:
0040-4020
Subject:
biochemical pathways,   etc   ; biosynthesis; models; synthesis;     Show all 4 Subjects
Abstract:
... A first total synthesis of alstofonidine is described from the pentacyclic core, an advanced intermediate reported previously. The pentacyclic core facilitated putative biosynthetic congener access, thereby allowing a rapid synthesis of alstofonidine from the proposed biosynthetic pathway. Besides, the model substrate to obtain a simplified bicyclic acetal portion also leveraged in accomplishing s ...
DOI:
10.1016/j.tet.2021.131930

4. Pentacyclic triterpenoids, fuscotorunones A and B, with ε-caprolactone in ring E from Fuscoporia torulosa

Author:
Noji, Masaaki; Yoneyama, Tatsuro; Nishihama, Kouichi; Elshamy, Abdelsamed I.; Hashimoto, Toshihiro; Umeyama, Akemi
Source:
Phytochemistry 2021 v.187 pp. 112748
ISSN:
0031-9422
Subject:
biochemical pathways,   etc   ; Fuscoporia; mushrooms; plant biochemistry; triterpenoids;     Show all 5 Subjects
Abstract:
... Fuscoporia torulosa (Pers.) (Hymenochaetaceae) is a mushroom forming woody fruiting body on living or dead trees. Two curious pentacyclic triterpenoids, fuscotorunones A and B, each of which has a unique ε-caprolactone in ring E, were isolated from the fruiting bodies of F. torulosa. The structures of fuscotorunones A and B were elucidated using MS analyses, IR spectrum and extensive 2D-homo and h ...
DOI:
10.1016/j.phytochem.2021.112748

5. Biorecovery of nanogold and nanogold compounds from gold-containing ores and industrial wastes

Author:
Maluckov, Biljana S.
Source:
Applied microbiology and biotechnology 2021 v.105 no.9 pp. 3471-3484
ISSN:
0175-7598
Subject:
biochemical pathways,   etc   ; biotechnology; gold; nanogold; weather;     Show all 5 Subjects
Abstract:
... In nature, microorganisms developed at various places and adapted to the various weather and geological conditions. Microorganisms participate in geological transformations leading to the dissolution of some minerals and conversion to others. While some microorganisms with their metabolic activity increase the mobility of metals, others cause precipitation of metals and the formation of new minera ...
DOI:
10.1007/s00253-021-11277-z

6. The chemical mechanisms of the enzymes in the branched-chain amino acids biosynthetic pathway and their applications

Author:
Liang, Yan-Fei; Long, Zi-Xian; Zhang, Ya-Jian; Luo, Cai-Yun; Yan, Le-Tian; Gao, Wen-Yun; Li, Heng
Source:
Biochimie 2021 v.184 pp. 72-87
ISSN:
0300-9084
Subject:
biochemical pathways,   etc   ; carbon; leucine; mammals; valine;     Show all 5 Subjects
Abstract:
... l-Valine, l-isoleucine, and l-leucine are three key proteinogenic amino acids, and they are also the essential amino acids required for mammalian growth, possessing important and to some extent, special physiological and biological functions. Because of the branched structures in their carbon chains, they are also named as branched-chain amino acids (BCAAs). This review will highlight the advance ...
DOI:
10.1016/j.biochi.2021.02.008

7. Spatiotemporal metabolic modeling of bacterial life in complex habitats

Author:
Borer, Benedict; Or, Dani
Source:
Current opinion in biotechnology 2021 v.67 pp. 65-71
ISSN:
0958-1669
Subject:
biochemical pathways,   etc   ; bacterial communities; biotechnology; metabolism;     Show all 4 Subjects
Abstract:
... The combination of genome-scale metabolic networks with spatially explicit representation of microbial habitats (spatiotemporal metabolic network modeling) paves the way to predict complex metabolic landscapes to a hitherto unparalleled detail, thus providing new insights into trophic interactions occurring at different scales. Placing detailed bacterial metabolism in realistic physical environmen ...
DOI:
10.1016/j.copbio.2021.01.004

8. Total Syntheses of FR-901235, Auxarthrones A–D, and Lamellicolic Anhydride

Author:
Kiyotaki, Kotaro; Kayukawa, Takuto; Imayoshi, Ayumi; Tsubaki, Kazunori
Source:
Organic letters 2020 v.22 no.23 pp. 9220-9224
ISSN:
1523-7052
Subject:
biochemical pathways,   etc   ; anhydrides; benzene;     Show all 3 Subjects
Abstract:
... In our previous study, an unusual rearrangement reaction was discovered whereby dinaphthyl ketones with three hydroxy groups at restricted positions were transformed into a phenalenone ring and a benzene ring. Using the rearrangement as a key reaction, the first total syntheses of FR-901235 and auxarthrones A–D from an unstable triketone common intermediate are described. Furthermore, lamellicolic ...
DOI:
10.1021/acs.orglett.0c03401

9. Total Synthesis of 6-Amino-2,6-dideoxy-α-Kdo from d-Mannose

Author:
Gamboa Marin, Oscar Javier; Hussain, Nazar; Ravicoularamin, Gokulakrishnan; Ameur, Nassima; Gormand, Paul; Sauvageau, Janelle; Gauthier, Charles
Source:
Organic letters 2020 v.22 no.15 pp. 5783-5788
ISSN:
1523-7052
Subject:
biochemical pathways,   etc   ; antibiotics; mannose;     Show all 3 Subjects
Abstract:
... 3-Deoxy-d-manno-oct-2-ulosonic acid (Kdo) biosynthetic pathway is a promising target in antibacterial drug discovery. Herein, we report the total synthesis of 6-amino-2,6-dideoxy-α-Kdo in 15 steps from d-mannose as a potential inhibitor of Kdo-processing enzymes. Key steps of the synthetic sequence involve a Horner–Wadsworth–Emmons reaction for the two-carbon chain homologation followed by either ...
DOI:
10.1021/acs.orglett.0c01847

10. Changes in the expression of cardiac genes responsive to thyroid hormones in the chickens with cold-induced pulmonary hypertension

Author:
Bahadoran, S.; Hassanpour, H.; Arab, S.; Abbasnia, S.; Kiani, A.
Source:
Poultry science 2021 v.100 no.8 pp. 101263
ISSN:
0032-5791
Subject:
biochemical pathways,   etc   ; cold stress; gene expression; genes; heart; hypertension; hypertrophy;     Show all 7 Subjects
Abstract:
... Cold stress is an environmental cause of pulmonary hypertension syndrome (PHS) in broiler chickens. This factor could increase the rate of metabolic activity via thyroid hormones (T3 and T4). To evaluate the effect of these hormones on the heart, the plasma concentration of T3, T4, and the gene expression of their receptors (THRα and THRβ) and many contractile proteins (ACTC1, MHCα, MHCβ, RYR2, SE ...
DOI:
10.1016/j.psj.2021.101263

11. Robustness analysis and identification for an enzyme-catalytic complex metabolic network in batch culture

Author:
Yang, Qi; Chen, Qunbin; Niu, Teng; Feng, Enmin; Yuan, Jinlong
Source:
Bioprocess and biosystems engineering 2021 v.44 no.7 pp. 1511-1524
ISSN:
1615-7591
Subject:
biochemical pathways,   etc   ; algorithms; bioprocessing; biotransformation; energy; fermentation; glycerol; humans; models;     Show all 9 Subjects
Abstract:
... Bioconversion of glycerol to 1,3-propanediol is a promising way to mitigate the shortage of energy. To maximize the production of 1,3-propanediol, it needs to control precisely microbial fermentation process. However, it might consume lots of human and material resources when conducting experimental tests many times. In this study, a nonlinear enzyme-catalytic dynamical system is developed to desc ...
DOI:
10.1007/s00449-021-02535-5

12. A multi-objective hybrid machine learning approach-based optimization for enhanced biomass and bioactive phycobiliproteins production in Nostoc sp. CCC-403

Author:
Saini, Dinesh Kumar; Rai, Amit; Devi, Alka; Pabbi, Sunil; Chhabra, Deepak; Chang, Jo-Shu; Shukla, Pratyoosh
Source:
Bioresource technology 2021 v.329 pp. 124908
ISSN:
0960-8524
Subject:
biochemical pathways,   etc   ; Nostoc; biomass; dietary supplements; dyes; models; pH; phycobiliprotein;     Show all 8 Subjects
Abstract:
... The cyanobacterial phycobiliproteins (PBPs) are an important natural colorant for nutraceutical industries. Here, a multi-objective hybrid machine learning-based optimization approach was used for enhanced cell biomass and PBPs production simultaneously in Nostoc sp. CCC-403. A central composite design (CCD) was employed to design an experimental setup for four input parameters, including three BG ...
DOI:
10.1016/j.biortech.2021.124908

13. Bioproduction of biomacromolecules for antiviral applications

Author:
Connor, Alexander J; Zha, Runye H; Koffas, Mattheos
Source:
Current opinion in biotechnology 2021 v.69 pp. 263-272
ISSN:
0958-1669
Subject:
biochemical pathways,   etc   ; antiviral properties; biotechnology; health services; molecular weight; stereochemistry;     Show all 6 Subjects
Abstract:
... The societal damage brought on by viral epidemics indicates that next-generation antiviral treatments must be developed and deployed. Biomacromolecules are a diverse class of compounds that can potentially exhibit potent antiviral activity. Their efficacy and mechanisms of action are dependent upon multiple structural factors, including molecular weight, degree and position of sulfation, and backb ...
DOI:
10.1016/j.copbio.2021.01.022

14. Enhanced Lutein Production in Chlamydomonas reinhardtii by Overexpression of the Lycopene Epsilon Cyclase Gene

Author:
Tokunaga, Saki; Morimoto, Daichi; Koyama, Takahisa; Kubo, Yuki; Shiroi, Mai; Ohara, Kanta; Higashine, Tokuhiro; Mori, Yuki; Nakagawa, Satoshi; Sawayama, Shigeki
Source:
Applied biochemistry and biotechnology 2021 v.193 no.6 pp. 1967-1978
ISSN:
0273-2289
Subject:
biochemical pathways,   etc   ; Chlamydomonas reinhardtii; biotechnology; genes; lutein; lycopene; metabolism; microalgae;     Show all 8 Subjects
Abstract:
... Chlamydomonas reinhardtii is a well-established microalgal model species with a shorter doubling time, which is a promising natural source for the efficient production of high-value carotenoids. In the microalgal carotenoid biosynthetic pathway, lycopene is converted either into β-carotene by lycopene β-cyclase or into α-carotene by lycopene ε-cyclase (LCYE) and lycopene β-cyclase. In this study, ...
DOI:
10.1007/s12010-021-03524-w

15. Pathway elucidation and engineering of plant-derived diterpenoids

Author:
Shao, Jie; Sun, Yuwei; Liu, Haili; Wang, Yong
Source:
Current opinion in biotechnology 2021 v.69 pp. 10-16
ISSN:
0958-1669
Subject:
biochemical pathways,   etc   ; biosynthesis; biotechnology; chemosynthesis; diterpenoids; humans; plant development;     Show all 7 Subjects
Abstract:
... Plant-derived diterpenoids are indispensable to plant development, stress-resistance and interaction with environmental microorganisms. Besides significant roles in plant fitness and adaption, many bioactivities beneficial to human beings are also found in diterpenoids from terrestrial plants. However, these high-value compounds are always present in limited species with low-abundance. Complicated ...
DOI:
10.1016/j.copbio.2020.08.007

16. Positive allometry of sexually selected traits: Do metabolic maintenance costs play an important role?

Author:
Somjee, Ummat
Source:
BioEssays 2021 v.43 no.6 pp. e2000183
ISSN:
0265-9247
Subject:
biochemical pathways,   etc   ; allometry; body size; energy; sexual selection;     Show all 5 Subjects
Abstract:
... Sexual selection drives the evolution of some of the most exaggerated traits in nature. Studies on sexual selection often focus on the size of these traits relative to body size, but few focus on energetic maintenance costs of the tissues that compose them, and the ways in which these costs vary with body size. The relationships between energy use and body size have consequences that may allow lar ...
DOI:
10.1002/bies.202000183

17. Synthetic production of prenylated naringenins in yeast using promiscuous microbial prenyltransferases

Author:
Isogai, Shota; Okahashi, Nobuyuki; Asama, Ririka; Nakamura, Tomomi; Hasunuma, Tomohisa; Matsuda, Fumio; Ishii, Jun; Kondo, Akihiko
Source:
Metabolic Engineering Communications 2021 v.12 pp. e00169
ISSN:
2214-0301
Subject:
biochemical pathways,   etc   ; dimethylallyltranstransferase; genomics; naringenin; phenylalanine; regioselectivity; synthesis; tryptophan; yeasts;     Show all 9 Subjects
Abstract:
... Reconstitution of prenylflavonoids using the flavonoid biosynthetic pathway and prenyltransferases (PTs) in microbes can be a promising attractive alternative to plant-based production or chemical synthesis. Here, we demonstrate that promiscuous microbial PTs can be a substitute for regiospecific but mostly unidentified botanical PTs. To test the prenylations of naringenin, we constructed a yeast ...
DOI:
10.1016/j.mec.2021.e00169

18. Tropane alkaloid biosynthesis in Datura innoxia Mill. roots and their differential transport to shoots

Author:
Schlesinger, Daniel; Davidovich Rikanati, Rachel; Faigenboim, Adi; Vendramin, Vera; Cattonaro, Federica; Inbar, Moshe; Lewinsohn, Efraim
Source:
Phytochemistry letters 2021 v.43 pp. 219-225
ISSN:
1874-3900
Subject:
biochemical pathways,   etc   ; Datura inoxia; atropine; biosynthesis; phenylalanine; plant biochemistry; scopolamine;     Show all 7 Subjects
Abstract:
... Pharmacologically important tropane alkaloids such as hyoscyamine, and scopolamine, are synthesized in the roots of several Solanaceae and also accumulate in their shoots. The tropane alkaloids content in roots of D. innoxia seedlings was almost 3-fold higher than in their shoots. Moreover, scopolamine accounted for 77 % of the total tropane alkaloid content in shoots as compared to only 20 % in r ...
DOI:
10.1016/j.phytol.2021.04.012

19. Microbial Metabolic Pathways and the “Fermented Plant Foods—Human Health” Axis

Author:
Di Cagno, Raffaella; Filannino, Pasquale; Gobbetti, Marco
Source:
Foods 2021 v.10 no.5
ISSN:
2304-8158
Subject:
biochemical pathways,   etc   ; Axis axis; fermentation; functional foods; plant health; planting;     Show all 6 Subjects
Abstract:
... Plant matrices are widely recognized as valuable sources of several health promoting compounds [...] ...
DOI:
10.3390/foods10051105

20. Advances in the World of Bacterial Microcompartments

Author:
Stewart, Andrew M.; Stewart, Katie L.; Yeates, Todd O.; Bobik, Thomas A.
Source:
Trends in biochemical sciences 2021 v.46 no.5 pp. 406-416
ISSN:
0968-0004
Subject:
biochemical pathways,   etc   ; biotechnology; human diseases; organelles; proteins; toxicity;     Show all 6 Subjects
Abstract:
... Bacterial microcompartments (MCPs) are extremely large (100–400 nm) and diverse proteinaceous organelles that compartmentalize multistep metabolic pathways, increasing their efficiency and sequestering toxic and/or volatile intermediates. This review highlights recent studies that have expanded our understanding of the diversity, structure, function, and potential biotechnological uses of MCPs. Se ...
DOI:
10.1016/j.tibs.2020.12.002